Article
Chemistry, Multidisciplinary
Ke Liu, Jiaxing Su, Jiangong Liang, Yuan Wu
Summary: Mesoporous MnFe2O4 magnetic nanoparticles exhibit intrinsic peroxidase-like activity and can be used as a colorimetric sensor for glucose detection in urine. The sensor is fast, sensitive, specific, and has the potential for on-site glucose detection.
Article
Chemistry, Multidisciplinary
Danielle Mulder, Cornelius Johannes Francois Taute, Mari van Wyk, Pieter J. Pretorius
Summary: The study found that functionalized GNPs caused genotoxicity in HepG2 cells, but the cells were able to initiate repair mechanisms and recover DNA damage, except for two functionalization chemistries.
Review
Biochemistry & Molecular Biology
Vera Alexandra Spirescu, Cristina Chircov, Alexandru Mihai Grumezescu, Bogdan Stefan Vasile, Ecaterina Andronescu
Summary: The development of drug-resistant microorganisms poses a critical challenge to modern medicine and drug discovery, necessitating innovative strategies to combat global health issues. Metal and metal oxide nanoparticles have shown promise as effective nanobiocides and nanocarriers for antimicrobial drugs, offering potential solutions to combat infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Mohamad Zandieh, Juewen Liu
Summary: The article discusses the issue of calculating catalytic turnover rates of nanozymes, emphasizing that only surface atoms should be considered as active sites. Different types of nanozymes exhibit varying catalytic activity characteristics, which may be influenced by the adsorption of reaction products.
Article
Chemistry, Multidisciplinary
Sharafaldin Al-Musawi, Salim Albukhaty, Hassan Al-Karagoly, Faizah Almalki
Summary: A dual-targeting nanomedicine composed of pH-sensitive superparamagnetic iron oxide core-gold shell SPION@Au, chitosan (CS), and folate (FA) was developed for doxorubicin (DOX) antitumor medication. The nanocomposite exhibited elevated drug loading behavior and sustained drug release capacity, with long-term anti-cancer efficacy shown in SkBr3 cell lines. In vivo results demonstrated significant tumor size reduction in treated mice, indicating the potential of this formulation for clinical breast cancer treatment.
Review
Chemistry, Multidisciplinary
Xianghui Li, Shichao Ai, Xiaofeng Lu, Song Liu, Wenxian Guan
Summary: Nanotechnology has made significant breakthroughs in gastric cancer imaging and treatment, integrating different imaging modalities and enhancing therapeutic efficacy.
Article
Nanoscience & Nanotechnology
Nour K. Younis, Joseph A. Ghoubaira, Emmanuel P. Bassil, Houda N. Tantawi, Ali H. Eid
Summary: Cardiovascular disease is a leading cause of death globally, and nanotechnology has shown promise in developing more effective treatments. Different types of nanoparticles, such as iron oxide, gold, and silver, have various effects on the management and treatment of CVD.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Mariam Abdulaziz M. Tarkistani, Varsha Komalla, Veysel Kayser
Summary: This review discusses the synthesis methods of iron-gold-based hybrid nanostructures, various forms of hybrids, and their potential applications as multifunctional nanoprobes.
Article
Materials Science, Biomaterials
Cristina de la Encarnacion, Felix Jungwirth, David Vila-Liarte, Carlos Renero-Lecuna, Safiyye Kavak, Inaki Orue, Claire Wilhelm, Sara Bals, Malou Henriksen-Lacey, Dorleta Jimenez de Aberasturi, Luis M. Liz-Marzan
Summary: Hyperthermia has been shown to be an effective and selective cancer therapy strategy by heating malignant cells above 42 degrees C to trigger cell death. Magnetic and photothermal hyperthermia can benefit from the use of nanomaterials. This hybrid colloidal nanostructure, consisting of plasmonic gold nanorods covered by a silica shell and subsequently grown with iron oxide nanoparticles, is responsive to both external magnetic fields and near-infrared irradiation, enabling targeted magnetic separation and photothermal heating.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Physical
Ricardo Alvarado, Nisreen Al-Hajj, Mathieu Chazot, Thierry Buffeteau, Luc Vellutini, Marc Dussauze
Summary: In this study, successful biofunctionalization of Ge-Sb-S Chalcogenide glasses was achieved through three different approaches, including traditional silane chemistry and novel strategies based on maleimide and cyclooctyne derivatives. This functionalization process can be easily adapted for substrates with any type of geometry, allowing for the future development of infrared optical sensing systems with surface bio selectivity.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: Magnetization is a measurable property of materials that provides information about their electronic structure, phase purity, and impurities. Superparamagnetism, a size-dependent property of magnetic materials, has been underexplored in the field of quantum materials. In this study, a statistical model is used to analyze a dataset of variable-size superparamagnetic Fe3O4 particles. The results show that parameters of the intrinsic probability distribution, such as the maximum susceptibility, are more suitable for describing the superparamagnetic behavior compared to standard measures like saturation magnetization. This analysis has potential applications in synthesis diagnostics and prediction of new properties and functionality.
