Article
Chemistry, Multidisciplinary
Motoki Tsuchiya, Hazuki Maeda, Ryo Inoue, Yasuhiro Morisaki
Summary: In this study, optically active conjugated molecules with one-handed helical structures were prepared, showing excellent chiroptical properties such as circularly polarized luminescence. Optical resolution of planar chiral pseudo-meta-disubstituted [2.2]paracyclophane was also achieved on a sub-gram scale.
CHEMICAL COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Tao Ma, Juan Wang, Shibo Chen, Zilong Guo, Miaoshui Mo, Haixia Wu, Yu Yang, Xiaohong Cheng
Summary: A series of bisnaphthalimide (BNI) mesogens with torsional or planar configurations can self-assemble into local helical structures in liquid crystal phases and long-range helical nanostructures in gels. The different molecular configurations lead to different self-assembly processes.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Physical
Zhuoer Wang, Aiyou Hao, Pengyao Xing
Summary: The researchers successfully realized chiroptical properties in the near-infrared (NIR) region using a charge-transfer strategy and applied it to photothermal agents. They self-assembled pyrene-conjugated amino acid derivatives into helical structures with supramolecular tilt chirality. By manipulating the amino acid domains, they achieved chiroptical activity evolution in the NIR region and controlled the photothermal performance using circularly polarized NIR light.
CHEMISTRY OF MATERIALS
(2022)
Review
Chemistry, Physical
Wang Li, Chunru Wang, Taishan Wang
Summary: Metallofullertubes are a new type of molecular material with endohedral metal atom, fullerene cap, and nanotube segment, which may exhibit unexpected properties. Although several pioneer metallofullertubes have been successfully reported, further exploration into their physical and chemical properties is still needed to be conducted.
Review
Nanoscience & Nanotechnology
Sourabh Bera, Hemanta Kumar Datta, Parthasarathi Dastidar
Summary: A self-drug-delivery system against melanoma has been developed using metallogelators derived from coordination polymers. Amongst these metallogelators, CPG3 showed promising results in inhibiting melanoma cell growth by inducing apoptosis through mitochondrial membrane potential depolarization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Pablo Reine, Ana M. Ortuno, Sandra Resa, Luis Alvarez de Cienfuegos, Maria Ribagorda, Antonio J. Mota, Sergio Abbate, Giovanna Longhi, Delia Miguel, Juan M. Cuerva
Summary: This paper describes the optical and chiroptical properties of a chiral multipodal ortho-oligophenylethynylene molecule with sulfoxide groups, which can coordinate with Ag(I) and Zn(II) cations to form double helical structures. The absorption, fluorescence, ECD, and CPL spectra show different behaviors depending on the metal stoichiometry and nature. Computational studies support the experimental results.
Article
Chemistry, Multidisciplinary
Jeong Sang Oh, Ka Young Kim, Jaehyeon Park, Hyeonju Lee, Younwoo Park, Jaeheung Cho, Shim Sung Lee, Hyungjun Kim, Sung Ho Jung, Jong Hwa Jung
Summary: A unique dynamic morphology transformation of a Ag+-coordinated supramolecular nanostructure in aqueous solution was reported, involving the generation of thermodynamically stable products. The kinetic study revealed that the NO3- anion acted as an accelerator for the transformation process. This study provides insight into the dynamic morphology transformation process in biological systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Tatiana A. Shestimerova, Nikita A. Golubev, Mikhail A. Bykov, Andrei Mironov, Sergey A. Fateev, Alexey B. Tarasov, Ivan Turkevych, Zheng Wei, Evgeny Dikarev, Andrei Shevelkov
Summary: This study demonstrated the synthesis of two triiodides by reacting two aromatic diamines with iodine in hydroiodic acid, which were further converted into related compounds with the addition of bismuth sources. These compounds, with band gaps suitable for efficient solar light absorption, all presented organic-inorganic hybrid structures based on a variety of intermolecular forces.
