Review
Environmental Sciences
Yi Zhao, Qiu E. Yang, Xue Zhou, Feng-Hua Wang, Johanna Muurinen, Marko P. Virta, Kristian Koefoed Brandt, Yong-Guan Zhu
Summary: The use of antibiotics in animal production has led to the transmission of antibiotic resistance genes between animals and humans, highlighting the urgent need to take measures to mitigate this public health crisis.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2021)
Article
Biology
Lea Pradier, Stephanie Bedhomme
Summary: Antibiotic consumption alone does not fully explain the persistence of antibiotic resistance, as shown by the widespread presence of aminoglycoside-modifying enzyme (AME) genes in bacteria from various ecological contexts. This study demonstrates that the prevalence of AME-carrying bacteria is influenced by ecological factors more than antibiotic use. Analysis of resistome compositions reveals the importance of exchanges between soil, wildlife, and human samples in the dissemination of AME genes. Intervention strategies should consider both reducing antibiotic use and controlling exchanges between ecosystems.
Article
Biology
Emma Mendelsohn, Noam Ross, Carlos Zambrana-Torrelio, T. P. Van Boeckel, Ramanan Laxminarayan, Peter Daszak
Summary: This study examines the factors related to antimicrobial resistance (AMR) emergence in humans using global data. It finds a positive correlation between AMR emergence and antibiotic consumption in humans. The study also suggests that human travel may contribute to the spread of novel AMR strains.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Editorial Material
Microbiology
Santiago Castillo-Ramirez
Summary: A recent study published in mBio sequenced the genomes of 313 carbapenem-resistant A. baumannii isolates from over 100 hospitals in almost 50 countries, providing an updated view of the global distribution of major international clones and their carbapenemase genes. Future global genomic epidemiology studies can be enhanced by considering both human and non-human isolates and their antibiotic resistance profiles.
Article
Infectious Diseases
Carlotta Gamberini, Sabine Donders, Salwan Al-Nasiry, Alena Kamenshchikova, Elena Ambrosino
Summary: This study explores how healthcare practitioners make decisions about antibiotic prescriptions for pregnant women and what factors play a role in this process. A cross-sectional exploratory survey was conducted, and both quantitative and qualitative data were collected to identify trends and challenges in antibiotic prescription practices. The findings emphasize the importance of clinical guidelines and hospital protocols and highlight the need for tailored interventions to address emerging resistance.
Review
Biotechnology & Applied Microbiology
Dragana Stanley, Romeo Batacan, Yadav Sharma Bajagai
Summary: The control of infectious diseases has always been a top priority in medicine. However, the lack of appreciation and safeguarding of the benefits of antibiotic era has led us into a grim post-antibiotic era. Antibiotic resistance is a major global health risk, abundant in agricultural produce, soil, food, water, air, and probiotics. New approaches are being developed to control and reduce antimicrobial resistance.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Anna Abramova, Thomas U. Berendonk, Johan Bengtsson-Palme
Summary: The environment plays a crucial role in the emergence and spread of antimicrobial resistance (AMR), yet monitoring efforts outside of clinical and veterinary settings have been limited. This is partly due to a lack of comprehensive reference data for most environments. To establish a baseline of AMR in various settings, a literature survey was conducted, identifying 150 papers with relevant qPCR data on antimicrobial resistance genes (ARGs) in environments associated with potential routes for AMR dissemination. The collected data, spanning from 2001 to 2020 and representing 1594 samples from 30 countries and 12 sample types, revealed that the abundances of most ARGs in human impacted environments fell within a range of 10-5 to 10-3 copies per 16S rRNA, approximately one ARG copy in a thousand bacteria. Overall, these findings provide a comprehensive overview of ARG occurrence and levels in different environments, contributing to the development of risk assessment models in AMR monitoring frameworks.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Engineering, Environmental
Xiaole Yin, Liguan Li, Xi Chen, Yang-Yu Liu, Tommy Tsan-Yuk Lam, Edward Topp, Tong Zhang
Summary: This study retrieved resistome profiles from various habitats and benchmarked their features. The results showed that wastewater and wastewater treatment works harbored more diverse genotypes of ARGs, while fecal samples had higher ARG abundance. Bacterial taxonomy composition was significantly correlated with resistome composition. The study also developed a resistome-based microbial attribution prediction model to identify source-sink connectivities.
