Article
Pathology
Gregory R. Goodwin, Jonathan P. Bestwick, Alastair J. Noyce
Summary: Although smell tests alone may not have high enough predictive power for future screening programs, they could be a valuable component of a battery of tests or a stepwise process that together could accurately identify early neurodegeneration in large populations.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Biochemistry & Molecular Biology
Will Ao, Megan Grace, Candace L. Floyd, Cole Vonder Haar
Summary: To address the lack of automated behavioral tasks for pigs in research, a touchscreen device was developed to train pigs for behavioral testing. The device allowed pigs to interact with the screen and complete specific tasks using custom-written programs and a radio frequency dispenser. The device proved effective in testing large pigs and can be easily recreated at a low cost, making it suitable for various research fields. However, further development is needed to create tests specific to each discipline.
Article
Clinical Neurology
Sara K. Quinney, Kandasamy Murugesh, Adrian Oblak, Kristen D. Onos, Mike Sasner, Anna K. Greenwood, Kara H. Woo, Stacey J. Sukoff Rizzo, Paul R. Territo
Summary: We propose an unbiased methodology for ranking compounds for preclinical testing in Alzheimer's disease (AD) in order to enhance successful translation to the clinic. Previously compound selection was based solely on physiochemical properties, making ranking challenging. The STOP-AD framework overcomes this limitation by evaluating drug-like properties and performing Monte-Carlo simulations. Highlights: Promising preclinical studies for AD drugs have not translated to clinical success. Systematic assessment of AD drug candidates may increase clinical translatability. We describe a well-defined compound selection framework with clear selection metrics.
ALZHEIMERS & DEMENTIA
(2023)
Article
Multidisciplinary Sciences
Dylan Shea, Elizabeth Colasurdo, Alec Smith, Courtnie Paschall, Suman Jayadev, C. Dirk Keene, Douglas Galasko, Andrew Ko, Ge Li, Elaine Peskind, Valerie Daggett
Summary: The formation of toxic Amyloid beta-peptide oligomers is an early event in Alzheimer's Disease. A designed alpha-sheet peptide can inhibit the deleterious effects on neuronal signaling and serve as a capture agent in a soluble oligomer binding assay. This method can detect toxic oligomers in Alzheimer's Disease and discriminate them from other forms of dementia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Yibiao Liu, Xingyun Liu, Mifang Li, Qiong Liu, Tailin Xu
Summary: In this study, a portable electrochemical sensing platform was developed for the detection of AD biomarkers in blood. The integration of nanoAu-modified vertical graphene into the working electrode improved sensitivity and reduced detection limit. The platform showed great potential for the detection of tau protein in blood, offering a promising approach for AD diagnosis and personal healthcare.
Article
Microbiology
Freda E-C Jen, Jennifer L. Edwards, Ibrahim M. El-Deeb, Mark J. Walker, Mark von Itzstein, Michael P. Jennings
Summary: The ionophore PBT2, when used alone, has shown potential in killing both N.meningitidis and MDR N. gonorrhoeae, making it a candidate therapy for MDR N. gonorrhoeae infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Gerontology
Kenneth Hepburn, Joe Nocera, Melinda Higgins, Fayron Epps, Glenna S. Brewster, Allison Lindauer, Darby Morhardt, Raj Shah, Rachel Nash, Patricia C. Griffiths
Summary: This study demonstrated the effectiveness of the Tele-Savvy program in improving emotional well-being and caregiving mastery among family caregivers over a 6-month period. Significant benefits were found in areas such as depression, perceived stress, and caregiver mastery, although expected benefits for caregiver burden and anxiety were not observed. The next steps involve finding alternative ways to deliver the program to caregivers facing connectivity or time constraint issues.
