Article
Multidisciplinary Sciences
Hagar S. S. Abd-Rabou, Hanem M. M. Mansour, O. H. Matloup, S. M. A. Sallam, M. A. Elazab
Summary: This research aimed to investigate the properties of bio rayeb milk that results from goats fed on feed supplemented with different concentrations of coriander oil. The study found that supplementing feed with a low concentration of coriander oil significantly decreased the viscosity and monounsaturated fatty acid content of the bio rayeb milk, while increasing the DPPH inhibition and monounsaturated fatty acid content.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Sifan Yan, Satoshi Komasa, Akinori Agariguchi, Giuseppe Pezzotti, Joji Okazaki, Kenji Maekawa
Summary: This study aims to improve the surface properties of pure titanium and circumvent the negative effects of material aging on dental implants. The results show that nonthermal atmospheric-pressure nitrogen plasma treatment can enhance the hydrophilicity of pure titanium and promote cell attachment, proliferation, and osseointegration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Jin Leng, Ye He, Zhang Yuan, Bailong Tao, Ke Li, Chuanchuan Lin, Kun Xu, Maowen Chen, Liangliang Dai, Xuemin Li, Tony Jun Huang, Kaiyong Cai
Summary: A hybrid hydrogel coating was constructed on ZnO structure of titanium, demonstrating enzymatic-degradability when bacteria exist and antibacterial activity. The coating provided a stable buffer zone for cell ingrowth and soft tissue integration, while reducing ZnO toxicity and improving fibroblast viability. This study proposes a self-adaptive strategy for ZnO improvement, preserving both antibacterial ability and soft tissue compatibility under different conditions.
BIOACTIVE MATERIALS
(2021)
Article
Food Science & Technology
Sara Alvarez, Shihan Weng, Carlos Alvarez, Ismael Marcet, Manuel Rendueles, Mario Diaz
Summary: This study successfully described a new method to prepare water-insoluble edible films from bovine and porcine blood plasma, without the use of crosslinkers, for the production of sustainable packaging materials. The new films showed superior visual appearance, microstructure, and mechanical properties compared to the control film.
FOOD PACKAGING AND SHELF LIFE
(2021)
Article
Multidisciplinary Sciences
Juliane D. Glaeser, Xianchao Bao, Giselle Kaneda, Pablo Avalos, Phillip Behrens, Khosrowdad Salehi, Xiaoyu Da, Angel Chen, Chloe Castaneda, Pawel Nakielski, Wensen Jiang, Wafa Tawackoli, Dmitriy Sheyn
Summary: Cranial bone loss is a clinical challenge for craniofacial reconstruction. Induced pluripotent stem cells (iPSCs) can differentiate into mesenchymal stromal cells (MSCs) which show potential for bone regeneration. Overexpression of BMP6 in iPSC-derived cells via neural crest or mesoderm, embedded in 3D printable bio-ink, can generate viable bone graft alternatives for cranial reconstruction.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Maria Kitsara, Gaelle Revet, Jean-Sebastien Vartanian-Grimaldi, Alexandre Simon, Mathilde Minguy, Antoine Miche, Vincent Humblot, Thierry Dufour, Onnik Agbulut
Summary: In this study, the hydrophilicity and biocompatibility of polyvinylidene fluoride (PVDF) scaffolds were enhanced using cold plasma treatment, showing potential application in cardiovascular tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hitomi Tsujita, Hiroshi Nishizaki, Akiko Miyake, Seiji Takao, Satoshi Komasa
Summary: The study showed that titanium implants treated with atmospheric-pressure plasma induced more new bone formation in rat femurs, exhibiting higher hard tissue differentiation ability and contributing to achieving initial stability after implant placement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Adriana Vilaca, Rui M. A. Domingues, Hanna Tiainen, Barbara B. Mendes, Alejandro Barrantes, Rui L. Reis, Manuela E. Gomes, Manuel Gomez-Florit
Summary: A multifunctional implant surface, based on the controlled deposition of cellulose nanocrystals (CNC) and biological activity derived from platelet lysate (PL) biomolecules, is proposed to promote soft tissue integration to metallic implants while preventing bacterial invasion, tissue inflammation, and failure of biomedical metallic implants. The anisotropic radial nanopatterns on polished titanium surfaces guide fibroblasts growth and alignment, while PL-derived biomolecules polarize macrophages toward the M2-like anti-inflammatory phenotype.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Shailja Mishra, Biswajit Hansda, Ankit Ghosh, Sneha Mondal, Bhabatosh Mandal, Pallavi Kumari, Basudev Das, Tanay Kumar Mondal, Tirtha Biswas
Summary: Enzymes have great potential in industrial applications, but utilizing them at high efficiency levels, especially above room temperature, has not been fully realized. The immobilization of papain onto homo-functionalized silica gel via multipoint covalent attachment has successfully addressed this issue, resulting in a stable and reusable enzyme catalyst with improved activity and adaptability to higher temperatures.