Review
Microbiology
Amy Pruden, Peter J. Vikesland, Benjamin C. Davis, Ana Maria de Roda Husman
Summary: Antimicrobial resistance (AMR) poses a growing global health threat that requires coordinated action across different sectors. Recent progress in sewage monitoring infrastructure for viruses provides momentum for similar monitoring of AMR. Tracking methodologies for AMR are advancing rapidly and efforts are needed to standardize and make them accessible globally.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Magnus N. Osnes, Lucy van Dorp, Ola B. Brynildsrud, Kristian Alfsnes, Thamarai Schneiders, Kate E. Templeton, Koji Yahara, Francois Balloux, Dominique A. Caugant, Vegard Eldholm
Summary: A study on Neisseria gonorrhoeae multilocus sequence type (ST) 1901 found that this lineage is commonly associated with treatment failure, particularly due to alleles linked to reduced susceptibility to extended-spectrum cephalosporins (ESCs). The genetic diversity of ST-1901 was classified into minor and major clades, both originating in East Asia and dispersing globally in waves, with one clade acquiring a gene that significantly reduces susceptibility to ESCs. Despite declining effective population sizes, the lineage has become a reservoir for clones resistant to ceftriaxone, a key drug for gonorrhea treatment.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Engineering, Environmental
Jie Hou, Xiang Long, Xiaolong Wang, Linyun Li, Daqing Mao, Yi Luo, Hongqiang Ren
Summary: There is an association between antibiotic consumption and antibiotic resistance globally, with low- and middle-income countries being major hotspots for resistance.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Infectious Diseases
Alessandra Romandini, Arianna Pani, Paolo Andrea Schenardi, Giulia Angela Carla Pattarino, Costantino De Giacomo, Francesco Scaglione
Summary: Antibiotic resistance poses a significant public health threat to children, with multiple factors contributing to its emergence, including overuse and misuse of antibiotics, lack of pediatric-specific data and trials. The evolving nature of children's development requires consideration of the diversity in biochemical characteristics and pharmacokinetics in drug treatment.
Article
Infectious Diseases
Md Asiful Islam, Shoumik Kundu, Tengku Muhammad Hanis, Khalid Hajissa, Kamarul Imran Musa
Summary: This study conducted a bibliometric analysis of articles on antibiotic-resistant active pulmonary TB over the past 25 years. The results show that researchers and funders from the USA dominate in this field, followed by the UK. It is recommended to collaborate with low- and middle-income countries with high TB burden to enhance the productivity and translational impact of antibiotic-resistant TB research.
Article
Environmental Sciences
Temitope C. Ekundayo, Aboi Igwaran, Yinka D. Oluwafemi, Anthony Okoh
Summary: The study highlighted the significant performance of MCR research in public health and sustainable concern subjects, particularly in Environmental Sciences & Ecology, Engineering, Microbiology, Water Resources, Biotechnology & Applied Microbiology, Food Science & Technology. Research on biofilm-related thrusts was identified as a main research hotspot of MCR.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Engineering, Environmental
Nuohan Xu, Danyan Qiu, Zhenyan Zhang, Yan Wang, Bingfeng Chen, Qi Zhang, Tingzhang Wang, Wenjie Hong, Ning-Yi Zhou, Josep Penuelas, Michael Gillings, Yong-Guan Zhu, Haifeng Qian
Summary: Oceans contain a large amount of antibiotic-resistant bacteria and antibiotic resistance genes (ARGs), but their traits and expression in response to environmental factors are not well understood. This study analyzed metagenomes and metatranscriptomes and found that the distribution and abundance of ARGs vary with latitude and depth. The core marine resistome mainly confers glycopeptide and multidrug resistance. Anthropogenic activity may affect the expression of ARGs by altering environmental factors. Machine-learning models predict that the expression of marine ARGs will change significantly in the future. Certain ARGs play a dual role in antibiotic resistance and element cycling. Comprehensive understanding of their functions is necessary to determine whether changes in ARG expression are beneficial or harmful.
