Review
Chemistry, Multidisciplinary
Amaal Abdulraqeb Ali, Amani Al-Othman, Mohammad H. Al-Sayah
Summary: Hybrid nanogels are emerging as novel and multifunctional cancer therapeutic strategies, with the potential to possess cytotoxic effects, carry drugs/enzymes, improve imaging, and target tumor cells. Despite their promising abilities, their clinical application is limited and further research is needed. Factors affecting their future include lack of hemocompatibility studies, toxicological evaluations, and information on tumor heterogeneity and interaction with physiological fluids.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Polymer Science
Kyungsene Lee, Taehyung Kim, Young Min Kim, Kyungjik Yang, Inseok Choi, Young Hoon Roh
Summary: Multifunctional DNA nanogels have been developed for potential cancer-targeted delivery and stimuli-responsive release of cancer therapeutics, exhibiting features such as temperature-induced disassembly, aptamer-mediated cancer cell targeting, and light-triggered temperature increase.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Yunhao Gao, Yu Liu, Xueyin Qin, Ziping Guo, Donglin Li, Chenggang Li, Hu Wan, Fuxing Zhu, Jianhong Li, Zhuo Zhang, Shun He
Summary: The study presented controlled-release formulations with pH/cellulase dual stimuli responsiveness for efficient fungicidal activity against Magnaporthe oryzae and reduced genotoxicity of pyraclostrobin. These formulations are promising for sustainable crop disease protection.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Chenxi Peng, Weizhen Lv, Xue Chen, Yung Doug Suh, Xiaowang Liu
Summary: This study reports a novel strategy for synthesizing stimuli-responsive fluorescent hollow nano/microparticles in the field of supramolecular multifunctional metal-organic networks. The created hollow bisphosphonate-spiropyran (BPSP)-Zn2+ microparticles exhibit responsiveness to light, pH, and glutathione (GSH). The reversible conversion between spiropyran and zwitterionic merocyanine components, as well as between merocyanine and protonated merocyanine, contribute to the photochromic and pH responses, respectively. The stronger affinity of Zn2+ to thiol groups than to phosphonate groups leads to the GSH response. These hollow BPSP-Zn2+ microparticles show high promise in stimulus-triggered drug delivery and offer potential for innovative materials development in the biomedical field.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Physical
Kuang-Ming Lin, Fu-Cheng Wang
Summary: The study demonstrates that employing multiple fuel-cell vehicles in distributed hybrid power systems can effectively reduce system costs while maintaining system sustainability.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Biophysics
Qiang Li, Dongsheng Fu, Jie Zhang, Hong Yan, Huifang Wang, Baolong Niu, Ruijie Guo, Yiming Liu
Summary: A new type of polypeptide-based dual-sensitive drug delivery system was synthesized for efficient chemotherapy. The nanoparticles showed enhanced drug release in acidic and hypoxic environments, leading to higher cytotoxicity against lung cancer cells. This system has the potential to be a promising platform for stimuli-responsive controlled drug release in cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Automation & Control Systems
Jiyong Li, Xinyu Bian, Hai Huang, Tao Jiang, Yihui Liu, Lei Wan
Summary: This article proposes a hybrid visual servoing control scheme for underwater vehicle manipulator systems (UVMSs) to achieve accurate vision-based operations in underwater environments. The scheme combines a position-based visual servoing (PBVS) scheme using a binocular camera and an uncalibrated visual servoing (UVS) control scheme using a monocular camera. The proposed scheme also includes a Jacobian matrix fusion algorithm to enable accurate long-range operations and minimize the influence of trial movements.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
Article
Medicine, Research & Experimental
Maxim S. Kupryushkin, Anton Filatov, Nadezhda L. Mironova, Olga A. Patutina, Ivan Chernikov, Elena L. Chernolovskaya, Marina A. Zenkova, Dmitrii Pyshnyi, Dmitry A. Stetsenko, Sidney Altman, Valentin V. Vlassov
Summary: Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups were successfully synthesized and shown to have increased nuclease resistance in serum-containing medium. Replacing two internucleotidic phosphates with PG groups did not decrease cellular uptake, and increasing the number of PG groups affected cellular uptake.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Liqun Zhao, Lei Zhu, You-Take Oh, Guoqing Qian, Zhen Chen, Shi-Yong Sun
Summary: The study found that rictor is a substrate of caspase-3 and undergoes cleavage during apoptosis. These results provide new information for understanding the role of rictor in regulating cell survival and growth.
