Article
Gastroenterology & Hepatology
Mahya Faghih, Anna E. Phillips, Louise Kuhlmann, Elham Afghani, Asbjorn M. Drewes, Dhiraj Yadav, Vikesh K. Singh, Soren S. Olesen
Summary: This study utilized pancreatic QST to differentiate patients into distinct pain phenotypes, finding that patients with widespread hyperalgesia had higher pain intensity, increased rates of constant pain, decreased quality of life and physical functioning. Psychiatric comorbidities were similar across all groups.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Health Care Sciences & Services
M. Rifqi Rokhman, Yulia Wardhani, Dwi Lestari Partiningrum, Barkah Djaka Purwanto, Ika Ratna Hidayati, Arofa Idha, Jarir At Thobari, Maarten J. Postma, Cornelis Boersma, Jurjen van der Schans
Summary: This study evaluated the psychometric properties of KDQOL-36 Bahasa Indonesia in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients in Indonesia. The results showed that the instrument has good validity and reliability, making it suitable for assessing the quality of life in these patients.
QUALITY OF LIFE RESEARCH
(2023)
Article
Oncology
Eisho Kanemitsu, Toshihiko Masui, Kazuyuki Nagai, Takayuki Anazawa, Yosuke Kasai, Akitada Yogo, Tatsuo Ito, Akira Mori, Kyoichi Takaori, Shinji Uemoto, Etsuro Hatano
Summary: This study compared the safety of completion TP and initial TP and found that there was no significant difference between the two procedures. This can serve as a reference for decision-making in pancreatic tumor surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Guillaume Le Cosquer, Charlotte Maulat, Barbara Bournet, Pierre Cordelier, Etienne Buscail, Louis Buscail
Summary: Chronic alcoholic pancreatitis is a major risk factor for pancreatic cancer. The risk is higher for hereditary pancreatitis, with PRSS1 and SPINK1 mutations having a risk of 19% and 12% respectively. The diagnosis is difficult due to the similarity in clinical and radiological features of chronic pancreatitis and pancreatic cancer. Endoscopic ultrasound-guided fine-needle biopsy with molecular biology can assist in diagnosis. Short-term follow-up is necessary for chronic pancreatitis patients with clinical and radiological suspicion of cancer, and pancreatic surgery may be required if doubt persists.
Article
Multidisciplinary Sciences
Jihao Tu, Zhehao Huang, Yin Wang, Meijing Wang, Zukun Yin, Xianglin Mei, Meiying Li, Lisha Li
Summary: This study analyzed transcriptome data and constructed co-expression networks to reveal gradually activated gene networks during the progression of pancreatic diseases. The number of differentially expressed genes increases as the pancreatic disease worsens, with upregulation of gene networks involving T cells and interferon.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Miyuna Kimura, Junji Yamauchi, Tomoo Sato, Naoko Yagishita, Natsumi Araya, Satoko Aratani, Kenichiro Tanabe, Erika Horibe, Toshiki Watanabe, Ariella Coler-Reilly, Misako Nagasaka, Yukari Akasu, Kei Kaburagi, Takayuki Kikuchi, Soichiro Shibata, Hirofumi Matsumoto, Akihito Koseki, Soichiro Inoue, Ayako Takata, Yoshihisa Yamano
Summary: This study aimed to reveal the impact of human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) on health-related quality of life (HRQoL). The results showed that HRQoL of patients with HAM was worse than that of the general population and was associated with all major symptoms.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Mariagrazia Coluzzi, Morihito Takita, Giovanna Saracino, Abdul Rub Hakim Mohammed, Carly M. Darden, Giuliano Testa, Ernest Beecherl, Nicholas Onaca, Bashoo Naziruddin
Summary: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for chronic pancreatitis patients, improving quality of life and preserving pancreatic endocrine function. This study used EORTC surveys to examine a large cohort of patients and found significant improvements in quality of life post-TPIAT.
