Article
Nutrition & Dietetics
Chu-Lin Chou, Ching-Hao Li, Te-Chao Fang
Summary: High fructose intake is associated with obesity and metabolic syndrome, but the blockers of renin-angiotensin system and calcium channel can reduce triacylglycerol storage in fructose-induced adiposity by inhibiting PU.1 activation.
Review
Chemistry, Analytical
K. S. Kokilambigai, J. Kavitha, R. Seetharaman, K. S. Lakshmi, A. Sai Susmitha
Summary: Hypertension is a condition where blood pressure is elevated, with the risk of complications proportional to the level of increase. Calcium channel blockers, particularly the dihydropyridine subclass, are commonly used in treating hypertension, with amlodipine being the most popular choice. Long-acting DHPs are preferred to avoid fluctuations in drug concentration and associated side effects.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Adhimoorthy Prasannan, Chung-Yi Lee, Ravichandran Jayachitra, Retno Damastuti, Hao Yu, Subash Vetri Selvi, Po-Da Hong
Summary: This study presents a facile, green, and versatile approach to preparing self-organized redox polymers on 2D-MoS2 nanosheets, which were used as modified electrode materials for electrochemical detection of amlodipine. The self-assembled P(CA-LA)-MoS2 nanocomposite exhibited excellent electrochemical oxidation of AMD with good selectivity and detection limits.
MICROCHEMICAL JOURNAL
(2024)
Article
Toxicology
Ian Zhirui Hong, Mingwei Ng, Duu Wen Sewa, Yi Ju Yao, Mathew Chakaramakkil Jose, Kenneth Boon Kiat Tan, R. Ponampalam
Summary: Overdose of calcium-channel blockers can lead to vasodilatation and cardiogenic shock, which may progress to multi-organ failure and death. ECMO therapy, as a potential life-saving salvage therapy, should be considered and initiated early before irreversible multi-organ failure occurs to ensure good clinical outcomes.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Toxicology
Ponmathi Panneerpandian, Divya Bhaskar Rao, Kumaresan Ganesan
Summary: Elevated expression of YY1 confers anti-apoptotic phenotype, making it an attractive target for cancer therapeutics. Calcium channel blockers lercanidipine and amlodipine have been identified to inhibit YY1 more efficiently in gastric cancer cells, and enhance the inhibitory effect of doxorubicin on gastric cancer cell growth by inhibiting pathways activated by doxorubicin. This study demonstrates the potential of these calcium channel blockers in sensitizing gastric cancer cells to doxorubicin and improving treatment efficiency.
TOXICOLOGY IN VITRO
(2021)
Article
Medicine, General & Internal
Thomas Russo, Sarkis Kouyoumjian, Hithem Fargaly
Summary: This article presents a case of a 38-year-old man who presented to the emergency department with severe upper lip swelling. The patient had a history of hypertension treated with amlodipine and denied any known drug allergies or other relevant factors. Physical examination showed hypertension and isolated upper lip edema. Laboratory results were unremarkable except for slight normocytic anemia. The patient was diagnosed with angioedema, suspected to be caused by amlodipine, and was successfully treated with IV glucocorticoids and diphenhydramine.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Chemistry, Medicinal
Mingming Zhao, Ziyan Zhang, Zhiyu Pan, Sijia Ma, Meiying Chang, Jiao Fan, Shunxuan Xue, Yuejun Wang, Hua Qu, Yu Zhang
Summary: This meta-analysis of 12 randomized controlled trials demonstrates that N-/T-type calcium channel blockers are more effective than L-type calcium channel blockers in reducing urine albumin/protein excretion in patients with chronic kidney disease treated with renin-angiotensin system inhibitors, without affecting serum creatinine, glomerular filtration rate, and adverse effects.
Article
Medicine, General & Internal
Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng, Dipender Gill
Summary: This study investigates the effects of beta-blocker and calcium channel blocker antihypertensive drugs on maternal and foetal outcomes. The results suggest that beta-blocker use may lower birthweight, while calcium channel blocker use may reduce the risk of pre-eclampsia and eclampsia.
Review
Endocrinology & Metabolism
Michael M. Gezalian, Luigi Mangiacotti, Padmesh Rajput, Nicklaus Sparrow, Konrad Schlick, Shouri Lahiri
Summary: Adrenoceptor and calcium channel modulating medications have cerebrovascular-specific effects related to the unique characteristics of cerebrovascular anatomy, which differ from their systemic effects. Future research should consider lesion location when selecting vasoactive medications, aiming to improve neurological outcomes in acute neurological and systemic disorders.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Peripheral Vascular Disease
Junxiong Lin, Qinghui Guo, Zhuoqiang Lu, Dajun Chai, Feng Peng, Jinxiu Lin
Summary: This retrospective study compared cardiovascular outcomes between initial beta-blocker + calcium channel blocker dual therapy (B + C) and other initial dual therapies in Chinese newly diagnosed hypertensive patients. After propensity score matching, patients receiving B + C had a significantly lower risk of major adverse cardiovascular events (MACE), non-fatal stroke, and non-fatal chronic heart failure (CHF) compared to patients receiving other initial dual therapies. The study suggests that B + C initial dual therapy may be more beneficial for Chinese newly diagnosed hypertensive patients in terms of cardiovascular outcomes.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
L. Koliastasis, I Lampadakis, A. Milkas, P. Strempelas, V Sourides, K. Kakava, P. Tsioufis, S. Papaioannou
Summary: Intoxication from calcium channel blockers, particularly amlodipine, can result in high mortality rates. High-dose intravenous insulin infusion to maintain euglycemic hyperinsulinemia appears to be an effective treatment for this toxicity by improving hemodynamics and ultimately benefiting the patient's prognosis.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Psychiatry
Miao Li, Ning Yuan, John Nurnberger, Ney Alliey-Rodriguez, Jiaqi Zhou, Fangyuan Duan, Jiacheng Dai, Yu Chen, Jiaqi Lu, Li Xie, Fang Liu, Xuli Yang, Philippe Tapon, Vijay Gorrepati, Xuejun Liu, Chao Chen, Chunyu Liu, Elliot S. Gershon
Summary: Common genetic variants in calcium channel genes are important markers of genetic susceptibility for bipolar disorder (BD). Previous clinical trials have shown that Calcium Channel Blocker (CCB) medication can improve mood stability in some BD patients. In this pilot study, 50 BD patients (39 from China and 11 from the US) hospitalized for manic episodes were given add-on CCB treatment. The study found that certain intronic variants of the Calcium Voltage-Gated Channel Subunit Alpha1 B (CACNA1B) were associated with treatment outcomes for manic patients, suggesting that these variants could be predictors for response to add-on CCB treatment for bipolar mania patients.
