Article
Psychology, Multidisciplinary
Sharon H. X. Lu, Hanita A. Assudani, Tammie R. R. Kwek, Shaun W. H. Ng, Trisha E. L. Teoh, Geoffrey C. Y. Tan
Summary: This study provides evidence for the efficacy and acceptability of iCBT for outpatients with depression in Singapore. Treatment led to significant reductions in symptoms of depression, anxiety and psychological distress, with high levels of satisfaction among participants.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Oncology
Selin Akkol-Solakoglu, David Hevey
Summary: This study evaluated the effectiveness of internet-delivered cognitive behavioural therapy (iCBT) in reducing depression and anxiety, improving quality of life, reducing fear of recurrence, and enhancing coping and perceived social support in breast cancer survivors. The results showed that the iCBT intervention demonstrated its preliminary effectiveness in reducing distress in breast cancer survivors.
Article
Psychiatry
Noortje P. Janssen, Peter Lucassen, Marcus J. H. Huibers, David Ekers, Theo Broekman, Judith E. Bosmans, Harm Van Marwijk, Jan Spijker, Richard Oude Voshaar, Gert-Jan Hendriks
Summary: This study evaluated the effectiveness of behavioural activation (BA) by mental health nurses (MHNs) for depressed older adults in primary care. The results showed that BA was more effective than treatment as usual (TAU) in reducing depressive symptoms at post-treatment and 3-month follow-up, but not at 6- to 12-month follow-up.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2023)
Review
Behavioral Sciences
Lampros Bisdounis, Kate E. A. Saunders, Hannah J. Farley, Charlotte K. Lee, Niall M. McGowan, Colin A. Espie, Simon D. Kyle
Summary: This review evaluates the effectiveness of psychological and behavioral interventions that target sleep and circadian rhythms in bipolar disorder (BD) and finds limited evidence and lack of consistency in protocols and outcomes for these interventions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Roger Munoz-Navarro, Leonardo Adrian Medrano, Joaquin T. Limonero, Cesar Gonzalez-Blanch, Juan A. Moriana, Paloma Ruiz-Rodriguez, Antonio Cano-Vindel
Summary: This study evaluated the impact of different emotion regulation strategies on treatment outcomes in primary care patients. The results showed that targeting certain maladaptive strategies, such as worry, rumination, suppression, and negative metacognition, could reduce emotional symptoms and improve well-being. Adaptive strategies, such as reappraisal, did not have a significant impact on treatment outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Hanin Salem, Anne E. Kazak, Elisabeth Wreford Andersen, Federica Belmonte, Christoffer Johansen, Kjeld Schmiegelow, Jeanette Falck Winther, Peder Skov Wehner, Henrik Hasle, Steen Rosthoj, Pernille E. Bidstrup
Summary: The study evaluated the effect of FAMily-Oriented Support (FAMOS) intervention on parents of young children after cancer treatment. The results showed a significant decrease in symptoms of PTSD and depression in the intervention group at 12 months, but not at 6 months. The reduction in symptoms of anxiety was not statistically significant.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Geriatrics & Gerontology
Osvaldo P. Almeida, Hema Patel, Rachael Kelly, Andrew Ford, Leon Flicker, Suzanne Robinson, Ricardo Araya, Simon Gilbody, Sandra Thompson
Summary: This study aimed to test if a behavioural activation (BA) programme was more effective than usual care at reducing the risk of major depression among adults aged 65 years or older living in rural Western Australia. The results showed significant improvements in depression and anxiety symptoms, as well as mental health-related quality of life among participants who received the BA intervention over 52 weeks.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Psychology, Clinical
Julia Rodriguez-Sanchez, Gemma Lewis, Francesca Solmi, Jessica K. Bone, Michael Moore, Nicola Wiles, Catherine J. Harmer, Larisa Duffy, Glyn Lewis
Summary: This study investigated the effect of discontinuing maintenance antidepressant treatment on self-referential recall and its association with the risk of relapse. The results showed that discontinuation did not affect self-referential recall at 12 and 52 weeks, and there was no association between recall and later relapse at baseline or 12 weeks.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Heather E. Condon, Leonie F. Maurer, Simon D. Kyle
Summary: There is limited attention to adverse events in psychological treatment trials, with only a small percentage of studies meeting criteria for adequate reporting. While there did not appear to be consistent differences between trial arms in studies reporting adverse events by group, the heterogeneity in monitoring and reporting makes it difficult to draw clear conclusions at this time.
