Article
Respiratory System
Ana Cristina Carvalho, Jorge Moreira, Pedro Cubelo, Pedro Cantista, Catarina Aguiar Branco, Bruno Guimaraes
Summary: COVID-19 has increased the number of patients in ICUs, with many vulnerable to post-intensive care syndrome. A study was conducted to analyze the respiratory and functional effects of a multidisciplinary rehabilitation program on COVID-19 patients hospitalized in the ICU. The intervention group showed better muscular strength, respiratory capacity, and shorter hospitalization duration. The follow-up results also demonstrated significant improvements in the intervention group's 6-minute walk test compared to the control group. These findings highlight the importance of implementing rehabilitation programs in ICUs for critically ill COVID-19 patients.
Article
Geriatrics & Gerontology
Tom P. M. M. Vluggen, Jolanda C. M. van Haastregt, Frans E. Tan, Jeanine A. Verbunt, Caroline M. van Heugten, Jos M. G. A. Schols
Summary: The integrated multidisciplinary rehabilitation programme did not have an impact on daily activity of older stroke patients. However, patients participating in the programme had a higher level of perceived autonomy in outdoor activities, and their informal caregivers perceived a lower care burden. The programme may show promise in providing adequate (after) care, but further adaptation is recommended to increase feasibility and improve outcomes.
Article
Clinical Neurology
Roseanne D. Dobkin, Sarah L. Mann, Daniel Weintraub, Kailyn M. Rodriguez, Rachael B. Miller, Lauren St. Hill, Arlene King, Michael A. Gara, Alejandro Interian
Summary: This study compared the efficacy of individual Parkinson's-informed, video-to-home cognitive-behavioral therapy with clinic-based treatment for depression in Parkinson's disease. The results showed that video-to-home cognitive-behavioral therapy outperformed clinic-based treatment across multiple depression measures, with effects maintained through 6 months follow-up.
MOVEMENT DISORDERS
(2021)
Review
Psychology, Multidisciplinary
Seyed-Mohammad Fereshtehnejad, Mayela Rodriguez-Violante, Monica S. Ponce-Rivera, Daniel Martinez-Ramirez, Adolfo Ramirez-Zamora
Summary: The diverse clinical manifestations of Parkinson's disease require the involvement of multiple healthcare professionals. The COVID-19 pandemic has posed challenges to implementing multidisciplinary care models, but innovative virtual platforms are being developed to address this issue.
BEHAVIORAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Fiona E. E. Lithander, Emma Tenison, Jan Ypinga, Angelika Halteren, Matthew D. D. Smith, Katherine Lloyd, Edward W. W. Richfield, Danielle E. E. Brazier, Micheal O. Breasail, Agnes J. J. Smink, Chris Metcalfe, William Hollingworth, Bas Bloem, Marten Munneke, Yoav Ben-Shlomo, Sirwan K. L. Darweesh, Emily J. J. Henderson
Summary: This study aims to evaluate whether a complex and innovative model of integrated care can improve patients' ability to achieve personal goals, have a positive impact on health and symptom burden, and be more cost-effective compared to usual care.
Article
Clinical Neurology
Lubos Brabenec, Patricia Klobusiakova, Patrik Simko, Milena Kostalova, Jiri Mekyska, Irena Rektorova
Summary: This study evaluated the long-term effects of repetitive transcranial magnetic stimulation on hypokinetic dysarthria in Parkinson's disease, showing that real stimulation led to improvements in speech articulation compared to sham stimulation. The neural mechanisms of these improvements involve activation increases in specific brain regions and enhanced intrinsic connectivity.
Article
Gastroenterology & Hepatology
Pietro Familiari, Federica Borrelli de Andreis, Rosario Landi, Francesca Mangiola, Ivo Boskoski, Andrea Tringali, Vincenzo Perri, Guido Costamagna
Summary: This study demonstrated that there was no difference in the efficacy of POEM with a shorter cut length of 8 cm compared to the standard treatment of 13 cm. The shorter cut length also reduced the procedure time significantly. However, reducing the cutting length did not reduce the rate of GORD.
Article
Clinical Neurology
Takao Mitsui, Yoshiharu Arii, Koichiro Taniguchi, Satoshi Tsutsumi, Mika Takahara, Masaru Mabuchi, Nichika Sumitomo, Mieko Matsuura, Yukiko Kuroda
Summary: This study evaluated the effect of repetitive trans-spinal magnetic stimulation (rTSMS) on patients with Parkinson's disease (PD). The results showed that rTSMS promotes the effect of rehabilitation on motor function in patients with PD.
