Article
Clinical Neurology
Gabriel Broocks, Andre Kemmling, Svenja Tessarek, Rosalie McDonough, Lukas Meyer, Tobias D. Faizy, Helge Kniep, Gerhard Schoen, Marie Teresa Nawka, Sarah Elsayed, Noel van Horn, Bastian Cheng, Goetz Thomalla, Jens Fiehler, Uta Hanning
Summary: This study investigated the feasibility of using quantitative lesion water uptake as an imaging biomarker in the diagnosis of patients undergoing mechanical thrombectomy in the extended time window. The results showed that net water uptake, age, and stroke severity were significantly associated with favorable clinical outcome. A predictive model including these parameters had a high diagnostic ability for functional outcome classification.
Article
Clinical Neurology
Katharina Goeral, Annalisa Hauck, Andrew Atkinson, Michael B. Wagner, Birgit Pimpel, Renate Fuiko, Katrin Klebermass-Schrehof, David Leppert, Jens Kuhle, Angelika Berger, Monika Olischar, Sven Wellmann
Summary: This study investigated the predictive value of serum neurofilament light chain (sNfL) in preterm infants with neonatal brain injury, specifically peri/intraventricular hemorrhage (PIVH). The results showed that sNfL levels were associated with poor motor outcome or death at 1 and 2 years, making sNfL an independent predictor of motor outcome in preterm infants with PIVH.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Zhidong Xuan, Ting Ma, Yue Qin, Yajie Guo
Summary: Ultrasound imaging combined with gene analysis has been found to be clinically significant in predicting brain metastases from breast cancer. The study identified the gene TRIM67 as a risk factor associated with brain metastases and overall survival prognosis. The study also found correlations between ultrasound features, such as microcalcifications, and TRIM67 expression. The nomogram constructed from multiple variables was shown to be an appropriate predictor of breast cancer metastasis occurrence.
FRONTIERS IN NEUROLOGY
(2022)
Review
Critical Care Medicine
Elisabeth A. Wilde, Ina-Beate Wanner, Kimbra Kenney, Jessica Gill, James R. Stone, Seth Disner, Caroline Schnakers, Retsina Meyer, Eric M. Prager, Magali Haas, Andreas Jeromin
Summary: Multi-modal biomarkers are necessary for the development of personalized and targeted therapies for traumatic brain injury. Optimal biomarkers should be specific, sensitive, easily accessible, minimally invasive, cost effective, and translatable for clinical and research use. Understanding how these biomarkers change over time is critical for identifying appropriate intervention time windows. This article summarizes current biomarkers under investigation and outlines steps to achieve short- and long-term goals in improving care for patients with traumatic brain injury.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Neuroimaging
Tim Vanderhasselt, Roya Zolfaghari, Maarten Naeyaert, Jeroen Dudink, Nico Buls, Gert-Jan Allemeersch, Hubert Raeymaekers, Filip Cools, Johan de Mey
Summary: Synthetic MRI is sensitive to age-related changes in brain tissue relaxation times in preterm born neonates close to term equivalent age (TEA). Severe postnatal morbidity results in prolonged relaxation times in specific brain regions, which can accurately predict high-risk status.
NEUROIMAGE-CLINICAL
(2021)
Review
Medicine, Research & Experimental
Anna Bergauer, Robin van Osch, Silke van Elferen, Sofia Gyllvik, Hrishikesh Venkatesh, Rudy Schreiber
Summary: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by cognitive, affective, and motor dysfunction. The main pathophysiological mechanisms are chronic neuroinflammation, hyperphosphorylated tau (p-tau) accumulation and neurodegeneration. Currently, CTE can solely be diagnosed post mortem based on the spatial pattern of tau-accumulation. This article discusses candidate imaging and fluid biomarkers for ante mortem diagnosis of CTE, highlighting the need for further validation and potential approaches using machine learning and proteomic profiling.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Marios Lampros, Nikolaos Vlachos, Parmenion P. Tsitsopoulos, Anastasia K. Zikou, Maria I. Argyropoulou, Spyridon Voulgaris, George A. Alexiou
Summary: Traumatic axonal injury (TAI) is a subtype of traumatic brain injury (TBI) that results from high-impact forces causing damage to axonal fibers. Conventional imaging methods often fail to detect TAI lesions, but novel imaging modalities and biomarkers show promise in improving diagnosis and prediction of outcomes in TAI patients. This review discusses the role of these imaging modalities and potential biomarkers in diagnosing, classifying, and predicting outcomes in TAI patients.
