Article
Biochemistry & Molecular Biology
Peng Yang, Decheng Bi, Keshi Lu, Lijun Yao, Yan Wu, Hong Xu, Zhangli Hu, Xu Xu
Summary: Polyguluronate liposomes (PGLs) were successfully prepared to enhance the macrophage-stimulating activity of polyguluronate (PG) derived from alginate. PGLs exhibited uniform round morphology and good stability, with high encapsulation efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Ali Al-Samydai, Walhan Alshaer, Emad A. S. Al-Dujaili, Hanan Azzam, Talal Aburjai
Summary: This study aimed to enhance the pharmacokinetic properties of capsaicin by loading it into nanoliposomes, which showed improved anticancer activity and selectivity compared to free capsaicin. The encapsulated capsaicin nanoliposomes demonstrated significant improvement in pharmacokinetics and enhanced anticancer effects against various cancer cell lines.
Article
Food Science & Technology
Yosra Ben-Fadhel, Behnoush Maherani, Stephane Salmieri, Monique Lacroix
Summary: The study developed food grade liposomes encapsulating citrus extract and essential oil mixtures by optimizing process and composition, showing the preference of liposomes to encapsulate citrus extract. The system was environmentally-friendly and suitable for food applications, with stable nanoliposomes formed under specific conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Fareeaa Ashar, Umme Hani, Riyaz Ali M. Osmani, Syed Mohammed Kazim, S. Selvamuthukumar
Summary: The main aim of this study was to optimize the formulation and process variables for the preparation of ibrutinib nanoliposomes and evaluate their stability. The phosphatidylcholine-to-cholesterol ratio was found to have the most significant impact on encapsulation efficiency, while all factors had notable influences on particle size. The study provided important information for the preparation of nanoliposomes with improved characteristics.
Article
Biochemistry & Molecular Biology
Zahra Najafi, Cyril J. F. Kahn, Fatih Bildik, Elmira Arab-Tehrany, Nese Sahin-Yesilcubuk
Summary: Saffron extract components were nanoencapsulated into rapeseed lecithin nanoliposomes through sonication, with an encapsulation efficiency of approximately 30% and a rapid release rate observed. This encapsulation method improved the oxygen barrier properties of the films, while minimally affecting the water vapor permeability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Qibin Li, Linao Lv, Ying Liu, Zhijia Fang, Qi Deng, Weiqi Liang, Yueying Wu, Zhibao Chen
Summary: Nanoliposomes are widely used as nanocarriers in the food industry due to their stability and controlled release. However, the common stabilizer, cholesterol, may pose risks in large intake. In this study, resveratrol was used as a novel stabilizer to construct resveratrol blank liposomes (RBLs) and bacteriocin-loaded nanoliposomes (BLLs). The RBLs and BLLs showed favorable particle sizes, stability, and improved release properties. Resveratrol altered the structure of the phospholipid layer and improved its activity. The proposed RBL system is an excellent way to improve the stability of water-soluble preservatives in complex food environments.
Article
Chemistry, Applied
Xiao Li, Xin Wang, Haoyu Zhang, Lei Gong, Xianghong Meng, Bingjie Liu
Summary: OSA-starch stabilized EPA nanoliposomes (OSA-EPA-NLs) were prepared via thin film rehydration/dispersion method. The physical properties and morphology of OSA-EPA-NLs were characterized. The study evaluated the stability, release and bioavailability of OSA-EPA-NLs, showing promising results for improved stability and enhanced bioavailability.
Article
Chemistry, Applied
Chenlu Han, Chen Yang, Xiao Li, Enchao Liu, Xianghong Meng, Bingjie Liu
Summary: DHA loaded nanoliposomes stabilized by p-sitosterol were prepared and characterized in this study. The results showed high encapsulation efficiency and stability, indicating promising potential for improving DHA absorption.