Article
Respiratory System
Steven P. Walker, Emma Keenan, Oliver Bintcliffe, Andrew E. Stanton, Mark Roberts, Justin Pepperell, Ian Fairbairn, Edward McKeown, James Goldring, Nadeem Maddekar, James Walters, Alex West, Amrithraj Bhatta, Matthew Knight, Rachel Mercer, Rob Hallifax, Paul White, Robert F. Miller, Najib M. Rahman, Nick A. Maskell
Summary: The study found that in the management of secondary spontaneous pneumothorax (SSP), using Atrium Pneumostat (AP) valve may be safer and more effective than Pleural Vents (PV).
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Elena S. George, Anjana Reddy, Amanda J. Nicoll, Marno C. Ryan, Catherine Itsiopoulos, Gavin Abbott, Nathan A. Johnson, Siddharth Sood, Stuart K. Roberts, Audrey C. Tierney
Summary: This study compared the efficacy of MedDiet and LFD in treating NAFLD patients. The results showed no significant differences between the two diets in reducing intrahepatic lipids and improving metabolic outcomes. However, the LFD group showed significant improvements in intrahepatic lipids and insulin resistance, and both groups had significant reductions in visceral fat.
LIVER INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Elena Ramirez-Maldonado, Marta Rodrigo-Rodrigo, Sandra Lopez Gordo, Ariadna Sanchez, Daniel Coronado Llanos, Raquel Sanchez, Joao Vaz, Constantino Fondevila, Rosa Jorba-Martin
Summary: This is a study comparing different management strategies for mild acute pancreatitis (MAP). It is a randomised, controlled, three-arm multicentre trial. The study aims to determine whether outpatient or home care is similar to hospital admission in terms of treatment failure rate for patients with MAP. Secondary endpoints include pain relapse, diet intolerance, hospital readmission, hospital length of stay, need for intensive care unit admission, organ failure, complications, costs and patient satisfaction. The study will provide evidence for the effectiveness of outpatient/home care management for MAP.
Article
Medicine, General & Internal
Carol Rovira, Pilar Modamio, Joaquim Pascual, Joan Armengol, Cristian Ayala, Joan Gallego, Eduardo L. Marino, Anna Ramirez
Summary: This study aims to explore the effects of an intervention based on person-centred care model on the therapeutic adequacy in polymedicated elderly patients. The intervention group will undergo multidimensional reviews and clinical interviews to improve the treatment plan and achieve consensus with the patients. The results of this study are important for improving the quality of care for elderly patients.
Article
Medical Informatics
Mireille N. Bekker, Maria P. H. Koster, Willem R. Keusters, Wessel Ganzevoort, Jiska M. de Haan-Jebbink, Koen L. Deurloo, Laura Seeber, David P. van der Ham, Nicolaas P. A. Zuithoff, Geert W. J. Frederix, Josephus F. M. van den Heuvel, Arie Franx
Summary: This study conducted a multicentre, randomised, controlled, non-inferiority trial to evaluate the safety, effectiveness, patient satisfaction, and costs of home telemonitoring compared to hospital care in complicated pregnancies. The results showed that telemonitoring might be as safe as hospital admission for monitoring complicated pregnancies.
LANCET DIGITAL HEALTH
(2023)
Article
Surgery
Kexi Liao, Kaijin Yang, Li Cao, Yao Lu, Bowen Zheng, Xuesong Li, Xiaojun Wang, Jianwei Li, Jian Chen, Shuguo Zheng
Summary: Comparing laparoscopic anatomical hepatectomy (LAH) and non-anatomical hepatectomy (LNAH) for hepatocellular carcinoma (HCC), LAH was found to have higher disease-free survival (DFS), lower intrahepatic ipsilateral recurrence rate, comparable long-term overall survival (OS), and similar postoperative complications for selected HCC patients.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Julia Das, Rosie Morris, Gill Barry, Rodrigo Vitorio, Paul Oman, Claire McDonald, Richard Walker, Samuel Stuart
Summary: Vision and cognition dysfunction are common in Parkinson's disease, and non-pharmacological interventions using technological visuo-cognitive training (TVT) may be effective in improving visuo-cognitive function. This study aims to evaluate the feasibility and acceptability of TVT versus standard care in Parkinson's disease patients through a randomized controlled trial.
