Article
Materials Science, Multidisciplinary
Yanbo Wu, Li Tang, Qiang Zhang, Fansheng Kong, Yongguang Bi
Summary: Nanoscale bioactive glasses were successfully synthesized with remarkable mono-dispersity and uniform spherical morphology using a surfactant-free microemulsion strategy combined with ultrasound irradiation. The bioactive glass nanoparticles demonstrated excellent apatite-forming activity, making them a promising candidate for local sustained delivery in bone tissue engineering.
Article
Materials Science, Multidisciplinary
Shengyu Li, Xijin Wu, Jianglin Chen, Jinwei Wang, Lihong Gong, Jianyu Ni, Saifei Xi, Hong Zhang, Huiying Fu, Qiyang Shou
Summary: Bioactive glass nanoparticles have excellent biomineralization ability and hemostatic properties, making them potential agents for bleeding control.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Lucas Fabricio Bahia Nogueira, Marcos Antonio Eufrasio Cruz, Guilherme Jose Aguilar, Delia Rita Tapia-Blacido, Marcia Eliana da Silva Ferreira, Bianca Chieregato Maniglia, Massimo Bottini, Pietro Ciancaglini, Ana Paula Ramos
Summary: Inspired by collagen fibrils, this study compares two methods to synthesize bioactive hybrid membranes and assesses the role of the organic matrix in mineral phase deposition. The hybrid membranes have uniform mineral particle dispersion and enhanced mechanical properties. They are bioactive, non-toxic to osteoblasts, and display antibacterial action against pathogenic microorganisms. These findings have potential for developing bioactive hybrid membranes with controllable degradation rates and antimicrobial properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Huijun Zhang, Jingjing Wu, Ying Wan, Stefan Romeis, Julian D. Esper, Wolfgang Peukert, Kai Zheng, Aldo R. Boccaccini
Summary: Novel bioactive glass flakes combined with chitosan in composite membranes show superior bioactivity and the ability to modulate swelling behavior, making them a promising material for guided bone regeneration.
ADVANCED ENGINEERING MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Sayli Jambhulkar, Dharneedar Ravichandran, Yuxiang Zhu, Varunkumar Thippanna, Arunachalam Ramanathan, Dhanush Patil, Nathan Fonseca, Sri Vaishnavi Thummalapalli, Barath Sundaravadivelan, Allen Sun, Weiheng Xu, Sui Yang, Arunachala Mada Kannan, Yuval Golan, Jessica Lancaster, Lei Chen, Erina B. Joyee, Kenan Song
Summary: This article provides a comprehensive review of nanoparticle assembly, discussing the balance of forces at the nanoscale and nanoparticle-template interactions in the formation of micropatterned surfaces. It focuses on the spatial organization and orientational preference of nanoparticles on non-templated and pre-templated surfaces. The article also explores the broad applications of micropatterned surfaces.
Article
Materials Science, Coatings & Films
Agnieszka Witecka, Svenja Valet, Michal Basista, Aldo Roberto Boccaccini
Summary: Composite coatings based on chitosan and bioactive glass particles fabricated by electrophoretic deposition on pre-treated magnesium alloys show promising potential in bone regeneration applications by suppressing substrate corrosion and promoting cell response.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Zeqian Xu, Xuanyu Qi, Minyue Bao, Tian Zhou, Junfeng Shi, Zhiyan Xu, Mingliang Zhou, Aldo R. Boccaccini, Kai Zheng, Xinquan Jiang
Summary: Type II diabetes mellitus (TIIDM) poses challenges for dentists and orthopedists, but 3D-printed bioscaffolds containing Sr-MBGNs and GelMA can remodel the diabetic microenvironment, enhance bone regeneration, and promote osteogenic, angiogenic, and immunomodulatory properties through the release of Sr, Ca, and Si ions.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Martin Kapp, Chunde Li, Zeqian Xu, Aldo R. Boccaccini, Kai Zheng
Summary: Bioactive glass nanoparticles (BGNs) were successfully synthesized with controllable Ca content, showing that the Ca did not significantly affect particle size and structure. The study revealed that the Ca content in BGNs is related to their protein adsorption behavior, with an initial increase in protein adsorption over time but a subsequent reduction with further incubation, especially in BGNs with higher Ca content.