Article
Engineering, Environmental
Haifeng Zhang, Jiajun Qiu, Min Xing, Xingdan Liu, Xiaohan Ma, Liping Ouyang, Yuqin Qiao, Wenhao Qian, Xuanyong Liu
Summary: This study successfully enhanced the antibacterial activity and tissue integration ability of medical titanium surfaces by applying cerium-based metal-organic framework (Ce-BTC) coatings using hydrogen plasma immersion ion implantation (H-PIII) treatment. The Ce-BTC coatings showed improved adenosine triphosphate (ATP) deprivation capacity, oxidase-like activity, fibroblast response, and antibacterial properties. This research provides a potential solution for implant-associated infections.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Cecilia Primo, Catherine Navarre, Francois Chaumont, Bruno Andre
Summary: This research discovered that TORC1 activity in tobacco cells is strongly influenced by the activity of plasma membrane H+-ATPases. When H+-ATPases are stimulated by fusicoccin, TORC1 activity can be activated. These results suggest that plant H+-ATPases play an important role in TOR signaling.
Article
Microbiology
S. Doublier, S. Cirrincione, R. Scardaci, C. Botta, C. Lamberti, F. Di Giuseppe, S. Angelucci, K. Rantsiou, L. Cocolin, E. Pessione
Summary: Probiotics may control the proliferation of colorectal cancer cells and improve their response to chemotherapy by releasing bioactive compounds, such as butyrate, extracellular polysaccharides, and specific proteins.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Biology
Steffen M. Recktenwald, Greta Simionato, Marcelle G. M. Lopes, Fabia Gamboni, Monika Dzieciatkowska, Patrick Meybohm, Kai Zacharowski, Andreas von Knethen, Christian Wagner, Lars Kaestner, Angelo D'Alessandro, Stephan Quint
Summary: The flow properties and shape of red blood cells in COVID-19 patients are significantly impaired, but these changes are reversible when suspended in healthy plasma. The study also reveals a new role of red blood cells in maintaining plasma equilibrium. These findings provide a framework for further investigations into the treatment of COVID-19 and other infectious diseases.
Article
Multidisciplinary Sciences
Kyoungmin Lee, Jongwon Lee, Jungmin Choi, Sung Hoon Sim, Jeong Eun Kim, Min Hwan Kim, Yeon Hee Park, Jee Hyun Kim, Su-Jin Koh, Kyong Hwa Park, Myoung Joo Kang, Mi Sun Ahn, Kyoung Eun Lee, Hee-Jun Kim, Hee Kyung Ahn, Han Jo Kim, Keon Uk Park, In Hae Park
Summary: We investigated the genetic alterations in heavily treated HER2+ metastatic breast cancer patients. Through targeted sequencing of ctDNA, we identified 65 pathogenic gene alterations in 99 samples. TP53 and PIK3CA mutations, as well as higher ctDNA fraction, correlated with shorter progression-free survival. HRD-related gene mutations were more frequent in ctDNA and associated with resistance to treatment. New pathogenic variants were found at the end of treatment.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Yujiro Kawai, Shugo Tohyama, Kenichi Arai, Tadashi Tamura, Yusuke Soma, Keiichi Fukuda, Hideyuki Shimizu, Koichi Nakayama, Eiji Kobayashi
Summary: Engineered heart tissues created using human induced pluripotent stem cells have potential as cardiac tissue substitutes. In this study, scaffold-free tubular heart tissues were constructed using bio-3D printing and transplanted into mice, showing higher maturity compared to other transplanted tissues. This could be a treatment option for patients with congenital heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Tao Zhu, Lening Shen, Dong Zhang, Jie Zheng, Xiong Gong
Summary: In this study, solution-processed ultrahigh detectivity broadband photodetectors based on ternary perovskite-organic composites were developed. By incorporating low optical gap n-type organic molecules into three-dimensional and two-dimensional perovskites, the photodetectors exhibited a broad spectral response from ultraviolet-visible to near-infrared region and showed improved film characteristics and enhanced photocurrent compared to the 2D/3D mixed perovskite composites.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Lening Shen, Yongrui Yang, Tao Zhu, Lei Liu, Jie Zheng, Xiong Gong
Summary: Perovskite solar cells (PSCs) are cost-effective solar technology. This study developed a novel all-inorganic perovskite that improved the performance and stability of the cells through heterovalent substitution. Additionally, surface passivation technique further enhanced the device performance. This approach provides a facile way to achieve high-performance PSCs.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemical Research Methods
Dongya Qin, Weichen Bo, Xin Zheng, Youjin Hao, Bo Li, Jie Zheng, Guizhao Liang
Summary: This study constructed a database of 6276 food-derived bioactive peptides from different sources and developed a series of analysis tools for studying their function, traceability, multifunctionality, and physicochemical properties. The study also discovered new food-derived bioactive peptides that have potential as drugs for cardiovascular diseases.
