Article
Infectious Diseases
James S. McCarthy, Ozkan Yalkinoglu, Anand Odedra, Rebecca Webster, Claude Oeuvray, Aliona Tappert, Deon Bezuidenhout, Marla J. Giddins, Satish K. Dhingra, David A. Fidock, Louise Marquart, Lachlan Webb, Xiaoyan Yin, Akash Khandelwal, Wilhelmina M. Bagchus
Summary: The safety, pharmacokinetics, and antimalarial activity of M5717 support its development as a component of a single-dose antimalarial combination therapy or for malaria prophylaxis.
LANCET INFECTIOUS DISEASES
(2021)
Article
Microbiology
Huong Giang Le, Haung Naw, Jung-Mi Kang, Tuan Cuong Vo, Moe Kyaw Myint, Zaw Than Htun, Jinyoung Lee, Won Gi Yoo, Tong-Soo Kim, Ho-Joon Shin, Byoung-Kuk Na
Summary: This study analyzed the antimalarial drug resistance genes in malaria parasites in the Mandalay region of Myanmar and found substantial levels of mutations conferring antimalarial drug resistance. Continuous monitoring of these mutations is necessary to provide useful information for policymakers.
Article
Immunology
Neta Simon, Jaclyn Shallat, John Houck, Prasanna Jagannathan, Mary Prahl, Mary K. Muhindo, Abel Kakuru, Peter Olwoch, Margaret E. Feeney, Whitney E. Harrington
Summary: This study found that maternal peripheral Plasmodium falciparum parasitemia during early pregnancy is associated with increased detection of cord blood maternal microchimerism, but the first parasitemia episode in the infant is not associated with increased maternal microchimerism in cord blood.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Mariestefany Romero, Elizabeth Leiba, Fhabian S. Carrion-Nessi, Diana C. Freitas-De Nobrega, Serris Kaid-Bay, Angel F. Gamardo, Melynar Chavero, Luisamy Figuera, Natasha A. Camejo-Avila, Maria Marcano, Mary Lopez-Perez, David A. Forero-Pena
Summary: This study investigated malaria infections in pregnant women in southern Venezuela, revealing a high prevalence of pregnant women infected with malaria, with diagnoses often made in the third trimester of pregnancy. Some patients experienced complications during pregnancy or delivery, emphasizing the importance of routine malaria testing during prenatal check-ups.
Article
Public, Environmental & Occupational Health
Noy Norman Kambuaya, Hasrini Rini, Putu Ayu Indra Shanti, King Alexander, Freis Candrawati, Pak Prayoga, Leo Leonardo, Dewi Sri Margayani, Bagus Tesa Gina Yayang, Enny Kenangalem, Pierre A. Buffet, Nicholas M. Anstey, Jeanne Rini Poespoprodjo, Steven Kho
Summary: In this case report, a severe case of Plasmodium vivax malaria with symptoms of hypotension, prostration, and acute kidney injury was described in a patient who had undergone splenectomy 2 months prior. The patient was successfully treated with intravenous artesunate.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Editorial Material
Public, Environmental & Occupational Health
Fatma Diyana Mohd Bukhari, Yee Ling Lau, Mun Yik Fong
Summary: The binding activity of PkDBP alpha II from P. knowlesi isolates is affected by the parasitemia level of patients' blood, with isolates from low parasitemia cases showing higher binding activity but significantly smaller rosettes compared to isolates from high parasitemia cases.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Multidisciplinary Sciences
Hugo O. Valdivia, Priyaleela Thota, Greys Braga, Leonila Ricopa, Keare Barazorda, Carola Salas, Danett K. Bishop, Christie A. Joya
Summary: Gazelle, a novel rapid malaria diagnostic device, showed comparable diagnostic accuracy to light microscopy for detecting P. vivax infections and outperformed two rapid diagnostic tests, even in cases of low parasitemia infections.
