Article
Chemistry, Multidisciplinary
Wei Zhang, Yang Luo, Jie Zhao, Chao Zhang, Xin-Long Ni, Zhu Tao, Xin Xiao
Summary: In this study, a linear supramolecular polymer with controllable features was constructed based on twisted cucurbit[14]uril and cucurbit[8]uril using an effective self-sorting strategy. By inserting and π-π stacking, the polymerization and depolymerization of the supramolecular polymer were achieved. This strategy provides a new approach for the design of supramolecular polymer materials and the application of twisted cucurbit[14]uril in supramolecular chemistry.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Hui Zhao, Fang-Fang Shen, Ji-Fu Sun, Zhong-Zheng Gao
Summary: The interaction between (E)-4-(4-(1-methyl-pyridinium)styryl)-1-methyl-pyridinium chloride (SMP) and cucurbit [8]uril (CB[8]) was characterized using various experimental techniques. The results showed the formation of a stable inclusion complex SMP@CB[8] with a host-guest binding ratio of 1:2, where the styryl group of SMP was located within the cavity of CB[8]. Isothermal titration calorimetry experiments revealed that the complexation between SMP and CB[8] was driven by both enthalpy and entropy, facilitated by ion dipole interactions. Additionally, the presence of CB[8] promoted the [2 + 2] photodimerization of the styryl units in the supramolecular complexes when exposed to visible light.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Zhimin Yang, Richard A. Stein, Maren Pink, Peter Madzelan, Thacien Ngendahimana, Suchada Rajca, Mark A. Wilson, Sandra S. Eaton, Gareth R. Eaton, Hassane S. Mchaourab, Andrzej Rajca
Summary: We report complex formation between the chloroacetamide 2,6-diazaadamantane nitroxide radical (ClA-DZD) and cucurbit[7]uril (CB-7), which significantly immobilizes the radical and allows for reliable measurement of interspin distances. These findings have important implications for supramolecular recognition-enabled long-distance DEER measurements at near physiological temperatures.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Wen-Wen Xu, Yong Chen, Yi-Lin Lu, Yue-Xiu Qin, Hui Zhang, Xiufang Xu, Yu Liu
Summary: This study presents a series of solid supramolecules with tunable room-temperature phosphorescence, with P-CF3/CB[7] showing the longest lifetime. The ultralong multicolor phosphorescence energy transfer supramolecular assembly can be used in anti-counterfeiting, information encryption, and painting applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Saurav Das, Tanushree Das, Priyam Das, Debapratim Das
Summary: Nature has developed a self-regulatory feedback mechanism that maintains an optimal internal cellular environment. Researchers have designed a pH responsive supramolecular peptide amphiphile to mimic the inhibitory behavior of certain enzymes. The resulting nanozymes showed tunable lifetimes and efficient reproducibility across multiple pH cycles.
Article
Chemistry, Multidisciplinary
Pim J. de Vink, Tim van der Hek, Luc Brunsveld
Summary: The research focuses on the light-induced release of CB[8] and activation of caspase-9, offering a new approach for tuning and applying switchable cucurbiturils. The design of a bivalent cage with high affinity to CB[8] enables affinity switching, matching the concentration required for activating caspase-9.
Review
Chemistry, Inorganic & Nuclear
Jian-Hang Hu, Ying Huang, Carl Redshaw, Zhu Tao, Xin Xiao
Summary: Hydrogels have gained increasing attention due to their potential uses in various fields and their dynamic qualities. The use of cucurbit[n]uril-based host-guest interactions has been crucial in advancing the field of supra-molecular chemistry. This review provides comprehensive insights into the design and creation of supra-molecular hydrogels using cucurbit[n]uril-mediated strategies, including the classification, properties, and applications of these hydrogels.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Medicinal
Zhaoxi Sun, Zhe Huai, Qiaole He, Zhirong Liu
Summary: Describing, understanding, and designing complex interaction networks within macromolecular systems remain challenging in modern chemical research. Host-guest systems, despite their relative simplicity in both the structural feature and interaction patterns, still pose problems in theoretical modeling. The barrel-shaped supramolecular container cucurbit[8]uril (CB8) shows promising functionalities in various areas.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Chemistry, Analytical
Chenrui Jiang, Geyuan Li, Yue Chen, Liping Xi, Meiru Liu, Jun Peng, Pierre Dramou, Hua He
Summary: A fast, simple, sensitive and stable turn-on fluorescent probe method was developed using the self-assembly of aggregation-induced emission luminogen 1,1,2,2-tetra(biphenyl-4-yl)ethene and cucurbit[7]uril for the selective determination of metformin. The host-guest complex improves the water solubility of traditional aggregation-induced emission material. The method shows good sensitivity and accuracy for metformin detection with a linear correlation between relative fluorescence intensity and metformin concentration in the range of 5 to 100 μM.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ramin Rabbani, Sima Saeedi, Md Nazimuddin, Hector Barbero, Nathalie Kyritsakas, Travis A. White, Eric Masson
Summary: A cucurbit[8]uril-secured platinum terpyridyl chloride dimer was utilized as a photosensitizer and hydrogen-evolving catalyst for the photoreduction of water, leading to significantly higher volumes of produced hydrogen compared to free platinum or cucurbit[7]uril-bound platinum monomer. Density functional theory calculations demonstrated that the thermodynamics of the proton-coupled electron transfer promoted by CB[8] secure the Pt(ii)-Pt(ii) dimer in a reactive conformation, ultimately facilitating hydrogen formation.
