Article
Chemistry, Physical
Mingyu You, Lei Zhang, Tobias A. Gmuer, Kaihuan Zhang, Stefan Zuercher, Wen Li, Guangyin Yuan, Nicholas D. Spencer, Jia Pei
Summary: The article introduces a surface modification method for synthetic pure hydroxyapatite (HA) material, which can provide antimicrobial properties and cytocompatibility. By synthesizing polyethylene glycol graft copolymers, a stable self-assembly layer was successfully formed on the surface of hydroxyapatite, effectively inhibiting non-specific protein adsorption, promoting osteoblast attachment, and preventing bacterial adhesion.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Physical
Ozkan Gokcekaya, Celaletdin Ergun, Thomas J. Webster, Abdurrahman Bahadir, Kyosuke Ueda, Takayuki Narushima, Takayoshi Nakano
Summary: Ag-containing hydroxyapatite (HA) can reduce risks of bacterial infections, and the biological properties of HA can be influenced by precursor solutions, this study found that P-deficient AgHA exhibited good antibacterial properties and osteoblast adhesion.
Article
Materials Science, Ceramics
Ozkan Gokcekaya, Celaletdin Ergun, Thomas J. Webster, Takayoshi Nakano
Summary: This study synthesized a group of boronated hydroxyapatite (BHA) crystals by altering the precursor chemistry and found that BHA synthesized by the gas-phase deposition method showed better biocompatibility in terms of cell adhesion than pure HA. This has potential implications for improving orthopedic applications.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ya-jing Ye, Yi-fan Xu, Ya-bo Hou, Da-chuan Yin, Dan-bo Su, Zi-xu Zhao
Summary: This study demonstrates that nano porous topography scaffold promotes the proliferation, cytoskeleton orientation, and tenogenic differentiation of tendon stem cells (TSCs).
Article
Biochemistry & Molecular Biology
Shiao-Wen Tsai, Yu-Wei Hsu, Whei-Lin Pan, Fu-Yin Hsu
Summary: Synthetic hydroxyapatite (HA) and strontium-substituted hydroxyapatite (SrHA) can be used as bone grafts and enhance osteogenic differentiation of osteoblast-like cells; nanofibrous bioceramic matrices have the potential to improve the differentiation of MG63 osteoblast-like cells.
Article
Biochemistry & Molecular Biology
Woojin Na, Min-Kyung Kang, Sin-Hye Park, Dong Yeon Kim, Su Yeon Oh, Moon-Sik Oh, Sohyun Park, II-Jun Kang, Young-Hee Kang
Summary: Research has shown that aesculetin can accelerate osteoblast differentiation, promote matrix vesicle biogenesis, and mineralization, making it a potential osteo-inductive agent for preventing bone pathologies or enhancing bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Ju An Park, Yejin Youm, Hwa-Rim Lee, Yongwoo Lee, Sarah L. Barron, Taejeong Kwak, Gyu Tae Park, Young-Cheol Song, Roisin M. Owens, Jae Ho Kim, Sungjune Jung
Summary: A cell sheet transfer method from a culture surface to a target tissue is introduced in this study. UV-treated parylene, a commercially available flexible material, is used as the culture surface to provide adequate cell adhesiveness for both cell attachment during culture and efficient transfer. Various cell types are successfully transferred using this versatile cell-transfer process. The mechanism of interfacial cell migration between surfaces with different adhesion preferences is observed, and the re-establishment and reversal of cell polarity after transfer are identified. The unique capabilities of 3D multilayer stacking, freeform design, and curved surface application are demonstrated. The therapeutic potential of the cell-sheet delivery system is demonstrated through experiments on cutaneous wound healing and skin-tissue regeneration in mice models.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Duho Jang, Haedam Jin, Min Kim, Yeong Don Park
Summary: Organic semiconductors show promise as sensing materials for printed organic gas sensors, but they face challenges related to low sensitivity and poor stability. Blending perovskite nanocrystals with conductive polymer can improve gas sensing performance while maintaining high responsivity and response rates. Surface modification of the perovskite enhances the adsorption of target gas molecules. Perovskite materials also protect the polymer thin film from oxidation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Qianqian Shi, Zijun Yong, Md Hemayet Uddin, Runfang Fu, Debabrata Sikdar, Lim Wei Yap, Bo Fan, Yiyi Liu, Dashen Dong, Wenlong Cheng
Summary: Tissues consist of closely packed cell arrays, resembling sheet-like biosynthesis plants. Soft polystyrene-encased nanoframe reactor arrays can synthesize novel nanocrystals in a unique confined environment, enabling directional inward crystallization.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chunzi Liu, Amy C. Madl, Daniel Cirera-Salinas, Wolfgang Kress, Frank Straube, David Myung, Gerald G. Fuller
Summary: Dry eye disease (DED) is a costly condition with unclear pathology. A novel in vitro mucin-deficient mimetic ocular surface (Mu-DeMOS) was developed to represent the diseased ocular surfaces. Results suggest that optimal surface roughness and surface chemistry play a key role in sustainable lubrication for healthy ocular surfaces.