SLEEP MEDICINE REVIEWS
(2021)
Article
Clinical Neurology
Gonzalo Salazar de Pablo, Ana Pascual-Sanchez, Urvashi Panchal, Bruce Clark, Georgina Krebs
Summary: Remotely-delivered CBT has been found to be effective in reducing symptoms of OCD and other related outcomes. There is no significant difference in efficacy between remotely-delivered CBT and face-to-face CBT, but individuals with severe OCD may benefit more from face-to-face treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Norin Ahmed, Jessica K. Bone, Gemma Lewis, Nick Freemantle, Catherine J. Harmer, Larisa Duffy, Glyn Lewis
Summary: The study did not find evidence that sertraline alters positive or negative recall in patients with depressive symptoms early in treatment, challenging assumptions of the cognitive neuropsychological model of antidepressant action.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Mitsuhiro Sado, Akihiro Koreki, Akira Ninomiya, Chika Kurata, Dai Mitsuda, Yasunori Sato, Toshiaki Kikuchi, Daisuke Fujisawa, Yutaka Ono, Masaru Mimura, Atsuo Nakagawa
Summary: This study compared the cost-effectiveness of augmented CBT adjunctive to treatment as usual (TAU) and TAU alone for pharmacotherapy-resistant depression at secondary mental health care settings. The results showed that augmented CBT was not cost-effective for all samples excluding mild depression, but appeared to be cost-effective for patients currently manifesting moderate/severe symptoms.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Nursing
Merete Berg Nesset, Johan Hakon Bjorngaard, Richard Whittington, Tom Palmstierna
Summary: This study compared the effects of cognitive-behavioral group therapy and mindfulness-based stress reduction group therapy on mental health and emotion regulation among perpetrators of intimate partner violence. The results showed a reduction in symptoms in both groups at the 12-month follow-up.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Review
Clinical Neurology
Ffion Curtis, Despina Laparidou, Chris Bridle, Graham R. Law, Simon Durrant, Alina Rodriguez, Robert H. Pierzycki, Aloysius N. Siriwardena
Summary: This study demonstrates that cognitive behavioral therapy (CBT) can significantly improve sleep quality and reduce the severity of insomnia in adults with tinnitus.
SLEEP MEDICINE REVIEWS
(2021)
Article
Medicine, General & Internal
Chloe Wilson, Joanne Sarah Carpenter, Alissa Nichles, Natalia Zmicerevska, Yun Ju Christine Song, Catherine McHugh, Blake Hamilton, Samuel Hockey, Jacob Crouse, Dagmar Koethe, Elizabeth M. Scott, Ian B. Hickie
Summary: This study aims to investigate the efficacy of metformin pharmacotherapy as an adjunct to a healthy lifestyle behavioral intervention in improving cardiometabolic outcomes, and depressive, anxiety, and psychotic symptoms in youth with clinically diagnosed major mood syndromes. At least 266 young people aged 16-25 presenting for mental healthcare will be invited to participate, and they will undergo a 12-week sleep-wake, activity, and metabolically focused behavioral intervention program. The results of this study will be disseminated through various outlets to reach the scientific and broader community.
Article
Psychology, Clinical
J. E. J. Buckman, Z. D. Cohen, C. O'Driscoll, E. Fried, R. Saunders, G. Ambler, R. J. DeRubeis, S. Gilbody, S. D. Hollon, T. Kendrick, E. Watkins, T. C. Eley, A. J. Peel, C. Rayner, D. Kessler, N. Wiles, G. Lewis, S. Pilling
Summary: This study developed models based on pre-treatment data to predict post-treatment outcomes for depressed adults. The models showed some effectiveness in predicting the severity of depressive symptoms post-treatment, but a significant amount of variance in prognosis remained unexplained. To improve predictive accuracy and clinical utility, it may be necessary to consider a broader range of variables.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Anne Maj van der Velden, Jacqueline Scholl, Else-Marie Elmholdt, Lone O. Fjorback, Catherine J. Harmer, Sara W. Lazar, Mia S. O'Toole, Jonathan Smallwood, Andreas Roepstorff, Willem Kuyken
Summary: Depression is a rising global disability, and one of its most debilitating aspects is depressive rumination. Mindfulness meditation has been found to be beneficial for individuals experiencing negative rumination. A study using functional magnetic resonance imaging showed that mindfulness-based cognitive therapy led to decreased connectivity in the salience network during rumination, and this change in connectivity was associated with improvements in attention to body sensations.
