Article
Chemistry, Physical
Gyuleen Park, Sung Pil Hong, Changha Lee, Jaehan Lee, Jeyong Yoon
Summary: This study achieved selective fluoride removal in a CDI system using rGO/HA composite material, which showed a significantly higher fluoride removal capacity compared to the traditional AC electrode. Experimental results demonstrate an increase in fluoride removal capacity with the application of adequate voltage. Furthermore, the rGO/HA electrode exhibits stability and reusability in operation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Infectious Diseases
Anne Brigitte Kruse, Nadine Schlueter, Viktoria Konstanze Kortmann, Cornelia Frese, Annette Anderson, Annette Wittmer, Elmar Hellwig, Kirstin Vach, Ali Al-Ahmad
Summary: This study aimed to compare the microbial composition in the saliva of participants using fluoride and stannous ion products versus those using stannous ion-free products. It was found that the use of stannous ions had no negative effects on the oral microbiota and could potentially have a stabilizing effect on health-associated bacteria.
Article
Engineering, Environmental
Daniel S. Mosiman, Andre Sutrisno, Riqiang Fu, Benito J. Marinas
Summary: Hydroxyapatite (HAP) is an effective material for removing excess fluoride from water. This study demonstrates the internalization of fluoride in HAP nanoparticles under environmentally relevant conditions and provides a model to quantify adsorption and total fluoride capacity. The discrepancies between experimental uptake and adsorption capacity indicate the range of fluoride that internalizes to satisfy conservation of mass.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yucong Gu, Yuting Yang, Jingfeng Yuan, Yifeng Ni, Jiahui Zhou, Mengjie Si, Kaishun Xia, Wenlin Yuan, Chunbin Xu, Shengqian Xu, Yisheng Xu, Guangyan Du, Dong Zhang, Weilian Sun, Si Yu Zheng, Jintao Yang
Summary: An injectable hydrogel with programmable mechanical kinetics has been developed for oral jaw repair, which undergoes instant gelation and gradual self-strengthening. The hydrogel also possesses multiple functions including bio-adhesion, self-healing, bactericidal, hemostasis, and X-ray in situ imaging.
Article
Biotechnology & Applied Microbiology
Dhiraj Kumar, Subhrangshu Mandal, Jake Bailey, Beverly E. Flood, Robert S. Jones
Summary: The addition of potential inhibitors of polyP kinases (gallein and fluoride) reduces the uptake and storage of extracellular orthophosphate (P_i) by Rothia dentocariosa, thereby decreasing the potential for mineral dissolution.
LETTERS IN APPLIED MICROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
W-T Huang, P. Anderson, T. Duminis, S. Shahid
Summary: This study investigates the demineralization inhibitory mechanisms of AgNO3, AgF, and SDF using a previously used hydroxyapatite caries demineralization model system.
Article
Dentistry, Oral Surgery & Medicine
Noriko Hiraishi, Mahmoud Sayed, Robert Hill, Ysushi Shimada
Summary: This study utilized solid-state magic angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy to investigate the formation of fluoride compounds in bovine enamel and dentin treated with silver diammine fluoride (SDF). The results revealed that SDF exhibited increased reactivity with dentin, leading to the formation of fluorhydroxyapatite (FHAp) and other fluoride compounds. Scanning electron microscopy (SEM) observations also showed pronounced precipitation and particle formation in dentin treated with SDF.