Article
Materials Science, Ceramics
Sudipta, Sarita Mishra, Sevi Murugavel
Summary: Ternary SiO2-CaO-P2O5 MBGs synthesized using acid assisted sol-gel process exhibit excellent bioactivity and multifunctional properties, providing potential applications in tissue regeneration, tumor suppression, antimicrobial activity and angiogenesis promotion for bone defect treatment.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2022)
Article
Polymer Science
Jing Chen, Yonglei Xing, Xiaozhuan Bai, Min Xue, Qi Shi, Beibei Li
Summary: Developing bioactive implants with strong mechanical properties and biomineralization activity is crucial for bone repair. In this study, modified cellulose nanofiber (mCNF)-reinforced bioactive glass (BG)-polycaprolactone (PCL) hybrids (mCNF-BP) with strong biomechanics and good apatite formation ability were successfully developed. The incorporation of mCNFs significantly improved the forming duration, biomechanical performance, and in vitro apatite-formation capability of the hybrid materials.
Article
Chemistry, Multidisciplinary
Qing Min, Congcong Wang, Yuchen Zhang, Danlei Tian, Ying Wan, Jiliang Wu
Summary: This study prepared mesoporous bioactive glass nanoparticles with high specific surface area and further modified their surfaces to produce three kinds of amino-functionalized bioactive glass nanoparticles. These nanoparticles were then crosslinked with glycol chitosan to construct ABG/GCH hydrogels, which showed strong and elastic features. The optimized hydrogels were injectable with tunable gelation time and supported cell growth and matrix deposition.
Article
Materials Science, Multidisciplinary
Daniela Acuna, Nicolas Cohn, Franck Quero
Summary: Silica/gelatin/polyethylene oxide hybrid membranes with maximized gelatin and bioactive glass nanoparticles contents were produced by electrospinning using water as main solvent. The membranes obtained from the precursor showed bioactive, non-toxic and enhanced ability for osteogenic differentiation, demonstrating their potential for dental tissue engineering applications.
Article
Materials Science, Ceramics
Raja Aqib, Sarang Kiani, Shaher Bano, Abdul Wadood, Muhammad Atiq Ur Rehman
Summary: This study investigated the surface and biological properties of Ag-Sr-doped mesoporous bioactive glass nanoparticle loaded chitosan/gelatin coatings deposited on 316L stainless steel by electrophoretic deposition. The optimized EPD parameters resulted in homogenous coatings with suitable wettability, adhesion strength, antibacterial properties, and promotion of osteoblast cell proliferation. The coatings also developed HA crystals upon immersion in simulated body fluid. The results confirmed the composite coatings' effectiveness against Escherichia coli cells.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2021)
Article
Materials Science, Ceramics
Silmara C. Santos, Katharina G. Spaniol, Nikolas E. Chaves-Silva, Roberta P. M. Fernandes, Debora S. Tavares, Wilson Acchar, Euler A. dos Santos
Summary: The study aimed to produce CuO-containing bioactive glass/PVA membranes with osteogenic and antibacterial properties for guided bone regeneration. The composite membranes showed ability to form an apatite layer in simulated body fluid, improved osteoblastic proliferation, and higher damage to bacteria. These membranes have low swelling rate, important surface bioactivity, and low degradation over time, meeting the basic requirements for GBR barriers while effectively controlling bacterial growth.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Materials Science, Ceramics
Marcelo da Silva Mantini Viana, Thalita Marcolan Valverde, Breno Rocha Barrioni, Alfredo Miranda de Goes, Marcos Augusto de Sa, Marivalda de Magalhaes Pereira
Summary: This study obtained cobalt-containing nanoparticles with the potential to release pro-angiogenic ions using a sol-gel based method, which can be applied for tissue repair and tissue engineering.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Shardul Bhusari, Shrikrishnan Sankaran, Aranzazu del Campo
Summary: This study investigates the growth and metabolic activity of bacteria within a hydrogel network. The results show that the mechanical properties of the matrix can control and regulate the behavior and function of the bacteria, providing new insights for the design of engineered living materials.