Review
Biochemistry & Molecular Biology
Emily A. Schiller, Koral Cohen, Xinhua Lin, Rania El-Khawam, Nazeeh Hanna
Summary: Premature neonates are at an increased risk of developing inflammatory conditions with high mortality rates. Research has focused on identifying diagnostic biomarkers, such as microRNAs, in extracellular vesicles. This article discusses the latest findings in biomarker discovery for common conditions affecting premature neonates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Jason Xia, Erika C. Claud
Summary: Necrotizing Enterocolitis (NEC) is an inflammatory intestinal disease that primarily affects premature infants. It is associated with an increased risk of neurodevelopmental delays in infants, but the connection between the gut microbiome and this risk is still unclear. This review discusses the current understanding of NEC and the potential role of the gut microbiome-brain axis in neurodevelopmental outcomes. Understanding this relationship may lead to improved therapeutic options for premature infants.
Article
Medicine, General & Internal
Robert Ryczek, Przemyslaw J. Kwasiborski, Agnieszka Rzeszotarska, Jolanta Dymus, Agata Galas, Anna Kazmierczak-Dziuk, Anna M. Karasek, Marta Mielniczuk, Malgorzata Buksinska-Lisik, Jolanta Korsak, Pawel Krzesinski
Summary: Measurements of NSE and S100B at admission can accurately identify patients with poor clinical outcomes after OHCA with 100% specificity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim, Steven G. Pavlakis, Neil Freidman, Nomazulu Dlamini, Osman Farooq, Ying Li, Guangming Zhu, Heather Fullerton, Max Wintermark, Warren D. Lo
Summary: In childhood arterial ischemic stroke patients, larger infarct volume and younger age at stroke onset are associated with poorer outcomes, but the strength of these relationships is weak. Specific infarct locations are significantly associated with poorer outcomes, but lose significance when adjusted for infarct volume.
Review
Pediatrics
Megan Dibble, Jin Zhe Ang, Liam Mariga, Eleanor J. Molloy, Arun L. W. Bokde
Summary: White matter abnormalities, as measured by diffusion tensor imaging, are more significant in very preterm infants compared to moderate-late preterm infants and full-term controls at term-equivalent age. These microstructural changes may contribute to the increased risk of neurodevelopmental disability in preterm infants later in life, making diffusion tensor imaging a potentially useful prognostic tool.
JOURNAL OF PEDIATRICS
(2021)
Article
Neurosciences
Heloise de Vareilles, Denis Riviere, Zhong-Yi Sun, Clara Fischer, Francois Leroy, Sara Neumane, Nusa Stopar, Rian Eijsermans, Marin Ballu, Maria-Luisa Tataranno, Manon Benders, Jean-Francois Mangin, Jessica Dubois
Summary: Despite limited knowledge about folding dynamics in the adult brain, this study aims to investigate the shape variability of the developing central sulcus in preterm infants. The results show that most of the shape features are encoded as early as 30 weeks post-menstrual age, and hemispheric asymmetries are observed at both ages. The study suggests that the shape of the central sulcus alone has a limited but relevant predictive capacity for manual performance outcomes. Studying the shape features of sulci during early neurodevelopment can contribute to a better understanding of the complex relationship between morphological and functional organization of the developing brain.
Review
Clinical Neurology
Francieli Cristina Krey, Bruna Alvim Stocchero, Kerstin Camile Creutzberg, Bernardo Aguzzoli Heberle, Saulo Gantes Tractenberg, Li Xiang, Wei Wei, Bruno Kluwe-Schiavon, Thiago Wendt Viola
Summary: The study conducted a meta-analysis of 16 studies and found significantly lower BDNF and NT-3 levels in preterm infants compared to term infants, with no significant difference in NGF and NT-4 levels. Sample type was identified as a significant moderator of heterogeneity in BDNF meta-analysis.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Rasheed Zakaria, Mark Radon, Samantha Mills, Drew Mitchell, Carlo Palmieri, Caroline Chung, Michael D. Jenkinson
Summary: Brain metastases present a significant clinical challenge, and immunotherapy has emerged as a promising treatment option. The unique microenvironment of the brain highlights the importance of the immune response in adapting systemic immune modulating agents. Imaging techniques, such as MRI and PET, play a crucial role in predicting and measuring the response to immunotherapy in brain metastases.