Article
Materials Science, Coatings & Films
Jinxing Cao, Ruizhe Lian, Xiaohong Jiang, Aleksandr Rogachev
Summary: The F-HA coating, forming a nanopore structure through ion exchange in simulated body fluid, can accelerate apatite-like deposition, enhance corrosion resistance, and promote cell proliferation.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Engineering, Environmental
Dagne Bayih Adamu, Lemma Teshome Tufa, Jaebeom Lee, Enyew Zereffa, Teshome Abdo Segne, Mohd Hasmizam Razali
Summary: This study presents a facile synthesis of bismuth and iron co-doped hydroxyapatite nanomaterials for high-performance fluoride ions adsorption. The nanomaterials exhibited excellent fluoride ion adsorption performance, as confirmed by batch adsorption experiments. The synthesized material showed a chemical process of fluoride uptake forming a monolayer, with homogenous surface. The proposed defluoridation mechanisms were electrostatic interaction and ion exchange. The ease of synthesis and the attractive fluoride adsorption performance make this nanomaterial promising for water treatment and environmental remediation applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Dentistry, Oral Surgery & Medicine
Danyal A. Siddiqui, Alikhan B. Fidai, Smriti G. Natarajan, Danieli C. Rodrigues
Summary: This study developed an oral bacterial biofilm model that simulates the temporal shifts of the oral microbiome during plaque formation and maturation. The results showed that oral bacterial adhesion was similar on surface-treated dental implant materials.
Article
Multidisciplinary Sciences
Jonathan M. Roberts, David J. Bradshaw, Richard J. M. Lynch, Susan M. Higham, Sabeel P. Valappil
Summary: The study found that in the absence of fluoride, starch and sucrose showed similar cariogenicity, but in the presence of fluoride, starch was more cariogenic than sucrose. This suggests that the focus on sugars as the primary cause of caries may need re-evaluating and more attention on carbohydrates is necessary as they may be equally or even more cariogenic than sugars.
Article
Dentistry, Oral Surgery & Medicine
Mohammed Nadeem Bijle, Usman Ashraf, Mohamed Mahmoud Abdalla, Prasanna Neelakantan, Cynthia Kar Yung Yiu
Summary: The study revealed that solutions containing 2%/4% arginine had significant effects in reducing biofilm thickness and proportion of dead bacteria. The Arg-F solution significantly affected the levels of polysaccharides, proteins, and extracellular DNA in the biofilms.
JOURNAL OF DENTISTRY
(2022)
Article
Materials Science, Coatings & Films
Cong Wu, Yufei Tang, Bobo Mao, Kang Zhao, Siyue Cao, Zixiang Wu
Summary: Coatings with piezoelectric characteristics were prepared on the titanium alloy's surface to improve its biological properties, promoting bone growth and shortening bone repair time. The introduction of HA along with the high piezoelectric coefficient significantly enhanced the coating's mineralization, allowing for rapid apatite deposition and excellent biological activity for potential application in the rapid repair of bone defects.
SURFACE & COATINGS TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jingyang Zhang, Sofiya-Roksolana Got, Iris Xiaoxue Yin, Edward Chin-Man Lo, Chun-Hung Chu
Summary: Research has shown that silver diamine fluoride (SDF) is effective in preventing and arresting dental caries due to its mineralizing and antibacterial properties. Although several laboratory studies have demonstrated that SDF can prevent bacterial adhesion to the tooth surface, there are also clinical studies that have failed to show significant changes in microbial diversity on tooth plaque after SDF treatment.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Physical
Mingyu You, Lei Zhang, Tobias A. Gmuer, Kaihuan Zhang, Stefan Zuercher, Wen Li, Guangyin Yuan, Nicholas D. Spencer, Jia Pei
Summary: The article introduces a surface modification method for synthetic pure hydroxyapatite (HA) material, which can provide antimicrobial properties and cytocompatibility. By synthesizing polyethylene glycol graft copolymers, a stable self-assembly layer was successfully formed on the surface of hydroxyapatite, effectively inhibiting non-specific protein adsorption, promoting osteoblast attachment, and preventing bacterial adhesion.
APPLIED SURFACE SCIENCE
(2022)
Article
Biology
Madalena Cipriano, Katharina Schluender, Christopher Probst, Kirstin Linke, Martin Weiss, Mona Julia Fischer, Lena Mesch, Kevin Achberger, Stefan Liebau, Marina Mesquida, Valeria Nicolini, Anneliese Schneider, Anna Maria Giusti, Stefan Kustermann, Peter Loskill
Summary: Researchers have developed a human immunocompetent Choroid-on-Chip model that mimics immune responses in the presence of immune cells, offering a potential tool for studying the interplay between the immune system and oncology. This model may provide insights into eye disorders causing visual impairment and serve as a platform for evaluating drug efficacy and toxicity mechanisms.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tanvi Shroff, Kehinde Aina, Christian Maass, Madalena Cipriano, Joeri Lambrecht, Frank Tacke, Alexander Mosig, Peter Loskill
Summary: Non-clinical models for studying metabolism have limitations in terms of species translatability and predictability. Organ-on-chip systems, specifically multi-organ chips, provide a species-specific platform for studying metabolism and can be integrated with in silico models to enhance predictive power. This technology also has potential for translational applications and personalized medicine.
