Review
Food Science & Technology
Chanez Bennacef, Stephane Desobry, Laurent Probst, Sylvie Desobry-Banon
Summary: Encapsulation is a technology used in various industries to protect active molecules and control their release. Coextrusion encapsulation methods can produce core-shell capsules. This review focuses on the applications of coextrusion encapsulation for preserving oils, essential oils, probiotics, and other bioactives. This technology isolates the active molecules, enhances their stability, and allows controlled release. Coextrusion offers valuable opportunities for preserving active molecules in pharmaceutical, food, and agriculture sectors.
Article
Chemistry, Physical
Xiaoli Zhang, Qingli Qu, Aying Zhou, Yulin Wang, Jian Zhang, Ranhua Xiong, Vincent Lenders, Bella B. Manshian, Dawei Hua, Stefaan J. Soenen, Chaobo Huang
Summary: Core-shell microparticles are intelligent and versatile carriers that have great potential in biomedical fields. This review provides an overview of recent developments in the design and applications of biodegradable core-shell systems. Various emerging methodologies and microfluidics technology are discussed. Furthermore, the characteristics of core-shell microparticles in artificial cells, drug release, and cell culture applications are explored along with their advantages for the generation of artificial cells. The respective developing orientations and limitations of these systems are also addressed.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Medicinal
Chanez Bennacef, Sylvie Desobry-Banon, Laurent Probst, Stephane Desobry
Summary: This paper provides an overview of coextrusion methods for encapsulation, exploring the different techniques available and their potential applications in various industries. The study examines four specific methods, discussing their parameters and the size of capsules they can produce. Coextrusion technology is a promising encapsulation technique for preserving active molecules and has significant economic implications.
Article
Chemistry, Multidisciplinary
Ke Luo, Kaiqiang Wang, Min-Cheol Lim, Ki-Baek Jeong, Young-Rok Kim
Summary: This study reports a simple and green approach for fabricating gold-shelled starch microbeads that exhibit significant broadband absorption. By controlling the concentration of gold seeds, the diameter of the resulting particles can be adjusted, allowing for size-controllable core-shell plasmonic particles with excellent SERS activity. The method offers an effective means of large-scale production and can be applied to various highly sensitive analytical systems.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Engineering, Mechanical
Duo Wang, Xu Zheng, Xiaodong Chen, Guoqing Hu
Summary: This paper introduces a three-phase microfluidic device that can directly generate core-shell or hole-shell microparticles, demonstrating the versatility of the device in fabrication of functionalized particles.
ACTA MECHANICA SINICA
(2021)
Article
Chemistry, Multidisciplinary
Meng-Yi Bai, Tsai-Hsuan Chen, Yu-Chi Wang, Yu-Ju Lai
Summary: In this study, alginate-based microbubbles with a unique morphology were synthesized through a novel method. By encapsulating chemotherapy drugs and imaging agents, these microbubbles showed strong inhibitory effects on ovarian cancer cells and improved ultrasound imaging.
Article
Nanoscience & Nanotechnology
Kaiyan Wang, Min Wang, Jingchao Yu, Dan Liao, Haiyang Shi, Xuefei Wang, Huogen Yu
Summary: The study developed a CupAu core-shell nanostructured cocatalyst to modify the BiVO4 photocatalyst, addressing the limitation of H2O2 production performance in Au/BiVO4 photocatalyst and achieving significant enhancement in photocatalytic performance.