TRANSPLANT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Signe E. J. Hansen, Anne Langsted, Anette Varbo, Christian M. Madsen, Anne Tybjaerg-Hansen, Borge G. Nordestgaard
Summary: The study found that extreme low and high plasma pancreatic amylase levels were associated with a 2-3 fold higher risk of pancreatic cancer and chronic pancreatitis in apparently healthy individuals from the general population.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohamed Saleh, Kartikeya Sharma, Ranjeet Kalsi, Joseph Fusco, Anuradha Sehrawat, Jami L. Saloman, Ping Guo, Ting Zhang, Nada Mohamed, Yan Wang, Krishna Prasadan, George K. Gittes
Summary: This study developed a new potential therapy for patients with chronic pancreatitis by injecting acetic acid in experimental animals, effectively reducing chronic inflammation and pain, improving glucose tolerance and insulin secretion. It shows the potential of treating chronic pancreatitis in a nonsurgical way.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Gastroenterology & Hepatology
Mikael Parhiala, Anne Waage, Povilas Ignatavicus, Jakob L. Poulsen, Engjom Trond, Georg Dimcevski, Ingrid Nordaas, Amer Hadi, Evangelos Kalaitzakis, Asbjorn M. Drewes, Camilla Nojgaard, Johanna Laukkarinen
Summary: This study aimed to determine the surgical treatment strategies for chronic pancreatitis (CP) in the Scandinavian and Baltic countries. The results showed that only 7% of CP patients underwent pancreatic surgery, with 51% of them undergoing surgery for chronic pain. After surgery, 47% of the patients were pain-free and half of the patients reported no pain.
Article
Gastroenterology & Hepatology
Rajiv M. Mehta, Stephen J. Pandol, Prachi R. Joshi
Summary: Chronic pancreatitis is a complex disease with gene-gene or gene-environment interactions, where the idiopathic form has shown an increasing incidence and changing phenotypes. While the beneficial effects of antioxidant therapy for CP remain unclear, research is ongoing to identify drugs that can improve symptoms and alter the natural history of the disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Soren S. Olesen, Anna E. Phillips, Mahya Faghih, Louise Kuhlmann, Emily Steinkohl, Jens B. Frokjaer, Benjamin L. Bick, Mitchell L. Ramsey, Phil A. Hart, Pramod K. Garg, Vikesh K. Singh, Dhiraj Yadav, Asbjorn M. Drewes
Summary: This study suggests that factors contributing to pain in chronic pancreatitis patients may overlap and have cumulative effects on patient-reported outcomes (PROs). Psychological distress had the strongest impact on PROs. Multidisciplinary strategies for pain management are recommended to address these findings.
Article
Health Care Sciences & Services
Ines Buchholz, You-Shan Feng, Maresa Buchholz, Lewis E. Kazis, Thomas Kohlmann
Summary: The German version of the VR-36 and VR-12 were validated in orthopedic and psychosomatic rehabilitation patients, showing them to be valid and reliable tools. Construct validity and known-groups validity were established through comparisons with other patient-reported outcome measures.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Article
Oncology
Sebastian Hempel, Florian Oehme, Ermal Tahirukaj, Fiona R. Kolbinger, Benjamin Mussle, Thilo Welsch, Jurgen Weitz, Marius Distler
Summary: The study found that primary total pancreatectomy and pylorus-preserving pancreaticoduodenectomy have similar outcomes in periampullary cancer surgeries, with no significant differences in adjuvant treatment and oncological survival rates. However, rescue completion pancreatectomy had high morbidity and mortality rates, as well as poor overall survival, with many patients not receiving indicated adjuvant therapy in time.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anna C. Lilly, Igor Astsaturov, Erica A. Golemis
Summary: Pancreatic cancer is difficult to detect and treat, resulting in poor survival outcomes. The increasing incidence of this cancer is related to aging populations, obesity, and pancreatitis. Risk factors for pancreatic cancer include signaling from fat cells, elevated levels of intrapancreatic adipocytes, inflammation from immune cells, and fibrosis caused by pancreatic obstruction and cell lysis. Further studies are needed to understand the role of adipocytes in the pre-cancerous niche and their implications in mouse models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Ilgar Aghalarov, Theodor Lutz, Waldemar Uhl, Orlin Belyaev
Summary: Anomalous anatomy of the celiac trunk, particularly of the right hepatic artery, can have a significant impact on major hepatobiliary and pancreatic surgery. Preoperative evaluation of CT angiograms, awareness of any anomalous arterial anatomy of the upper abdomen, and meticulous surgical technique are crucial for achieving oncologically radical surgery without compromising the arterial liver supply.