BIOLOGICAL PSYCHIATRY
(2023)
Review
Sport Sciences
Kearnan Myall, Jesus Montero-Marin, Paul Gorczynski, Nabeela Kajee, Rebecca Syed Sheriff, Robert Bernard, Eli Harriss, Willem Kuyken
Summary: Mindfulness-based programmes (MBPs) have a significant positive impact on the mental health of elite athletes, reducing symptoms of anxiety and stress while improving psychological well-being. However, more high-quality studies are needed to further validate these findings.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Genetics & Heredity
Maria Valkovskaya, Arsalan Hassan, Eirini Zartaloudi, Fahad Hussain, Muhammad Umar, Bakht Khizar, Inzemam Khattak, Shamshad Ahmed Gill, Shams-Ud-Din Ahmad Khan, Imtiaz Ahmad Dogar, Ali Burhan Mustafa, Moin Ahmed Ansari, Syed Hyder, Muhammad Ali, Nilofar Ilyas, Parveen Channar, Nazish Mughal, Sumera Channa, Khalid Mufti, Ali Ahsan Mufti, Mian Iftikhar Hussain, Sadia Shafiq, Muhammad Tariq, Muhammad Kamran Khan, Shahzad Tahir Chaudhry, Abdul Rashid Choudhary, Mian Nizam Ali, Gohar Ali, Ashfaq Hussain, Muhammad Rehman, Noman Ahmad, Saeed Farooq, Farooq Naeem, Tanveer Nasr, Glyn Lewis, James A. Knowles, Muhammad Ayub, Karoline Kuchenbaecker
Summary: Globally, the majority of the burden of major depressive disorder (MDD) is found in low- and middle-income countries. However, research on genetic and environmental risk factors has been limited to participants with European ancestry from high-income countries. The DIVERGE study aims to bridge this gap and investigate MDD risk factors in Pakistan.
PSYCHIATRIC GENETICS
(2023)
Article
Psychology, Clinical
Julia Rodriguez-Sanchez, Gemma Lewis, Francesca Solmi, Jessica K. Bone, Michael Moore, Nicola Wiles, Catherine J. Harmer, Larisa Duffy, Glyn Lewis
Summary: This study investigated the effect of discontinuing maintenance antidepressant treatment on self-referential recall and its association with the risk of relapse. The results showed that discontinuation did not affect self-referential recall at 12 and 52 weeks, and there was no association between recall and later relapse at baseline or 12 weeks.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Jonathan P. Rogers, Mark A. Oldham, Gregory Fricchione, Georg Northoff, Jo Ellen Wilson, Stephan C. Mann, Andrew Francis, Angelika Wieck, Lee Elizabeth Wachtel, Glyn Lewis, Sandeep Grover, Dusan Hirjak, Niraj Ahuja, Michael S. Zandi, Allan H. Young, Kevin Fone, Simon Andrews, David Kessler, Tabish Saifee, Siobhan Gee, David S. Baldwin, Anthony S. David
Summary: The British Association for Psychopharmacology has developed an evidence-based consensus guideline on the management of catatonia. The guideline covers the diagnosis, clinical features, and treatment options for catatonia. It emphasizes the need for more randomized controlled trials and prospective cohort studies in this area.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Gemma Lewis, Glyn Lewis
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Larisa Duffy, Louise Marston, Gemma Lewis, Glyn Lewis
Summary: We developed a retrospective Clinical Interview Schedule Revised (rCIS-R) to assess depression relapse in the previous 12 weeks, and found that it has excellent test-retest reliability and construct validity. The rCIS-R can be used in randomized controlled trials due to its simplicity and self-report format.
