Article
Chemistry, Multidisciplinary
Manuel G. Ricardo, Peter H. Seeberger
Summary: Biomaterials with improved biological features can be obtained by conjugating glycans to nanostructured peptides. Peptide-glycan chimeras were successfully obtained through the merging of peptide and glycan solid-phase syntheses using a bifunctional monosaccharide. Different chimeras containing various sugars and peptides were prepared and exhibited different self-assembling properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Manuel G. Ricardo, Peter H. Seeberger
Summary: Biomaterials with improved biological features can be obtained by conjugating glycans to nanostructured peptides. Creating peptide-glycan chimeras requires superb chemoselectivity. We expedite access to such chimeras by merging peptide and glycan solid-phase syntheses employing a bifunctional monosaccharide.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yanqing Ge, Chen Wang, Weiqiang Zhang, Shike Lai, Dong Wang, Jiqian Wang
Summary: In this study, the coassembly of CBHH peptide with dicarboxylates was investigated, showing that dicarboxylates could induce peptide folding and self-assembly, promoting gelation at low pH. The biocompatibility of the hydrogel was confirmed through toxicity assessments, making it suitable for cell culture applications.
Article
Chemistry, Physical
Fengyi Cao, Gangqing Ma, Meng Song, Genxing Zhu, Lin Mei, Qi Qin
Summary: Antimicrobial peptides with hydrophobic and cationic residues can self-assemble into hydrogels, and the number of residues affects the self-assembly behavior and structure characteristics. A strong crosslinked structure may have negative effects on antimicrobial activity.
Article
Chemistry, Multidisciplinary
Naohiro Kameta, Masaki Kogiso
Summary: The study found that different regioisomeric dihydroxy naphthalenes can lead to the formation of nanotubes or nanofibers with different structures when complexed with pyridine-based amphiphiles, and the inner diameter is strongly correlated with the aggregation states. These findings are crucial for fine-tuning the inner diameters of supramolecular nanotubes and controlling the aggregation states of functional aromatic molecules.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Medicine, Research & Experimental
Qinming Xu, Xing Li, Jingang Yang, Yan Zhang, Xiaocui Deng, Gang Li, Qingmei Yuan
Summary: Four peptide amphiphiles (PA1-4) with different degrees of polymerization were synthesized and characterized. The PAs could self-assemble into spherical micelles in low concentration aqueous solution, adopting random coil conformations. The water solubility of PAs increased with the increase of polymerization degree, and the micelles exhibited controlled drug release effects. The PA2 micelles showed promising potential as drug carriers for cancer therapy.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Xueyi Chang, Qun Luo, Yongfu Qiu, Zhiyu Cheng, Guiping Tan, Tao Guan, Biye Ren
Summary: In this study, two novel polymeric ferrocenyl amphiphiles were synthesized and their electrochemically redox-controlled self-assembly behaviors were investigated. The results showed that the polymeric amphiphiles could reversibly aggregate into spherical micelles and disassemble into irregular fragments in aqueous solution by electrochemical redox reaction. This research offers significant possibilities for the fundamental science of controlled self-assembly and drug release.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Jun Zhang, Yining Wang, Junfeng Wang, Youguo Yan, Jiawei Li, Zhen Li
Summary: Vesicle structures assembled from short peptides can be used as carriers for drug delivery. By modifying these peptides with photo-responsive azobenzene moieties, smart vesicles that release cargos under UV or visible light can be created. Molecular simulations have shown that grafting an azo moiety to phenylalanyl-alanine peptides can lead to self-assembling vesicles, and the addition of diphenylalanine improves the efficiency of self-assembly. The formation of vesicles involves nucleation, fusion, and curling, and the isomerization of the azo groups perturbs the packing of the membranes, causing a photo-responsive change in morphology and permeability. These findings have important implications for self-assembly behavior regulation and the design of smart materials.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Atsuya Yaguchi, Hirotsugu Hiramatsu, Atsuya Ishida, Mio Oshikawa, Itsuki Ajioka, Takahiro Muraoka