Article
Chemistry, Physical
Luyao Zheng, Lening Shen, Tao Zhu, Dong Zhang, Jie Zheng, Xiong Gong
Summary: This study demonstrates that the combination of three-dimensional and two-dimensional perovskites can create a bilayer structure that enables stable and efficient perovskite solar cells. The results show that discrete two-dimensional perovskite crystals on the surface of the three-dimensional perovskite film improve water resistance without sacrificing optoelectronic properties, resulting in over 23% power conversion efficiency and increased stability.
Article
Chemistry, Multidisciplinary
Yijing Tang, Dong Zhang, Xiong Gong, Jie Zheng
Summary: This study demonstrates a rational design strategy of an amyloid-aggregation-induced emission (AIE)-active molecule, G7-TBA, which serves as a multiple-target, dual-function amyloid probe and modulator for detecting, monitoring, and altering amyloid aggregation of different amyloid proteins.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Materials Science, Biomaterials
Tzu-Cheng Sung, Ting Wang, Qian Liu, Qing-Dong Ling, Suresh Kumar Subbiah, Remya Rajan Renuka, Shih-Tien Hsu, Akihiro Umezawa, Akon Higuchi
Summary: Human cells, especially stem cells, require interaction with extracellular matrix (ECM) proteins for various cellular functions. This review discusses the development of synthetic ECM protein-derived peptides that mimic the functions of natural ECM proteins. These peptides can act as agonists for specific ECM protein receptors and have been developed for coating or grafting on various materials to improve cell adhesion, proliferation, and differentiation. The review article provides valuable insights for the optimal choice of ECM protein-derived peptides in tissue engineering applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Polymer Science
Dong Zhang, Yijing Tang, Xiaomin He, William Gross, Jintao Yang, Jie Zheng
Summary: Bilayer hydrogels with smart functions are highly versatile soft materials for biological tissues and human-machine interfaces. However, current fabrication methods are complex and limit the potential applications of bilayer hydrogels. In this study, we developed a one-pot strategy to create bilayer hydrogels with a seamless interface and controllable layer separation efficiency. This approach enables the production of next-generation bilayer hydrogels using a diverse range of monomers.
Article
Materials Science, Biomaterials
Yijing Tang, Dong Zhang, Sarah Robinson, Jie Zheng
Summary: Neurodegenerative diseases and cancers are two families of diseases with opposite cell-death mechanisms. There seems to be an inverse correlation between them, but the pathological links between these two diseases, particularly from a protein-cell interaction perspective, have yet to be proven. A study investigates the effects of three amyloid proteins on pancreatic cancer cells, showing that amyloid proteins have inhibitory activity on cancer cell proliferation through ROS production and membrane disruption.
Article
Biochemistry & Molecular Biology
Yijing Tang, Dong Zhang, Jie Zheng
Summary: This study demonstrates a repurposing strategy for an antimicrobial peptide, PG-1, as an amyloid inhibitor in Alzheimer's disease. PG-1 inhibits Aβ aggregation, disassembles preformed Aβ fibrils, reduces cytotoxicity, and preserves antimicrobial activity against various strains. This work introduces a promising approach to target multiple pathological pathways in AD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Dong Zhang, Yijing Tang, Kaihang Zhang, Yaoting Xue, Si Yu Zheng, Baoyi Wu, Jie Zheng
Summary: A new working principle and fabrication strategy have been reported to construct bilayer hydrogels with a seamless interface and programmable layer thicknesses by controlling spontaneous macrophase separation. These hydrogels can mimic soft tissues and robots to adapt their shapes or motions in response to external stimuli.
