Review
Pharmacology & Pharmacy
Elisa Lacroce, Filippo Rossi
Summary: This review provides an overview of recent studies on the use of temperature as an external stimulus for drug delivery. Thermoresponsive hydrogels, which can be developed using different polymers and micro/nanoparticles, offer a novel approach for local and sustained drug release. The paper compares and discusses thermoresponsive hydrogels in terms of their physical properties and drug release mechanisms.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Chemistry, Inorganic & Nuclear
Hong-Ying Xia, Bo-Yi Li, Yi Zhao, Ya-Hui Han, Shi-Bin Wang, Ai-Zheng Chen, Ranjith Kumar Kankala
Summary: This article provides a comprehensive overview of different forms of MnO2-based nanoplatforms and their applications in the biomedical field. These platforms exhibit excellent physicochemical, morphological, and optoelectronic characteristics, making them suitable for a wide range of applications, including conventional and innovative therapeutic modalities, bioimaging, biosensing, biocatalysis, cell capture/enrichment, and tissue regeneration.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Antonio E. Barberio, Sean G. Smith, Ivan S. Pires, Sonia Iyer, Ferenc Reinhardt, Mariane B. Melo, Heikyung Suh, Robert A. Weinberg, Darrell J. Irvine, Paula T. Hammond
Summary: Ovarian cancer is difficult to treat and has been resistant to immunotherapies. However, a new study shows that systemically delivered nanoparticles can effectively target and engage the immune system as a treatment in multiple ovarian tumor models, including those with low immune response. This therapy demonstrates reduced toxicity and maintained anti-tumor efficacy, resulting in a 30% complete survival rate.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Ana M. Diez-Pascual, Abbas Rahdar
Summary: This review provides an overview of polyelectrolytes (PEs) research and applications. PE films prepared by layer-by-layer (LbL) approach offer precise control over properties and have wide biomedical applications. The review highlights the design and fabrication research of nanofilms and discusses their applications in the biomedical field.
Review
Pharmacology & Pharmacy
Lorenzo Marsili, Michele Dal Bo, Federico Berti, Giuseppe Toffoli
Summary: Chitosan is a natural polysaccharide with biocompatible properties, and has been combined with thermoresponsive polymers for drug delivery applications. This combination offers potential in biomedical applications due to the biodegradability and temperature responsiveness of the polymers.
Article
Medicine, Research & Experimental
Ningrong Chen, Rongguo Ren, Xin Wei, Roshni Mukundan, Guojuan Li, Xiaoke Xu, Gang Zhao, Zhifeng Zhao, Subodh M. Lele, Richard A. Reinhardt, Dong Wang
Summary: SIM is an effective anti-inflammatory and bone anabolic agent, but challenges including poor water solubility hinder its local delivery into periodontal pockets. Researchers developed a novel thermoresponsive hydrogel based on PF127 to dissolve SIM and mitigate periodontal bone loss.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biophysics
Rustem R. Zairov, Alexey P. Dovzhenko, Sergey N. Podyachev, Svetlana N. Sudakova, Timur A. Kornev, Anastasiya E. Shvedova, Alexey N. Masliy, Victor V. Syakaev, Ivan S. Alekseev, Ivan M. Vatsouro, Gulnaz Sh. Mambetova, Dmitry V. Lapaev, Irek R. Nizameev, Francesco Enrichi, Andrey M. Kuznetsov, Vladimir V. Kovalev, Asiya R. Mustafina
Summary: The present work introduces self-assembled polystyrenesulfonate (PSS) molecules as soft nanocapsules for incorporation of Eu3+-Sm3+ complexes. The high levels of Eu3+ and Sm3+ luminescence of the complexes derives from the ligand-to-metal energy transfer. The PSS-nanocapsules provide both colloid and chemical stabilization of the ultrasmall nanoprecipitates of the complexes, while their luminescence spectra patterns and excited state lifetimes differ from the values measured for the complexes in DMF solutions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Physical
Didier Gigmes, Thomas Trimaille