ACS APPLIED NANO MATERIALS
(2021)
Article
Agriculture, Multidisciplinary
Shanshan Tie, Wentao Su, Xuedi Zhang, Yannan Chen, Xue Zhao, Mingqian Tan
Summary: This study successfully constructed a delivery system using a microfluidic chip to protect procyanidins and achieve their pH-controlled release in simulated gastrointestinal fluid. The system showed improved stability and potential applications in delivering other nutrients.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Physical
Liyun Huang, Kui Wu, Xiaohui He, Zujin Yang, Hongbing Ji
Summary: This study presents a novel and facile method for generating spherical and non-spherical alginate microcapsules by controlling parameters such as flow rates. The release performance of the microcapsules was investigated using alpha-tocopherol as a model drug, showing differences in release rates and core behavior between spherical and bullet-like microcapsules.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Nanoscience & Nanotechnology
Eric Y. Liu, Yoon Choi, Hyunmin Yi, Chang-Hyung Choi
Summary: This study presents a novel microfluidic approach for fabricating core-shell hydrogel microspheres with high controllability and flexibility. The method allows for the production of monodisperse core-shell microspheres with independently controlled core and shell compartments. This technique shows promise for developing new applications in the fields of biomedical and biochemical research.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Fariba Malekpour Galogahi, Hongjie An, Yong Zhu, Nam-Trung Nguyen
Summary: This study investigates the behavior of core-shell microparticles with a liquid core under thermal and mechanical loads, establishing analytical models and conducting experiments to validate them. The results demonstrate that the maximum temperature and critical compression force before rupture of core-shell microparticles depend on the liquid, geometry, and material of the shell.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Dong Yang, Keyi Gao, Yang Bai, Lei Lei, Tongtong Jia, Kaidi Yang, Chaohua Xue
Summary: This study utilized a microfluidic approach to synthesize magnetic alginate microparticles and chitosan-coated magnetic alginate microparticles, achieving controlled drug release. By investigating the model drug amoxicillin, it was found that particle size affects drug release rate, while chitosan coating extended drug release time by two times.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Gayeong Yun, Kwon M. Koo, Yangsoo Kim
Summary: This study successfully prepared PS/PANI core-shell type microparticles and applied them to formaldehyde sensor device. The PS/PANI coated IDE sensor showed good sensitivity and reversibility for formaldehyde detection at room temperature.
Article
Biochemistry & Molecular Biology
Deepak Kumar, Sumit Kumar, Shailesh Kumar, Soma Rohatgi, Patit P. Kundu
Summary: The study successfully synthesized rifaximin-loaded chitosan-alginate core-shell nanoparticles (Rif@CS/Alg-NPs) with excellent antibacterial activities against various bacteria. The nanoparticles showed no cytotoxicity towards human lung adenocarcinoma cell line A549 and exhibited drug release at different pH levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
Wahyu Martumpal Hamonangan, Sangmin Lee, Ye Hun Choi, Wanzhao Li, Meiling Tai, Shin-Hyun Kim
Summary: This study presents a microfluidic method for producing submillimeter-sized capsules with an ultrathin shell through osmotic inflation. The capsules are formed by generating emulsion drops with a middle oil layer containing poly(lactic-co-glycolic acid) (PLGA) using a capillary microfluidic device. The drops are then inflated under hypotonic conditions, resulting in core volume expansion and reduction in oil layer thickness. The capsules can release their contents rapidly due to shell rupture, and the tactile sensation gradually disappears during this process.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Multidisciplinary
Tian Jiao, Qin Lian, Weilong Lian, Yonghui Wang, Dichen Li, Rui L. Reis, Joaquim Miguel Oliveira
Summary: This study examines the properties of Collagen/Sodium Alginate (Col/SA) hydrogels for the purpose of 3D printing skin. It found that increasing the sodium alginate content improves the mechanical and swelling properties of the hydrogel, but has negative effects on degradation ratio, pore size, and biological properties. A 1% collagen hydrogel was identified as the optimal bioink for printing skin, as it showed improved cell spreading and proliferation.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Thermodynamics
Ahmadreza Roosta, Reza Haghbakhsh, Ana Rita C. Duarte, Sona Raeissi
Summary: This study collected 1410 density data points of 166 different deep eutectic solvents (DESs) and used machine learning models and the group contribution (GC) method to predict their densities. The MLPANN-GC and LSSVM-GC models were found to be more accurate than the current correlations and GC models, making them suitable for industrial and academic applications.