Article
Materials Science, Multidisciplinary
Jun Feng, Yijun Zheng, Qiyang Jiang, Malgorzata K. Wlodarczyk-Biegun, Samuel Pearson, Aranzazu del Campo
Summary: This paper presents an extrusion printing method for manufacturing flexible optical waveguides, and demonstrates the performance of the printed fibers in terms of optical loss, Young's Modulus, and stretchability. This method simplifies the fabrication process of compliant and stretchable devices from materials approved for clinical use.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Engineering, Biomedical
Maria V. Monteiro, Luis P. Ferreira, Marta Rocha, Vitor M. Gaspar, Joao F. Mano
Summary: This article presents the latest advances in bioengineering methods for in vitro modeling of the biological features and microenvironment of pancreatic cancer stroma, as well as providing design guidelines. The overview provides valuable examples and starting guidelines for researchers interested in engineering and characterizing stroma-rich biomimetic tumor models.
Article
Engineering, Biomedical
Sara Nadine, Ines Fernandes, Sonia G. Patricio, Clara R. Correia, Joao F. Mano
Summary: This study proposes a method to bioengineer biomimetic bone niches using immune cells, particularly macrophages. The incorporation of macrophages within the fabricated microcapsules allows for the recreation of an appropriate bone microenvironment and the development of new bone mineralized microtissues. The findings indicate the potential of using this method in bone tissue engineering and disease modeling.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Ana F. Cunha, Andre F. V. Matias, Cristovao S. Dias, Mariana B. Oliveira, Nuno A. M. Araujo, Joao F. Mano
Summary: Studying the interactions between living cells and mechanically stable materials helps us understand physiological phenomena and potentially develop innovative applications. By examining how cells interact with objects of different stability, we can uncover biological responses and address healthcare challenges.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Catharina Husteden, Yazmin A. Brito Barrera, Sophia Tegtmeyer, Joao Borges, Julia Giselbrecht, Matthias Menzel, Andreas Langner, Joao F. Mano, Christian E. H. Schmelzer, Christian Woelk, Thomas Groth
Summary: This article presents a gene-activated surface coating strategy for designing smart biomaterials for bone tissue engineering. The thin-film coating is made of polyelectrolyte multilayers composed of collagen I and chondroitin sulfate, and further functionalized with DNA/lipid-nanoparticles. The successful formation of the thin-film, fibrillar structuring of collagen, and homogeneous embedding of lipoplexes is demonstrated. Culturing mesenchymal stem cells on the functionalized multilayer shows excellent attachment, growth, and uptake of cargo like fluorescence-labelled DNA from lipoplexes. Furthermore, the functionalization of the multilayer induces osteogenic differentiation of mesenchymal stem cells.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Joao Rocha Maia, Rita Sobreiro-Almeida, Franck Cleymand, Joao F. Mano
Summary: Three-dimensional printing has emerged as a promising method for biofabrication of tissue engineering constructs, aiming to create tissue/organ replacements for precision medicine. By using human-sourced biomaterials with optimal rheological properties, the best possible scaffolds can be created, enhancing clinical outcomes. This paper provides an overview of current efforts in achieving necessary ink properties for biofabrication and discusses crosslinking strategies. It also explores the state-of-the-art of using human-sourced inks and presents future perspectives on the field.
JOURNAL OF PHYSICS-MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Sara Trujillo, Jennifer Kasper, Adrian de Miguel-Jimenez, Britta Abt, Alina Bauer, Joelle Mekontso, Samuel Pearson, Aranzazu del Campo
Summary: This study finds that PEG hydrogels prepared by the methylsulfonyl-thiol reaction are biocompatible and can be used in clinical applications without causing inflammation. The cytocompatibility of these hydrogels is compared with those prepared by the maleimide-thiol reaction, and the results show that the methylsulfonyl-thiol reaction is more compatible with cells.
