Review
Clinical Neurology
Tim J. Hallenberger, Raphael Guzman, Leo H. Bonati, Ladina Greuter, Jehuda Soleman
Summary: This systematic review and meta-analysis aimed to investigate the differences in outcome, morbidity, and mortality between endoscopic surgery (ES) and conventional craniotomy (CC) or best medical treatment (BMT) for spontaneous supratentorial intracerebral haemorrhage (SSICH). The study found that ES showed significantly improved functional outcome and mortality rates compared to BMT, while also having lower morbidity rates and shorter duration of surgery compared to CC.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Arduino A. Mangoni, Angelo Zinellu
Summary: This study conducted a systematic review and meta-analysis on the serum concentrations of ischaemia-modified albumin (IMA) in patients with acute ischaemic stroke (AIS), intracerebral haemorrhage (ICH), and subarachnoid haemorrhage (SAH). The results showed significantly higher IMA concentrations in these patients, suggesting that IMA concentrations might be useful in diagnosing stroke and distinguishing between different types of stroke.
Review
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Dar Dowlatshahi, Qi Li, Michel Shamy, Rustam Al-Shahi Salman, Jonathan Rosand, Charlotte Cordonnier, Joshua N. Goldstein, Andreas Charidimou
Summary: Haematoma expansion occurs in a significant portion of patients with acute intracerebral haemorrhage within 24 hours of onset and is associated with negative outcomes. Factors such as baseline haemorrhage volume, antithrombotic treatment, and CT angiography spot signs increase the risk of haematoma expansion. Non-contrast CT features show promise as predictors, but their contribution to current models is still being investigated. Blood pressure lowering and haemostatic treatment can reduce haematoma expansion, but their impact on functional outcomes is inconclusive based on clinical trials. Future trials should focus on early enrolment and selecting participants based on non-contrast CT imaging markers to demonstrate clinical benefits in high-risk individuals or investigate treatment effects in a more diverse population.
Review
Clinical Neurology
Ulrike Hammerbeck, Aziza Abdulle, Calvin Heal, Adrian R. Parry-Jones
Summary: This study aimed to investigate the association between factors routinely available in the hyperacute care of spontaneous intracerebral hemorrhage (ICH) patients and functional outcomes. The findings showed that multiple factors, including age, pre-morbid dependence, level of consciousness, stroke severity, hematoma volume, intraventricular hemorrhage, and deep location, were predictive of outcome. Other factors such as sex, medical history, admission blood results, and other imaging features were also associated with outcome.
EUROPEAN STROKE JOURNAL
(2022)
Article
Clinical Neurology
Giuseppe Scopelliti, Barbara Casolla, Gregoire Boulouis, Gregory Kuchcinski, Solene Moulin, Didier Leys, Hilde Henon, Charlotte Cordonnier, Marco Pasi
Summary: Neuropsychiatric symptoms were present in more than half of 6-month ICH survivors, with higher prevalence and severity in patients with post-ICH dementia. Apathy and hyperactivity symptoms may be associated with cognitive status and can inform on long-term dementia risk.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Marco Pasi, Barbara Casolla, Maeva Kyheng, Gregoire Boulouis, Gregory Kuchcinski, Solene Moulin, Julien Labreuche, Hilde Henon, Didier Leys, Charlotte Cordonnier
Summary: In patients who survived 6 months after a spontaneous intracerebral hemorrhage (ICH), age, diabetes mellitus, ICH volume, higher mRS score at 6 months, and occurrence of new clinical events are major determinants of functional decline.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Review
Clinical Neurology
Quincy K. Tran, Vera Bzhilyanskaya, Leenah Z. Afridi, Mahmood Ahmad, Jamie Palmer, Mehboob A. Rehan, Alison Raffman, Asma Rashid, Ashley Menne, Ali Pourmand
Summary: This meta-analysis found that seizure prophylaxis following spontaneous intracerebral hemorrhage (ICH) does not effectively prevent seizures in adults, both at the longest follow-up time and within 14 days of ICH. Further randomized controlled trials are needed to explore the efficacy of seizure prophylaxis in high-risk patients and different types of antiepileptic drugs.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Review
Clinical Neurology
James J. M. Loan, Caoimhe Kirby, Katherine Emelianova, Owen R. Dando, Michael T. C. Poon, Leisan Pimenova, Giles E. Hardingham, Barry W. McColl, Catharina J. M. Klijn, Rustam Al-Shahi Salman, Floris H. B. M. Schreuder, Neshika Samarasekera
Summary: The study found increased abundance of interleukin-1 beta protein in human brain tissue after intracerebral hemorrhage (ICH), but replication of analyses of other inflammatory molecules is lacking. Modulators of interleukin-1 beta pathway may optimize inflammatory responses to ICH and should be tested in clinical trials.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Clinical Neurology
R. Beyrouti, J. G. Best, A. Chandratheva, R. J. Perry, D. J. Werring
Summary: This study described the characteristics of spontaneous symptomatic intracerebral hemorrhage (ICH) associated with COVID-19, finding differences in characteristics compared to ICH not associated with COVID-19, such as frequent lobar location, multifocality, and high rate of anticoagulation. These observations suggest different underlying mechanisms of ICH in COVID-19 with potential implications for clinical treatment and trials.
JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Dianjun Zou, Xiaolong Zhu
Summary: The meta-analysis showed that there is a significant association between a history of hypertension and a higher rate of diffusion-weighted imaging lesions in intracerebral hemorrhage patients. However, no significant relationship was found between DWI lesions and other factors such as diabetes, smoking, and a history of hypercholesterolemia. Patients with DWI lesions experienced a greater decrease in systolic pressure during the acute phase of intracerebral hemorrhage.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Clinical Neurology
Maaike P. Cliteur, Lotte Sondag, Laura Cunningham, Rustam Al-Shahi Salman, Neshika Samarasekera, Catharina J. M. Klijn, Floris H. B. M. Schreuder
Summary: This study aimed to determine the association between perihaematomal oedema (PHO) and outcome in patients with spontaneous intracerebral haemorrhage (ICH). The findings from the meta-analysis of 27 studies showed that larger PHO volume and PHO growth were associated with poor functional outcome at 3 months in patients with ICH.
EUROPEAN STROKE JOURNAL
(2023)
Article
Clinical Neurology
Xiaodong Ye, Guo Li, Xiaoyan Liu, Guini Song, Yuchao Jia, Chunmei Wu, Xiong Wang, Shanshan Huang, Suiqiang Zhu
Summary: The study identified APOE epsilon 2 allele as a predictor of subarachnoid extension in spontaneous supratentorial ICH, especially in lobar ICH. The association between APOE epsilon 2 and SAHE suggests genetically driven vessel pathology.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Chih-Hao Chen, Yung-Tsai Chu, Ya-Fang Chen, Tzu-Yu Ko, Yu-Wen Cheng, Ming-Jen Lee, Pei-Lung Chen, Sung-Chun Tang, Jiann-Shing Jeng
Summary: This study investigated the clinical/imaging features for identifying NOTCH3-mutation-related intracerebral haemorrhage (ICH) in a cohort of 749 cerebral small vessel disease (CSVD) patients. The study found that patients with NOTCH3 mutation were more likely to have thalamic haemorrhage, a family history of stroke and more severe CSVD neuroimaging markers. A NOTCH3-ICH score was developed to assist in identifying genetic causes of ICH.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Joao Paulo Mota Telles, Rebeka Bustamante Rocha, Giulia Isadora Cenci, Gabriela Borges Nager, Guilherme Diogo Silva, Eberval Gadelha Figueiredo
Summary: Prophylactic antiseizure medications can reduce seizures in patients with sICH through EEG monitoring, but they do not significantly improve functional outcomes.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Clinical Neurology
Zicheng Cheng, Wenyuan Zhang, Zhenxiang Zhan, Lingfan Xia, Zhao Han
Summary: In patients with spontaneous intracerebral hemorrhage, cerebral small vessel disease markers and the total burden of the disease are associated with functional outcome, mortality, stroke recurrence, and hematoma expansion.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Alexander C. Flint, Sheila L. Chan, Nancy J. Edwards, Vivek A. Rao, Jeffrey G. Klingman, Mai N. Nguyen-Huynh, Bernard Yan, Peter J. Mitchell, Stephen M. Davis, Bruce C. Campbell, Diederik W. Dippel, Yvo B. W. E. M. Roos, Wim H. van Zwam, Jeffrey L. Saver, Chelsea S. Kidwell, Michael D. Hill, Mayank Goyal, Andrew M. Demchuk, Serge Bracard, Martin Bendszus, Geoffrey A. Donnan