Review
Biochemistry & Molecular Biology
Leszek Szablewski
Summary: Alzheimer's disease is the most common cause of dementia in elderly people, with aging being a main risk factor. Impairment of brain energy and glucose hypometabolism are hallmarks of the disease. There are several hypotheses on the role of glucose hypometabolism in AD, but further investigations are needed on this subject.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Adrian L. Oblak, Peter B. Lin, Kevin P. Kotredes, Ravi S. Pandey, Dylan Garceau, Harriet M. Williams, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary A. Cope, Gabriela J. Little, Sean-Paul G. Williams, Carl Ash, Adam Bleckert, Tim Ragan, Benjamin A. Logsdon, Lara M. Mangravite, Stacey J. Sukoff Rizzo, Paul R. Territo, Gregory W. Carter, Gareth R. Howell, Michael Sasner, Bruce T. Lamb
Summary: The development of AD animal models depends on comprehensive characterization, current models have limitations and cannot fully recapitulate the full effects of AD in humans, hence the MODEL-AD consortium was formed by NIA to develop more relevant and clinically useful AD animal models.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Fred B. Ketchum, Nathaniel A. Chin, Joshua Grill, Carey E. Gleason, Claire Erickson, Lindsay R. Clark, Jane S. Paulsen, Amy J. H. Kind
Summary: This article discusses the safety and psychological effects of AD biomarker testing, as well as the counseling and risk management before and after testing. It proposes a conceptual model to guide the different phases of testing.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Jalayne J. Arias, Grace A. Lin, Ana M. Tyler, Michael P. Douglas, Kathryn A. Phillips
Summary: This study explores the perspectives of geriatricians on the utility of genetic testing for Alzheimer's disease (AD). The results show that geriatricians perceive limited clinical utility of genetic testing for AD, but recognize the potential personal utility, such as assisting with financial planning. They also express concerns about patients' anxiety from direct-to-consumer testing.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Public, Environmental & Occupational Health
Weiwei Ma, Liping Zhu, Jiangang Tang, Wanli Diao, Liqi Qian, Xiaoyang Feng, Xiaoling Zhang
Summary: This study aimed to investigate the knowledge status of Alzheimer's disease (AD) among community health service center (CHSC) staff in Jiaxing, China, and to compare the effects of online with offline training. The results showed that CHSC staff had limited knowledge of AD, especially in the symptom and caregiving dimensions. A single training session on AD-related knowledge helped improve awareness to some extent but fell short of meeting national requirements. There were no significant differences in the effects of offline and online training.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Danielle K. Bailey, Whitney Clark, Daniel J. Kosman
Summary: The study revealed that PBT434 modulates the uptake of iron by human brain microvascular endothelial cells through chelation of extracellular Fe2+, resulting in increased abundance of transferrin receptor and ceruloplasmin. Additionally, PBT434 increases chelatable, labile Fe2+ within the cell and promotes iron efflux. Importantly, PBT434 rapidly and bi-directionally equilibrates across the blood-brain barrier, presenting a novel mechanism for therapeutic iron chelation.
Article
Biochemistry & Molecular Biology
Thiago B. Taketa, Cynthia R. A. Mahl, Guilherme B. Calais, Marisa M. Beppu
Summary: Chitosan-based materials were shown to have enhanced copper ion adsorption capacity in the presence of histidine, with amino acid functionalization promoting an increase in adsorption capacity. The order of addition of histidine to the system influenced the adsorption behavior, and simultaneous addition of chitosan and histidine prevented a decrease in adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Clinical Neurology
Francisco Lopera, Nilton Custodio, Mariana Rico-Restrepo, Ricardo F. Allegri, Jose Domingo Barrientos, Estuardo Garcia Batres, Ismael L. Calandri, Cristian Calero Moscoso, Paulo Caramelli, Juan Carlos Duran Quiroz, Angela Marie Jansen, Alberto Jose Mimenza Alvarado, Ricardo Nitrini, Jose F. Parodi, Claudia Ramos, Andrea Slachevsky, Sonia Maria Dozzi Brucki
Summary: Alzheimer's disease is a significant burden in Latin America and the Caribbean due to limited access to diagnosis and treatment, fragmented healthcare systems, and various barriers such as genetic heterogeneity and social determinants of health. To address these issues, a group of experts convened a virtual meeting to discuss best practices and recommendations, including additional training for healthcare workers, adapted cognitive tests, expanded healthcare insurance coverage, and gene variant detection strategies.
FRONTIERS IN NEUROLOGY
(2023)