Letter
Clinical Neurology
Jules M. Janssen Daalen, Jessica Hubbers, Mirmohsen Sharifi Bonab, Soania Mathur, Dick H. J. Thijssen, Bastiaan R. Bloem, Marjan J. Meinders
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Bastiaan R. Bloem, Erik Post, Deborah A. Hall
Summary: The Rune Labs Kinematics System, a smartwatch-based monitoring system, has been cleared by the FDA to remotely track motor impairments in Parkinson's disease. While this new digital approach shows promise, further validation studies are needed to determine its clinical significance and use in research.
ANNALS OF NEUROLOGY
(2023)
Article
Biophysics
Luca Cerina, Gabriele B. Papini, Pedro Fonseca, Sebastiaan Overeem, Johannes P. van Dijk, Rik Vullings
Summary: The objective of this study is to accurately detect respiratory effort during polysomnography for the diagnosis of sleep-disordered breathing conditions. The current sensors used for estimating respiratory effort are either indirect or obtrusive for patients. The suprasternal notch pressure (SSP) sensor is a promising alternative that detects pressure swings in the trachea. The proposed method separates the signals generated by cardiac activity and breathing activity, and achieves high agreement with electrocardiography-derived heart rate.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Biophysics
Iris A. M. Huijben, Lieke W. A. Hermans, Alessandro C. Rossi, Sebastiaan Overeem, Merel M. van Gilst, Ruud J. G. van Sloun
Summary: This study investigates the continuity of sleep stages and the influence of expert scoring on the hypnodensity graph representation. It proposes a simplified model and conducts experiments to analyze the interpretation of the hypnodensity graph. The results show that unsupervised training leads to more diverse distributions of sleep stages, and pre-softmax predictions better reflect sleep stage-dependent characteristics in real data.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Clinical Neurology
Jaime K. K. Devine, Lindsay Schwartz, Steven Hursh, Jerryll Asin, Nicolaas de Vries, Patty E. E. Vonk, Annemiek Vermeeren, Claire E. H. M. Donjacour, Frederick Vinckenbosch, Johannes G. G. Ramaekers, Hennie Janssen, Grace Wang, Dan Chen, Lawrence P. P. Carter, Sebastiaan Overeem, Gert Jan Lammers
Summary: This study explored the use of the SAFTE model to approximate healthy controls in sleep disorder research. The results showed that there was no difference in task effectiveness between actual and modeled healthy control groups in participants with OSA treated with solriamfetol. However, in participants with narcolepsy, the actual task effectiveness was lower in the placebo group compared to the modeled healthy control group, which was not the case with solriamfetol treatment.
NEUROLOGY AND THERAPY
(2023)
Article
Clinical Neurology
Pierre-Emmanuel Sugier, Elise A. Lucotte, Cloe Domenighetti, Matthew H. Law, Mark M. Iles, Kevin Brown, Christopher Amos, James D. McKay, Rayjean J. Hung, Mojgan Karimi, Delphine Bacq-Daian, Anne Boland-Auge, Robert Olaso, Jean-francois Deleuze, Fabienne Lesueur, Evgenia Ostroumova, Ausrele Kesminiene, Florent de Vathaire, Pascal Guenel, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B. Deutschlaender, Georges M. Hadjigeorgiou, Efthimios Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart P. C. van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez-Fairen, Karin Wirdefeldt, Nancy Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Emil Ygland Roedstroem, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Kruger, Thomas Gasser, Manu Sharma, Therese Truong, Alexis Elbaz
Summary: By using genome-wide association studies, this study found that Parkinson's disease (PD) is genetically correlated with melanoma and prostate cancer, while it is inversely correlated with ovarian cancer. These findings suggest that pleiotropic genes contribute to the association between PD and specific cancers.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Jesco Streumer, Ashok K. Selvaraj, Erkan Kurt, Bastiaan R. Bloem, Rianne A. J. Esselink, Ronald H. M. A. Bartels, Dejan Georgiev, R. Saman Vinke
Summary: Axial disability, including gait disturbances, is common in Parkinson's disease (PD), especially in advanced stages. Epidural spinal cord stimulation (SCS) has been investigated as a treatment option for gait disorders in PD. This review examines the literature on SCS in PD and evaluates its efficacy, optimal stimulation parameters, optimal electrode locations, possible effects of concurrent deep brain stimulation, and possible working mechanisms on gait.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Irene Gottgens, Linda Modderkolk, Corine Jansen, Sirwan K. L. Darweesh, Bastiaan R. Bloem, Sabine Oertelt-Prigione
Summary: This study explores the salience of gender-related aspects in the illness experiences and care provision preferences of people with Parkinson's disease (PD). Most participants did not consider gender-related aspects salient towards their illness experiences, but some described stereotypical views related to visibility of PD, emotional experiences, help seeking, role patterns, and physical appearance. While most participants did not express specific gender-related preferences for their healthcare providers, those that did preferred women as healthcare providers, citing attributed feminine traits relevant in physical examinations of people with PD.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Education, Special
N. van den Broek, F. van Meulen, M. Ross, A. Cerny, P. Anderer, M. van Gilst, S. Pillen, S. Overeem, P. Fonseca
Summary: The study aimed to investigate whether analysis of heart rate variability and respiration variability is suitable for automatic scoring of sleep stages in people with intellectual disabilities (ID). Sleep stages scored by the CardioRespiratory Sleep Staging (CReSS) algorithm were compared with manually scored polysomnography (PSG) in 73 individuals with ID. The results showed that using the combination of electrocardiogram (ECG) and respiratory effort provided the best agreement in scoring sleep stages, indicating the potential use of wearables for less obtrusive sleep monitoring in this population.