Review
Medicine, General & Internal
Christian Klein, Christian Meller, Edgar Schaefer
Summary: Cell cultures are valuable tools for research, but the establishment and characterization of odontoblast-like cell cultures have not been standardized, posing challenges for their use in studies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Polymer Science
Zvikomborero Machikiti, Behnam Pourdeyhimi, Jan Genzer, Kirill Efimenko
Summary: This study investigates the adhesion strength between PA6 and PET modified with specific modifiers, aiming to tailor the adhesion at the PA6/PET interface for easy polymer splitting in microfibers production.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Physical
Mohamed Mohamady Ghobashy, Naeem M. El-Sawy, Ahmad S. Kodous
Summary: This study synthesized a carbonated hydroxyapatite nanocomposite using a hydrogel template and compared its effectiveness with hydroxyapatite for osteogenic ability. The results showed that CCaHAp might be more suitable for enhancing osteogenic capacity compared to HA.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Engineering, Biomedical
Laura M. S. dos Santos, Jonathas M. de Oliveira, Elaine C. O. da Silva, Vitor M. L. Fonseca, Juliane P. Silva, Emiliano Barreto, Noelio Oliveira Dantas, Anielle C. A. Silva, Alcenisio J. Jesus-Silva, Cleber R. Mendonca, Eduardo J. S. Fonseca
Summary: Microgrooved surfaces created by femtosecond laser writing technique were investigated for their mechanical and morphological effects on osteoblast cells. Circular microgrooves were found to enhance osteoblast alignment and stiffness, while the incorporation of TiO2 nanocrystals further improved the effects of circular microgrooves.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Chemistry, Multidisciplinary
Mengying Wang, Zixiang Cui, Yongqiang Xue
Summary: This paper presents a novel method to determine the interfacial tension, temperature coefficient, and Tolman lengths of nanomaterials using adsorption thermodynamics and kinetics. The experimental results indicate that the particle size of nanoparticles has significant effects on the interfacial tension and its temperature coefficient, as well as the Tolman length. The effects of particle size on interfacial tension and Tolman length become more significant when the particle radius approaches or reaches the order of magnitudes of molecular (or atomic) radius.
Article
Chemistry, Physical
Shota Yamada, Yadong Chai, Motohiro Tagaya
Summary: Silicate-containing hydroxyapatite particles were functionalized and their hydration layer states were studied in relation to collagen fibrillation. The ratio of free to intermediate water decreased with silicate components and increased with PEG-silane molecular occupancy. The water mobility and state changes were observed during collagen fibrillation at the interface.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Materials Science, Biomaterials
Zizhen Liu, Takuya Kataoka, Sadaki Samitsu, Daisuke Kawagoe, Motohiro Tagaya
Summary: The study successfully synthesized spherical and negatively charged Cit/HA nanoparticles to achieve highly transparent Cit/HA films. By controlling the sizes and shapes of the hybrid nanoparticles, the research demonstrated the formation of uniform transparent films with nanospaces, improving their dispersibility in water. This approach provides a simple way to achieve transparent nanoparticle film formation for biomedical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Takuya Kataoka, Takumi Hashimoto, Sadaki Samitsu, Zizhen Liu, Motohiro Tagaya
Summary: By changing the Ca/P molar ratio, we successfully controlled the coordination states of citric acid molecules on europium ion-doped hydroxyapatite nanoparticles and investigated their effect on the photoluminescence properties.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Iori Yamada, Takuya Kataoka, Ryota Ikeda, Sadaki Samitsu, Motohiro Tagaya
Summary: Methylene blue-immobilized hydroxyapatite nanoparticles were successfully synthesized by changing the initial P/Ca molar ratio. The immobilized amount of methylene blue increased with an increase in the initial P/Ca molar ratio. The shape of the hydroxyapatite nanoparticles remained elliptical, irrespective of the initial P/Ca molar ratio. The findings suggest that the initial P/Ca molar ratio can effectively control the interfacial interactions between methylene blue and the hydroxyapatite surface.
INORGANIC CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Yadong Chai, Yanni Zhou, Haruki Hosokai, Mari Miyata, Motohiro Tagaya
Summary: The formation of oriented collagen fibril arrays on polyimide films rubbed by different filament density clothes was investigated. Dense nano-grooves on PI-HDR effectively induced highly-oriented fibril arrays. The assembly of Col molecules into oriented fibrils was facilitated by the physicochemical properties of the films.
Article
Materials Science, Multidisciplinary
Hao Li, Jianan Zhang, Shuaishuai Li, Song Chen, Ren Guo, Toshiyuki Ikoma, Xiaona Li, Weiyi Chen
Summary: In this study, TiO2 hollow microspheres were successfully synthesized using chitosan/gelatin microspheres as both supporting matrix and sacrificial templates. The TiO2 hollow microspheres exhibited a spherical morphology with a hollow structure, and promoted cell attachment and proliferation.