Article
Biochemistry & Molecular Biology
Zhong-Zheng Gao, Lei Shen, Yu-Lu Hu, Ji-Fu Sun, Gang Wei, Hui Zhao
Summary: This study thoroughly investigated the use of naphthyl groups as building blocks for the self-assembly of supramolecular crystal networks in both aqueous solution and solid state. Experimental data showed that double guest molecules could reside within the cavity of Q[8], forming highly stable homoternary complexes NapA(2)@Q[8] and Nap1(2)@Q[8]. Strong hydrogen-bonding and π···π interactions played critical roles in the formation of 1D supramolecular chain, as well as 2D and 3D networks in solid state.
Article
Biochemistry & Molecular Biology
Jessica R. Kramer, Zachary S. Clauss, Rolande Meudom, Bo Su, Michael A. VandenBerg, Simranpreet S. Saini, Matthew J. Webber, Danny Hung-Chieh Chou
Summary: Protein aggregation is a challenge for the development of biopharmaceuticals, but this study demonstrates the potential of zwitterionic polypeptides conjugated to a supramolecular macrocycle in inhibiting aggregation of protein therapeutics.
Article
Chemistry, Multidisciplinary
Gao Li, Jun Hu, Huai Chen, Yong-Xiang Chen, Yan-Mei Li
Summary: By utilizing the interactions between tryptophan, methyl viologen, and cucurbit[8]uril, the study found that the distance between the targeted peptides/protein and the reactive peptide was shortened, facilitating the Michael addition reaction between cysteine and dehydroalanine. The system showed the highest acceleration on cysteines with suitable pK(a) and spatial location to tryptophan, suggesting potential for regioselective cysteine modification.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Jia Liu, Hugues Lambert, Yong-Wei Zhang, Tung-Chun Lee
Summary: A novel approach using electrochemistry was reported for estimating the binding constants of supramolecular complexes, achieving high precision and practical accuracy in a short measurement time. The study uncovered a linear correlation between the reduction potential of the ternary complexes and their binding constants, allowing for potential applications for sparsely soluble second guests.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Hong-Guang Fu, Jinmao You
Summary: Multicolor emission materials responsive to visible light stimuli have great potential in biomedical engineering and materials science. In this study, a dual-visible-light responsive quaternary supramolecular assembly with tunable multicolor fluorescence outputs was constructed. The assembly exhibited three different photoluminescent colors, yellow, white, and blue, by varying the irradiation time, and showed promising applications in photocontrolled cell imaging and photoerasable fluorescent ink.
Article
Chemistry, Medicinal
Camila Q. V. Costa, Ines I. Afonso, Sandra Lage, Pedro Reis Costa, Adelino V. M. Canario, Jose P. Da Silva
Summary: The analysis of marine lipophilic toxins in shellfish products is still a challenging task, and liquid chromatography coupled with mass spectrometry is the preferred technique for accurate quantitative measurements. The evaluation and correction of matrix effects (ME) are crucial, with the extent of ME in mussel samples depending on the sample matrix and preparation.
