Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Dorien Bamps, Joris Vriens, Jan de Hoon, Thomas Voets
Summary: Chronic pain treatment poses a challenge due to limited efficacy and abuse potential. Research on mechanisms underlying chronic pain states offers opportunities for novel interventions, with TRP channels representing innovative targets for addressing pain sensation at the root.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Biochemistry & Molecular Biology
Andrew P. Bischer, Timothy M. Baran, Andrew P. Wojtovich
Summary: Environmental surveillance-mediated behavior in Caenorhabditis elegans integrates multiple cues and is coordinated by neurons through signaling cascades. Despite lacking eyes, C. elegans is able to perceive and react to the color blue. This study explains this color perception by showing that internally-generated reactive oxygen species (ROS), in response to light, add to exogenous sources of ROS. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses with internal cues. Blue light affects C. elegans behavior through ROS generation by endogenous flavins, mediated by the neuronal gustatory photoreceptor like protein, LITE-1. Overall, this study demonstrates that ROS and LITE-1 play central roles in C. elegans foraging behavior through integration of multiple inputs, including light.
Article
Immunology
Nan-Nan Liang, Ying Zhao, Yue-Yue Guo, Zhi-Hui Zhang, Lan Gao, De-Xin Yu, De-Xiang Xu, Shen Xu
Summary: This study found that mitochondria-derived reactive oxygen species (ROS) contribute to renal cell ferroptosis during lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Inhibition of ferroptosis and scavenging of mitochondrial ROS with specific inhibitors, ferrostatin-1 and MitoQ, respectively, attenuated renal lipid peroxidation, ferroptosis-characteristic mitochondrial damage, and renal cell death. These findings suggest that mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Andrey Y. Vinokurov, Olga A. Stelmashuk, Polina A. Ukolova, Evgeny A. Zherebtsov, Andrey Y. Abramov
Summary: The brain produces various reactive oxygen species at different rates in different brain regions, with the brain stem and cerebellum being more sensitive to oxidative stress. Mitochondrial ROS has minor implications to total ROS production, and levels of lipid peroxidation and GSH vary across brain regions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Namasthee Harris-Gauthier, Annika Traa, Abdelrahman AlOkda, Alibek Moldakozhayev, Ulrich Anglas, Sonja K. Soo, Jeremy M. Van Raamsdonk
Summary: Mild impairment of mitochondrial function can increase lifespan in genetic model organisms. The upregulation of genes involved in the mitochondrial thioredoxin system, mediated by the mitochondrial unfolded protein response, is specifically required for the longevity of mitochondrial mutants. The mitochondrial thioredoxin system also plays a role in stress resistance.
Article
Cell Biology
Jing Tian, Caroline Geiss, Kim Zarse, Corina T. Madreiter-Sokolowski, Michael Ristow
Summary: Green tea catechins such as EGCG and ECG have been found to extend healthspan and lifespan in Caenorhabditis elegans by inhibiting mitochondrial complex I and temporarily lowering ATP levels, leading to activation of SKN-1 and DAF-16. These catechins also reduce fat content, enhance ROS defense, and ultimately improve overall healthspan through adaptive responses.
Article
Biochemistry & Molecular Biology
Michael O. Isei, Don Stevens, Collins Kamunde
Summary: The research found that heart mitochondria show different responses to copper and thermal stress, and the consumption capacity of H2O2 is influenced by the type of substrate, temperature, and copper. The NADPH-dependent peroxidase system is the centerpiece of ROS scavenging in heart mitochondria, and copper has the ability to inhibit specific mitochondrial ROS scavenging pathways.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Hulya Gizem Oezkan, Andriy Mokhir
Summary: Hybrid drugs containing ferrocene and phenol residues exhibit potent anticancer activity, but their mode of action, specificity, and metabolism need further investigation. In this study, we synthesized prodrugs of aminoferrocene-phenol hybrids and confirmed their activation in cancer cells while remaining inactive in normal cells. The anticancer activity of the prodrug relies on the generation of reactive oxygen species in cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ivan Menendez-Montes, Salim Abdisalaam, Feng Xiao, Nicholas T. Lam, Shibani Mukherjee, Luke I. Szweda, Aroumougame Asaithamby, Hesham A. Sadek
Summary: Mitochondrial utilization of fatty acids induces a significant increase in ROS detection at the chromatin level, indicating that mitochondrial metabolic perturbations directly alter the nuclear redox status, with chromatin being particularly sensitive to the prooxidant effect of FA utilization by the mitochondria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Environmental
Xiangyu Wang, Hanjiang Zhao, Zhenchuan Liu, Yitong Wang, Dan Lin, Long Chen, Jiewen Dai, Kaili Lin, Steve G. Shen
Summary: PDA nanoparticles exhibit a dual antioxidative and anti-inflammatory mechanism, effectively treating temporomandibular joint osteoarthritis by improving mitochondrial respiration efficiency and reducing ROS production. This nanoplatform opens up a new avenue for osteoarthritis treatment and offers valuable insights into the design of biomaterials with multiple biomedical applications by regulating cellular energy metabolism.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biology
Jules B. L. Devaux, Anthony J. R. Hickey, Gillian M. C. Renshaw
Summary: Anoxia/re-oxygenation (AR) can cause irreversible brain damage due to elevated oxidative stress. Two shark species, the epaulette shark and the grey carpet shark, have adapted to survive AR without significant brain injuries. The epaulette shark shows the capacity to suppress metabolism and depress succinate oxidation, resulting in lower ROS production compared to the grey carpet shark. The research sheds light on potential mechanisms to mitigate brain injury during AR.
