Meeting Abstract
Oncology
Wenping Song, Rongguang Shao, Liang Li
Article
Allergy
Wenping Song, Si Zheng, Meng Li, Xia Zhang, Rui Cao, Cheng Ye, Rongguang Shao, Guangxi Li, Jiao Li, Shigang Liu, Hui Li, Liang Li
Article
Oncology
Rui Cao, Wenping Song, Cheng Ye, Xiujun Liu, Liang Li, Yi Li, Hongjuan Yao, Xiaofei Zhou, Liang Li, Rongguang Shao
Article
Chemistry, Analytical
Samantha A. Byrnes, Toan Huynh, Tim C. Chang, Caitlin E. Anderson, James J. McDermott, Ciela Oncina, Bernhard H. Weigl, Kevin P. Nichols
ANALYTICAL CHEMISTRY
(2020)
Review
Pharmacology & Pharmacy
Rui Li, Xiaofei Zhou, Hongjuan Yao, Liang Li
JOURNAL OF DRUG TARGETING
(2020)
Article
Ophthalmology
Wen-ping Song, Si Zheng, Hong-juan Yao, Xiao-fei Zhou, Rui Li, Cheng-yue Zhang, Jun-yang Zhao, Lie-wei Wang, Rong-guang Shao, Liang Li
Article
Chemistry, Analytical
Benjamin D. Grant, Caitlin E. Anderson, John R. Williford, Luis F. Alonzo, Veronika A. Glukhova, David S. Boyle, Bernhard H. Weigl, Kevin P. Nichols
ANALYTICAL CHEMISTRY
(2020)
Article
Nanoscience & Nanotechnology
Hongjuan Yao, Lan Sun, Jingcao Li, Xiaofei Zhou, Rui Li, Rongguang Shao, Yingge Zhang, Liang Li
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Review
Oncology
Wenping Song, Jinhua Chen, Shuolei Li, Ding Li, Yongna Zhang, Hanqiong Zhou, Weijiang Yu, Baoxia He, Wenzhou Zhang, Liang Li
Summary: The study focuses on summarizing the role of ARHGAP9 gene in tumorigenesis and development as a potential therapeutic target for cancer treatment. The research found that the genetic/epigenetic variations and abnormal expression of ARHGAP9 gene are closely associated with various diseases, particularly cancer. ARHGAP9 can inactivate Rho GTPases and regulate cancer cellular events through signaling pathways. The study also assessed the potential of ARHGAP9 as a predictive biomarker and druggable target for cancer treatment through patent review. Overall, the characterization of ARHGAP9 is crucial for understanding its importance in different stages of cancer progression and therapy.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2022)
Article
Biochemical Research Methods
Yaowen Gu, Si Zheng, Zidu Xu, Qijin Yin, Liang Li, Jiao Li
Summary: This study proposes a curriculum learning-based training strategy, CurrMG, to improve the efficiency of molecular graph learning. Extensive experiments demonstrate that CurrMG can significantly enhance the performance of molecular graph learning models, particularly in resource-constrained scenarios.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Environmental Sciences
Wenping Song, Lingjie Bian, Mengran Xiong, Yuanyuan Duan, Yi Wang, Xia Zhang, Biao Li, Yulong Dai, Jiawei Lu, Meng Li, Zhiguo Liu, Shigang Liu, Li Zhang, Hongjuan Yao, Rongguang Shao, Guangxi Li, Liang Li
Summary: The study aimed to explore the relationship between variations in metabolic genes and urinary changes in mercapturic acids in humans. The results showed that the difference in mercapturic acids between polluted and clean/purified air was significantly associated with certain single nucleotide polymorphisms in genes. Five SNPs in GSTP1 were found to have the most prominent association with changes in SPMA expression, indicating their potential as biomarkers for susceptibility and prognosis of lung cancer.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Oncology
Peter A. Fasching, Duan Liu, Steve Scully, James N. Ingle, Paulo C. Lyra, Brigitte Rack, Alexander Hein, Arif B. Ekici, Andre Reis, Andreas Schneeweiss, Hans Tesch, Tanja N. Fehm, Georg Heinrich, Matthias W. Beckmann, Matthias Ruebner, Hanna Huebner, Diether Lambrechts, Ebony Madden, Jess Shen, Jane Romm, Kim Doheny, Gregory D. Jenkins, Erin E. Carlson, Liang Li, Brooke L. Fridley, Julie M. Cunningham, Wolfgang Janni, Alvaro N. A. Monteiro, Daniel J. Schaid, Lothar Haberle, Richard M. Weinshilboum, Liewei Wang
Summary: This study identified two loci in NLRC5 and TNFSF13B genes that are associated with grade 3/4 neutropenic or leukopenic events (NLE) after chemotherapy. It also revealed that the expression of these genes is influenced by genotypes and chemotherapy, and has an association with disease-free survival in patients.
CLINICAL CANCER RESEARCH
(2022)
Article
Environmental Sciences
Guang-xi Li, Yuan-yuan Duan, Yi Wang, Ling-jie Bian, Meng-ran Xiong, Wen-pin Song, Xia Zhang, Biao Li, Yu-long Dai, Jia-wei Lu, Meng Li, Zhi-guo Liu, Shi-gang Liu, Li Zhang, Hong-juan Yao, Rong-guang Shao, Liang Li
Summary: This study aimed to investigate the potential health effects of coexposure to outdoor air pollution and bioaerosols, particularly in the context of the COVID-19 pandemic. By analyzing urinary metabolites, the researchers identified potential biomarkers for predicting or diagnosing diseases related to airborne particle matter (PM) or bioaerosols. The study revealed dynamic changes in the urinary metabolic profiles of young healthy individuals exposed to clean or polluted air environments.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
Hongjuan Yao, Wenping Song, Rui Cao, Cheng Ye, Li Zhang, Hebing Chen, Junting Wang, Yuchen Shi, Rui Li, Yi Li, Xiujun Liu, Xiaofei Zhou, Rongguang Shao, Liang Li
Summary: Chemoresistance is a main limitation for the treatment of pancreatic ductal adenocarcinoma (PDAC). Here, the authors show that an antibody drug conjugate-like compound targeting both EGFR and HER2 overcomes gemcitabine resistance in PDAC preclinical models by mechanisms involving the tumour suppressor SMAD4.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Toan Huynh, Samantha A. Byrnes, Tim C. Chang, Bernhard H. Weigl, Kevin P. Nichols