Summary: THRIVE-EVT can be combined with the original THRIVE-c calculation to improve outcome probability estimation for patients with acute ischemic stroke and model the potential improvement in outcomes with endovascular treatment based on variables available at initial presentation.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Cardiac & Cardiovascular Systems
Jorge Pagola, Jesus Juega, Jaume Francisco-Pascual, Maite Rodriguez, Laura Dorado, Raquel Martinez, Mercedes De Lera-Alfonso, Juan F. Arenillas, Juan Antonio Cabezas, Francisco Moniche, Reyes de Torres, Joan Montaner, Marian Muchada, Sandra Boned, Manuel Requena, Alvaro Garcia-Tornel, Noelia Rodriguez-Villatoro, David Rodriguez-Luna, Matias Deck, Marta Olive, Marta Rubiera, Marc Ribo, Jose Alvarez-Sabin, Carlos A. Molina
Summary: The feasibility of 90-day cardiac monitoring with an external Holter device was demonstrated in stroke patients, with a high percentage of pAF detected. Older patients and those with enlarged left atria benefited more from the monitoring.
Article
Chemistry, Physical
Md. Munjur Hasan, Khadiza Tul Kubra, Md. Nazmul Hasan, Mrs Eti Awual, Md. Shad Salman, Md. Chanmiya Sheikh, Ariyan Islam Rehan, Adiba Islam Rasee, R. M. Waliullah, Md. Shahinoor Islam, Shahjalal Khandaker, Aminul Islam, Mohammed Sohrab Hossain, Abdulmohsen K. D. Alsukaibi, Hamed M. Alshammari, Md. Rabiul Awual
Summary: The chemical ligand BSBAE was embedded indirectly on mesoporous silica to fabricate optical composite materials (OCM) for detecting and removing toxic cadmium (Cd(II)) ions from wastewater solutions. The OCM demonstrated high sensitivity and selectivity towards Cd(II) ions in acidic pH conditions (pH 3.50) and showed distinguishable color changes upon the addition of trace levels of Cd(II) ions. Other metal ions did not significantly affect the performance of the OCM, which had a detection limit of 0.32 μg/L and a maximum adsorption capacity of 179.65 mg/g for Cd(II) ions. Cd(II) ions could be successfully desorbed from the saturated OCM using 0.25 M HCl, and the regenerated OCM maintained its selectivity and adsorption capacity. However, the adsorption efficiency slightly decreased after multiple cycles. Therefore, the OCM offers a cost-effective and viable alternative for detecting and removing toxic Cd(II) ions from wastewater.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Geriatrics & Gerontology
Leonard Radu Pinosanu, Bogdan Capitanescu, Daniela Glavan, Sanziana Godeanu, Israel Fernaundez Cadenas, Thorsten R. Doeppner, Dirk M. Hermann, Adrian-Tudor Balseanu, Catalin Bogdan, Aurel Popa-Wagner
Summary: The functions and activities of astroglia cells in brain development, aging, and neurodegenerative diseases differ. Comparing the transcriptomic activity of astroglia cells in these processes may provide new therapeutic strategies to protect the aging brain and improve clinical outcomes.
