Article
Chemistry, Multidisciplinary
Cheng Shi, Qiugang Huang, Ruirui Zhang, Xingtang Liang, Feng Wang, Zijie Liu, Min Liu, Huayu Hu, Yanzhen Yin
Summary: An antioxidant cassava starch (AO-ca-starch) was prepared with high catalytic activity for scavenging free radicals and serving as an antioxidant drug. The catalytic activity of AO-ca-starch was significantly higher than that of typical artificial selenoenzymes, exhibiting typical saturation kinetic catalytic behavior. The match of catalytic center and hydrophobic microenvironments played a key role in maintaining the high catalytic activity of AO-ca-starch.
Review
Biochemistry & Molecular Biology
Yu Ah Hong, Cheol Whee Park
Summary: Reactive oxygen and nitrogen species play crucial roles in kidney injuries, making antioxidant agents, especially catalytic antioxidants that mimic antioxidant enzymes, effective in combating oxidative stress-related kidney diseases. Research has shown the effectiveness of several catalytic antioxidants in treating disease models associated with oxidative stress.
Article
Chemistry, Physical
Yuzhong Hu, Lu You, Bin Xu, Tao Li, Samuel Alexander Morris, Yongxin Li, Yehui Zhang, Xin Wang, Pooi See Lee, Hong Jin Fan, Junling Wang
Summary: The study demonstrates a large shear strain in the hybrid ferroelectric C6H5N(CH3)(3)CdCl3, achieving up to 21.5% strain, two orders of magnitude greater than traditional piezoelectrics. This is attributed to organic molecules preventing 180 degrees polarization switching, showing potential for lightweight and high-energy-density devices.
Article
Chemistry, Multidisciplinary
Yijie Cheng, Yufei Zhang, Zhe Zhao, Gang Li, Jie Li, Anran Li, Yun Xue, Baolin Zhu, Zhongming Wu, Xinge Zhang
Summary: This study presents an activatable nanostructure for synergistic sonodynamic-catalytic therapy of MRSA-infected osteomyelitis. The nanostructure effectively kills bacteria and promotes inflammation resolution and bone cell proliferation, showing promising potential for osteomyelitis treatment.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xuefeng Li, Yixin Wang, Qiang Yan
Summary: Fabricating nanoscale assemblies that respond to gas signaling molecules, this study presents a SO2-responsive polymersome system that can be transformed into long nanotubes upon intake of SO2 gas. The membrane of the polymersomes exhibits dose-dependent permselectivity to SO2, enabling selective transfer of cargos across the bilayers. These findings provide insights into the understanding and mimicking of gas signaling molecules in shaping biomembranes and managing transmembrane traffic.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Yu Liang, Chao Peng, Ning Su, Qiuyu Li, Siwen Chen, Dong Wu, Bin Wu, Yang Gao, Ziting Xu, Qing Dan, Si Zheng, Bingxia Zhao, Yingjia Li
Summary: The use of FCSP MOFs and AuFCSP MOFs as ferroptosis inducers can significantly enhance the therapeutic efficiency of radiotherapy through their synergistic effects, as demonstrated in both in vitro and in vivo experiments.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Tingting Zhang, Yu Liu, Jiuchan Pi, Nannan Lu, Renshuai Zhang, Wujun Chen, Zhiquan Zhang, Dongming Xing
Summary: Researchers have developed a nanozyme with triple peroxisomal-like activities (oxidase, peroxidase, and catalase), demonstrating its potential in exploring artificial peroxisomes.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Federico Droghetti, Agnese Amati, Fabien Pascale, Aurelien Crochet, Mariachiara Pastore, Albert Ruggi, Mirco Natali
Summary: This study reports the catalytic activity of a cobalt complex and its iron analog towards CO2 reduction reaction in acetonitrile/water mixtures. The cobalt complex shows selectivity towards formate and H2, while the iron complex predominantly generates CO. The results are further confirmed under photochemical conditions.