Article
Multidisciplinary Sciences
Arne Alder, Cecilia P. Sanchez, Matthew R. G. Russell, Lucy M. Collinson, Michael Lanzer, Michael J. Blackman, Tim-Wolf Gilberger, Joachim M. Matz
Summary: Malaria parasites use a complex to acidify the digestive vacuole and degrade host erythrocyte hemoglobin, which is essential for their survival in the human bloodstream.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Camila Fabbri, Glenda Quaresma Ramos, Djane Clarys Baia-da-Silva, Alexandre Oliveira Trindade, Luis Carlos Salazar-Alvarez, Juliana Costa Ferreira Neves, Ivanildes dos Santos Bastos, Allyson Guimaraes Costa, Marcus Vinicius Guimaraes Lacerda, Wuelton Marcelo Monteiro, Fabio Trindade Maranhao Costa, Stefanie Costa Pinto Lopes
Summary: This study evaluated the potential of methylene blue (MB) against the asexual and sexual forms of Plasmodium vivax. The results showed that MB had high efficacy against the asexual stages and demonstrated some inhibition in the sexual forms. These findings suggest that MB may be a potential drug for the treatment of vivax malaria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Chemistry, Medicinal
Lekkala Ravindar, Siti Aishah Hasbullah, K. P. Rakesh, Nurul Izzaty Hassan
Summary: Malaria is a deadly parasitic infection ranked as the fifth most lethal worldwide. Antimalarial medications are crucial for preventing and eradicating malaria. The 4-aminoquinoline moiety has diverse biological applications and has been favored in antimalarial drug discovery. This review focuses on its efficacy when hybridized with various heterocyclic scaffolds, aiding the development of more effective antimalarial agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Microbiology
Awtum M. Brashear, Liwang Cui
Summary: Malaria elimination is a challenging task that includes neglected human malaria parasites. Recent advancements in population genomics have allowed us to gain a better understanding of the biology and epidemiology of these parasites, as well as track their migration and evolutionary response. This knowledge could contribute to the development of effective elimination strategies.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
James S. McCarthy, Azrin N. Abd-Rahman, Katharine A. Collins, Louise Marquart, Paul Griffin, Anne Kummel, Aline Fuchs, Cornelis Winnips, Vishal Mishra, Katalin Csermak-Renner, J. Prakash Jain, Preetam Gandhi
Summary: The new antimalarial compound cipargamin showed antimalarial activity in healthy volunteers infected with blood-stage Plasmodium falciparum, although some subjects experienced serious liver function changes during treatment. Further evaluation of the compound's hepatic safety profile is needed despite the promising antimalarial activity observed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Neena Valecha
Summary: Prompt and effective treatment is crucial in managing malaria cases to minimize morbidity and mortality rates, reduce transmission, and prevent the emergence and spread of drug resistance. India, having the highest burden of malaria in the Southeast Asia Region, has made significant progress in reducing the disease burden. WHO has published new treatment strategy guidelines for malaria control and elimination, and updating national policies in India to align with these guidelines is necessary to meet elimination targets. This article discusses the technical aspects of the new WHO guidelines that should be considered for updating India's treatment policy.
Article
Pharmacology & Pharmacy
Anne Cristine Almeida, Anna Beatriz Ribeiro Elias, Maria Paula Marques, Gisely Cardoso de Melo, Allyson Guimaraes da Costa, Erick Frota Gomes Figueiredo, Larissa Wanderley Brasil, Fernanda Rodrigues-Soares, Wuelton Marcelo Monteiro, Marcus Vinicius Guimaraes de Lacerda, Vera Lucia Lanchote, Guilherme Suarez-Kurtz
Summary: The study investigated the impact of Plasmodium vivax malaria and chloroquine-primaquine chemotherapy on CYP2D6 and CYP2C19 activity in patients from the Brazilian Amazon. Results showed alterations in CYP2D6 and CYP2C19 metabolic phenotypes, potentially due to changes in pharmacokinetics and cytokine levels during different stages of vivax malaria illness and treatment.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jack Adderley, Christian Doerig
Summary: This study fills gaps in the kinomes of Plasmodium falciparum and Plasmodium vivax, highlighting their similarities and differences for target selection. It also identifies kinases that are not suitable targets for drug discovery due to their high similarity with human counterparts.
Review
Obstetrics & Gynecology
Theophilus K. Adu-Bredu, Marcus J. Rijken, Albaro Jose Nieto-Calvache, Vedran Stefanovic, Rozi Aditya Aryananda, Karin Anneliese Fox, Sally L. Collins
Summary: This article provides a simple three-step approach to guide clinicians and sonographers with minimal experience in placenta accreta spectrum through risk stratification and basic prenatal screening for this condition.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Stephanie Thierens, Annelien van Binsbergen, Barbara Nolens, Thomas van den Akker, Kitty Bloemenkamp, Marcus J. Rijken
Summary: Comparison of vacuum extraction (VE) and second-stage caesarean section (SSCS) revealed no significant difference in adverse outcomes for mothers and infants. VE should be recommended when safe anesthesia and surgery are not immediately available.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Medicine, General & Internal
Makoto Saito, Rose McGready, Halidou Tinto, Toussaint Rouamba, Dominic Mosha, Stephen Rulisa, Simon Kariuki, Meghna Desai, Christine Manyando, Eric M. Njunju, Esperanca Sevene, Anifa Vala, Orvalho Augusto, Christine Clerk, Edwin Were, Sigilbert Mrema, William Kisinza, Josaphat Byamugisha, Mike Kagawa, Jan Singlovic, Mackensie Yore, Anna Maria van Eijk, Ushma Mehta, Andy Stergachis, Jenny Hill, Kasia Stepniewska, Melba Gomes, PhilippeJ Guerin, Francois Nosten, Feiko O. ter Kuile, Stephanie Dellicour
Summary: This study compared adverse pregnancy outcomes in the first trimester of pregnancy after artemisinin-based treatment (ABT) versus non-ABTs. The results showed no evidence of embryotoxicity or teratogenicity associated with ABT during the first trimester. Artemether-lumefantrine was found to be the preferred treatment for uncomplicated P falciparum malaria in the first trimester, with fewer adverse pregnancy outcomes compared to quinine.