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2023)
Editorial Material
Clinical Neurology
Jules M. Janssen Daalen, Thomas H. Oosterhof, Bastiaan R. Bloem, Sirwan K. L. Darweesh
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Jiali Xie, Pedro Fonseca, Johannes P. Van Dijk, Xi Long, Sebastiaan Overeem
Summary: Sleep apnea, a common sleep disorder, can be detected using electrocardiographic (ECG) signals. However, respiratory effort is a better alternative to ECG-derived respiration (EDR) for breath signal replacement. Our study with 198 patients showed improved performance in detection, estimation, and classification of sleep apnea using respiratory effort instead of EDR.
Proceedings Paper
Computer Science, Artificial Intelligence
Shuhao Que, Rik J. C. van Esch, Iris C. Cramer, Cindy Verstappen, Carla Kloeze, Marcel van 't Veer, Angelique Dierick, Susan Hommerson, Fokke van Meulen, Sebastiaan Overeem, Leon Montenij, Lukas Dekker, R. Arthur Bouwman, Erik Korsten, Jan Bergmans, Svitlana Zinger, Sander Stuijk
Summary: In this study, we investigated the feasibility of extracting continuous respiratory parameters using a single RGB camera in a short-stay ward. We implemented two algorithms, chest optical flow (COF) and energy variance maximization (EVM), to extract respiration from the patient's thoracic and facial areas, respectively. The results showed that COF and EVM achieved errors within 3 breaths per minute and 3.5 breaths per minute, respectively, for average breath-to-breath rate estimation. Furthermore, using respiratory features extracted from COF measurements, we achieved an average AUC value of 0.64 for detecting atrial fibrillation (AF) in the respiratory signal. This highlights the potential of using camera-based respiratory parameters as predictors for AF or as surrogate predictors when facial area extraction is not possible.
MEDICAL IMAGING 2023
(2023)
Article
Pediatrics
Dandan Zhang, Zheng Peng, Carola Van Pul, Sebastiaan Overeem, Wei Chen, Jeroen Dudink, Peter Andriessen, Ronald M. Aarts, Xi Long
Summary: This study explores the effectiveness of incorporating video-based actigraphy analysis alongside cardiorespiratory signals for classifying the sleep states of preterm infants. The results suggest that combining video-based actigraphy with cardiorespiratory signals can potentially enhance the performance of sleep-state classification.
Article
Clinical Neurology
Iris A. M. Huijben, Ruud J. G. van Sloun, Bertram Hoondert, Sylvie Dujardin, Angelique Pijpers, Sebastiaan Overeem, Merel M. van Gilst
Summary: Non-rapid eye movement parasomnia disorders, characterized by abnormal nocturnal behaviours, have been studied to understand the timing and probability of awakenings from slow-wave sleep. Patients with these disorders have a higher probability of waking up after a bout of slow-wave sleep, and this probability increases with the duration of the bout. The occurrence of behavioural episodes reduces over sleep cycles, and there is a difference in the duration of slow-wave sleep prior to behavioural and non-behavioural awakenings in patients.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Bernice M. Wulterkens, Lieke W. A. Hermans, Pedro Fonseca, Hennie C. J. P. Janssen, Pauline V. van Hirtum, Sebastiaan Overeem, Merel M. van Gilst
Summary: This study found that patients with COMISA have a prolonged heart rate recovery phase after cortical arousals related to respiratory events compared to patients with OSA alone, indicating the potential role of the insomnia component in COMISA.
SLEEP AND BREATHING
(2023)