Article
Crystallography
Ivan Fedyanin, Aida Samigullina, Ivan A. Krutov, Elena L. Gavrilova, Dmitry Zakharychev
Summary: Two polymorphic forms of a conformationally flexible molecule were obtained and characterized, showing that the first form with higher cohesion energy and crystal lattice energy transforms into the second form at room temperature via two endothermic phase transitions due to high energy difference between molecular conformations in crystals.
Article
Chemistry, Multidisciplinary
Alan M. Downward, Matteo Granelli, Celine Besnard, Laure Guenee, Alan F. Williams
Summary: This study investigates the structural properties of a chiral ligand forming helical cubanes with cobalt(II) and manganese(II). It is found that a (P)-quadruple helicate can be obtained with a (S)-ligand and cobalt(II). However, when the ligand binds to manganese(II), there are two possible orientations, resulting in the observation of either (P)- or (M)-quadruple helicates for a given ligand enantiomer. The helicates can be linked into extended structures by p-nitrobenzoate capping ligands, which exhibit stacking interactions with neighboring complexes. Interestingly, the study reveals the presence of extended (M)-helices coexisting with extended (P)-helices when manganese(II) is used.
HELVETICA CHIMICA ACTA
(2023)
Article
Construction & Building Technology
Elena Kriklenko
Summary: This work presents an innovative approach to developing a new structural system for temporary or semi-permanent structures, using parametric design and prefabrication to optimize its structural and sustainable characteristics. The CBA-CFS structures are made of flexible materials, featuring a bending-active surface bent in a complex buckled geometry, with an innovative concept of avoiding tessellation or cuts. Supported by physical and digital models, the proposal showcases a new understanding of bending-active surfaces.
ARCHITECTURAL ENGINEERING AND DESIGN MANAGEMENT
(2021)
Article
Engineering, Marine
Hamid Ahmadi, Mohammad Akhtegan
Summary: This paper presents the results of a parametric study on the local joint flexibility of three-planar tubular T-joints. The study found that the multi-planarity effect can significantly impact the results, which may lead to inaccurate predictions when using equations developed for uniplanar T-joints. A new parametric formula was developed based on finite element results for predicting the local joint flexibility in axially loaded three-planar T-joints.
SHIPS AND OFFSHORE STRUCTURES
(2022)
Article
Engineering, Chemical
I. O. Mikulionok
Summary: The article proposes a classification of structures for folding tubular plastic sheets into flat material and presents a critical survey of the most characteristic designs of flattening structures.
CHEMICAL AND PETROLEUM ENGINEERING
(2021)
Article
Engineering, Ocean
Hamid Ahmadi, Mahdi Ghorbani
Summary: The through-the-thickness stress distribution in a tubular member has a significant impact on the fatigue behavior of tubular joints in steel offshore structures, which can be characterized by the degree of bending (DoB). However, there have been few investigations on the DoB in multi-planar joints due to the complexity and high cost involved. This study utilizes data from stress analysis of finite element models to develop new DoB parametric equations for the fatigue analysis and design of axially loaded two-planar DYT-joints.
OCEAN SYSTEMS ENGINEERING-AN INTERNATIONAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Guanqun Du, Alessandra Del Giudice, Viveka Alfredsson, Anna M. Carnerup, Kaizheng Zhu, Bo Nystrom, Yilin Wang, Luciano Galantini, Karin Schillen, Domagoj Belic
Summary: The condensation of DNA helices into hexagonally packed bundles and toroids is a fascinating example of functional organization of biological macromolecules at the nanoscale. Researchers have successfully reproduced a DNA-like condensation with supramolecular helices of small chiral molecules, suggesting a more general phenomenon. The study reveals unknown similarities between covalent and supramolecular non-covalent helical polyelectrolytes, potentially inspiring the construction of supramolecular versions of biological macromolecules in the future.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Aida Jover, Francisco Fraga, Francisco Meijide, Jose Vazquez Tato, Jacopo Cautela, Alessandra Del Giudice, Maria Chiara di Gregorio
Summary: Sodium deoxycholate exhibits various self-assembled structures in water, with novel phases and reversible transitions observed under conditions suitable for physiological working environment. These findings enhance the understanding of its diversity and help clarify its role in vivo.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Medicine, Research & Experimental
Sara Battista, Pierangelo Bellio, Lorenza Fagnani, Elena Allegritti, Lisaurora Nazzicone, Luciano Galantini, Giuseppe Celenza, Luisa Giansanti
Summary: Although primarily investigated for drug delivery, liposomes can also exhibit pharmacological activity based on their composition. The molecular structure of liposome components affects their interaction with bacterial cells and antimicrobial properties. Liposomal formulations with N-oxide are effective against Gram-positive bacteria.
