Review
Medicine, Research & Experimental
Vasanti Suvarna, Bhunesh Bore, Chaitanya Bhawar, Rashmi Mallya
Summary: Bioactive phytochemicals from natural sources have diverse therapeutic activities, but their application is hindered by drawbacks such as poor solubility and bioavailability. However, complexation with cyclodextrins provides a solution to these issues. This article summarizes the complexation of various phytochemicals with cyclodextrins and the impact on their stability and dissolution rate, leading to enhanced bioactivity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Wanbing Li, Haibo Zhang, Zhaolan Zhai, Xujuan Huang, Shibin Shang, Zhanqian Song
Summary: Novel rosin-based photo-responsive amphiphilic polymers were synthesized with PEG and AZOMPA, showing high photoresponsive efficiency and morphological changes for polymers with different chain lengths. UV irradiation triggered structural transformation and release of loaded probes for these bola amphiphilic polymers.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Applied
Hyun-Mo Jeong, Yeontaek Lee, Yu-Jeong Shin, Seung-Hye Woo, Ji-Soo Kim, Da-Woon Jeong, Sooyong Shin, Sung Ho Jeon, Jae-Hoon Shim
Summary: A novel encapsulation process based on the cyclization activity of CGTase was developed to encapsulate resveratrol in cyclodextrins, significantly increasing its water solubility. Experimental results showed that CA-RVT in aqueous solution exhibited similar activities as an equal amount of RVT in dimethyl sulfoxide.
Article
Biochemistry & Molecular Biology
Eun-A Kim, Eun-Hyeong Lee, Hyun-Mo Jeong, Byung Sik Kang, Byung-Hak Kim, Sang Jae Park, Jae-Hoon Shim
Summary: Amylopectin clusters (APCs) with a solubility rate of 16.7% were produced using cyclodextrin glucanotransferase (EC 2.4.1.19). Their weight-average molecular weight was determined to be around 10(5) Da. During the preparation of APCs, the proportions of side chains with certain degree of polymerization changed. In exercise experiments, rats treated with APCs had higher blood glucose levels and increased endurance compared to the glucose administration group, indicating the potential of APCs in enhancing endurance when added to sports drinks.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Amy Oo, Panupong Mahalapbutr, Kuakarun Krusong, Ponsiri Liangsakul, Sariyarach Thanasansurapong, Vichai Reutrakul, Chutima Kuhakarn, Phornphimon Maitarad, Atit Silsirivanit, Peter Wolschann, Siyaporn Putthisen, Khanittha Kerdpol, Thanyada Rungrotmongkol
Summary: Encapsulation with beta-cyclodextrin (β-CD) has been explored to enhance the solubility of emodin (ED) for pharmaceutical applications. In this study, inclusion complexation of ED with β-CD and its derivatives was performed to identify the most promising drug carrier. The ED/DM-β-CD complex showed the highest stability and water solubility, followed by ED/SBE7-β-CD and ED/HP-β-CD complexes. The SEM micrographs and DSC thermograms confirmed the inclusion complex formation, and molecular docking suggested C-form insertion as the preferred binding mode. Moreover, the inclusion complexes, especially ED/DM-β-CD, showed significantly higher anti-proliferative effects on cancer cell lines compared to ED alone.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Sonaimuthu Mohandoss, Naushad Ahmad, Mohammad Rizwan Khan, Yong Rok Lee
Summary: The aim of this study is to improve the solubility and dissolution rate of naproxen by forming inclusion complexes with 13-cyclodextrin derivatives. Various techniques were used to examine the interaction and characterize the inclusion complexes. The antibacterial activity of these complexes was also evaluated, showing enhanced activity against Staphylococcus aureus and Escherichia coli.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Polymer Science
Naoki Ozawa, Shunji Kosaka, Shota Fujii, Tomoki Nishimura
Summary: Researchers report on the nanostructures of polymers incorporated in phospholipid membranes and their permeability to water-soluble molecules. Neutron-scattering experiments reveal that polymers form disk-like bilayer domains on the membranes, whose thickness is almost equivalent to that of the bilayer membranes when the polymers alone are self-assembled into vesicles. These domains act as synthetic molecular channels for low-molecular-weight poly(ethylene glycol), and their permeability can be regulated by changing the molecular weight of the poly(propylene oxide).