Review
Immunology
Joseph Cooper, Ylenia Pastorello, Mark Slevin
Summary: Alzheimer's disease is a common type of dementia and poses a growing challenge for global health systems. Inflammation has emerged as a key focus in Alzheimer's disease research, and it has been found to drive the associated pathologies. This study investigates whether chronic inflammation caused by diseases like inflammatory bowel disease and rheumatoid arthritis could increase the risk of developing dementia. The results show a higher risk of dementia in patients with chronic inflammation and an independent association with high levels of CRP. This meta-analysis provides evidence that chronic elevation of CRP in autoimmune diseases is directly linked to an increased risk of Alzheimer's disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Radhika Nair, Jeremy Rempel, Khurshid Khan, Thomas Jeerakathil, Rene Van Dijk, Brian H. Buck, Mahesh P. Kate, Sibi Thirunavukkarasu, Kimberly Gilbertson, Sathvika Thermalingem, Ashfaq Shuaib
Summary: This study retrospectively analyzed the experience of using a mobile stroke unit (MSU) for direct to angiosuite (DTAS) transfer in patients with acute ischemic stroke (AIS). The results showed that the DTAS strategy can reduce the workflow time for endovascular thrombectomy (EVT).
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
P. N. Sylaja, P. R. Jaya, Mahesh Pundlik Kate, Aneesh Dhasan, Vivek Nambiar, Sunil Narayan, Vishnu Renjith, Deepti Arora, Shweta Jain Verma, Meenakshi Sharma, R. S. Dhaliwal, Himani Khatter, P. S. Sarma, Jeyaraj Durai Pandian, RESTORE Collaborators
Summary: This study aims to compare the effects of traditional Ayurvedic rehabilitative treatment and conventional physiotherapy on the recovery of sensory and motor impairments in patients with ischemic stroke. The study includes stable adult patients with their first acute ischemic stroke within 1 to 3 months, who will be randomly assigned to receive either Ayurvedic treatment or conventional physiotherapy for 1 month. The primary outcome measure is the Fugl Meyer Assessment-Upper extremity for physical performance at 90 days, and the secondary outcomes include the modified Rankin Scale, Barthel Index, Berg Balance, and SF-36 at 90 days. Safety outcomes include a composite of irreversible morbidity and mortality rates.
CEREBROVASCULAR DISEASES
(2023)
Article
Neurosciences
Zhongsong Xiao, Peizheng Li, Yiqing Shen, Anatol Manaenko, Wensong Yang, Peng Wang, Xinhui Li, Fangyu Liu, Peng Xie, Qi Li
Summary: Despite limited treatment options for intracerebral hemorrhage (ICH), recent evidence suggests that the ultra-early stage of ICH may have significant importance. This study investigated the metabolic changes induced by ICH in the ultra-early stage using a mouse model and identified key pathological mechanisms associated with this stage.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Critical Care Medicine
Xiao-Fang Wu, Lan Deng, Xin-Ni Lv, Zuo-Qiao Li, Zi-Jie Wang, Xiao Hu, Ming-Jun Pu, Chu Chen, Li-Bo Zhao, Qi Li
Summary: This study investigated the clinical, imaging, and outcome characteristics of intracerebral hemorrhage (ICH) caused by structural vascular lesions. Compared to primary ICH, ICH caused by structural vascular lesions was found to occur in younger patients with a lower incidence of hypertension and diabetes. These patients predominantly had lobar hemorrhages and smaller baseline hematoma volumes. Additionally, they had lower mortality rates at 30 days and 3 months and better functional outcomes at 3 months.
NEUROCRITICAL CARE
(2023)
Review
Medicine, General & Internal
Xin-Ni Lv, Zuo-Qiao Li, Qi Li
Summary: Intracerebral hemorrhage is a dangerous subtype of stroke with high rates of morbidity and mortality. Targeting prevention of hematoma growth and perihematomal edema expansion shows promise as a therapeutic approach. Blood-based biomarkers are being studied as potential diagnostic, predictive, and prognostic markers due to their accessibility and acceptance in clinical practice. Validation studies are needed to determine the usefulness of these biomarkers in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andrada Soanca, Daniel Corneliu Leucuta, Alexandra Roman, Andreea Ciurea, Marius Negucioiu, Laurentiu Catalin Pascu, Andrei Picos, Ada Gabriela Delean, Iulia Cristina Micu, Aurel Popa Wagner, Darian Rusu
Summary: This clinical study compared the additional clinical benefits of combining a local desiccant antimicrobial agent (HY) with subgingival mechanical instrumentation (SRP) to SRP alone in treating severe periodontitis. Full-mouth periodontal examinations were performed at baseline and after a three-month follow-up for patients with stages III and IV periodontitis. The results showed no significant differences in the periodontal parameters between the test group (SRP plus HY) and the control group (SRP alone) after the treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Adrian R. Parry-Jones, Katie Stocking, Mary Joan MacLeod, Brian Clarke, David J. Werring, Keith W. Muir, Andy Vail
Summary: This study aimed to test the effect of anakinra on perihaematomal oedema in acute intracerebral haemorrhage (ICH) and explore its effects on inflammatory markers. The results showed that anakinra had some effects on oedema extension distance and inflammatory markers, but further research is needed to validate it due to the limited sample size.
