Article
Medicine, General & Internal
Manfred Accrombessi, Jackie Cook, Edouard Dangbenon, Boulais Yovogan, Hilaire Akpovi, Arthur Sovi, Constantin Adoha, Landry Assongba, Aboubacar Sidick, Bruno Akinro, Razaki Osse, Rock Aikpon, Aurore Ogouyemi-Hounto, Germain Gil Padonou, Immo Kleinschmidt, Louisa A. Messenger, Mark Rowland, Corine Ngufor, Natacha Protopopoff, Martin Akogbeto, Filemon Tokponnon
Summary: This study evaluated the efficacy of pyriproxyfen-pyrethroid LLINs and chlorfenapyr-pyrethroid LLINs compared to standard LLINs in an area with high pyrethroid resistance. The findings showed that chlorfenapyr-pyrethroid LLINs provided greater protection from malaria than pyrethroid-only LLINs in an area with pyrethroid-resistant mosquitoes. Pyriproxyfen-pyrethroid LLINs conferred protection similar to pyrethroid-only LLINs.
Editorial Material
Public, Environmental & Occupational Health
Steve W. Lindsay, Matthew B. Thomas, Immo Kleinschmidt
Summary: Insecticide-treated bednets (ITNs) have been effective in reducing malaria morbidity and mortality in sub-Saharan Africa from 2004 to 2019, but the decline in malaria cases and deaths has stalled recently. It is important to consider factors beyond insecticide resistance, such as access to nets, use of nets, bioefficacy, and durability, in evaluating the effectiveness of ITNs. To improve the impact of ITNs, efforts should focus on increasing net coverage, funding for programmes, strategies to increase ITN uptake, and developing novel vector control tools.
LANCET GLOBAL HEALTH
(2021)
Article
Multidisciplinary Sciences
Jean Baptiste Yaro, Alfred B. Tiono, Alphonse Ouedraogo, Ben Lambert, Z. Amidou Ouedraogo, Amidou Diarra, Adama Traore, Malik Lankouande, Issiaka Soulama, Antoine Sanou, Eve Worrall, Efundem Agboraw, N'Fale Sagnon, Hilary Ranson, Thomas S. Churcher, Steve W. Lindsay, Anne L. Wilson
Summary: Burkina Faso has a high burden of malaria despite the implementation of malaria control measures. A study conducted in the country found that malaria infections were highest in children aged 5 to 15 years, despite the use of insecticide-treated nets. The study also showed that administering seasonal malaria chemoprevention to children aged 10 and 15 could significantly reduce malaria cases.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Nelson Grisales, Rosemary S. Lees, James Maas, John C. Morgan, Dimitri W. Wangrawa, Wamdaogo M. Guelbeogo, Sagnon N'Fale, Steven W. Lindsay, Philip J. McCall, Hilary Ranson
Summary: This study found that exposure to a mixture of PPF and pyrethroids on netting shortens the lifespan of mosquitoes and reduces reproductive output. Sterilization of vectors lasted at least one year under operational conditions.
Article
Infectious Diseases
Aristide S. Hien, Dieudonne D. Soma, Samina Maiga, Dramane Coulibaly, Abdoulaye Diabate, Allison Belemvire, Mame B. Diouf, Djenam Jacob, Adama Kone, Ellen Dotson, Taiwo S. Awolola, Richard M. Oxborough, Roch K. Dabire
Summary: High intensity pyrethroid resistance in An. gambiae s.l. is widespread in Burkina Faso, prompting the need for alternative insecticide-treated nets. Bioassays showed that susceptibility to chlorfenapyr was confirmed in most sites, while resistance to pyrethroids remains a challenge despite some partial restoration of susceptibility with PBO pre-exposure.