Meeting Abstract
Biochemistry & Molecular Biology
Seol-Hee Kim, Stephen Hadley, Mayur Patil, Marian Kollarik, Thomas Taylor-Clark
Article
Physiology
Parmvir K. Bahia, Stephen H. Hadley, Ivan Barannikov, Isobel Sowells, Seol-Hee Kim, Thomas E. Taylor-Clark
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2020)
Article
Neurosciences
Seol-Hee Kim, Parmvir K. Bahia, Mayur Patil, Sydney Sutton, Isobel Sowells, Stephen H. Hadley, Marian Kollarik, Thomas E. Taylor-Clark
Article
Multidisciplinary Sciences
Parveen Bazard, Bo Ding, Harish K. Chittam, Xiaoxia Zhu, Thomas A. Parks, Thomas E. Taylor-Clark, Venkat R. Bhethanabotla, Robert D. Frisina, Joseph P. Walton
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Thomas E. Taylor-Clark
Summary: The lower airways are protected and regulated by a complex neural network, with different sources of nociceptors responding to harmful stimuli with defensive reflexes. Understanding the origins and functions of these nociceptors is crucial for targeting therapeutic interventions in respiratory diseases.
NEUROSCIENCE LETTERS
(2021)
Article
Physiology
Stephen Hadley, Mayur J. Patil, Nikoleta Pavelkova, Marian Kollarik, Thomas E. Taylor-Clark
Summary: Multiple Na(V)1 subtypes contribute to electrical signaling in esophageal mechanoreceptors, and inhibiting individual Na(V)1s would likely have minimal effect on afferent regulation of esophageal motility.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Physiology
J. Shane Hooper, Thomas E. Taylor-Clark
Summary: Irritant inhalation is associated with increased incidence of atrial fibrillation (AF) and stroke. The study shows that irritant-evoked pulmonary-cardiac reflex in spontaneously hypertensive (SH) rats is remodeled, leading to altered P wave morphologies that could be triggers for AF initiation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Reena Mehra, Olga A. Tjurmina, Olujimi A. Ajijola, Rishi Arora, Donald C. Bolser, Mark W. Chapleau, Peng-Sheng Chen, Colleen E. Clancy, Brian P. Delisle, Michael R. Gold, Jeffrey J. Goldberger, David S. Goldstein, Beth A. Habecker, M. Louis Handoko, Robert Harvey, James P. Hummel, Thomas Hund, Christian Meyer, Susan Redline, Crystal M. Ripplinger, Marc A. Simon, Virend K. Somers, Stavros Stavrakis, Thomas Taylor-Clark, Bradley Joel Undem, Richard L. Verrier, Irving H. Zucker, George Sopko, Kalyanam Shivkumar
Summary: This virtual workshop aimed to bring together experts in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster collaborations in the field of autonomic neural mechanisms of cardiopulmonary regulation. The workshop discussed the roles of the autonomic nervous system in regulating cardiopulmonary function and its implications in arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities for nonpharmacologic neuromodulation and device-based therapies were explored. The workshop also focused on developing predictive markers of autonomic dysfunction and targeting neural pathophysiological mechanisms for new therapies.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Neurosciences
Seol-Hee Kim, Mayur J. Patil, Stephen H. Hadley, Parmvir K. Bahia, Shane G. Butler, Meghana Madaram, Thomas E. Taylor-Clark
Summary: The sensory innervation of the mouse lung was analyzed, revealing distinct patterns of innervation in the conducting airways, alveoli, and blood vessels. These findings provide a neuroanatomical basis for understanding the responses of sensory nerves in vivo.
Editorial Material
Neurosciences
Thomas E. Taylor-Clark
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Meeting Abstract
Clinical Neurology
R. H. Rasmussen, S. L. Christensen, K. Callo, A. Rehfeld, T. E. Taylor-Clark, K. A. Haanes, O. Taboureau, K. Audouze, D. Klaerke, J. Olesen, D. M. Kristensen
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Biochemistry & Molecular Biology
Thomas A. Parks, Parmvir K. Bahia, Thomas E. Taylor-Clark
Summary: TRPA1 channel activation is crucial for nociceptive responses, and this study found that C621 plays a key role in electrophile-induced TRPA1 activation, while the role of C665 depends on the size of the electrophile. It was discovered that supplementing with the antioxidant glutathione can rescue the slower TRPA1 activation in whole-cell recordings. Single-channel recordings revealed distinct phases of electrophilic-induced TRPA1 activation, indicating different activation states.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Biology
Parmvir K. Bahia, Thomas E. Taylor-Clark
Summary: The study demonstrates differential sensitivity of TRPA1 to cinnamaldehyde in mouse and guinea pig sensory neurons. This suggests variations in ligand affinity for TRPA1 in animal models, which is relevant for drug development.
BMC RESEARCH NOTES
(2021)
Review
Physiology
Thomas E. Taylor-Clark
Meeting Abstract
Gastroenterology & Hepatology
Mayur Patil, Jana Harsanyiova, Seol-Hee Kim, Thomas E. Taylor-Clark, Marian Kollarik