Article
Chemistry, Multidisciplinary
Stephanie M. Gallant, Liam D. Whelan, Lucas D. Stewart, Erika F. S. Merschrod
Summary: The newly developed hierarchically structured plasmonic substrate, utilizing patterned multilayers of magnetic iron oxide nanospheres, shows significant Raman signal enhancement and reliable detection capability for dilute but persistent environmental pollutants such as polycyclic aromatic hydrocarbons. The substrate exhibits remarkable stability and robustness suitable for real-world applications, with simple fabrication methods and strong potential for scalability.
Article
Biochemistry & Molecular Biology
Edurne Tellechea, Aaron C. Asensio, Paula Ciaurriz, Javier Buezo, Pedro Lopez-Gomez, Marina Urra, Jose F. Moran
Summary: This study investigates the characteristics of the recombinant cowpea FeSOD immobilized onto gold nanoparticles (AuNPs) and the effects of NP surface chemistry and biofunctionalization methods on enzyme activity. The results highlight the importance of the biomolecule and AuNP interaction for the functionality of the hybrid and demonstrate the potential of these strategies in biomedical applications.
Article
Polymer Science
Azita Sharifi Saqezi, Mehraneh Kermanian, Ali Ramazani, Somayeh Sadighian
Summary: This study focused on developing a superparamagnetic graphene oxide-based nanocomposite for quercetin delivery. The structure, morphology, biocompatibility, and drug delivery efficiency of the nanocomposite were investigated. The results showed that the nanocomposite is highly biocompatible and can effectively deliver quercetin to cancer cells.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Mauro Sousa de Almeida, Eva Susnik, Barbara Drasler, Patricia Taladriz-Blanco, Alke Petri-Fink, Barbara Rothen-Rutishauser
Summary: Nanoparticles have diverse applications, particularly in nanomedicine for detecting and treating diseases like cancer and inflammation. Understanding the mechanisms of cellular uptake and intracellular localization of nanoparticles is crucial for therapeutic applications. Factors such as physicochemical properties, endocytic pathways, and cellular uptake regulators play key roles in the application of nanoparticles in medicine.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Physics, Multidisciplinary
Macia Esteve Pallares, Irina Pi-Jauma, Isabela Corina Fortunato, Valeria Grazu, Manuel Gomez-Gonzalez, Pere Roca-Cusachs, Jesus M. de la Fuente, Ricard Alert, Raimon Sunyer, Jaume Casademunt, Xavier Trepat
Summary: The migratation of cellular clusters is important for various biological processes, but the mechanisms underlying collective durotaxis are not fully understood. This study reveals a connection between collective durotaxis and the wetting properties of cellular clusters. The findings show that the wetting behavior of cancer cells on substrates is dependent on the stiffness of the substrates. The study also demonstrates a physical mechanism of collective durotaxis based on the wetting properties of active droplets.
Review
Biotechnology & Applied Microbiology
Enrica Soprano, Ester Polo, Beatriz Pelaz, Pablo del Pino
Summary: Nanoparticles have demonstrated attractive capabilities in biology and medicine. However, the number of candidates reaching clinical trials or commercialization is minimal due to issues with their synthetic and foreign surface. The use of cell-derived surfaces as an alternative to artificial coatings has emerged, aiming to improve therapeutic behavior and overcome limitations of synthetic approaches. These biomimetic formulations have the potential to address challenges in drug delivery and show promise in cancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Archaeology
M. Nunes, G. Wanzeller Martins, J. Sarraguca, F. Olival, P. Moita, Scott G. Mitchell, A. Claro, T. Ferreira
Summary: Historical and archival research on the Portuguese Inquisition documents revealed the use of blotting sands, a writing accessory that accelerates ink drying. This study combines various techniques, including image analysis, SEM/EDS, and mu-Raman, to characterize the blotting sands and hypothesize their origin. The dominant species found were iron-titanium and iron oxide minerals, indicating that they were likely extracted from fluvial or beach contexts and processed. Chemometrics revealed trends over time by clustering samples based on morphology and composition data. This groundbreaking research aims to uncover the intricacies of this writing tool.
JOURNAL OF CULTURAL HERITAGE
(2023)
Article
Environmental Sciences
Ajay Vikram Singh, Aaron Katz, Romi Singh Maharjan, Ashish K. Gadicherla, Martin Heinrich Richter, Jan Heyda, Pablo del Pino, Peter Laux, Andreas Luch
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted through breathing and speech droplets emitted by infected carriers, including asymptomatic cases. In this study, the transmission of aerosolized air mimicking infected speech droplets was investigated. It was found that speech produces nanoaerosols that can travel distances longer than 1 m. These speech-generated aerosol droplets are believed to play a major role in the current COVID-19 pandemic. The study also touched upon the role of residual water in aerosol droplet stability and explored the influence of air pollution on respiratory virus transmission.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Thanpisit Lomphithak, Selin Helvacioglu, Ilaria Armenia, Sandeep Keshavan, Jesus G. Ovejero, Giovanni Baldi, Costanza Ravagli, Valeria Grazu, Bengt Fadeel
Summary: This study evaluated the cytotoxicity of iron oxide nanoparticles and their Co-functionalized counterparts, and found that cell death with features of ferroptosis occurred at higher concentrations, with the functionalized nanoparticles demonstrating stronger toxicity. Furthermore, it was shown that the cell death triggered by the nanoparticles was autophagy-dependent. Overall, high concentrations of polymer-coated iron oxide nanoparticles induce ferroptosis in susceptible human cancer cells.