EUROPEAN STROKE JOURNAL
(2023)
Article
Medicine, Research & Experimental
Daniel F. F. Hanley Jr, Gordon R. Bernard, Consuelo H. Wilkins, Harry P. Selker, Jamie P. Dwyer, J. Michael Dean, Daniel Kelly Benjamin Jr, Sarah E. Dunsmore, Salina P. Waddy, Kenneth L. L. Wiley Jr, Marisha E. Palm, W. Andrew Mould, Daniel F. Ford, Jeri S. Burr, Jacqueline Huvane, Karen Lane, Lori Poole, Terri L. Edwards, Nan Kennedy, Leslie R. Boone, Jasmine Bell, Emily Serdoz, Loretta M. Byrne, Paul A. Harris
Summary: New technologies and disruptions caused by COVID-19 have led to the expansion of decentralized clinical trials, which hold promise for increasing efficiency and reducing barriers. The Trial Innovation Network has provided recommendations for decentralized approaches and has consulted on numerous research proposals. While some elements of decentralized trials have worked well, others require further refinement and assessment. Efforts are needed to build trust and ensure access to remote technology for inclusive participation in decentralized clinical trials.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Clinical Neurology
Ana Dominguez-Mayoral, Carmen Gutierrez, Jesus Sanchez-Gomez, Soledad Perez-Sanchez, Natalia Fouz, Patricia Guerrero-Zamora, Marta Ferrer, Marfa Aguilar, Victoria Galiani, Carmen Albala, Jose Moreno, Miguel A. Gamero, Cristina Garcia-Campos, Sara Banda, Joan Montaner
Summary: This study aimed to determine the effect of obstructive sleep apnea (OSA) intervention on the quality of life and modified Rankin score of stroke patients. The results showed that a significant improvement in quality of life was observed in the intervention group, particularly among patients with good adherence to continuous positive airway pressure (CPAP) treatment. However, no significant improvement was observed in stroke patients. Therefore, OSA intervention has a significant impact on improving the quality of life in patients.
REVISTA DE NEUROLOGIA
(2023)
Article
Clinical Neurology
Francisco Moniche, Juan Antonio Cabezas-Rodriguez, Roberto Valverde, Irene Escudero-Martinez, Lucia Lebrato-Hernandez, Blanca Pardo-Galiana, Leire Ainz, Manuel Medina-Rodriguez, Javier de la Torre, Virginia Escamilla-Gomez, Joaquin Ortega-Quintanilla, Elena Zapata-Arriaza, Asier de Alboniga-Chindurza, Fernando Mancha, Miguel-Angel Gamero, Soledad Perez, Raul Espinosa-Rosso, Lucia Forero-Diaz, Miguel Moya, Pilar Pinero, Cristina Calderon-Cabrera, Sonia Nogueras, Rosario Jimenez, Vanesa Martin, Fernando Delgado, Juan-Jose Ochoa-Sepulveda, Blanca Quijano, Rosario Mata, Monica Santos-Gonzalez, Gloria Carmona-Sanchez, Concha Herrera, Alejandro Gonzalez, Joan Montaner
Summary: This study aimed to investigate the safety and efficacy of different doses of intra-arterial bone marrow mononuclear cells (BMMNCs) transplantation in patients with acute stroke. The results showed no significant improvement in the primary efficacy outcome at 180 days compared to the control group. Further clinical trials are needed to explore potential improvements at different timepoints.