MOLECULAR PHARMACEUTICS
(2022)
Article
Environmental Sciences
Neda Amanat, Berardino Barbati, Marta M. Rossi, Marco Bellagamba, Marco Buccolini, Luciano Galantini, Marco Petrangeli Papini
Summary: This study investigated the abilities of sugar-based synthetic surfactants and biosurfactants to dissolve and mobilize non-aqueous phase liquid components adsorbed on porous matrices. The results show that a synthetic surfactant from the APG family with a long fatty acid chain and a di-rhamnolipid biosurfactant with a shorter hydrophobic group offered the highest efficiency values.
Article
Nanoscience & Nanotechnology
Sara Battista, Mariana Koeber, Pierangelo Bellio, Giuseppe Celenza, Luciano Galantini, Guillem Vargas-Nadal, Lorenza Fagnani, Jaume Veciana, Nora Ventosa, Luisa Giansanti
Summary: The newly developed nanovesicle system of the quatsome family shows noticeable antibacterial activity, demonstrating great potential for the treatment of bacterial infections and can also serve as nanocarriers of pharmaceutical actives.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemical Research Methods
Roberto Marotta, Alessandra Del Giudice, Libero Gurrieri, Silvia Fanti, Paolo Swuec, Luciano Galantini, Giuseppe Falini, Paolo Trost, Simona Fermani, Francesca Sparla
Summary: GAPDH is a key enzyme in the Calvin-Benson cycle and is regulated differently in land plants. This study reveals the structural basis of its regulation and the existence of different oligomeric states. The C-terminal extension of the B subunits plays a crucial role in inhibiting enzyme activity by preventing substrate binding. The whole mechanism is controlled by pyridine nucleotides.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Davide Piccinino, Eliana Capecchi, Valentina Trifero, Elisabetta Tomaino, Claudia Marconi, Alessandra Del Giudice, Luciano Galantini, Stefano Poponi, Alessandro Ruggieri, Raffaele Saladino
Summary: In this study, lignin nanoparticles were used as sustainable carriers and photostabilizers for common UV chemical filters. The stability of the compounds was significantly improved by encapsulation, and further enhanced by coencapsulation with hydroxytyrosol.
Article
Chemistry, Multidisciplinary
Liangchen Zhang, Yaxun Fan, Luciano Galantini, Karin Schillen, Alessandra Del Giudice, Guanqun Du, Yilin Wang
Summary: A class of noncovalent antimicrobials composed of bile acid oligomers and polyamines has been developed, showing strong antibacterial activity against methicillinand vancomycin-resistant Staphylococcus aureus without significant cytotoxicity and skin irritation.
Article
Chemistry, Analytical
Cristina Tortolini, Valeria Gigli, Antonio Angeloni, Luciano Galantini, Federico Tasca, Riccarda Antiochia
Summary: In this work, a simple electrochemical immunosensor was developed for the detection of D-dimer protein in human plasma samples. The immunosensor was constructed by drop-casting chitosan nanoparticles (CSNPs) as a biocompatible support, Protein A (PrA) to facilitate antibody orientation, and D-dimer antibody onto a carboxyl functionalized multi-walled carbon nanotubes screen printed electrode (MWCNTs-SPE). The immunosensor showed promising performance in antibody immobilization and specific D-dimer detection, with a linear range from 2 to 500 μg L-1, LOD of 0.6 μg L-1, and sensitivity of 1.3 μA L μg(-1) cm(-2). The stability and fast response time (5 s) were also reported. Moreover, the immunosensor demonstrated satisfactory results in detecting D-dimer in human plasma samples.