Article
Chemistry, Multidisciplinary
Julia Rogal, Julia Roosz, Claudia Teufel, Madalena Cipriano, Raylin Xu, Wiebke Eisler, Martin Weiss, Katja Schenke-Layland, Peter Loskill
Summary: Obesity and associated diseases have become epidemic globally. Researchers have developed a microphysiological in vitro model of human white adipose tissue, leveraging Organ-on-Chip technology, which can recapitulate crucial adipose tissue functions and offers advantages such as low inter-donor variability and controllability, making it a valuable tool for metabolism research and personalized medicine applications.
Article
Oncology
Julia Marzi, Matthias B. Stope, Melanie Henes, Andre Koch, Thomas Wenzel, Myriam Holl, Shannon L. Layland, Felix Neis, Hans Boesmueller, Felix Ruoff, Markus Templin, Bernhard Kraemer, Annette Staebler, Jakob Barz, Daniel A. Carvajal Berrio, Markus Enderle, Peter M. Loskill, Sara Y. Brucker, Katja Schenke-Layland, Martin Weiss
Summary: The study characterized the use of noninvasive physical plasma (NIPP) as a treatment for cervical intraepithelial neoplasia (CIN) and conducted a prospective trial, which showed a success rate of 95% in treating CIN1/2 patients with NIPP without significant post-intervention complications.
Article
Biochemistry & Molecular Biology
Minh-Thu Nguyen, Leonhard Hubert Schellerhoff, Silke Niemann, Frieder Schaumburg, Mathias Herrmann
Summary: This article introduces an improved protocol for preparing monocytes, which allows the assessment of cytokine release upon external stimulation. By adding a quiescence step, the protocol provides a stable and activatable pure monocyte population.
Review
Microbiology
Chantal Akoua-Koffi, Adele Kacou N'Douba, Joseph Allico Djaman, Mathias Herrmann, Frieder Schaumburg, Silke Niemann
Summary: The Staphylococcus aureus-related complex is composed of multiple species, with S. schweitzeri mainly found in African wildlife and rarely causing infections in humans. However, misidentification may lead to underreporting of S. schweitzeri in humans. Despite the low number of isolates in humans, in vitro assays suggest that S. schweitzeri might be as virulent as S. aureus. Antimicrobial resistance studies show that S. schweitzeri is susceptible to tested antibiotics.
Article
Engineering, Biomedical
Oliver Schneider, Alessia Moruzzi, Stefanie Fuchs, Alina Grobel, Henrike S. Schulze, Torsten Mayr, Peter Loskill
Summary: Over the past decade, Organ-on-Chip (OoC) has emerged as a promising technology for advanced in vitro models that mimic key physiological cues. A novel concept using spheroids derived from induced pluripotent stem cells is presented for cell injection and tissue generation, allowing for large-scale production of uniform-sized spheroids. These spheroids are then transported and accumulated in dogbone-shaped tissue chambers, where they fuse and form aligned, contracting cardiac muscle fibers. The study also demonstrates electrical stimulation capabilities using fluidic media connectors as electrodes and incorporates optical O2 sensor spots into resin-based microfluidic systems for in situ determination of O2 partial pressures. Overall, this system provides a blueprint for integrating biophysical stimulation and probing capabilities in advanced Organ-on-Chip technology, facilitating the facile and robust generation of high-density microtissues that can be scaled-up and automated.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Physical
Angelo A. Severin, Daniel Rauber, Stavroula Pachoula, Frederik Philippi, Ivan Radev, Anne Holtsch, Frank Mueller, Manfred Baumgaertner, Rolf Hempelmann, Christopher W. M. Kay
Summary: Research on heteroatom doping of carbon materials has been focused on in the past decade, with the aim of improving longevity and performance of electrochemical devices like fuel cells. However, phosphorus-containing, nitrogen-free carbons have been overlooked in these studies. In this research, it was found that carbon precursors coated with P-containing carbon can enhance the performance and durability of fuel cell cathodes. The addition of small amounts of surface phosphorus on carbon supports can reduce resistances and improve key characteristics.