Article
Engineering, Electrical & Electronic
Chun-Yi Wei, Yung Kai Wang
Summary: This study investigates relay-assisted mode 1 sidelink multicast transmission for low-latency vehicle-to-everything communications, and proposes a hybrid multiple access approach to accommodate mode 1-mode 2 sidelink traffic.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2022)
Article
Engineering, Aerospace
Zhao Wei, Teng Long, Renhe Shi, Yufei Wu, Nianhui Ye
Summary: This article proposes a scheduling optimization scheme for efficiently implementing space debris removal missions in geostationary Earth orbit (GEO). The scheme formulates the removal sequences of debris targets and develops a hybrid-propulsive orbit transfer strategy to save propellant consumption and removal time. The scheduling optimization problem is then formulated to minimize total propellant consumption, and a clustering based adaptive differential evolution algorithm with potential individual reservation (CADE-PIR) is proposed to solve it. The effectiveness and practicality of the proposed optimization scheme is demonstrated through a real-world GEO space debris removal mission.
IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS
(2022)
Article
Chemistry, Multidisciplinary
Nguyen T. N. Linh, Ngo T. Dung, Le T. T. Tam, Le T. Tam, Nguyen P. Hung, Nguyen D. Vinh, Ngo T. Ha, Pham. H. Nam, Le V. Thanh, Nguyen V. Dong, Le G. Nam, Nguyen V. Dang, Nguyen X. Phuc, Le D. Tung, Nguyen T. K. Thanh, Le T. Lu
Summary: In this research, hollow Fe3O4@Au hybrid nanoparticles were synthesized through seeded growth and galvanic replacement reactions. The formation of h-NPs was influenced by parameters such as reaction time and precursor concentration. The hydrophobic h-NPs were made water-compatible by coating with an amphiphilic polymer, resulting in highly stable colloids. The coated h-NPs showed enhanced signal intensity in T-1- and T-2-weighted MRI and exhibited magnetic and photothermal properties suitable for cancer theranostics.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Transportation Science & Technology
Ruixue Gu, Mark Poon, Zhihao Luo, Yang Liu, Zhong Liu
Summary: This paper proposes an efficient hierarchical solution evaluation method for a general VRPD problem with multiple visits (VRPD-MV), which accelerates the feasibility evaluation of a solution and reduces the time complexity to O(1). The computational results show a positive impact of powerful drones on reducing solution costs, and the proposed algorithm outperforms a state-of-the-art algorithm on the multi-visit traveling salesman problem with multi-drones in terms of solution qualities and computational times required.
TRANSPORTATION RESEARCH PART C-EMERGING TECHNOLOGIES
(2022)
Review
Green & Sustainable Science & Technology
Azuka Affam, Yonis M. Buswig, Al-Khalid Bin Hj Othman, Norhuzaimin Bin Julai, Ohirul Qays
Summary: This paper identifies and examines the contemporary development in multiple input dc-dc converters, analyzing new topologies and features, and summarizing the similarities and differences between different connection modes. It is pointed out that converter properties depend on specific application requirements, and future research trends are suggested.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2021)
Article
Engineering, Mechanical
Xingzhen Zhou, Xiaofei Pei, Bo Yang
Summary: This paper proposes a novel hybrid trajectory planning method that combines A* algorithm and quintic polynomial for autonomous vehicles. The method consists of two layers: an upper layer that uses an improved A* algorithm to search for feasible paths based on various factors, and a lower layer that utilizes segmented quintic polynomial to smooth the trajectory. Experimental results show that the proposed method ensures safe and adaptable trajectory planning in complex scenarios.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART D-JOURNAL OF AUTOMOBILE ENGINEERING
(2023)
Article
Polymer Science
Shiou-Fen Hung, Yu-Han Wen, Lu-Yi Yu, Hsin-Cheng Chiu, Yi-Ting Chiang, Chun-Liang Lo
Summary: In this study, two copolymers were synthesized and characterized for assembling siRNA to form polyplex-mixed micelles for the treatment of human colon cancer cells. The cationic pyridoxal molecules and pH-sensitive properties of the copolymers played key roles in attracting and protecting the siRNA, leading to reduced FAK expression and demonstrated cytotoxicity towards cancer cells within 24 hours. The results suggest the promising potential of pH-sensitive polyplex-mixed micellar system in siRNA delivery for cancer treatment.