FLUID PHASE EQUILIBRIA
(2023)
Article
Oncology
Sara Monteiro-Reis, Joao P. S. Ferreira, Ricardo A. Pires, Joao Lobo, Joao A. Carvalho, Rui L. Reis, Renato Natal Jorge, Carmen Jeronimo
Summary: This study found that the presence of a tumor can alter the stiffness of the bladder wall, which may affect the progression of bladder cancer. Using atomic force microscopy, the researchers measured the micromechanical properties of the bladder wall layers and observed that tumors promote the development of muscle-like structures in the mucosa.
Article
Materials Science, Multidisciplinary
Xuelian Yin, Lin Zhan, Lin Ding, Xuerui Chen, Junfeng Zhang, Chenchen Li, Yuxi Zhang, Murad Khan, Rui L. Reis, Yanli Wang
Summary: We report a facile synthesis method for mitochondria-specific anchored nano-complexes (AG-C-NP) comprised of a skeleton of gold and carbon atoms for cancer therapy. Compared to gold nanoclusters (Au NCs), AG-C-NP showed enhanced fluorescence imaging effects, which can be used for tumor monitoring. AG-C-NP targeted the mitochondria and increased ROS damage in cancer cells, leading to a significant inhibition of tumor growth.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Engineering, Biomedical
Anita Akbarzadeh Solbu, David Caballero, Spyridon Damigos, Subhas C. Kundu, Rui L. Reis, Oyvind Halaas, Aman S. Chahal, Berit L. Strand
Summary: Cell migration plays a crucial role in various biological processes, and recent advancements in materials science have allowed for the development of biomimetic in vitro assays to study cell migration. Three-dimensional hydrogels have been particularly useful in mimicking the extracellular environment and studying cell migration in a more physiologically relevant manner. This article provides an overview of the different types of hydrogels and their characteristics, as well as established methods for cell migration assays and tracking in three-dimensional environments.
MATERIALS TODAY BIO
(2023)
Article
Pharmacology & Pharmacy
Filipa Santos, David Pires, Elsa Anes, Ana Rita C. Duarte
Summary: This study evaluated the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. The results showed that these mixtures have antibacterial effects against drug-susceptible Mycobacterium tuberculosis strains, with the mixtures incorporating ethambutol showing particularly prominent effects. The findings suggest the potential for further research and evaluation of clinical applicability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Encarnacion Cruz Sanchez, Maria Teresa Garcia, Joana Pereira, Filipe Oliveira, Rita Craveiro, Alexandre Paiva, Ignacio Gracia, Jesus Manuel Garcia-Vargas, Ana Rita C. Duarte
Summary: This study proposes the use of chitosan (CHT) or alginate (ALG) to prepare membranes for wound healing, with the incorporation of lavender essential oil (LEO). The composition of the membranes was analyzed using Fourier Transform Infrared Spectroscopy (FTIR). The water absorption capacity and oil release profile of the membranes were evaluated, and the cytotoxicity and biocompatibility of the membranes were studied using a HaCaT cell line. The results showed that the CHT/ALG + LEO membrane increased cell proliferation and exhibited potential for wound healing applications.
Article
Chemistry, Physical
Andreas S. Croft, Slavko Corluka, Janine Fuhrer, Michael Woeltje, Joana Silva-Correia, Joaquim M. Oliveira, Georg F. Erbach, Rui L. Reis, Benjamin Gantenbein
Summary: Intervertebral disc herniation often causes severe pain and is associated with disc degeneration. We propose an annulus fibrosus repair approach using GG-MA and silk fibroin. The repaired discs showed no significant differences compared to the damaged discs, indicating the repair approach was successful.