Article
Gastroenterology & Hepatology
Andreas Minh Luu, Chris Braumann, Orlin Belyaev, Monika Janot-Matuschek, Henrik Rudolf, Michael Praktiknjo, Waldemar Uhl
Summary: In this study, the overall rate of long-term survival (LTS) and its contributing factors after pancreatic ductal adenocarcinoma (PDAC) surgery were investigated. Clinical and laboratory parameters such as carbohydrate antigen 19-9 levels, tumor grade, and lymph vessel invasion were found to be significantly associated with LTS. The study concluded that cancer related characteristics play a role in predicting LTS in multimodally treated patients after curative PDAC surgery.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2021)
Article
Surgery
Andreas Minh Luu, Sina Rabea Vogel, Chris Braumann, Michael Praktiknjo, Philipp Hoehn, Sarah Foerster, Monika Janot, Waldemar Uhl, Orlin Belyaev
Summary: This study investigated the incidence and risk factors of perforated marginal ulcers (PMUs) following pancreaticoduodenectomy (PD), identifying age, chronic pancreatitis, smoking, and alcohol consumption as important factors. Additionally, the overall incidence of marginal ulcers post-PD was found to be 5-5.9% over 5 years.
Article
Surgery
Andreas Minh Luu, Bella Olchanetski, Torsten Herzog, Andrea Tannapfel, Waldemar Uhl, Orlin Belyaev
Summary: Comparison between TP and PD in treating pancreatic head lesions showed lower overall morbidity and lower postpancreatectomy hemorrhage rate in the TP group. However, the duration of surgery, hospital stay, major morbidity, and mortality were similar between the two groups.
Article
Surgery
Waldemar Uhl, Karl Oldhafer, Andreas A. Schnitzbauer, Christiane Bruns, Michael Schoen, Orlin Belyaev
Summary: IQWiG was commissioned by G-BA to conduct a study on the association between hospital and surgeon volume of cases and the quality of treatment results in complex pancreatic surgery. The report indicates a positive association with higher case numbers leading to better treatment outcomes, but does not specify minimum volume requirements for complex pancreatic interventions.
Article
Gastroenterology & Hepatology
Illya Slobodkin, Andreas Minh Luu, Philipp Hoehn, Tim Fahlbusch, Andrea Tannapfel, Waldemar Uhl, Orlin Belyaev
Summary: Surgery for symptomatic patients with serous cystic neoplasms (SCN) of the pancreas is considered reasonable and safe. The main reason for futile resections of benign asymptomatic SCN is preoperative diagnostic uncertainty about suspected malignancy, therefore surgery for supposed SCN without symptoms is justified only in carefully selected patients with suspected malignancy.
Article
Oncology
Andreas Minh Luu, Orlin Belyaev, Philipp Hoehn, Michael Praktiknjo, Monika Janot, Waldemar Uhl, Chris Braumann
Summary: In long-term survival patients with pancreatic cancer, lymph vessel invasion is identified as an independent risk factor for tumor recurrence. Tumor recurrence in these patients is typically asymptomatic, highlighting the importance of structured follow-up programs.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Maximilian Brunner, Orlin Belyaev, Florian Boesch, Tobias Keck, Helmut Witzigmann, Robert Gruetzmann, Waldemar Uhl, Jens Werner
Summary: Pancreatic neoplasia, including adenocarcinomas, neuroendocrine, and cystic neoplasms, requires individualized surgical indications based on tumor type and condition. Surgery may be indicated for resectable pancreatic carcinomas, neuroendocrine tumors, and cystic neoplasms with malignant signs or symptoms.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)
Article
Surgery
Tim Fahlbusch, Andreas Minh Luu, Philipp Hoehn, Carsten Klinger, Jens Werner, Tobias Keck, Helmut Friess, Joerg Koeninger, Thomas Kraus, Guido Alsfasser, Winfried Padberg, Joerg Peter Ritz, Waldemar Uhl, Orlin Belyaev
Summary: This study retrospectively analyzed the impact of pylorus preservation or resection on the occurrence of delayed gastric emptying (DGE) in patients undergoing pancreaticoduodenectomy (PD). The results showed that pylorus preservation had no effect on DGE, but other risk factors were identified. Future research should focus on register-based, prospective, randomized-controlled studies.