Article
Biophysics
Chih-Wei Ting, Ya-Hsuan Chou, Shih-Yu Huang, Wen-Hsuan Chiang
Summary: In this study, hybrid polymeric nanoparticles carrying ICG were fabricated to improve the anticancer efficacy of ICG-mediated photothermal therapy by accelerating ICG release through pH-responsive mechanisms and increasing the aqueous photostability of ICG molecules. The nanoparticles demonstrated efficient cellular uptake and rapid intracellular liberation of ICG, enhancing the anticancer effect of ICG-mediated PTT.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Arjun Sabu, Te- Liu, Siew Suan Ng, Ruey-An Doong, Yu-Fen Huang, Hsin-Cheng Chiu
Summary: This review discusses the therapeutic strategies and underlying mechanisms of glioma stem cells (GSCs) in the treatment of glioblastoma (GBM). GSCs play a crucial role in tumor propagation, treatment resistance, and tumor recurrence. The review highlights the methods of targeting GSC surface markers, blocking essential signaling pathways of GSCs, and manipulating the tumor microenvironment for GBM treatment. In addition, the application of nanotechnology in GSC-targeted therapy is also discussed.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Pei-Wei Shueng, Lu-Yi Yu, Hsiao-Hsin Hou, Hsin-Cheng Chiu, Chun-Liang Lo
Summary: Mitochondrial-targeting therapy is an important strategy for cancer treatment. pH-sensitive polymer-liposome complexes have been developed to efficiently deliver anti-cancer drugs into cancer cellular mitochondria, leading to cell apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Jin-Wun Jhang, Ya-Hsuan Chou, Tzu-Hao Wang, Ming-Hung Hsieh, Wen-Hsuan Chiang
Summary: This study successfully developed PCS20k-decorated rGO nanosheets, which exhibited excellent dispersion in high salt and serum-containing environment. These nanosheets had higher photothermal conversion efficiency under near-infrared irradiation and effectively suppressed the growth of cancer cells.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Pharmacology & Pharmacy
Bhanu Nirosha Yalamandala, Pin-Hua Chen, Thrinayan Moorthy, Thi My Hue Huynh, Wen-Hsuan Chiang, Shang-Hsiu Hu
Summary: This study reports a functional core-shell metal-organic framework nanocube (dual MOF) that acts as a catalytic agent and T cell infiltration inducer, programming ROS and inhibiting autophagy. The purpose of this material design was to inhibit autophagy and ROS efficacy of the tumor, and eventually improve T cell recruitment for immune therapy of lung metastasis.
Article
Engineering, Biomedical
I. -Lin Lu, Ting-Wei Yu, Te- Liu, Hsin-Hung Chen, Ying-Chieh Yang, Chun-Liang Lo, Chi-Ya Wang, Hsin-Cheng Chiu
Summary: A multifunctional sequential targeted delivery system has been developed for efficient treatment of malignant tumors with selective accumulation and minimal systemic drug absorption. This system consists of microfluidized dextran microgels encapsulating LNPs and SPIONs, which achieve hierarchical dual targeting and enhance the retention and cellular uptake of therapeutic LNPs in the colon. The system demonstrates a strong therapeutic effect and reduces unnecessary drug absorption and side effects.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Lu-Yi Yu, Pei-Wei Shueng, Hsin-Cheng Chiu, Yu-Wei Yen, Tzu-Yu Kuo, Chieh-Ru Li, Ming-Wei Liu, Chia-Hsin Ho, Tzu-Hao Ho, Bo-Wei Wang, Cheng-En Li, Ming-Hung Chen, Yao-An Shen, Chun-Liang Lo
Summary: Tumour hypoxia plays a crucial role in various aspects of cancer progression, including angiogenesis, invasion, immunosuppression, and stemness maintenance. By targeting the glucose transporter 1 (GLUT1)-mediated transcytosis, a potential therapeutic strategy for tumor hypoxia was developed. Glucosamine-labeled liposomal ceramide was efficiently transported by GLUT1 and accumulated in the hypoxic area, while exogenous ceramide showed significant effects on tumor hypoxia and disrupted key signaling pathways.