Article
Chemistry, Organic
Manish Kumar, Babli Chhillar, Divya Verma, Sumit Nain, Vijay P. Singh
Summary: Copper-catalyzed direct selenation of substituted 2-bromo-N-phenylbenzamide substrates with elemental selenium powder provides methoxysubstituted isoselenazolones through C-Se and Se-N bond formations. O-demethylation of the methoxy-substituted analogues using boron tribromide yields phenolic substituted isoselenazolones. Isoselenazolones exhibit good glutathione peroxidase-like antioxidant activity.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Yung-Fang Hsiao, Shao-Bin Cheng, Chia-Yu Lai, Hsiao-Tien Liu, Shih-Chien Huang, Yi-Chia Huang
Summary: This study compared the changes in oxidative stress and GSH-related antioxidant capacities before and after tumor resection in HCC patients, showing a decrease in plasma malondialdehyde level and varying increases in GSH and related enzyme activities. The findings suggest a potential therapeutic use of GPx or GR as targets for reducing HCC recurrence.
Article
Nanoscience & Nanotechnology
Tianpei Guan, Ming Cheng, Lisi Zeng, Xiaoya Chen, Yuan Xie, Ziying Lei, Qiang Ruan, Jin Wang, Shuzhong Cui, Yao Sun, Haibing Li
Summary: This study presents a redox-reactive artificial nanochannel inspired by the transport of glutathione through redox regulation, achieving high selectivity for glutathione transmission and the ability to switch between ON and OFF states. This system has the potential for applications in detecting/binding biological analytes and redox-controlled drug release.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Snehal Nirgude, Bibha Choudhary
Summary: GPx3, a well-known antioxidant enzyme, plays a vital role as a tumor suppressor in various cancers and can serve as a potential target for clinical intervention.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Monojit Batabyal, Aditya Upadhyay, Rahul Kadu, Nihal Chaitanya Birudukota, Deepak Chopra, Sangit Kumar
Summary: Research has found that organoselenium compounds with chalcogen-bonding interactions can play a significant role as catalysts in oxidation reactions, and can efficiently catalyze the disproportionation of hydrogen peroxide and bromination of arenes.
INORGANIC CHEMISTRY
(2022)
Article
Engineering, Environmental
Xinxin Sun, Xiaohong Yang, Jing Wang, Yibo Shang, Pengfei Wang, Xia Sheng, Xiaohong Liu, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: This study presents a novel lipid peroxidation nano-amplifier based on a drug-deliver-drug (DDD) engineering strategy for efficient ferroptosis induction in cancer therapy. The nano-amplifier is formed by co-assembling a GPX4 inhibitor (FIN56) and arachidonic acid (AA) into stable nanoparticles without any excipients. Additionally, a disulfide bond-containing amphipathic PEG polymer is decorated on the nano-amplifier for long blood circulation and tumor-specific drug release. The AA not only generates abundant lipid reactive oxygen species (ROS), but also induces membranous lipid peroxidation in tumor cells, synergistically inducing tumor ferroptosis with FIN56-mediated GPX4 depletion. The nano-amplifier demonstrates potent ferroptosis-driven antitumor activity in mice with breast tumors. This study provides a conceptual advance in ferroptosis-driven nanotherapeutics and offers a novel DDD co-delivery paradigm for combination cancer therapy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ashmeet Singh, Jeong-Un Joo, Dong-Pyo Kim
Summary: The study demonstrates an ultrafast self-assembly method using microfluidic reactors to obtain different nanostructures, and investigates their hydrolase enzyme activity mimicking performance. The well-ordered nanostructures obtained through this ultrafast self-assembly process show improved catalytic efficiency.
Article
Nanoscience & Nanotechnology
Tengfei Yan, Fei Li, Jun Tian, Liang Wang, Quan Luo, Chunxi Hou, Zeyuan Dong, Jiayun Xu, Junqiu Liu
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Polymer Science
Shuaiwei Qi, Chenyang Zhang, Tengfei Yan, Feihu Yang, Jing Zhang, Shizhong Mao, Zeyuan Dong
MACROMOLECULAR RAPID COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Chenyang Zhang, Jun Tian, Shuaiwei Qi, Bing Yang, Zeyuan Dong
Article
Chemistry, Organic
Jing Zhang, Shuaiwei Qi, Chenyang Zhang, Zengming Fan, Qinwen Ding, Shizhong Mao, Zeyuan Dong
Article
Chemistry, Multidisciplinary
Shuaiwei Qi, Chenyang Zhang, Hao Yu, Jing Zhang, Tengfei Yan, Ze Lin, Bing Yang, Zeyuan Dong
Summary: Small molecules with natural channel-like functions have potential in treating human diseases. Aromatic helical scaffolds were used to develop foldamer-based ion channels of varying sizes, demonstrating the importance of channel size in ion transport selectivity and leading to the discovery of promising artificial K+ and sodiumpreferential channels.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Chenyang Zhang, Jing Zhang, Wencan Li, Shizhong Mao, Zeyuan Dong
Summary: Anion transmembrane nanochannels constructed from dynamic covalent helices show high transport activity, anion selectivity, and the ability to accelerate anion movement across lipid membranes. These channels also exhibit dehydration energy dependent anion selectivity, highlighting their importance as general channel scaffolds with economical synthesis and special nanocavities.