Article
Immunology
Jeffrey D. Jenks, Juergen Prattes, Johanna Frank, Birgit Spiess, Sanjay R. Mehta, Tobias Boch, Dieter Buchheidt, Martin Hoenigl
Summary: The study demonstrated that the Aspergillus Galactomannan Lateral Flow Assay showed good diagnostic performance for invasive aspergillosis, and its performance was consistent across different patient cohorts and centers.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Marcio Nucci, Jeffrey Jenks, George R. Thompson, Martin Hoenigl, Marielle Camargo dos Santos, Fabio Forghieri, Juan Carlos Rico, Valentina Bonuomo, Leyre Lopez-Soria, Cornelia Lass-Florl, Anna Candoni, Carolina Garcia-Vidal, Chiara Cattaneo, Jochem Buil, Ricardo Rabagliati, Maria Pia Roiz, Carlota Gudiol, Nicola Fracchiolla, Maria Isolina Campos-Herrero, Mario Delia, Francesca Farina, Jesus Fortun, Gianpaolo Nadali, Enric Sastre, Arnaldo L. Colombo, Elena Perez Nadales, Ana Alastruey-Izquierdo, Livio Pagano
Summary: The study did not find a clear correlation between MIC and mortality at 6 weeks in patients with invasive fusariosis, but persistent neutropenia and receipt of corticosteroids were strong predictors of 6 week mortality.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Martin Hoenigl, Jon Salmanton-Garcia, Thomas J. Walsh, Marcio Nucci, Chin Fen Neoh, Jeffrey D. Jenks, Michaela Lackner, Rosanne Sprute, Abdullah M. S. Al-Hatmi, Matteo Bassetti, Fabianne Carlesse, Tomas Freiberger, Philipp Koehler, Thomas Lehrnbecher, Anil Kumar, Juergen Prattes, Malcolm Richardson, Sanjay Revankar, Monica A. Slavin, Jannik Stemler, Birgit Spiess, Saad J. Taj-Aldeen, Adilia Warris, Patrick C. Y. Woo, Jo-Anne H. Young, Kerstin Albus, Dorothee Arenz, Valentina Arsic-Arsenijevic, Jean-Philippe Bouchara, Terrence Rohan Chinniah, Anuradha Chowdhary, G. Sybren de Hoog, George Dimopoulos, Rafael F. Duarte, Petr Hamal, Jacques F. Meis, Sayoki Mfinanga, Flavio Queiroz-Telles, Thomas F. Patterson, Galia Rahav, Thomas R. Rogers, Coleman Rotstein, Retno Wahyuningsih, Danila Seidel, Oliver A. Cornely
Summary: With an increasing number of patients requiring intensive care or being immunosuppressed, infections caused by molds other than Aspergillus spp or Mucorales are on the rise. Antifungal prophylaxis has been effective, but breakthrough infections by other rare molds are also increasing. Regional differences should be considered in providing practical clinical decision guidance.
LANCET INFECTIOUS DISEASES
(2021)
Review
Dermatology
Jeffrey D. Jenks, Hannah H. Nam, Martin Hoenigl
Summary: This review focuses on the epidemiology, definitions, diagnostic tests, clinical presentation, and imaging findings of invasive aspergillosis (IA) in critically ill patients in the intensive care unit, providing direction for further research.
Letter
Immunology
Jeffrey D. Jenks, Saima Aslam, Lucy E. Horton, Nancy Law, Ajay Bharti, Cathy Logan, Mahnaz Taremi, Florin Vaida, Michele Ritter
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Juergen Prattes, Joost Wauters, Daniele Roberto Giacobbe, Jon Salmanton-Garcia, Johan Maertens, Marc Bourgeois, Marijke Reynders, Lynn Rutsaert, Niels Van Regenmortel, Piet Lormans, Simon Feys, Alexander Christian Reisinger, Oliver A. Cornely, Tobias Lahmer, Maricela Valerio, Laurence Delhaes, Kauser Jabeen, Joerg Steinmann, Mathilde Chamula, Matteo Bassetti, Stefan Hatzl, Riina Rautemaa-Richardson, Philipp Koehler, Katrien Lagrou, Martin Hoenigl
Summary: Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a common complication among critically ill COVID-19 patients in ICU. It is more prevalent in older patients, those receiving invasive ventilation, and those receiving tocilizumab treatment. CAPA is an independent predictor of ICU mortality.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Dermatology
Martin Hoenigl, Matthias Egger, Johannes Boyer, Eduard Schulz, Juergen Prattes, Jeffrey D. Jenks
Summary: The Aspergillus galactomannan Lateral Flow assay with digital readout from serum showed good performance for the diagnosis of probable/proven aspergillosis, with substantial agreement to serum GM. This indicates that the LFA from serum may serve as a more rapid test compared to conventional GM, particularly in settings where GM is not readily available.