Summary: Insertion of central alkylene chains in peptides can enhance beta-sheet hydrogen bonds and modulation of packing order, leading to the formation of hydrogels with increased stiffness. However, amphiphilic peptides bearing internal alkylene chains longer than C2 show decreased cell-adhesive properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
A. Yaguchi, H. Hiramatsu, A. Ishida, M. Oshikawa, I Ajioka, T. Muraoka
Summary: The cover of this issue showcases the nanofiber formation of an amphiphilic peptide with a central alkylene chain that exhibits non-cell adhesive properties, by the group of Takahiro Muraoka at Tokyo University of Agriculture and Technology and collaborators.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Pin-Wei Lee, Adrian Saura-Sanmartin, Christoph A. Schalley
Summary: This study presents a supramolecular assembly method for superhydrophobic coatings using a low molecular weight gelator and acrylate polymers, resulting in scratch-resistant and transparent coatings. The incorporation of covalent polymers improves the mechanical resistance and optical transparency of the coatings while maintaining their water and oil repellency.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Organic
Paula B. Chamorro, Fatima Aparicio, Raquel Chamorro, Nerea Bilbao, Santiago Casado, David Gonzalez-Rodriguez
Summary: The study found that dinucleobase amphiphilic monomers can self-assemble into helical nanotubes under different conditions, but may undergo different reactions when experimental conditions are changed, including disassembly, chiral reorganization or morphological restructuring.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Xuening Feng, Huanyu Liu, Hanjun Liu, Xuebin Jiang, Liwei Shen, Yuqi Tang, Qian Qu, Dong Xiang, Xuemin Yan, Yuanzhu Mi
Summary: A new type of ionic liquid demulsifier, HDEA-TFA, with both hydrophilic and hydrophobic chains, was synthesized and identified with its chemical structure. It showed excellent demulsifying ability for two water-in-crude oil (W/O) emulsions with different ratios. The influences of demulsification conditions on the demulsifying efficiency (DE) were discussed, and the results indicated that HDEA-TFA could achieve 100% DE within 120 minutes at a concentration of 500 mg/L and a temperature of 60℃. Moreover, HDEA-TFA exhibited remarkable resistance to acidity, alkalinity, and salinity. The demulsifying mechanism was investigated through various measurements, and this study provided a reference for further research on demulsification mechanisms.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Zejun Zhang, Zhansheng Wang, Hua Zhang, Qingji Wang, Yuqi Tang, Qian Qu, Liwei Shen, Yuanzhu Mi, Xuemin Yan
Summary: In this study, an ionic liquid demulsifier (MDBr-IL) with dual cationic centers and multiple hydrophobic chains was synthesized using N,N,N,N,-tetraglycidyl-4,4-diaminodiphenylmethane as the starting material. The structure of MDBr-IL was characterized using Fourier transform infrared spectrometer (FT-IR) and 1H nuclear magnetic resonance spectrometer (1H NMR). The demulsifying efficiency (DE) of MDBr-IL was investigated in a water-in-crude oil emulsion, and it was found that the DE reached 95.24% at a concentration of 500 mg/L, a temperature of 60 degrees C, and a demulsifying time of 180 min. Moreover, MDBr-IL showed outstanding resistance to acid, alkali, and salt and higher DE at a demulsifying temperature of 70 degrees C.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Nanoscience & Nanotechnology
Ankita Kumari, Ipsita Pani, Mohammad Umer Lone, Aditi Aggarwal, Santanu Kumar Pal, Raj Kumar Roy
Summary: Due to simple synthetic strategies, randomly functionalized amphiphilic polymers have become highly researched. Recent studies have shown that these polymers can self-assemble into various nanostructures, similar to amphiphilic block copolymers. The study explored the self-assembly behavior of randomly functionalized hyperbranched polymers and their linear analogues in solution and at the liquid crystal-water interfaces. Regardless of their architecture, the designed amphiphiles formed spherical nanoaggregates in solution and influenced the ordering transitions of liquid crystal molecules at the liquid crystal-water interface. However, the linear analogues required 10 times less amphiphiles compared to the hyperbranched polymers to achieve the same ordering transition of liquid crystal molecules. Additionally, only the linear analogues responded to biorecognition events, which can be attributed to both of the aforementioned differences.
ACS APPLIED MATERIALS & INTERFACES
(2023)