FRONTIERS IN ONCOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jessica Dubois, Marianne Alison, Serena J. Counsell, Hertz-Pannier Lucie, Petra S. Hueppi, Manon J. N. L. Benders
Summary: In recent years, there has been a significant focus on exploring the developing brain to understand how children acquire unique abilities and the impact of early disruptions on neurodevelopmental disorders. Noninvasive neuroimaging methods, such as MRI, are crucial for establishing connections between brain and behavioral changes in newborns and infants. Through various techniques like anatomical MRI and functional MRI, researchers can assess neurodevelopmental mechanisms and make strides in early interventions for long-term disability prevention in children.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Pediatrics
Alexandra Adam-Darque, Lorena Freitas, Frederic Grouiller, Julien Sauser, Francois Lazeyras, Dimitri Van de Ville, Philippe Pollien, Clara L. Garcia-Rodenas, Gabriela Bergonzelli, Petra S. Hueppi, Russia Ha-Vinh Leuchter
Summary: The study investigates the neural mechanisms of infant colic by examining newborns' brain responses to sensory stimuli, finding that infants who develop colic exhibit distinct brain activation patterns compared to non-colicky infants. This early sensitivity to stimuli explains a significant portion of subsequent crying behavior. The findings have implications for understanding and potentially advising families with colicky infants.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Kristina Wendel, Helle Cecilie Viekilde Pfeiffer, Drude Merete Fugelseth, Eirik Nestaas, Magnus Domelloef, Bjorn Steen Skalhegg, Katja Benedikte Presto Elgstoen, Helge Rootwelt, Rolf Dagfinn Pettersen, Are Hugo Pripp, Tom Stiris, Sissel J. Moltu
Summary: This study aims to investigate the effects of early supply of ARA and DHA on brain maturation and neonatal outcomes in infants born before 29 weeks of gestation. Infants will receive a fatty acid supplement from the second day of life to 36 weeks' postmenstrual age, with the primary outcome being brain maturation assessed by MRI.
Article
Neurosciences
Joana Sa de Almeida, Djalel-Eddine Meskaldji, Serafeim Loukas, Lara Lordier, Laura Gui, Francois Lazeyras, Petra S. Huppi
Summary: Prematurity disrupts brain development and network organization, leading to increased segregation and decreased integration capacity in preterm infants. Compared to full-term infants, preterm infants demonstrate delayed transition in brain network architecture and decreased connectivity strength in specific regions, potentially underlying behavioral and social cognition difficulties.
Article
Neurosciences
O. De Wel, S. Van Huffel, M. Lavanga, K. Jansen, A. Dereymaeker, J. Dudink, L. Gui, P. S. Huppi, L. S. de Vries, G. Naulaers, M. J. N. L. Benders, M. L. Tataranno
Summary: The study explored the relationship between early brain function and brain morphology, finding that continuity and complexity of EEG gradually increase with postnatal age and are associated with cerebellar size, which undergoes significant development in preterm infants. Brain activity is important for later structural brain development.
Article
Clinical Neurology
N. Ceren Askin Incebacak, Yao Sui, Laura Gui Levy, Laura Merlini, Joana Sa de Almeida, Sebastien Courvoisier, Tess E. Wallace, Antoine Klauser, Onur Afacan, Simon K. Warfield, Petra Huppi, Francois Lazeyras
Summary: The study compares the image quality of 2D high-resolution image acquisition with 3D reconstruction from low-resolution images in neonatal subjects, finding that they have comparable quality for clinical and morphometric assessments, with no loss of anatomical details and similar edge definition. Quantitative assessments show the reconstructed images accurately detect fine anatomical structures and allow for comparable morphometric measurements.
JOURNAL OF NEUROIMAGING
(2022)
Review
Pediatrics
Elodie Zana-Taieb, Jacques Sizun, Pierre Kuhn, Audrey Reynaud
Summary: This article investigates the impact of neonatal unit design on the neurodevelopment of hospitalized neonates and the well-being of parents and healthcare staff. It provides recommendations regarding the minimum area required for a hospital room for a single neonate and their family.