Article
Infectious Diseases
Athanase Badolo, Aboubacar Sombie, Felix Yameogo, Dimitri W. Wangrawa, Aboubakar Sanon, Patricia M. Pignatelli, Antoine Sanon, Mafalda Viana, Hirotaka Kanuka, David Weetman, Philip J. Mccall
Summary: The emergence of dengue in West Africa, particularly the outbreaks in Burkina Faso in 2016 and 2017, has led to surveys of Aedes populations in the capital city of Ouagadougou. The results show that the abundance of adult Ae. aegypti is significantly higher in urban areas compared to the rural site, which has a higher population of Anopheles spp. The vector population is highly anthropophilic and exhibits a high proportion of bloodfed females caught inside houses. The primary larval habitats are waste tires, animal troughs, and large water barrels. Factors influencing adult and immature stage densities include rainfall, container water level, collection month, and container type/purpose.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Kasia Stepniewska, Georgina S. Humphreys, Bronner P. Goncalves, Elaine Craig, Roly Gosling, Philippe J. Guerin, Ric N. Price, Karen Barnes, Jaishree Raman, Menno R. Smit, Umberto D'Alessandro, Will J. R. Stone, Anders Bjorkman, Aaron M. Samuels, Maria Arroyo-Arroyo, Guido J. H. Bastiaens, Joelle M. Brown, Alassane Dicko, Badria B. El-Sayed, Salah-Eldin G. Elzaki, Alice C. Eziefula, Simon Kariuki, Titus K. Kwambai, Amanda E. Maestre, Andreas Martensson, Dominic Mosha, Richard O. Mwaiswelo, Billy E. Ngasala, Joseph Okebe, Michelle E. Roh, Patrick Sawa, Alfred B. Tiono, Ingrid Chen, Chris J. Drakeley, Teun Bousema
Summary: A meta-analysis of individual patients was conducted to assess the gametocytocidal and transmission-blocking activities of single-dose primaquine. The results showed that primaquine, when administered with artemisinin-based combination therapies, can effectively reduce the gametocyte carriage rate after 7 and 14 days, especially in patients with existing gametocytes at the start of treatment. Furthermore, the combination of primaquine and artemether-lumefantrine showed a faster decline in gametocyte carriage compared to the combination with dihydroartemisinin-piperaquine. Additionally, the addition of 0.25 mg/kg primaquine can nearly completely prevent transmission to mosquitoes.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Sodiomon B. Sirima, Alphonse Ouedraogo, Nouhoun Barry, Mohamadou Siribie, Alfred B. Tiono, Issa Nebie, Amadou T. Konate, Gloria Damoaliga Berges, Amidou Diarra, Moussa Ouedraogo, Issiaka Soulama, Alimatou Hema, Shrimati Datta, Yuanyuan Liang, Elizabeth T. Rotrosen, J. Kathleen Tracy, Leslie P. Jamka, Kathleen M. Neuzil, Matthew B. Laurens
Summary: This study in Burkina Faso tested the co-administration of a single-dose typhoid conjugate vaccine with routine meningococcal conjugate vaccine and measles-rubella vaccine. The results showed that TCV can be safely co-administered with MCV-A at 15 months without interference, providing data to support large-scale uptake in sub-Saharan Africa.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
John Muthii Muriuki, Alexander J. Mentzer, Ruth Mitchell, Emily L. Webb, Anthony O. Etyang, Catherine Kyobutungi, Alireza Morovat, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Caroline J. Ngetsa, Johnstone Makale, Swaib A. Lule, Solomon K. Musani, Laura M. Raffield, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Michal Fried, Moses Gwamaka, Seth Adu-Afarwuah, James P. Wirth, Rita Wegmueller, Shabir A. Madhi, Robert W. Snow, Adrian V. S. Hill, Kirk A. Rockett, Manjinder S. Sandhu, Dominic P. Kwiatkowski, Andrew M. Prentice, Kendra A. Byrd, Alex Ndjebayi, Christine P. Stewart, Reina Engle-Stone, Tim J. Green, Crystal D. Karakochuk, Parminder S. Suchdev, Philip Bejon, Patrick E. Duffy, George Davey Smith, Alison M. Elliott, Thomas N. Williams, Sarah H. Atkinson
Summary: The study found a significant association between genetically predicted malaria risk and the prevalence of iron deficiency in African children, with a potential 49% reduction in ID if malaria episodes are halved as an intervention. Using HbAS as an instrumental variable in Mendelian randomization analyses, a 30% reduction in ID risk was observed in children living in malaria-endemic areas.
Article
Entomology
Billy Tene-Fossog, Yvan Gaetan Fotso-Toguem, Nathalie Amvongo-Adjia, Hilary Ranson, Charles S. Wondji
Summary: This study monitored the dynamics of insecticide resistance in malaria vectors in Yaounde over two years. The results showed an escalation in resistance to pyrethroids, with seasonal variations. This has implications for the effectiveness of malaria control strategies.
MEDICAL AND VETERINARY ENTOMOLOGY
(2022)
Article
Nutrition & Dietetics
Reagan M. Mogire, John Muthii Muriuki, Alireza Morovat, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: There is a significant association between vitamin D and iron deficiency in African children. The risk of iron deficiency is increased in children with vitamin D deficiency, and vitamin D concentration variably influences iron status. Therefore, the link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies.
Article
Entomology
Rosemary S. Lees, Jennifer S. Armistead, Salum Azizi, Edi Constant, Christen Fornadel, John E. Gimnig, Janet Hemingway, Daniel Impoinvil, Seth R. Irish, William Kisinza, Natalie Lissenden, Henry D. Mawejje, Louisa A. Messenger, Sarah Moore, Corine Ngufor, Richard Oxborough, Natacha Protopopoff, Hilary Ranson, Graham Small, Joseph Wagman, David Weetman, Sarah Zohdy, Angus Spiers
Summary: To test the effectiveness and durability of new bed nets, it is necessary to study and test insecticide-resistant mosquitoes. A group of experts collaborated to develop a protocol for standardized monitoring and accurate characterization of resistant mosquitoes, providing valuable guidance for malaria control programs and stakeholders.