Article
Biology
Xuanting Wang, Carolina Q. Sacramento, Steffen Jockusch, Otavio Augusto Chaves, Chuanjuan Tao, Natalia Fintelman-Rodrigues, Minchen Chien, Jairo R. Temerozo, Xiaoxu Li, Shiv Kumar, Wei Xie, Dinshaw J. Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, Patricia T. Bozza, James J. Russo, Thiago Moreno L. Souza, Jingyue Ju
Summary: This paper discovers that hepatitis C virus inhibitors Pibrentasvir and Ombitasvir can inhibit the SARS-CoV-2 exonuclease and have therapeutic potential when combined with SARS-CoV-2 polymerase inhibitors in viral cell cultures. Combination drugs that inhibit both the SARS-CoV-2 polymerase and exonuclease are supported for effective COVID-19 treatment.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Liya Thurakkal, Pandurangan Nanjan, Mintu Porel
Summary: The design and synthesis of a versatile class of macrocycles with tunable functional groups and ring size are described. The synthesis approach allows for the production of macrocycles in large quantities and incorporates dithiocarbamates, an important functional group, into the macrocyclic backbone without the use of metals. The physicochemical properties of the macrocycles suggest their potential as drug candidates, as demonstrated by their interaction with a model protein.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Naishka E. Caldero-Rodriguez, Enrique M. Arpa, Diego J. Cardenas, Lara Martinez-Fernandez, Steffen Jockush, Sourav Kanti Seth, Ines Corral, Carlos E. Crespo-Hernandez
Summary: This study investigates the excited-state dynamics of 2-oxopurine riboside in aqueous solution and demonstrates its potential use as a dual fluorescent and photosensitizer analog for DNA and RNA research.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Plant Sciences
Teresa Saavedra, Florinda Gama, Maria A. Rodrigues, Javier Abadia, Amarilis de Varennes, Maribela Pestana, Jose Paulo Da Silva, Pedro Jose Correia
Summary: The economic costs and environmental impacts of iron-chelate treatments have led researchers to explore alternative methods for controlling iron deficiency chlorosis. This study examined the effects of applying malic acid, citric acid, and succinic acid to strawberry plants and found that succinic acid improved chlorophyll levels and altered the overall nutritional balance in the plants.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Chemistry, Applied
Sandra Lage, Ines I. Afonso, Pedro Reis Costa, Adelino V. M. Canario, Jose P. Da Silva
Summary: TTX and its analogues were found in the tissues of trumpet shell specimens purchased in a market in southern Portugal, suggesting the potential risk of consuming these edible gastropods. Regular monitoring of TTX and analogues in trumpet shell and other edible gastropods is recommended to prevent poisoning incidents.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Biochemistry & Molecular Biology
Liya Thurakkal, Subba Rao Cheekatla, Mintu Porel
Summary: In this report, a dithiocarbamate-based organic polymer was developed for the fast removal of iodine, showing high uptake in a short time. The material exhibited faster iodine capture than any existing material and was fully recyclable.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Liya Thurakkal, Mintu Porel
Summary: A novel class of organic polymer was designed and synthesized to efficiently remove toxic Hg2+ ions by tuning its structure, showing promising applications.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2022)
Article
Chemistry, Physical
Revathy Sahadevan, Anna Jose, Mintu Porel, Sushabhan Sadhukhan
Summary: In this study, lysine, a non-aromatic amino acid, was used as a fluorescence sensor for the detection of Cu2+ and Co2+ ions, as well as colorimetric distinction. The sensor exhibited low cost and ease of use.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Luis A. Ortiz-Rodriguez, Ye-Guang Fang, Germain Niogret, Kaivin Hadidi, Sean J. Hoehn, Heather J. Folkwein, Steffen Jockusch, Yitzhak Tor, Ganglong Cui, Liraz Levi, Carlos E. Crespo-Hernandez
Summary: In this study, a new DNA and RNA fluorescent probe was developed by thionation, which showed high photodynamic efficacy against melanoma and cervical cancer cells under both normoxic and hypoxic conditions. The experimental and computational results demonstrated that the thionated pyrimidine derivative is the most promising thiobase photosensitizer developed to date.
Article
Chemistry, Multidisciplinary
Sapna Ahuja, Sruthy Baburaj, Lakshmy Kannadi Valloli, Sarvar Aminovich Rakhimov, Kavyasree Manal, Aakrati Kushwaha, Steffen Jockusch, Malcolm D. E. Forbes, Jayaraman Sivaguru
Summary: Aryl-maleimides undergo a novel [2+4]-photodimerization instead of the expected [2+2]-photodimerization, and the stereochemistry of the photodimer formed complements the product observed under thermal conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Debashis Barik, Geethanjali Anand, Subba Rao Cheekatla, Mintu Porel
Summary: In this study, a novel class of star-shaped molecules with tunable properties was designed and synthesized by incorporating two important functional groups, triazole and dithiocarbamate (DTC). The bioactivity of these molecules was compared by binding with blood plasma proteins. The results from both experimental and molecular docking studies showed that the triazole molecule exhibited higher binding affinity towards the proteins compared to the DTC molecule.
Review
Chemistry, Organic
Subba Rao Cheekatla, Debashis Barik, Geethanjali Anand, Rakhi Mol K. M., Mintu Porel
Summary: This review focuses on the synthesis of different varieties of macrocycles bearing indole units using metal-catalyzed strategies. Indole is a valuable constituent in macrocyclic systems and plays a prominent role in various biological applications. The review provides a comprehensive insight into the synthesis of indole-based macrocycles catalyzed by various transition metals over the last two decades. It highlights the importance of novel strategies for C-C bond macrocyclization using metal-catalyzed protocols.
Article
Psychology, Biological
Samyar Ashouri, Jose P. Da Silva, Adelino V. M. Canario, Peter C. Hubbard
Summary: Chemical cues, specifically bile acids found in feces, play a crucial role in attracting male Mozambique tilapia to reproductive females.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Chemistry, Analytical
Yaakov Weiss, Steffen Jockusch, Janne M. Koornneef, Oded Elazar, Gareth R. Davies
Summary: This study applied a new laser ablation technique combined with mass spectrometry measurements to analyze trace elements and radiogenic isotopes in high-density fluid microinclusion-bearing diamonds. The results showed that the new technique produced enough material for quantitative analysis of rare-earth elements and revealed that HDF microinclusions within individual diamonds are rather homogeneous in their isotopic composition.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)