Editorial Material
Medicine, General & Internal
Lindsey Baden, Flaminia Catteruccia, Abdoulaye Diabate, Cristina Donini, Francois Nosten, Scott O'Neill, Faith Osier, Aung Pyae Phyo, Nicholas White
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Nicoletta Basilico, Silvia Parapini, Sarah D'Alessandro, Paola Misiano, Sergio Romeo, Giulio Dondio, Vanessa Yardley, Livia Vivas, Shereen Nasser, Laurent Renia, Bruce M. Russell, Rossarin Suwanarusk, Francois Nosten, Anna Sparatore, Donatella Taramelli
Summary: The novel pyrrolizidinylmethyl derivative MG3 showed excellent antimalarial activity against drug-resistant parasites, both in vitro and in vivo. The compound exhibited comparable or better efficacy than chloroquine and other quinolines in rodent models of malaria, and its pharmacological profile met the requirements for further development.
Review
Public, Environmental & Occupational Health
Ahmar Hashmi, Mu Chae Darakamon, Ko Ko Aung, Mu Mu, Prapatsorn Misa, Podjanee Jittamala, Cindy Chu, Aung Pyae Phyo, Claudia Turner, Francois Nosten, Rose McGready, Verena I. I. Carrara
Summary: This study examined the care and outcomes of preterm neonates in a special care baby unit (SCBU) along the Myanmar-Thailand border. The study found significant reductions in neonatal mortality rates and identified implementation factors that impact the delivery of evidence-based care, such as financial issues and social support systems.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Ali Haghiri, David J. Price, Phoebe Fitzpatrick, Saber Dini, Megha Rajasekhar, Caterina Fanello, Joel Tarning, James Watson, Nicholas J. White, Julie A. Simpson
Summary: The majority of deaths from malaria occur in young African children, so it is important to determine the appropriate dosage of medication for them. The US FDA has challenged the World Health Organization's recommendation of a lower dose for younger children, but a study showed that younger children given the lower dose did not reach the same drug exposures as older children. Therefore, it is suggested to withdraw the FDA's recent lower dose recommendation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Infectious Diseases
C. R. Walker, R. I. Hickson, E. Chang, P. Ngor, S. Sovannaroth, J. A. Simpson, D. J. Price, J. M. McCaw, R. N. Price, J. A. Flegg, A. Devine
Summary: Plasmodium falciparum and P. vivax are the two most common causes of malaria, with P. vivax posing a greater challenge to eliminating malaria due to its ability to cause relapsing episodes. Mixed infections of both species can complicate treatment and detection. A stochastic mathematical model was used to assess different treatment strategies, and it was found that a unified radical cure strategy and mass drug administration with schizonticidal treatment were effective in reducing malaria cases and deaths.
Article
Immunology
Aude Mondeilh, Emmanuel Yovo, Manfred Accrombessi, Cornelia Hounkonnou, Gino Agbota, William Atade, Olaiitan T. Ladikpo, Murielle Mehoba, Auguste Degbe, Bertin Vianou, Dariou Sossou, Nicaise Tuikue Ndam, Achille Massougbodji, Rose McGready, Nadine Fievet, Marcus J. Rijken, Gilles Cottrell, Valerie Briand
Summary: This study evaluated the effect of malaria in pregnancy on uterine artery and umbilical artery blood flow. The results showed that malaria infections in the early stages of pregnancy can impair placental blood flow, highlighting the need to prevent malaria from the very beginning of pregnancy.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
James A. Watson, Thomas J. Peto, Nicholas J. White
Article
Medicine, General & Internal
Aye Sandar Zaw, Ei Shwe Sin Win, Soe Wai Yan, Kyaw Sithu Thein, Vasundhara Verma, Alistair R. D. Mclean, Thar Tun Kyaw, Nicholas J. White, Frank M. Smithuis
Summary: The introduction of community health workers providing early diagnosis and treatment for malaria in remote communities in Mon state, Myanmar, has resulted in a significant reduction in malaria cases.