Article
Materials Science, Biomaterials
Yijing Tang, Dong Zhang, Xiong Gong, Jie Zheng
Summary: Aurein, an antimicrobial peptide, has been found to have the potential to modulate hIAPP aggregation and inhibit microbial infection, which may have significant implications for the prevention and treatment of type II diabetes (T2D).
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Ting Wang, Tzu-Cheng Sung, Tao Yu, Hui-Yu Lin, Yen-Hung Chen, Zhe-Wei Zhu, Jian Gong, Jiandong Pan, Akon Higuchi
Summary: RNA, including mRNA, siRNA, and miRNA, is a new class of patient treatments that can prevent and treat various diseases. LNPs are commonly used as carriers for RNA drugs and have been shown to efficiently express RNA in vitro and in vivo. Freeze-dried RNA-LNPs offer a method for long-term storage under mild conditions. Future research should focus on optimizing lipid components and cryoprotectants for the development of freeze-dried RNA-LNPs.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Kun-Chih Cheng, Yi-Ming Sun, Shan-hui Hsu
Summary: This study developed a novel ternary soft segment-based biodegradable polyurethane (tPU) for 3D bioprinting and tissue engineering applications. The tPU2 demonstrated lower stiffness, higher tan delta value, and good vitality of neural stem cells (NSCs). It could form double network composite hydrogels with gelatin or agarose, achieving high-resolution bioprinting. Additionally, a series of polyurethane-chitosan composite hydrogels were developed, which exhibited self-healing properties and bioprintability, promoting cell proliferation and neural differentiation of NSCs.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Engineering, Chemical
Yu-Ling Chen, Chi-Chun Lo, Ying-Ling Liu, Yi-Ming Sun
Summary: The study processed brown solid residue from rice straw biorefinery using membrane separation in combination with the Soda-EG process to extract high-purity lignin. After lignin fragmentation, depolymerization, and solubilization, microfiltration was applied to recover the dissolved lignin in the filtrate. Further molecular weight fractionation was achieved by ultrafiltration, resulting in high-value-added lignin products within a specific molecular weight range.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Haoran Wang, Qiyao Li, Parvej Alam, Haotian Bai, Vandana Bhalla, Martin R. Bryce, Mingyue Cao, Chao Chen, Sijie Chen, Xirui Chen, Yuncong Chen, Zhijun Chen, Dongfeng Dang, Dan Ding, Siyang Ding, Yanhong Duo, Meng Gao, Wei He, Xuewen He, Xuechuan Hong, Yuning Hong, Jing-Jing Hu, Rong Hu, Xiaolin Huang, Tony D. James, Xingyu Jiang, Gen-ichi Konishi, Ryan T. K. Kwok, Jacky W. Y. Lam, Chunbin Li, Haidong Li, Kai Li, Nan Li, Wei-Jian Li, Ying Li, Xing-Jie Liang, Yongye Liang, Bin Liu, Guozhen Liu, Xingang Liu, Xiaoding Lou, Xin-Yue Lou, Liang Luo, Paul R. McGonigal, Zong-Wan Mao, Guangle Niu, Tze Cin Owyong, Andrea Pucci, Jun Qian, Anjun Qin, Zijie Qiu, Andrey L. Rogach, Bo Situ, Kazuo Tanaka, Youhong Tang, Bingnan Wang, Dong Wang, Jianguo Wang, Wei Wang, Wen-Xiong Wang, Wen-Jin Wang, Xinyuan Wang, Yi-Feng Wang, Shuizhu Wu, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai-Bo Yang, Lin-Lin Yang, Mingwang Yang, Ying-Wei Yang, Juyoung Yoon, Shuang-Quan Zang, Jiangjiang Zhang, Pengfei Zhang, Tianfu Zhang, Xin Zhang, Xin Zhang, Na Zhao, Zheng Zhao, Jie Zheng, Lei Zheng, Zheng Zheng, Ming-Qiang Zhu, Wei-Hong Zhu, Hang Zou, Ben Zhong Tang
Summary: This review provides a comprehensive summary of the advantages and applications of aggregation-induced emission (AIE) luminogens in imaging of biological structure, dynamic physiological processes, disease diagnosis and treatment, as well as detection and monitoring of specific analytes. It also discusses future directions to promote research and development in the fields of life and health.