Summary: Amphiphilic copolymer micelles are key candidates in drug delivery, with PLA-based micelles and controlled radical polymerizations offering new opportunities for advanced drug delivery systems. Key properties such as stealth character, cell targeting and stimuli-responsiveness have been advanced in the past decade for PLA/vinyl polymer based nano-carriers.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Engineering, Environmental
Xinyu Wang, Yeli Fan, Junjie Yan, Min Yang
Summary: Polyphenols, compounds found in natural plants, have various beneficial effects such as anti-tumor, anti-inflammatory, and antibacterial capacities. Polyphenol-based polymeric nanoparticles have emerged as promising drug carriers in biomedical engineering.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Stephanie Kong, Pearl Moharil, Abram Handly-Santana, Natalie Boehnke, Richard Panayiotou, Victoria Gomerdinger, Gil Covarrubias, Ivan S. Pires, Ioannis Zervantonakis, Joan Brugge, Paula T. Hammond
Summary: This study demonstrates that co-encapsulation of drug combinations in layer-by-layer nanoparticles (LbL NPs) shows promising results in treating recurrent HGSOC, reducing systemic toxicities and achieving selective uptake by tumor cells.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mariola M. Blaszczyk, Jerzy Sek, Lukasz Przybysz
Summary: This study proposed a model to predict the transport of nanoparticles through the skin based on the diffusion and adsorption concept. Experimental studies on the diffusion process of silver and copper nanoparticles through different membrane layers were conducted. The degree of adsorption was described using a modified Langmuir equation, and its dependence on surface parameters was investigated. The model was then related to the structure of the stratum corneum to predict the changes in mass of penetrating nanoparticles as a function of transport path length. The discussion also covered the influence of nanoparticle size, skin cell thickness, and viscosity of the intercellular cement on the presented model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Applied
Somaye Rashki, Kasra Asgarpour, Hossein Tarrahimofrad, Maryam Hashemipour, Mohammad Saeid Ebrahimi, Hadis Fathizadeh, Ahmad Khorshidi, Haroon Khan, Zeynab Marzhoseyni, Masoud Salavati-Niasari, Hamed Mirzaei
Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.
CARBOHYDRATE POLYMERS
(2021)
Review
Polymer Science
Sagar Pardeshi, Fouad Damiri, Mehrukh Zehravi, Rohit Joshi, Harshad Kapare, Mahendra Kumar Prajapati, Neha Munot, Mohammed Berrada, Prabhanjan S. Giram, Satish Rojekar, Faraat Ali, Md. Habibur Rahman, Hasi Rani Barai
Summary: Temperature-induced changes in the viscosity and formation of 3-D structure make thermosensitive hydrogels ideal for cell scaffolds or drug reservoirs. This review presents a comprehensive overview of the synthesis, mechanism, and biomedical applications of thermosensitive hydrogels, and discusses their commercial potential.
Review
Pharmacology & Pharmacy
Chong Yu, Shuai Wang, Wing-Fu Lai, Dahong Zhang
Summary: Bladder cancer (BC) is the most common cancer of the urinary system and non-muscle-invasive bladder cancer (NMIBC) accounts for the majority of cases. Patients with NMIBC have a good survival rate but are at high risk for tumor recurrence and progression. The use of antitumor agents instilled into the bladder is the standard treatment for NMIBC, but their efficacy is limited due to chemo-resistance and poor drug retention. Chitosan-based nanoparticles offer a promising solution by enhancing drug penetration and improving biomedical applications in bladder cancer treatment.
Review
Pharmacology & Pharmacy
Lorenzo Marsili, Michele Dal Bo, Federico Berti, Giuseppe Toffoli
Summary: Microgels are soft, porous, and deformable particles with an internal gel structure that are swollen by a solvent, making them potential candidates for drug delivery systems. Recent advancements in biodegradable polymer fabrication have led to new strategies in combining synthetic and natural-origin polymers with inorganic nanoparticles for controlled drug release. The use of chitosan-grafted-poly-(N-vinylcaprolactam) microgels in drug delivery and oncology applications is reviewed in this study.