Review
Chemistry, Multidisciplinary
Michele Clerc, Sara Sandlass, Omar Rifaie-Graham, Julie A. Peterson, Nico Bruns, Javier Read de Alaniz, Luciano F. Boesel
Summary: Donor-acceptor Stenhouse adduct (DASA) photoswitches have attracted a lot of attention due to their negative photochromism, visible light absorbance, synthetic tunability, and large property changes. However, there are still challenges in understanding their behavior and incorporating them into polymers. This review summarizes the current understanding of DASA design and switching properties, discusses strategies of incorporating DASAs into polymers, and explores emerging applications of DASA photoswitches in polymeric materials.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Sara Trujillo, Jennifer Kasper, Adrian de Miguel-Jimenez, Britta Abt, Alina Bauer, Joelle Mekontso, Samuel Pearson, Aranzazu del Campo
Summary: The cytocompatibility of the in situ cross-linking reaction by methylsulfonyl-thiol chemistry is evaluated, and compared with maleimide-thiol cross-linked PEGs. The results show that methylsulfonyl-thiol chemistry is cytocompatible and does not trigger high pro-inflammatory responses in endothelial cells and monocytes, making it eligible for in vivo testing and potential clinical application in the future.
Review
Medicine, Research & Experimental
Daniela Patricio, Joana Santiago, Joao F. Mano, Margarida Fardilha
Summary: This article provides an overview of organoid technology and its applications in healthcare and research, with a focus on male reproductive system organoids and other biomaterials. The article also discusses current applications and highlights the research gaps, challenges, and opportunities in the field.
WIRES MECHANISMS OF DISEASE
(2023)
Article
Polymer Science
Patricia Remuinan-Pose, Clara Lopez-Iglesias, Ana Iglesias-Mejuto, Joao F. Mano, Carlos A. Garcia-Gonzalez, M. Isabel Rial-Hermida
Summary: This study introduces alginate aerogel particles loaded with vancomycin obtained through a novel processing strategy combining gel inkjet printing and water-repellent surfaces, which can sustain release the antibiotic for more than 7 days. The green aerogel processing strategy significantly improves drug loading yields and has the potential to enhance antibacterial treatments for chronic wounds.
Article
Materials Science, Multidisciplinary
Dora C. S. Costa, Patricia D. C. Costa, Maria C. Gomes, Amit Chandrakar, Paul A. Wieringa, Lorenzo Moroni, Joao F. Mano
Summary: This study reports a versatile method to convert non-thermoresponsive hydrogels into thermoresponsive systems with shape memory ability. By embedding a thermoresponsive polyurethane mesh into different hydrogel networks, hydrogel composites with good shape fixity and recovery ability were achieved. This method has significant implications for conveying shape memory properties to hydrogels in various biological and nonbiological applications.
ACS MATERIALS LETTERS
(2022)
Review
Chemistry, Physical
Diana Jesus, Ana R. Pinho, Maria C. Gomes, Claudia S. Oliveira, Joao F. Mano
Summary: Bone tissue engineering aims to recreate the bone microenvironment for bone regeneration by guiding cell fate towards the osteogenic lineage. It is important to consider the synergistic effect of biochemical/physical cues, as cells in their native microenvironment are stimulated by multiple signals simultaneously. Therefore, combined modifications are crucial for developing innovative bone regenerative therapies.
Review
Materials Science, Biomaterials
Bruno M. Ladeira, Catarina A. Custodio, Joao F. Mano
Summary: Core-shell microcapsules have the potential to recreate the hierarchical structure of biological systems by independently modulating the composition of the core and shell layers. They can be tailored to recreate specific cell niches.
BIOMATERIALS SCIENCE
(2022)