Article
Entomology
Jessica Williams, Victoria A. Ingham, Marion Morris, Kobie Hyacinthe Toe, Aristide S. Hien, John C. Morgan, Roch K. Dabire, Wamdagogo Moussa Guelbeogo, N'Fale Sagnon, Hilary Ranson
Summary: Targeting mosquitoes with insecticides is an effective method to prevent malaria transmission. Burkina Faso, a country with high malaria burden, is also a hotspot for insecticide resistance evolution. This study establishes laboratory colonies from multiple species of malaria vectors and provides a profile of insecticide resistance in each colony. The findings highlight the importance of screening potential new insecticides against a wide range of mosquito populations and provide valuable insights into the genetic changes driving resistance.
Article
Entomology
Simon P. Sawadogo, Didier A. Kabore, Ezechiel B. Tibiri, Angela Hughes, Olivier Gnankine, Shannon Quek, Abdoulaye Diabate, Hilary Ranson, Grant L. Hughes, Roch K. Dabire
Summary: This study re-evaluated the occurrence of Wolbachia in Anopheles gambiae mosquitoes from Burkina Faso and found a very low prevalence of infection. Only 29 out of 5341 samples analyzed were positive for Wolbachia, representing a prevalence of 0.54%. Phylogenetic analysis suggested these positive samples clustered with supergroup B, with similarity to sequences found in Anopheles from Burkina Faso.
MEDICAL AND VETERINARY ENTOMOLOGY
(2022)
Editorial Material
Anesthesiology
B. Morton, H. Ranson, K. El-Boghdadly
Article
Biology
Iris Wagner, Linda Grigoraki, Peter Enevoldson, Michael Clarkson, Sam Jones, Jane L. L. Hurst, Robert J. J. Beynon, Hilary Ranson
Summary: The rapid evaporative ionisation mass spectrometry (REIMS) method can accurately identify the species and age of mosquitoes, with high accuracy in both laboratory-reared and wild populations.
Article
Cell Biology
Sodiomon B. Sirima, Alphonse Ouedraogo, Alfred B. Tiono, Jean M. Kabore, Edith C. Bougouma, Maurice S. Ouattara, Desire Kargougou, Amidou Diarra, Noelie Henry, Issa N. Ouedraogo, Peter F. Billingsley, Anita Manoj, Yonas Abebe, K. C. Natasha, Adam Ruben, Thomas L. Richie, Eric R. James, Sudhaunshu Joshi, Biraj Shrestha, Kathy Strauss, Kirsten E. Lyke, Christopher Plowe, Gail E. Potter, Catherine Cox, Walter Jones, B. Kim Lee Sim, Stephen L. Hoffman, Matthew B. Laurens
Summary: Despite decades of research, an effective malaria vaccine has not yet been found. A three-dose regimen of Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine) has shown safety and efficacy in malaria-experienced adults in Burkina Faso.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Yvan Fotso-Toguem, Billy Tene-Fossog, Leon M. J. Mugenzi, Murielle J. Wondji, Flobert Njiokou, Hilary Ranson, Charles S. Wondji
Summary: The polymorphisms of CYP6M2 and CYP6P4 were analyzed to detect potential resistance markers in Anopheles coluzzii and Anopheles gambiae. The study found significant overexpression of CYP6M2 and CYP6P4 in resistant mosquitos, and a lower diversity in the upstream region of CYP6P4 potentially associated with resistance.
Article
Multidisciplinary Sciences
Jacques D. Charlwood, Thomas A. Smith, Ayubo Kampango, Erzelia V. E. Tomas, Nakul Chitnis
Summary: This study estimated the survival rate and oviposition cycle duration of malaria vectors using a time-series analysis approach. The findings suggest that female mosquitoes have lower survival rates compared to males, and that male survival is not influenced by temperature or the use of long-lasting insecticidal nets. However, there is considerable uncertainty in the estimates of oviposition cycle duration.
Article
Multidisciplinary Sciences
Majo Carrasco-Tenezaca, Musa Jawara, Mahamed Y. Abdi, John Bradley, Otis Sloan Brittain, Sainey Ceesay, Umberto D'Alessandro, David Jeffries, Margaret Pinder, Hannah Wood, Jakob B. Knudsen, Steve W. Lindsay
Summary: The study found that raising buildings off the ground can effectively reduce malaria transmission in rural Gambia, as most malaria mosquitoes fly close to the ground and showed significantly reduced entry when buildings were elevated.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2021)
Article
Multidisciplinary Sciences
Ebrima Jatta, Majo Carrasco-Tenezaca, Musa Jawara, John Bradley, Sainey Ceesay, Umberto D'Alessandro, David Jeffries, Balla Kandeh, Daniel Sang-Hoon Lee, Margaret Pinder, Anne L. Wilson, Jakob Knudsen, Steve W. Lindsay
Summary: In sub-Saharan Africa, improved ventilation through screened windows or doors can reduce indoor temperature, decrease malaria mosquito house entry, and enhance the effectiveness of insecticide-treated bednets. This study demonstrates that increased ventilation not only cools houses and makes them more comfortable, but also significantly reduces the density of malaria mosquitoes entering houses by weakening CO2 plumes.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2021)