Article
Medicine, Research & Experimental
Debbie Tallon, Laura Thomas, Sally Brabyn, Brian Chi Fung Ching, Jane Sungmin Hahn, Berry Jude, Mekeda Logan, Alex Burrage, Fiona Fox, Simon Gilbody, Paul Lanham, Glyn Lewis, Jinshuo Li, Stephanie J. MacNeill, Irwin Nazareth, Steve Parrott, Tim J. Peters, Roz Shafran, Katrina Turner, Chris Williams, David Kessler, Nicola Wiles
Summary: The INTERACT trial will evaluate the clinical and cost-effectiveness, as well as the acceptability to therapists and clients, of the integration of online CBT materials and high-intensity therapist-led CBT delivered remotely. If successful, this model could increase access to and equity of CBT provision.
Article
Psychiatry
Philipp Frank, G. David Batty, Jaana Pentti, Markus Jokela, Lydia Poole, Jenni Ervasti, Jussi Vahtera, Glyn Lewis, Andrew Steptoe, Mika Kivimaeki
Summary: Depression is associated with an increased risk of physical illness and the most common causes of hospitalization among people with depression are endocrine, musculoskeletal, and vascular diseases, rather than psychiatric disorders.
Editorial Material
Psychology, Clinical
Willem Kuyken, Sarah-Jayne Blakemore, Sarah Byford, Tim Dalgleish, Tamsin Ford, Verena Hinze, Karen Mansfield, Jesus Montero-Marin, Obioha C. Ukoumunne, Russell M. Viner
JOURNAL OF MENTAL HEALTH
(2023)
Article
Medicine, General & Internal
Anna Pease, Nicholas Turner, Jenny Ingram, Peter Fleming, Karen Patrick, Tom Williams, Vicky Sleap, Kieren Pitts, Karen Luyt, Becky Ali, Peter Blair
Summary: This study aims to investigate background characteristics and risk factors associated with sudden infant death syndrome (SIDS) and compare the prevalence with previous studies. The vulnerability of SIDS infants has become more marked, with younger age, higher prevalence of low birth weight and preterm births. Socioeconomically deprived families, male infants, and high levels of maternal smoking during pregnancy are still evident. Despite risk reduction advice over three decades, there is no significant change in the proportion of infants found in different sleeping positions. Co-sleeping with adults remains hazardous, especially when accompanied by alcohol consumption, smoking, sleeping on a sofa, or when the infant is premature or low birth weight and less than 3 months old.
Article
Medicine, General & Internal
Jesus Montero-Marin, Verena Hinze, Karen Mansfield, Yasmijn Slaghekke, Sarah-Jayne Blakemore, Sarah Byford, Tim Dalgleish, Mark T. Greenberg, Russell M. Viner, Obioha C. Ukoumunne, Tamsin Ford, Willem Kuyken, MYRIAD Team
Summary: This study examined the impact of the COVID-19 pandemic on the mental health of secondary school students and its association with individual, family, friendship, and school characteristics. The results showed that mental health difficulties increased among students exposed to the pandemic, including risk of depression, social, emotional, and behavioral difficulties, and mental well-being. Positive school climate, high home connectedness, and having a friend during lockdown were protective factors during the pandemic. Female gender and initial low risk for mental health difficulties were associated with greater mental health deteriorations. Partial school attendance during lockdown was associated with better adjustment when returning to school.
Article
Psychology, Clinical
Javier Garcia-Campayo, Alberto Barcelo-Soler, David Martinez-Rubio, Jaime Navarrete, Adrian Perez-Aranda, Albert Feliu-Soler, Juan V. Luciano, Ruth Baer, Willem Kuyken, Jesus Montero-Marin
Summary: This study explores the relationship between self-compassion and compassion for others using two different operationalizations. The results show that the relationship between self-compassion and compassion for others varies depending on the operationalization used, and both constructs are positively associated with wellbeing. Only self-compassion is associated with decreased psychological distress.
Article
Psychology, Clinical
Shannon Maloney, Christina Surawy, Maryanne Martin, Jesus Montero-Marin, Willem Kuyken
Summary: The primary aim of this study was to explore the effects and potential mechanisms of four Mindfulness-Based Cognitive Therapy (MBCT) practices at both state and trait levels. One hundred sixty adults were randomly assigned to one of four mindfulness practices and the results showed state-level effects in various mechanisms and outcomes, except for state decentering. However, after controlling for pre-scores and additional covariates, no significant between-group effects were found. Trait-level effects were demonstrated in psychological quality of life and most mechanisms, but no between-group effects were found. Changes in mindfulness, self-compassion, decentering, and interoceptive awareness were associated with improvements in psychological quality of life.