Article
Biochemistry & Molecular Biology
Rui Zhang, Qian Zhang, Helder Oliveira, Nuno Mateus, Shuxin Ye, Sijia Jiang, Jingren He, Muci Wu
Summary: Anthocyanin nanoliposomes (ANLs) were prepared to improve the stability and bioavailability of anthocyanins (ACNs) obtained from grape skin extracts. Encapsulation in nanoliposomes enhanced the stability and cellular transport efficiency of ACNs, and exhibited antiproliferative effects against certain cancer cells.
Article
Pharmacology & Pharmacy
Delia Alkhatib, Noha Zelai
Summary: The study demonstrated the stability and release properties of silver sulfadiazine nanoliposomes under different pH, UV exposure, and heat conditions, with the nanoliposomes not altering the drug's release characteristics. Research focusing on enhancing the lipophilicity of silver sulfadiazine may find these results beneficial.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Chemistry, Applied
Chen Yang, Lei Gong, Xiao Li, Weiwei Li, Xianghong Meng, Bingjie Liu
Summary: This study employed nanoliposome encapsulation combined with carboxymethyl chitosan (CMCS) surface decoration to improve the physicochemical stability and oral bioavailability of alpha-linolenic acid (ALA). The results showed that CMCS-coated nanoliposomes had good encapsulation efficiency and stability, and were able to regulate the release of ALA in a simulated gastrointestinal environment. In vivo testing found that the ALA concentration of CMCS-coated nanoliposomes was higher than other formulations, indicating that it could be an effective delivery strategy for ALA.
Article
Computer Science, Software Engineering
Xu Wang, Weiyin Ma
Summary: This paper presents an extended tuned subdivision scheme for quadrilateral meshes that recovers optimal convergence rates while preserving high-quality limit surfaces. The proposed scheme relaxes Catmull-Clark subdivision rules for 2-ring refined vertices and introduces additional degrees of freedom in tuning masks to achieve curvature continuity at extraordinary positions. The scheme produces tighter curvature bounds and has significant improvements in surface quality compared with other schemes.
COMPUTER-AIDED DESIGN
(2023)
Article
Nanoscience & Nanotechnology
Jiangrong Zhou, Zhigang Zhan, Feiding Zhu, Yuge Han
Summary: This study successfully prepared a flexible wavelength-selective metasurface based on metal-dielectric-metal resonators, which utilizes magnetic polariton for infrared radiation regulation with thermal management. It achieved low emissivity in atmosphere windows (infrared stealth) and high emissivity in the wavelength of 5-8 μm nonatmospheric window (radiative cooling). The study also investigated the temperature and infrared radiation distributions of flexible metasurfaces with different curvatures, demonstrating that larger curvature leads to better infrared camouflage performance. The findings provide guidance for preparing flexible composite metasurfaces and broaden the application potential of effective bonding of metasurfaces to curved target surfaces.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemical Research Methods
Rand Alquraishi, Ali Al-samydai, Khaldun M. Al Azzam, Moath Alqaraleh, Lidia Al-Halaseh, Alaa Sanabrah, Maha N. Abu Hajleh, Arwa Al Khatib, Walhan Alsaher, El-Sayed Negim, Khaled Khleifat
Summary: Chronic wounds, such as diabetic foot ulcers, venous leg ulcers and pressure ulcers, are a major concern in healthcare systems. Oleuropein, extracted from olive leaves, has the potential to improve wound healing due to its antioxidant effect. However, the poor pharmacokinetics of oleuropein limit its clinical use. This study investigates the impact of PEGylated and non-PEGylated nanoliposomes loaded with oleuropein on wound-healing activity. The results suggest that non-PEGylated compositions have higher encapsulation efficiency and PEGylated liposomal compositions exhibit faster wound healing activity.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Changfeng Qu, Nianxu Li, Tianlong Liu, Yingying He, Jinlai Miao