SUSTAINABLE ENERGY & FUELS
(2023)
Article
Education & Educational Research
Alessia Moruzzi, Tanvi Shroff, Silke Keller, Peter Loskill, Madalena Cipriano
Summary: OoC technology combines biology and engineering principles to create new in vitro models, requiring interdisciplinary collaboration. A questionnaire was used to evaluate training aspects and identify stakeholders, professional levels, and specific skillsets. The respondents agreed on the need to train the next generation of OoC researchers early and in interdisciplinary subjects throughout their careers.
EDUCATION SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Timothy MacLucas, Silas Schuetz, Sebastian Suarez, Frank Mueller, Frank Muecklich
Summary: This study investigates the coating thickness evolution of pristine and oxidized carbon nanotubes (CNT) on stainless steel substrates. Potentiostatic electrophoretic deposition (EPD) with two different additives, triethylamine (TEA) and magnesium nitrate hexahydrate (Mg-Nit), is used as a coating technique. Confocal laser scanning microscopy is used to determine the thickness of the CNT depositions at different voltages. The results show that higher voltages lead to increased deposition rates and Mg-Nit allows for a higher CNT deposition rate and forms thicker layers compared to TEA.
Article
Nanoscience & Nanotechnology
Aisha Saddiqa Ahmed, Daniel Wyn Mueller, Stephanie Bruyere, Anne Holtsch, Frank Mueller, Jenifer Barrirero, Kristina Brix, Sylvie Migot, Ralf Kautenburger, Karin Jacobs, Jean-Francois Pierson, Frank Muecklich
Summary: In recent decades, antibiotic resistance has become a crucial challenge for human health. One potential solution is the use of antibacterial surfaces, such as copper and copper alloys. This study investigates the antibacterial properties of brass with topographic surface functionalization via laser interference patterning. The findings reveal the role of chemical modification in the antimicrobial efficiency of the Cu-based alloy within the superficial layers.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Infectious Diseases
Ahmed Mohamed Mostafa Abdrabou, Issa Sy, Markus Bischoff, Manuel J. Arroyo, Soeren L. Becker, Alexander Mellmann, Lutz von Mueller, Barbara Gaertner, Fabian K. Berger
Summary: This study evaluated the feasibility of using MALDI-TOF technology combined with machine learning models to distinguish between hypervirulent and non-hypervirulent strains of Clostridioides difficile. The results showed that certain machine learning models could accurately differentiate between hypervirulent and non-hypervirulent strains with a high accuracy rate and further sub-cluster the hypervirulent strains into three subgroups. The conclusion is that MALDI-TOF combined with machine learning is a reliable tool for rapid identification of major European hypervirulent strains.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Microbiology
Nadhuma Youssouf, Marianne Martin, Markus Bischoff, Philippe Soubeyran, Laila Gannoun-Zaki, Virginie Molle
Summary: Staphylococcus aureus inhibits the host SUMOylation response to enhance its survival and persistence within the host.
MICROBIOLOGY SPECTRUM
(2023)
Meeting Abstract
Cell & Tissue Engineering
Max Urbanczyk, Aline Zbinden, Shannon L. Layland, Lucas Becker, Julia Marzi, Mariella Bosch, Peter Loskill, Garry P. Duffy, Katja Schenke-Layland
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Daniel Alejandro Carvajal Berrio, Aline Zbinden, Max Urbanczyk, Shannon L. Layland, Mariella Bosch, Sandro Fliri, Chuan-En Lu, Abiramy Jeyagaran, Peter Loskill, Garry P. Duffy, Katja Schenke-Layland
TISSUE ENGINEERING PART A
(2022)