Article
Polymer Science
Ines Machado, Catarina F. Marques, Eva Martins, Ana L. Alves, Rui L. Reis, Tiago H. Silva
Summary: Marine-origin gelatin, a safe alternative to mammalian-origin materials, has the benefits of structural similarity and low production cost. Gelatin-methacryloyl (GelMA)-based hydrogels have shown excellent capacity for biomedical applications, such as tissue engineering. In this study, fish gelatin was extracted from Greenland halibut skins and functionalized with methacrylation to develop a photosensitive GelMA. By combining GelMA with glycosaminoglycans (GAGs), biomechanically stable hydrogels with tunable physicochemical features were produced. These hybrid hydrogels, tested as a matrix for chondrocyte culture, showed improved cell viability and have potential for cartilage tissue engineering applications.
Article
Chemistry, Multidisciplinary
Dylan J. Walsh, Weizhong Zou, Ludwig Schneider, Reid Mello, Michael E. Deagen, Joshua Mysona, Tzyy-Shyang Lin, Juan J. de Pablo, Klavs F. Jensen, Debra J. Audus, Bradley D. Olsen
Summary: This article presents the design of a general material data model that supports the application of polymer materials in nearly every aspect of modern life.
ACS CENTRAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Christian P. Haas, Maximilian Luebbesmeyer, Edward H. Jin, Matthew A. McDonald, Brent A. Koscher, Nicolas Guimond, Laura Di Rocco, Henning Kayser, Samuel Leweke, Sebastian Niedenfu, Rachel Nicholls, Emily Greeves, David M. Barber, Julius Hillenbrand, Giulio Volpin, Klavs F. Jensen
Summary: This study introduces an open-source Python project called MOCCA for the analysis of HPLC-DAD raw data, showcasing its broad applicability in data analysis. MOCCA features an automated peak deconvolution routine that can identify known signals and distinguish overlapped signals from unexpected impurities or side products. By releasing MOCCA as a Python package, the researchers aim to foster an open-source community project, advancing its scope and capabilities.
ACS CENTRAL SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Sara Gimondi, Helena Ferreira, Rui L. L. Reis, Nuno M. M. Neves
Summary: The use of nanoparticles in nanomedicine has great potential in overcoming the limitations of conventional therapies and improving early diagnosis and follow-up of diseases. Microfluidic systems offer an efficient and cost-effective method for nanoparticle synthesis and screening by simulating dynamic fluid flows and specific microenvironments. Microfluidic devices allow for controlled synthesis of nanoparticles, enhancing batch-to-batch reproducibility, and provide versatile platforms for rapid and efficient in vitro and in vivo screening. This review summarizes the major microfluidic platforms for controlled nanoparticle synthesis, discusses innovative platforms for mimicking in vitro environments and organism-on-a-chip, and evaluates the current challenges and future directions of microfluidic systems in nanomedicine.
Article
Engineering, Biomedical
David Caballero, Rui L. Reis, Subhas C. Kundu
Summary: Researchers have developed a cancer trap based on mechanical ratchet structures to capture metastatic cells. The trap exhibits high efficiency in capturing invasive cancer cells and may have therapeutic implications for cancer treatment and controlling cell motility in biological processes.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Applied
Daniel J. Griffin, Connor W. Coley, Scott A. Frank, Joel M. Hawkins, Klavs F. Jensen
Summary: The goals of this Perspective are to inform the audience about synthetic drug substance process development, break down the task into subtasks, and highlight potential applications of machine learning and artificial intelligence. While computer-aided synthesis planning tools have been developed for retrosynthetic analysis, opportunities for aiding the process chemist or engineer in commercial drug substance process development remain largely untapped.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Review
Engineering, Biomedical
Raul Fontelo, Rui L. Reis, Ramon Novoa-Carballal, Iva Pashkuleva
Summary: This paper summarizes the importance and development trends of block copolymer (BCP) self-assembly in nanofabrication, and discusses its potential and challenges in the field of bioapplications.
ADVANCED HEALTHCARE MATERIALS
(2023)