Article
Medicine, Research & Experimental
Syed Faisal Badshah, Naveed Akhtar, Muhammad Usman Minhas, Kifayat Ullah Khan, Samiullah Khan, Orva Abdullah, Abid Naeem
Summary: The aim of this study was to enhance the solubility of Chlorthalidone by developing beta-cyclodextrin crosslinked hydrophilic nanomatrices. Nine different formulations were fabricated and characterized, showing successful enhancement of solubility. The synthesized nanomatrices exhibited satisfactory in vitro drug release profiles and high solubility compared to the drug alone, with confirmed biocompatibility.
Article
Energy & Fuels
Lei Tao, Xiankun Liu, Haichi Shang, Na Zhang, Wenyang Shi, Jiajia Bai, Zhengxiao Xu, Qingjie Zhu, Yonglin Zhong
Summary: Many edge-bottom water fault-block reservoirs in China have low recovery factors due to issues such as water channeling, rapid increase in water cut, and low sweeping efficiency. This study focuses on reservoirs with edge-bottom water and fault blocks, and evaluates the effects of nitrogen foam flooding and viscosity reducer flooding. Through experiments and physical modeling, the study clarifies the mechanisms and potential of these technologies in increasing the recovery factor of the reservoirs.
Article
Pharmacology & Pharmacy
Mahsa Shahriari, Prashant Kesharwani, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Cancer is a widespread disease with various treatment modalities and challenges. Chemotherapy has limitations due to toxicity and drug resistance. Curcumin, a natural compound with multiple therapeutic properties, has poor solubility and limited bioavailability. Cyclodextrin complexes of curcumin improve its properties, and beta-cyclodextrin is commonly used. This review focuses on comparing different curcumin-cyclodextrin formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Silvia Navarro-Orcajada, Irene Conesa, Adrian Matencio, Pilar Rodriguez-Bonilla, Francisco Garcia-Carmona, Jose Manuel Lopez-Nicolas
Summary: The ability of cyclodextrins to enhance water solubility of lipophilic compounds can interfere with fluorescent readings, leading to contradictory results. The encapsulation of other substrates in the reaction is the main cause of this interference.
Article
Chemistry, Applied
Yuanyuan Li, Bingxue Liu, Xiaoxue Zhang, Yanjie Liu, Siying Wang, Shujun Li, Xiuhua Zhao
Summary: A new amphiphilic oligosaccharide derivative was synthesized by lutein modification onto the OH position of stachyose through esterification. It showed better digestibility, scavenging ability, and inhibition of lutein degradation in the gastrointestinal tract compared to free lutein. In rats, it exhibited significantly higher oral bioavailability than free lutein, making stachyose modification a promising strategy for improving the oral bioavailability of fat-soluble lutein.