Article
Chemistry, Multidisciplinary
Beatriz Torres-Herrero, Ilaria Armenia, Maria Alleva, Laura Asin, Sonali Correa, Cecilia Ortiz, Yilian Fernandez-Afonso, Lucia Gutierrez, Jesus M. de la Fuente, Lorena Betancor, Valeria Grazu
Summary: Here, researchers have developed nanohybrids (nHs) for remote activation of a therapeutic enzyme in Directed Enzyme Prodrug Therapy (DEPT). The nanosized hybrids, composed of magnetic nanoparticles (MNPs) and horseradish peroxidase (HRP) encapsulated in biomimetic silica, were optimized for efficient remote activation of the therapeutic enzyme. The application of alternating magnetic fields (AMFs) to MNPs increased the bioconversion rate of HRP, demonstrating the possibility of enzyme nanoactuation with co-encapsulated MNPs. In vitro and in vivo experiments showed that the enzyme-loaded nHs triggered cell death and significantly reduced tumor volume growth when exposed to AMFs, highlighting the potential of this spatiotemporally controlled DEPT strategy to overcome off-target effects.
Article
Biochemical Research Methods
Christian Castro-Hinojosa, Susel Del Sol-Fernandez, Eduardo Moreno-Antolin, Beatriz Martin-Gracia, Jesus G. Ovejero, Jesus Martinez de la Fuente, Valeria Grazu, Raluca M. Fratila, Maria Moros
Summary: In this study, we describe a simple and efficient method for the functionalization of proteins with magnetic nanoparticles (MNPs) using metal affinity binding. Our method preserves the functionality and colloidal stability of the MNPs while allowing for the precise control of protein orientation and density. This approach has potential applications in various fields.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Federica Gamberoni, Marina Borgese, Christina Pagiatakis, Ilaria Armenia, Valeria Grazu, Rosalba Gornati, Simone Serio, Roberto Papait, Giovanni Bernardini
Summary: Despite the progress in nanotoxicology, the cellular mechanisms of nanoparticles' adverse effects and the role of epigenetics in nanotoxicity remain unclear. This study investigated changes in histone modifications and transcriptome after exposing NIH3T3 cells to iron-based magnetic NPs. The results suggest that alterations in the epigenetic landscape play a key role in defining gene expression changes and nanotoxicity.
Article
Chemistry, Physical
Ilaria Armenia, Jesus G. Ovejero, Nicoll Zeballos Lema, Fernando Lopez-Gallego, F. Javier Palomares, Sabino Veintemillas-Verdaguer, Jesus M. de la Fuente, M. Puerto Morales, Valeria Grazu
Summary: This article describes an innovative procedure to functionalize MNPs by growing a thin layer of TM2+ hydroxides on the MNP surface, which enhances the surface interaction with the protein and achieves oriented protein binding. The one-step Co coated MNPs showed the highest selectivity and specificity towards His-tags compared to the conventional NTA-TM2+ coating. This coating reduces the functionalization steps and increases the immobilization yields of His-tagged proteins.
APPLIED SURFACE SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Manuela Cedrun-Morales, Manuel Ceballos, Ester Polo, Pablo del Pino, Beatriz Pelaz
Summary: Metal-organic frameworks (MOFs) are versatile materials that create highly porous and reactive platforms. When produced at the nanoscale, they can be combined with inorganic nanoparticles (NPs) to create nanocomposites (NCs) with unique features. These NCs can be remotely controlled and catalyze abiotic reactions in living cells, making them potential tools for advanced therapies.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Manuel Ceballos, Manuela Cedrun-Morales, Manuel Rodriguez-Perez, Samuel Funes-Hernando, Jose Manuel Vila-Fungueirino, Giulia Zampini, Maria F. Navarro Poupard, Ester Polo, Pablo del Pino, Beatriz Pelaz
Summary: The study focused on the synthesis of nanosized metal-organic frameworks (NMOFs) and highlighted the significant role of halide ions in producing NMOFs with precise morphology and size, as well as improving reaction yield. The resulting NMOFs demonstrated high crystallinity and sustained colloidal stability in various biologically relevant media, showcasing their potential application as drug delivery systems.
Article
Chemistry, Multidisciplinary
Hector Soria-Carrera, Elena Atrian-Blasco, Jesus M. de la Fuente, Scott G. Mitchell, Rafael Martin-Rapun
Summary: This study reports the self-assembly of POM-peptide hybrids into nanoparticles, showing enhanced catalytic activity and antimicrobial properties.