Article
Biochemistry & Molecular Biology
Alessandra Del Giudice, Libero Gurrieri, Luciano Galantini, Silvia Fanti, Paolo Trost, Francesca Sparla, Simona Fermani
Summary: CP12 is a redox-dependent conditionally disordered protein found in oxygenic photosynthetic organisms. It acts as a light-dependent redox switch in regulating the metabolic phase of photosynthesis. A small angle X-ray scattering analysis confirmed the disordered nature of this protein and showed a decrease in size and conformational disorder upon oxidation. The presence of disulfide bonds in the oxidized form does not confer rigidity to the protein structure, highlighting the importance of recruiting partner proteins for its final folding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Julia Jianwei Tan, Natalie Gjerde, Alessandra Del Giudice, Kenneth D. Knudsen, Luciano Galantini, Guanqun Du, Karin Schillen, Sverre Arne Sande, Bo Nystrom
Summary: This study investigates the interactions between cationic hydroxyethyl cellulose (catHEC) and sodium deoxycholate (NaDC) or sodium cholate (NaC). It is found that there are strong interactions between catHEC and NaDC, while the interactions with NaC are weak. This difference may be due to the ability of NaDC to form more connections and entanglements.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Iolanda Francolini, Luciano Galantini, Fernando Rea, Cristiano Di Cosimo, Pierpaolo Di Cosimo
Summary: Polymeric wet-strength agents are important additives used in the paper industry to improve paper products' mechanical properties when exposed to water. They enhance durability, strength, and dimensional stability. This review provides an overview of wet-strength agents, their mechanisms, challenges, and recent advances in developing sustainable and environmentally friendly agents. As demand for sustainable and durable paper products grows, the use of wet-strength agents is expected to increase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Elena Allegritti, Sara Battista, Maria Anna Maggi, Claudia Marconi, Luciano Galantini, Luisa Giansanti
Summary: This study focuses on the preparation and characterization of mixed liposomes for delivering levodopa and two natural substances to treat Parkinson's disease. The results show that the composition of the liposomes plays a significant role in the delivery of levodopa.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Natalie Solfrid Gjerde, Alessandra Del Giudice, Kaizheng Zhu, Kenneth D. Knudsen, Luciano Galantini, Karin Schillen, Bo Nystrom
Summary: In this study, a diblock copolymer called methoxy-poly(ethyleneglycol)-block-poly(epsilon-caprolactone) (MPEG-b-PCL) was synthesized with a unique block composition that allows it to exhibit both an upper critical solution temperature (UCST) and a lower critical solution temperature (LCST) in aqueous solutions. The UCST value was found to be 32°C upon heating and 23°C upon cooling, while the LCST remained unaffected. Various characterization techniques revealed that the solution consisted of spherical core-shell particles and rodlike objects at intermediate temperatures, cylindrical core-shell crystals at low temperatures, and large aggregation complexes at temperatures above 52°C. This work provides valuable insights into the complex interplay between UCST and LCST and the resulting structures formed in aqueous solutions of MPEG-b-PCL diblock copolymers.
Article
Chemistry, Physical
Natalie Solfrid Gjerde, Alessandro Nicola Nardi, Cheng Giuseppe Chen, Paolo Di Gianvincenzo, Marco D'Abramo, Anita Scipioni, Luciano Galantini, Sergio E. Moya, Mauro Giustini
Summary: Anthracycline doxorubicin hydrochloride (DX), a positively charged fluorescent drug, can self-associate into non-fluorescent antiparallel dimers in water. When complexed with polyanion polystyrene sulfonate (PSS), the fluorescence of DX is quenched, but can be recovered with increased ionic strength. Molecular dynamics studies suggest a preferential orientation of DX into parallel dimers when interacting with PSS.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)