Article
Polymer Science
Ming -Yen Shen, Yu-Hsin Chen, Nien-Tzu Yeh, Tzu-Hao Wang, Wen-Hsuan Chiang
Summary: A pH and hydrogen peroxide-responsive nanoparticle system comprising melanin-like polydopamine (PDA) and PEGylated chitosan (PEG-CS) conjugates is developed for effective photothermal conversion and intracellular drug delivery in cancer treatment. The system shows well-dispersed spherical shape and colloidal stability in physiological salt concentration. The nanoparticles efficiently incorporate the chemotherapy drug doxorubicin (DOX) and exhibit robust photo-thermal effect and stability, while being significantly degraded by hydrogen peroxide.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Physical
Tzu-Hao Wang, Ming -Yen Shen, Nien-Tzu Yeh, Yu-Hsin Chen, Tsai-Ching Hsu, Hao-Yang Chin, Yi-Ting Wu, Bor-Show Tzang, Wen-Hsuan Chiang
Summary: Chemodynamic therapy (CDT) is a promising strategy for tumor treatment, but its efficacy is limited by low Fenton catalytic efficiency and high glutathione (GSH) concentration in cancer cells. To overcome these limitations, a novel photothermal nanozyme was developed to deplete GSH and generate hydroxyl radicals in an acidity-activated manner. The nanozyme showed excellent stability, photothermal conversion efficiency, and Fe3+ release. It effectively killed cancer cells in vitro and suppressed tumor growth in vivo without significant toxicity.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Biomaterials
Ya-Hsuan Chou, Yu-Ling Liu, Tsai-Ching Hsu, Jia-Le Yow, Bor-Show Tzang, Wen-Hsuan Chiang
Summary: This study developed acidity-sensitive polymeric nanoparticles for enhanced intracellular delivery of Zoledronic acid (ZA) in the treatment of extraskeletal solid tumors. The nanoparticles showed improved cellular uptake and anticancer efficacy by responding to tumor acidity and releasing the loaded ZA. In vivo experiments demonstrated that these nanoparticles accumulated in solid tumors and inhibited tumor growth, suggesting their potential in tumor treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Engineering, Biomedical
Bhanu Nirosha Yalamandala, Wei-Ting Shen, Sheng-Hao Min, Wen-Hsuan Chiang, Shing-Jyh Chang, Shang-Hsiu Hu
Summary: Hybrid materials like MOFs show promise in tumor therapy by enabling precise drug release and energy delivery, including thermal or dynamic therapy. Overcoming tumor heterogeneity and leveraging innate immune system are crucial for the clinical translation of MOFs, requiring further comprehensive studies and strategies.
ADVANCED NANOBIOMED RESEARCH
(2021)
Review
Materials Science, Multidisciplinary
Arjun Sabu, Jui-Yen Lin, Ruey-An Doong, Yu-Fen Huang, Hsin-Cheng Chiu
Summary: Theranostics, including both therapeutic and diagnostic functions, is an innovative technology in personalized nanomedicine. Lanthanide-doped upconversion nanoparticles (UCNPs) have unique properties that allow them to be targeted using specific tumor-homing ligands, leading to effective treatment outcomes.
MATERIALS ADVANCES
(2021)
Article
Nanoscience & Nanotechnology
Keiko Tezuka, Masakazu Umezawa, Te- Liu, Koki Nomura, Kyohei Okubo, Hsin-Cheng Chiu, Masao Kamimura, Kohei Soga
Summary: A biodegradable hybrid nanostructure for NIR-induced photodynamic therapy was designed, utilizing ultrasmall upconversion phosphor and hydrocarbonized rose bengal dye encapsulated in a micelle. The structure efficiently emitted green UC luminescence and released singlet oxygen to surrounding water, degrading through hydrolysis of PEG-b-PCL for potential clinical use in deep tissue cancer PDT.
ACS APPLIED BIO MATERIALS
(2021)
Article
Materials Science, Biomaterials
Min-Cong Xiao, Ya-Hsuan Chou, Yu-Ning Hung, Shang-Hsiu Hu, Wen-Hsuan Chiang
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)