Article
Chemistry, Multidisciplinary
Shuaiwei Qi, Jun Tian, Jing Zhang, Lei Zhang, Chenyang Zhang, Ze Lin, Jing Min, Shizhong Mao, Zeyuan Dong
Summary: This study investigates the relationship between channel size and ion selectivity by developing a new type of artificial ion channel based on pore-forming helical polymers. The artificial channel exhibits high transport activity and Na+ selectivity, and it transports Na+ ions in a different manner compared to natural Na+ channels. Overall, this research provides crucial insights into ion selectivity in the field of ion channels.
Article
Chemistry, Multidisciplinary
Jing Zhang, Shuaiwei Qi, Hao Yu, Ze Lin, Bao Li, Ming Wang, Zeyuan Dong
Summary: In this study, a simple supramolecular strategy was adopted to effectively control the tautomerism of ureidopyrimidinone (UPy) moiety and achieve the complete arrangement of enol configuration. The UPy derivatives containing self-complementary quadruple hydrogen bonding interactions could spontaneously self-assemble into well-controlled, self-organized supramolecular nanostructures in both chloroform and water. This study demonstrates the utility and feasibility of multiple hydrogen bonds for directing the self-assembly of small-molecule building blocks in aqueous media, providing a strategy for constructing well-defined and stable supramolecular architectures with chemical functionalities and physical properties as advanced materials for biological applications.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Min Jing, Zhang Chenyang, Qi Shuaiwei, Wang Liyan, Dong Zeyuan
Summary: Responsive coordination polymers can undergo conformational changes and exhibit unique functions in different microenvironments, making them promising candidates for the design of smart materials.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2022)
Article
Chemistry, Multidisciplinary
Chenglong Liu, Zhenzhu Wang, Lei Zhang, Zeyuan Dong
Summary: In this study, a soft imine-based 2D covalent organic framework (S-COF) with a compacted honeycomb topology was synthesized. The compacted topological structure was characterized using various techniques. This research opens up new possibilities for the development of covalent organic frameworks.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Lei Zhang, Chenyang Zhang, Xin Dong, Zeyuan Dong
Summary: In this study, artificial supramolecular lithium channels composed of pore-containing small aromatic molecules were developed for the treatment of psychiatric disorders. These channels showed unprecedented transmembrane transport of exogenous lithium ions with high selectivity. The discovery of the basic requirements for ion transport function in these channels may have important implications in studying the physiological role of intracellular lithium ions and treating psychiatric disorders.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jing Zhang, Shuaiwei Qi, Chenyang Zhang, Wenzhe Wang, Qinwen Ding, Hongyu Zhang, Zeyuan Dong
Summary: A straightforward and rational approach was used to construct supramolecular assemblies with ordered nanostructures in a two-dimensional arrangement. By taking advantage of the synergistic effect of multiple non-covalent interactions, the designed molecular monomer had a specific orientation in the self-assembly process, thus achieving two-dimensional control. The strategy of collaborative self-assembly using multiple non-covalent interactions is expected to be extended to the construction of various unique supramolecular 2D materials.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tengfei Yan, Fei Li, Shuaiwei Qi, Jun Tian, Ruizhen Tian, Jinxing Hou, Quan Luo, Zeyuan Dong, Jiayun Xu, Junqiu Liu
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Chenyang Zhang, Xiaoli Deng, Chenxi Wang, Chunyan Bao, Bing Yang, Houyu Zhang, Shuaiwei Qi, Zeyuan Dong
Article
Chemistry, Multidisciplinary
Tengfei Yan, Feihu Yang, Shuaiwei Qi, Xiaotong Fan, Shengda Liu, Ningning Ma, Quan Luo, Zeyuan Dong, Junqiu Liu
CHEMICAL COMMUNICATIONS
(2019)