Summary: This study demonstrates the potential of Antarctic CPD photolyases in skincare products against UVB-induced skin damage and photoaging. CPDNL can prevent UVB-induced erythema, epidermal thickness, and wrinkles in mice. It repairs DNA damage, reduces inflammation, and protects collagen by regulating the NF-κB/MAPK/MMP signaling pathways, exhibiting antioxidant properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemical Research Methods
Xhensila Shkembi, Marketa Svobodova, Vasso Skouridou, Abdulaziz S. Bashammakh, Abdulrahman O. Alyoubi, Ciara K. O'Sullivan
Summary: This review discusses the selection of aptamers against mycotoxins and their incorporation into optical and electrochemical aptasensors. The strategies, advantages, and disadvantages of each approach are outlined, along with the different materials used and immobilization methods employed to achieve the highest sensitivity and selectivity.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Greta Gaiani, Anna Toldra, Karl B. Andree, Maria Rey, Jorge Diogene, Carles Alcaraz, Ciara K. O'Sullivan, Monica Campas
Summary: The study developed three molecular assays for detecting Gambierdiscus and Fukuyoa genera, as well as G. australes and G. excentricus species, achieving a remarkable limit of detection of a single cell. These assays provide a rapid and cost-effective strategy for reliable screening of samples and ciguatera risk assessment, ensuring seafood safety and protection of human health.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
David Kodr, Cansu Pinar Yenice, Anna Simonova, Dijana Pavlovic Saftic, Radek Pohl, Veronika Sykorova, Mayreli Ortiz, Ludek Havran, Miroslav Fojta, Zbigniew J. Lesnikowski, Ciara K. O'Sullivan, Michal Hocek
Summary: A series of modified nucleoside triphosphates bearing dicarba-nido-undecaborate or metal bis(dicarbollide) groups were prepared and utilized for DNA synthesis and redox labeling. The combination of these redox labels allowed for the first fully orthogonal redox coding of all four canonical nucleobases, enabling determination of nucleobase composition of short DNA stretches with electrochemical readout in one simple primer extension experiment.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biophysics
Mayreli Ortiz, Miriam Jauset-Rubio, David Kodr, Anna Simonova, Michal Hocek, Ciara K. O'Sullivan
Summary: This study developed an electrochemical platform for the detection of SNP in the MYH7 gene associated with hypertrophic cardiomyopathies using fingerprick blood samples. The platform uses solid-phase primer elongation and recombinase polymerase amplification to accurately identify SNPs, and only requires a small amount of fingerprick blood for analysis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Materials Science, Biomaterials
Muge Asik, Ismail Kutlugun Akbay, Sadin Ozdemir, Rukan Genc
Summary: pH-responsive self-healing hydrogels from cross-linked tragacanth gum (TG) were developed as a controlled antibiotic release system. These hydrogels can sustain multiple cycles of healing and separation while maintaining their mechanical and healing properties. The loaded Cf-TG hydrogels showed slow drug release and excellent antibacterial activity against both gram-negative and gram-positive bacteria, with a robust inhibition of biofilm formation.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Polymer Science
Didem Demir, Muge Asik Ugurlu, Seda Ceylan, Burcu Sakim, Rukan Genc, Nimet Bolgen
Summary: This study investigated the characteristics of chitosan-gum tragacanth polysaccharide scaffolds. Porous scaffolds with suitable mechanical properties and biocompatibility were successfully fabricated through cryotropic gelation.
