期刊
LANCET INFECTIOUS DISEASES
卷 10, 期 7, 页码 499-503出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1473-3099(10)70117-1
关键词
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资金
- Regione Autonoma della Sardegna (Italy)
- Swedish Medical Council
- Swedish International Development Cooperation Agency
- SIDA-SAREC
- Karolinska Institutet
- EU [Health-F3-2007-201433]
- Stockholm County Council
Although HIV-1 infection does not directly target B cells, B-cell numbers are reduced and their function is impaired during HIV infection. Antibody titres against antigens previously encountered through vaccination or natural infection are low in patients with HIV. Intrinsic B-cell defects might be involved in the impairment of humoral immunity during early HIV infection. Abnormal T-cell activation and the altered expression of molecules involved in the B-cell homing process cause dysfunctional interaction between T and B cells in the germinal centres of lymphoid tissues, which might impair B-cell responses during HIV infection. Class-switch recombination is also impaired in individuals with HIV. Protective immune responses against T-cell-dependent antigens, including influenza antigens, rely on the production of neutralising antibodies. Impaired B-cell responses during HIV infection could therefore hamper the effectiveness of vaccinations against seasonal influenza or the new pandemic influenza A H1N1 vaccines in individuals with HIV. By maintaining B-cell responses, highly active antiretroviral therapy might improve the efficacy of influenza vaccines in individuals with HIV.
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