Article
Surgery
Philipp Hoehn, Fabian Runde, Andreas Minh Luu, Tim Fahlbusch, Daniel Fein, Carsten Klinger, Waldemar Uhl, Orlin Belyaev, Tobias Keck, Jens Werner, Natascha Nuessler, Detlef K. Bartsch, Christoph-Thomas Germer, Helmut Friess, Christian Monch, Karl-Jurgen Oldhafer, Jorg C. Kalff
Summary: This study evaluated the predictive value of the American College of Surgeons' Surgical Risk Calculator in German patients undergoing total pancreatectomy. The overall performance was found to be poor, possibly due to biased input data. Its applicability to an external cohort remains unclear.
Article
Gastroenterology & Hepatology
Ioannis Mintziras, Lisa Stollenwerk, Waldemar Uhl, Jennifer Niescery, Orlin Belyaev, Andreas Minh Luu, Johanna Munding, Andrea Tannapfel, Beat Kuenzli, Torsten Herzog
Summary: This study analyzed data from patients who underwent pancreaticoduodenectomy (PD) and required completion pancreatectomy (CP), finding that patients who developed acute necrotizing pancreatitis after PD and required CP within 3 days had characteristic laboratory and histopathological findings and a trend towards higher mortality.
Meeting Abstract
Oncology
Daniel Benitez Reinhardt, Celine Lugnier, Anna-Lena Kraeft, David Witte, Jens Christmann, Rabia Safaei, Peter Leukers, Georgia Evripidou, Thies Lindert, Nadine Hoeffken, Inke Feder, Magdalena Keller, Lukas Witkowski, Monika Janot-Matuschek, Orlin Belyaev, Waldemar Uhl, Andrea Tannapfel, Anke Reinacher-Schick, Stefanie Noepel-Duennebacke
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Article
Gastroenterology & Hepatology
Ilgar Aghalarov, Sarah Foerster, Andrea Tannapfel, Burkhard Ubrig, Waldemar Uhl, Orlin Belyaev
Summary: This case report presents a rare double distant metachronic metastasis to the right ureter and right renal pelvis from rectal cancer. The patient underwent surgery for ureteral obstruction and showed no signs of tumor relapse during follow-up.
CASE REPORTS IN GASTROENTEROLOGY
(2021)
Article
Surgery
Tim Fahlbusch, Andreas Minh Luu, Philipp Hoehn, Carsten Klinger, Jens Werner, Tobias Keck, Helmut Friess, Joerg Koeninger, Thomas Kraus, Guido Alsfasser, Winfried Padberg, Jorg Peter Ritz, Waldemar Uhl, Orlin Belyaev
Summary: This study aimed to assess the impact of pylorus preservation and resection on the occurrence of delayed gastric emptying in patients undergoing pancreaticoduodenectomy, with results showing that pylorus preservation had no effect on DGE, but other risk factors were identified.
Article
Surgery
Dmitri Nepogodiev, Aneel Bhangu
Summary: Preoperative SARS-CoV-2 vaccination can support safer elective surgery. The number needed to vaccinate (NNV) to prevent COVID-19-related deaths is more favorable in surgical patients compared to the general population. Prioritizing preoperative vaccination of patients needing elective surgery globally could prevent additional COVID-19-related deaths in 1 year.
BRITISH JOURNAL OF SURGERY
(2021)