Article
Chemistry, Physical
Hang Li, Ming-Yue Cui, Sheng-Hua Zha, Rong-Rong Tian, Qing-Sheng Zhao
Summary: This study demonstrates the use of cyclodextrin-based nanosponges (CDNSs) as a delivery system for Crocetin (CRT), an otherwise poorly soluble compound with promising health benefits. The inclusion and non-inclusion structures of CRT-loaded 13-CDNS were confirmed, and the water solubility of CRT was significantly increased. The antioxidant activity of CRT was enhanced and its cytotoxicity on normal cells was reduced while increased for tumor cells through the loading of 13-CDNS.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Applied
Caiming Li, Zexi Li, Tonghui Liu, Zhengbiao Gu, Xiaofeng Ban, Xiaoshu Tang, Yan Hong, Li Cheng, Zhaofeng Li
Summary: In this study, the performance of tributyrin microcapsules prepared using a new method (CGT) was compared with those prepared using other common microcapsule wall materials. The results showed that CGT had superior emulsion stability and controlled release of tributyrin content, demonstrating its potential application in intestinal health. These findings further illustrate the relationship between wall material type and microcapsule performance.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Physical
Anna Garibyan, Ekaterina Delyagina, Mikhail Agafonov, Ilya Khodov, Irina Terekhova
Summary: Baricitinib's solubility was found to be pH dependent, with slight solubility at pH 4-12 and better solubility in acidic and strongly alkaline media. The use of cyclodextrins improved the physicochemical properties of baricitinib, and the formation of host-guest complexes was studied. The influence of cyclodextrin structure and baricitinib's ionization state on complex formation and the impact of cyclodextrins on solubility and membrane permeability were analyzed.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Francisco Mura, Daniel Zuniga-Nunez, Jean-Maurice Mallet, Solange Lavielle, Pascal Matton, Pablo Barrias, Denis Fuentealba, Alexis Aspee
Article
Chemistry, Multidisciplinary
Sylvestre P. J. T. Bachollet, Cyril Addi, Nicolas Pietrancosta, Jean-Maurice Mallet, Blaise Dumat
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Antonio Mazzoleni, Feliciana Real-Fernandez, Maud Larregola, Francesca Nuti, Olivier Lequin, Anna Maria Papini, Jean-Maurice Mallet, Paolo Rovero
JOURNAL OF PEPTIDE SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Agathe Peyrottes, Garance Coquant, Loic Brot, Dominique Rainteau, Philippe Seksik, Jean-Pierre Grill, Jean-Maurice Mallet
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Nutrition & Dietetics
Antonin Lamaziere, Dominique Rainteau, K. C. Pukar, Lydie Humbert, Emilie Gauliard, Farid Ichou, Maharajah Ponnaiah, Nadine Bouby, Joe-Elie Salem, Jean-Maurice Mallet, Maryse Guerin, Philippe Lesnik
Article
Multidisciplinary Sciences
Boualem Sendid, Karine Lecointe, Mayeul Collot, Pierre-Marie Danze, Sebastien Damiens, Anne-Sophie Drucbert, Chantal Fradin, Jean-Pierre Vilcot, Frederic Grenouillet, Faustine Dubar, Jerome de Ruyck, Samir Jawhara, Jean-Maurice Mallet, Daniel Poulain
Summary: The distribution of anti-C. albicans mannan antibodies in terms of epitope specificity varies significantly, with different specificities of antibodies reacting differently to alpha- and beta-linked BSTOs. The alpha/beta ratio plays a crucial role in diagnosing colonization or infection status. Additionally, the unexpected interaction of MBL with the protective epitope suggests the importance of further investigations on the finely tuned C. albicans anti-mannose immune response for medical translation.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Antonio Mazzoleni, Feliciana Real-Fernandez, Francesca Nuti, Roberta Lanzillo, Vincenzo Brescia Morra, Paolo Dambruoso, Monica Bertoldo, Paolo Rovero, Jean-Maurice Mallet, Anna Maria Papini
Summary: The use of specific polymeric structures can successfully capture specific antibodies in the sera of patients with multiple sclerosis, offering a promising proof-of-concept for selectively purifying high affinity autoantibodies from the sera of autoimmune patients.
Article
Nanoscience & Nanotechnology
Florent Voisin, Gerald Lelong, Jean-Michel Guigner, Thomas Bizien, Jean-Maurice Mallet, Florent Carn
Summary: Stable nanocrystal aggregates can be obtained in water using a milli-flow system, and the aggregation number can be controlled by adjusting the reaction time, leading to maximized optical absorption. This has important implications for cost-effective mass production of nanostructures.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Organic
Laurent Cattiaux, Jean-Maurice Mallet
Summary: An alternative method for the synthesis of oligosaccharides based on polyol multi-glycosylation is proposed in this study. The method allows for simple separation based on an increase in molecular mass, without the need for aqueous workup or TLC/detector.