Article
Obstetrics & Gynecology
Vanessa Siffredi, Maria Chiara Liverani, Mariana Magnus Smith, Djalel Eddine Meskaldji, Francoise Stuckelberger-Grobety, Lorena G. A. Freitas, Jiske De Albuquerque, Emilie Savigny, Fanny Gimbert, Petra Susan Hueppi, Arnaud Merglen, Cristina Borradori Tolsa, Russia Ha-Vinh Leuchter
Summary: This study aimed to explore the feasibility and acceptability of an 8-week mindfulness-based intervention program to enhance executive and socio-emotional competences in very preterm young adolescents through a randomized controlled trial and pre-post intervention designs. Results indicated that the MBI program was feasible and well-received by participants, showing high attendance rates and positive feedback evaluation.
EARLY HUMAN DEVELOPMENT
(2021)
Article
Neurosciences
Ingrid Dudink, Petra S. Huppi, Stephane V. Sizonenko, Margie Castillo-Melendez, Amy E. Sutherland, Beth J. Allison, Suzanne L. Miller
Summary: Fetal growth restriction (FGR) is mainly caused by suboptimal placental function, leading to limited nutrient and oxygen supply to the developing fetus, particularly affecting brain development. FGR results in altered brain morphology, disrupted connectivity, and region-specific brain network disturbances, which are associated with cognitive and behavioral impairments.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Serafeim Loukas, Lara Lordier, Djalel-Eddine Meskaldji, Manuela Filippa, Joana Sa de Almeida, Dimitri Van de Ville, Petra S. Hueppi
Summary: Research indicates that even during the newborn period, familiar music and unfamiliar music are processed differently by the brain. After music listening, functional connectivity between brain regions in all newborns is modulated. Premature infants exposed to music experience enhanced functional connectivity between brain regions after listening to music.
HUMAN BRAIN MAPPING
(2022)
Article
Pediatrics
Mark Adams, Sven M. Schulzke, Giancarlo Natalucci, Juliane Schneider, Thomas Riedel, Cristina Borradori Tolsa, Riccardo Pfister, Dirk Bassler
Summary: The study found differences in patent ductus arteriosus treatment between Swiss perinatal centers, with infants who underwent surgical ligation having higher odds of major morbidities and neurodevelopmental impairment compared to those who received pharmacologic treatment. In centers with higher rates of surgical ligation, infants had increased odds of major morbidities.
JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Vanessa Siffredi, Maria Chiara Liverani, Petra Susan Huppi, Lorena G. A. Freitas, Jiske De Albuquerque, Fanny Gimbert, Arnaud Merglen, Djalel Eddine Meskaldji, Cristina Borradori Tolsa, Russia Ha-Vinh Leuchter
Summary: The study aimed to evaluate the effectiveness of mindfulness-based intervention (MBI) in improving executive, behavioral, and socio-emotional abilities in very preterm (VPT) children and adolescents. The results showed a beneficial effect of MBI on these competencies, especially in enhancing executive abilities. The findings suggest that MBI could be a valuable tool for reducing the detrimental consequences of prematurity in young adolescents.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Multidisciplinary
Filippa Manuela, Francisca Barcos-Munoz, Maria Grazia Monaci, Lara Lordier, Marice Pereira Camejo, Joana Sa De Almeida, Didier Grandjean, Petra S. Hueppi, Cristina Borradori-Tolsa
Summary: The study did not find significant differences in postnatal depression, stress, and attachment between mothers during the COVID-19 pandemic and before the pandemic. However, there was a trend of increased depression symptoms in mothers during the pandemic, which correlated significantly with attachment and stress scores.
FRONTIERS IN PSYCHOLOGY
(2021)
Editorial Material
Pediatrics
Petra S. Huppi, Manuela Filippa
PEDIATRIC RESEARCH
(2023)
Article
Neuroimaging
Lorena G. A. Freitas, Maria Chiara Liverani, Vanessa Siffredi, Armin Schnider, Cristina Borradori Tolsa, Russia Ha-Vinh Leuchter, Dimitri Van de Ville, Petra S. Huppi
Summary: Preterm birth can affect brain development and functioning, leading to differences in tasks like reality filtering. The involvement of the orbitofrontal cortex in cognitive tasks may vary between preterm and full-term individuals.
NEUROIMAGE-CLINICAL
(2021)
