期刊
LANGMUIR
卷 25, 期 16, 页码 8894-8898出版社
AMER CHEMICAL SOC
DOI: 10.1021/la9019537
关键词
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资金
- Roy J. Carver Charitable Trust
- Camille and Henry Dreyfus Foundation
- National Science Foundation Graduate Research Fellowship
We describe ail approach to generate multicomponent surface-immobilized patterns and gradients oil the basis of the photochemically controlled covalent coupling of solution-phase biomolecules to benzophenone-modified substrates. Gradients were simply achieved by continuously varying the exposure to nondamaging UV light across the surface with the gradient profile controlled by biomolecule concentration and the spatial and temporal illumination of the surface. Sequential exposure of the same surface in the presence of different biomolecules resulted in overlapping patterns and gradients of proteins and carbohydrates. Finally, we preliminarily demonstrate that the resulting Surfaces are suitable for generating model substrates to probe cell-substrate interactions.
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