Article
Biochemistry & Molecular Biology
Lucie Dardevet, Feten Najlaoui, Sonia Aroui, Mayeul Collot, Celine Tisseyre, Michael W. Pennington, Jean-Maurice Mallet, Michel De Waard
Summary: Natural peptide analogs of chlorotoxin, including Lqh-8/6, were synthesized and evaluated for their ability to label, detect, and inhibit glioma growth. It was found that a biotinylated version of Lqh-8/6 could label glioma cell lines and detect glioma in brain sections. Lqh-8/6 exhibited anti-invasive properties and was non-toxic to glioma cells. Moreover, the conjugation of doxorubicin to Lqh-8/6 efficiently induced apoptosis in glioma cells.
Article
Chemistry, Physical
Florent Voisin, Gerald Lelong, Jean Michel Guigner, Thomas Bizien, Jean Maurice Mallet, Florent Carn
Summary: This article demonstrates the stabilizing effect of polyelectrolyte chains on globally neutral aggregates formed through electrostatic complexation. These stabilized complexes, composed of citrate-stabilized gold particles and quater-nized chitosan, are able to retain their nanometric size and stability in saline environment and cell culture media. The plasmonic coupling in these complexes allows for maximized optical absorption.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Antoine Dowek, Florent Voisin, Laetitia Le, Celine Tan, J. M. Mallet, Florent Carn, Eric Caudron
Summary: This study focuses on the improvement and control of SERS analysis by optimizing the aggregation/self-assembly of AuNPs using quaternized chitosan. The results show that the use of polyelectrolyte chains can stabilize neutral AuNPs aggregates, leading to significant enhancement of Raman signal. The stable and sensitive measurements of epinephrine at low concentrations were achieved, and the signal remained stable in complex media such as isotonic sodium chloride and glucose.
Article
Chemistry, Applied
Daniel Zuniga-Nunez, Francisco Mura, Nory Marino-Ocampo, Patricio Briones-Rebolledo, Horacio Poblete, Jean-Maurice Mallet, Denis Fuentealba, Alexis Aspee
Summary: A fluorescent probe C-DMPE was synthesized to monitor interfacial membrane properties. The probe showed shorter fluorescence lifetimes and rotational correlation times in mixed vesicles containing DPPC and DOPC, indicating favorable sensing of lipid domain boundaries.
Article
Chemistry, Multidisciplinary
Sylvestre P. J. T. Bachollet, Nicolas Pietrancosta, Jean-Maurice Mallet, Blaise Dumat
Summary: We present a strategy that combines a protein fluorogen with the BAPTA sensing group for fluorogenic and genetic targeting of a calcium indicator. The resulting dual-input probe behaves like a fluorescent AND logic gate, with a red emission sensitive to Ca2+ that is activated only upon reaction with HaloTag, showing a 25-fold intensity enhancement. This probe can be used for wash-free calcium imaging in HeLa cells. The modular design, based on a well-established self-labeling protein tag, allows for potential tuning of photophysical properties or targeting of different analytes.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Sylvestre P. J. T. Bachollet, Yuriy Shpinov, Fanny Broch, Hela Benaissa, Arnaud Gautier, Nicolas Pietrancosta, Jean-Maurice Mallet, Blaise Dumat
Summary: This study reports the development of HaloTag fluorogens based on dipolar flexible molecular rotor structures. By modulating the electron donating and withdrawing groups, the absorption and emission wavelengths were tuned to design a palette of fluorogens with emissions spanning the green to red range, enabling multicolor imaging. Experimental and theoretical investigations were conducted, offering new insights into the design of molecular rotor-based fluorogenic HaloTag probes to improve reaction rates and imaging contrast.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)