Article
Microbiology
Matthias Egger, Samuel Penziner, Karl Dichtl, Max Gornicec, Lisa Kriegl, Robert Krause, Ethan Khong, Sanjay Mehta, Milenka Vargas, Sara Gianella, Magali Porrachia, Jeffrey D. Jenks, Iswariya Venkataraman, Martin Hoenigl
Summary: Invasive pulmonary aspergillosis (IPA) is a life-threatening disease mainly affecting immunocompromised hosts. Testing for galactomannan in serum and bronchoalveolar lavage fluid is crucial for diagnosing the disease. The novel Aspergillus-specific galactomannoprotein enzyme-linked immunosorbent assay (ELISA) demonstrates strong correlation and similar test performance to the established Platelia Aspergillus GM ELISA, making it a potential alternative test for BALF samples from patients at risk for IPA.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Review
Dermatology
Matthias Egger, Martin Hoenigl, George R. Thompson, Agostinho Carvalho, Jeffrey D. Jenks
Summary: Biological sex has a significant impact on the epidemiology of invasive fungal diseases, with higher proportions of females in invasive candidiasis cases and higher proportions of males in other invasive fungal infections. Further investigations are needed to understand the association between biological sex/gender and the pathogenesis of these diseases.
Article
Infectious Diseases
Jeffrey D. Jenks, Lizeth Hester, Emily Ryan, Candy Stancil, Quinn Hauser, John-Paul Zitta, Marissa Mortiboy, Malkia Rayner, Elizabeth Stevens, Savannah Carrico, Rodney Jenkins
Summary: This study analyzed the demographic and clinical characteristics, return rates for test-of-cure, and percent positivity for Neisseria gonorrhoeae in pharyngeal specimens at a local public health department in Durham, NC. Findings showed low rates of return for test-of-cure after treatment of pharyngeal gonorrhea, suggesting the need for alternative strategies to increase test-of-cure rates.
SEXUALLY TRANSMITTED DISEASES
(2022)
Review
Microbiology
Jeffrey D. Jenks, Chioma Inyang Aneke, Mohanad M. Al-Obaidi, Matthias Egger, Lorena Garcia, Tommi Gaines, Martin Hoenigl, George R. Thompson III
Summary: Racial and ethnic identities may affect the risk of acquiring infectious diseases, including fungal infections, through genetic and immunologic differences as well as underlying social determinants of health. Environmental exposures and healthcare disparities may contribute to racial and ethnic groups being more prone to certain diseases that increase the risk of fungal infections. While the reasons for the higher risk among black and African American individuals for Candida infections and cryptococcosis are unclear, social determinants of health and socioeconomic disparities may play a role. Overall, social determinants of health and immunologic mechanisms likely contribute to the risk factors for fungal infections.
Article
Public, Environmental & Occupational Health
Marissa Mortiboy, John-Paul Zitta, Savannah Carrico, Elizabeth Stevens, Alecia Smith, Corey Morris, Rodney Jenkins, Jeffrey D. Jenks
Summary: Throughout the COVID-19 pandemic, populations of color have experienced disproportionate impacts, including higher rates of infection, hospitalization, and mortality compared to non-Hispanic whites. These disparities are influenced by various factors, such as socioeconomic inequities, unequal access to healthcare, employment in essential or public-facing occupations, language barriers, and disparities in COVID-19 vaccination. This manuscript discusses the strategies employed by a local health department to address vaccine inequities and improve vaccination rates in historically marginalized communities, particularly the Black or African American population in Durham County, North Carolina during the early stages of the pandemic in 2021.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Article
Public, Environmental & Occupational Health
Savannah Carrico, John-Paul Zitta, Elizabeth Stevens, Rodney Jenkins, Marissa Mortiboy, Jeffrey D. Jenks
Summary: This study investigates the association between mpox vaccine administration and social vulnerability index (SVI) in Durham County, North Carolina. The results show that non-Hispanic white individuals, males, and those between the ages of 20 and 40 are overrepresented in mpox vaccine reception. Surprisingly, lacking education, health insurance, a household vehicle, and living below the poverty line are all positively associated with receiving the mpox vaccine.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Article
Immunology
Thaidra Gaufin, Jill Blumenthal, Claudia Ramirez-Sanchez, Sanjay Mehta, David T. Pride, Joshua Fierer, Jeffrey D. Jenks
Summary: Shigella spp. causes a substantial number of diarrheal disease cases globally, and antimicrobial resistance is becoming a growing concern. A retrospective study conducted in San Diego, California, USA, found that Shigella flexneri was slightly more common than S. sonnei, with most cases occurring in gay or bisexual cisgender men, individuals living with HIV, homeless individuals, or methamphetamine users. The rates of antimicrobial resistance to azithromycin, fluoroquinolones, ampicillin, and trimethoprim/sulfamethoxazole were similar to national data, although the resistance rate to TMP/SMX was slightly higher.
EMERGING INFECTIOUS DISEASES
(2022)
Letter
Immunology
Jeffrey D. Jenks, Juergen Prattes, Dieter Buchheidt, Martin Hoenigl
CLINICAL INFECTIOUS DISEASES
(2021)