Article
Materials Science, Multidisciplinary
Cunfang Zhang, Xinyan Zhang, Song Chen, Jianan Zhang, Shuaishuai Li, Xiaona Li, Toshiyuki Ikoma, Weiyi Chen
Summary: Novel silk fibroin-decorated TiO2 nanowire microspheres were successfully synthesized through in situ decoration method, and the presence of silk fibroin enhanced the biocompatibility of the microspheres.
Article
Pharmacology & Pharmacy
Ken Takahashi, Yasuhiro Nakagawa, Yu Sato, Ryo Wakita, Maeda Shigeru, Toshiyuki Ikoma
Summary: In this study, QX-OH was loaded onto carboxyl-functionalized mesoporous silica nanoparticles (MSN) using an ester-based drug loading method to achieve pH-responsive release. The introduction of an ester bond efficiently provided a local anesthetic via pH-responsive release.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Ren Guo, Congcong Rong, Song Chen, Jianan Zhang, Akiyoshi Osaka, Toshiyuki Ikoma, Xiaona Li, Weiyi Chen
Summary: In this study, chitosan/Fe3O4/TiO2@TiO2 nanowire microspheres with extracellular matrix-like fibrous surface and photothermal antibacterial property were synthesized. The microspheres significantly enhanced the attachment and proliferation of human umbilical vein endothelial cells and exhibited photothermal antibacterial activity due to the presence of nanofibrous surface and Fe3O4 component.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Chemistry, Physical
Yuta Aida, Yasuhiro Nakagawa, Tetsuo Kishi, Toshiyuki Ikoma
Summary: This study investigated the identification of star-shaped Au-Ag nanoparticles with spinous morphology using discrete dipole approximation and morphological symmetric consideration. By varying the Au/Ag ratio, nanoparticles with different aspect ratios and number of spines were obtained and their morphology was identified by comparing the optical absorption spectra with the calculated absorption efficiency. Taking the particle size distribution into consideration improved the calculation accuracy. In conclusion, this study demonstrated the potential of computational morphological identification in predicting nanoparticles with complexed morphology.
Article
Chemistry, Inorganic & Nuclear
Reo Kimura, Kota Shiba, Kanata Fujiwara, Yanni Zhou, Iori Yamada, Motohiro Tagaya
Summary: In this study, a method for controlling the morphology of a calcium phosphate (CP) coating on silica-titania (SiTi) porous nanoparticles was developed. It was demonstrated that controlled surface roughness of CP coatings could be achieved using SiTi nanoparticles with a well-defined spherical shape, uniform size, and tunable nanoporous structure in simulated body fluid (SBF). The pore size distribution of SiTi nanoparticles significantly influenced the surface morphology of the CP coating in SBF immersion, with bimodal pore sizes leading to rough surfaces and a unimodal pore size maintaining smooth surfaces.
Review
Engineering, Multidisciplinary
Kazuto Sugimoto, Yanni Zhou, Tania Guadalupe Penaflor Galindo, Reo Kimura, Motohiro Tagaya
Summary: This review examines the influence of added ions and surface states on the biocompatibility of hydroxyapatite (HA). HA is a calcium phosphate found in biological hard tissues and has been extensively studied for its osteogenic properties. The chemical composition and crystalline structure of HA can change based on synthetic methods and added ions, affecting its biocompatibility. The importance of surface characteristics and hydration layers for controlling biomedical function and improving biocompatibility is highlighted. Understanding these properties can provide insights into bone formation and regeneration mechanisms.
Article
Engineering, Multidisciplinary
Tania Guadalupe Penaflor Galindo, Kazuto Sugimoto, Shota Yamada, Taito Sugibuchi, Zizhen Liu, Motohiro Tagaya
Summary: This study investigated the effects of silicate ions on the properties of hydroxyapatite (HA) particles, finding that increased silicate ions reduced crystallinity, expanded crystalline size, and led to the formation of a silicate coating on the particle surfaces, enhancing bioactivity.
Review
Chemistry, Inorganic & Nuclear
Zizhen Liu, Shota Yamada, Yuichi Otsuka, Tania Guadalupe Penaflor Galindo, Motohiro Tagaya
Summary: It is suggested to develop and design bioceramic nanoparticles to promote effective bone regeneration, such as hydroxyapatite (HA), which can support proteins related to bone repair and regeneration. The control of the hydration layer and protein adsorption states on the surfaces of HA nanoparticles is important for their high biocompatibility and further application in the biomedical field.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Daichi Noda, Norio Saito, Iori Yamada, Motohiro Tagaya
Summary: This study provides the first report on the interface behavior of calcium phosphate-porphyrin interaction changes and proposes a new concept of organizing a well-arranged molecular assembly on bioceramic surfaces.