POLYMER INTERNATIONAL
(2022)
Article
Environmental Sciences
Greta Gaiani, Francesca Cucchi, Anna Toldra, Karl B. Andree, Maria Rey, Takeshi Tsumuraya, Ciara K. O'Sullivan, Jorge Diogene, Monica Campas
Summary: Several genera of marine dinoflagellates are capable of producing bioactive compounds that can impact human health, with Gambierdiscus and Fukuyoa standing out for their production of toxins, including ciguatoxins. A multiplex detection system and rapid DNA extraction technique have been developed for identifying toxin-producing species, enabling swift detection in field samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Analytical
Koena L. Moabelo, Teresa M. Lerga, Miriam Jauset-Rubio, Nicole R. S. Sibuyi, Ciara K. O'Sullivan, Mervin Meyer, Abram M. Madiehe
Summary: This study presents the development of a rapid aptasensor based on gold nanoparticles for the detection of RBP4. The method utilizes the specific binding of aptamers to RBP4 and the color change of gold nanoparticles to achieve rapid detection, with results available within 5 minutes.
Article
Chemistry, Analytical
Miriam Jauset-Rubio, Mayreli Ortiz, Ciara K. O'Sullivan
Summary: Aptamer-based assays and sensors show promise as alternatives to antibodies for their flexibility in assay formats. This study demonstrates the use of a biotin-modified aptamer in enhancing sensitivity and achieving lower detection limits in a colorimetric enzyme-linked oligonucleotide assay and electrochemical detection. The generic nature of this assay format allows for easy and cost-effective application to various aptamers.
Article
Chemistry, Analytical
David Kodr, Mayreli Ortiz, Veronika Sykorova, Cansu Pinar Yenice, Zbigniew J. Lesnikowski, Ciara K. O'Sullivan, Michal Hocek
Summary: The previous approach of orthogonal multipotential redox coding only allowed analysis of relative nucleotide composition of short DNA stretches. In this study, two methods for normalization of electrochemical readout were presented, enabling determination of total nucleotide composition. The first method involved the presence or absence of an internal standard in the DNA primer, while the second method utilized a viologen-modified primer acting as a reference label for signal normalization. Both methods accurately analyzed DNA sequences and demonstrated potential for targeted DNA sequence analysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Cansu Pinar Yenice, Nassif Chahin, Miriam Jauset-Rubio, Matthew Hall, Phil Biggs, Hans-Peter Dimai, Barbara Obermayer-Pietsch, Mayreli Ortiz, Ciara K. O'Sullivan
Summary: The detection of single nucleotide polymorphisms (SNPs) is increasingly important in various fields. This study presents a semi-automated system for solid-phase electrochemical melting curve analysis (e'MCA) to identify the allele present at a specific SNP site associated with an increased risk of bone fracture and predisposition to osteoporosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mayreli Ortiz, Miriam Jauset-Rubio, Olivia Trummer, Ines Foessl, David Kodr, Josep Lluis Acero, Mary Luz Botero, Phil Biggs, Daniel Lenartowicz, Katerina Trajanoska, Fernando Rivadeneira, Michal Hocek, Barbara Obermayer-Pietsch, Ciara K. O'Sullivan
Summary: A generic platform was developed for cost-effective and rapid electrochemical SNP genotyping from fingerprick blood samples, enabling early diagnosis of osteoporosis. The platform utilizes isothermal solid-phase primer elongation with ferrocene-labeled nucleoside triphosphates, allowing for targeted genotyping of SNPs associated with osteoporosis. The system was validated using real blood samples, with results matching those from Taqman SNP genotyping assays and Sanger sequencing. The platform is highly versatile and has the potential to be deployed in an automated device for targeted SNP genotyping.
ACS CENTRAL SCIENCE
(2023)
Article
Chemistry, Analytical
Nassif Chahin, Santiago Escobar-Nassar, Johann Osma, Abdulaziz S. S. Bashammakh, Abdulrahman O. O. AlYoubi, Mayreli Ortiz, Ciara K. K. O'Sullivan
Summary: Detection and identification of single nucleotide polymorphisms (SNPs) have gained increasing interest for potential applications in medicine such as antibiotic resistance detection and clinical diagnostics. Various techniques have been developed, with electrochemical detection emerging as an attractive alternative due to its high sensitivity and cost-effectiveness.
ACS MEASUREMENT SCIENCE AU
(2021)