PSYCHIATRY RESEARCH
(2023)
Article
Physiology
Yasufumi Seki, Satoshi Morimoto, Shihori Kimura, Noriyoshi Takano, Kaoru Yamashita, Kanako Bokuda, Nobukazu Sasaki, Daisuke Watanabe, Atsuhiro Ichihara
Summary: Aliskiren monotherapy did not show any superiority to amlodipine monotherapy on VFA, estimated glomerular filtration rates, or urinary albumin excretion in obese or type 2 diabetic hypertensive patients.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Dermatology
Jangyoun Choi, Yu Na Han, Eun Young Rha, Hwi Ju Kang, Ki Joo Kim, Il Kyu Park, Hyun-Jung Kim, Jong Won Rhie
Summary: It has been demonstrated that adding verapamil to topical silicone gel can enhance the treatment outcomes of hypertrophic scars. This approach significantly alleviates the features of hypertrophic scars, reducing SEI, fibroblast count, and promoting capillary formation. Further research is needed to determine the most effective concentration of verapamil-added silicone gel and explore the underlying mechanisms of action.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Medicine, General & Internal
Chan Joo Lee, Jung-Hoon Sung, Tae-Soo Kang, Sungha Park, Sang-Hak Lee, Jong-Youn Kim, Byeong-Kuek Kim
Summary: This study compared the effects of telmisartan and amlodipine on glucose metabolism in hypertensive atherosclerotic cardiovascular disease (ASCVD) patients with impaired fasting glucose (IFG) requiring high-intensity rosuvastatin therapy. The results showed that telmisartan did not decrease the insulin resistance, but preserved insulin secretion, leading to a regression from IFG to normal glucose levels and preventing the onset of new-onset diabetes mellitus.
Article
Medicine, General & Internal
Pawel Krzemien, Slawomir Kasperczyk, Maciej Banach, Aleksandra Kasperczyk, Michal Dobrakowski, Tomasz Tomasik, Adam Windak, Miroslaw Mastej, Alberico Catapano, Kausik K. Ray, Dimitri P. Mikhailidis, Peter P. Toth, George Howard, Gregory Y. H. Lip, Maciej Tomaszewski, Fadi J. Charchar, Naveed Sattar, Bryan Williams, Thomas M. MacDonald, Peter E. Penson, Jacek J. Jozwiak
Summary: The study found that oxidative stress may be associated with an increased probability of ANA formation in a sex-specific manner. In women, the presence of ANA was associated with lower physical activity, less frequent smoking and drinking, significant changes in the activity of SOD isoenzymes, and higher uric acid (UA) concentration. In ANA positive males, lower concentrations of PSH and increased concentrations of MDA were observed.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Amy Rogers, Giorgia De Paoli, Selvarani Subbarayan, Rachel Copland, Kate Harwood, Joanne Coyle, Lyn Mitchell, Thomas M. MacDonald, Isla S. Mackenzie
Summary: This study aims to evaluate the design and conduct of decentralised clinical trials using quantitative and qualitative approaches. The quantitative analysis included 45 randomised clinical trials, with the primary outcome being the number of randomised participants. The qualitative analysis included 117 documents discussing or evaluating decentralised clinical trials. The results showed heterogeneity in the design and reporting of trials, and insufficient evidence to support the effectiveness of DCT methods in trial recruitment. The qualitative analysis identified four themes: value, burden, safety and equity. Further research on participant and stakeholder experiences of DCTs is recommended to maximize potential benefits.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nicolas H. Thurin, Romin Pajouheshnia, Giuseppe Roberto, Caitlin Dodd, Giulia Hyeraci, Claudia Bartolini, Olga Paoletti, Hedvig Nordeng, Helle Wallach-Kildemoes, Vera Ehrenstein, Elena Dudukina, Thomas MacDonald, Giorgia De Paoli, Maria Loane, Christine Damase-Michel, Anna-Belle Beau, Cecile Droz-Perroteau, Regis Lassalle, Jorieke Bergman, Karin Swart, Tania Schink, Clara Cavero-Carbonell, Laia Barrachina-Bonet, Ainhoa Gomez-Lumbreras, Maria Giner-Soriano, Maria Aragon, Amanda J. Neville, Aurora Puccini, Anna Pierini, Valentina Ientile, Gianluca Trifiro, Anke Rissmann, Maarit K. Leinonen, Visa Martikainen, Sue Jordan, Daniel Thayer, Ieuan Scanlon, Mary E. Georgiou, Marianne Cunnington, Morris Swertz, Miriam Sturkenboom, Rosa Gini
Summary: The ConcePTION project aims to reduce uncertainty about the safety of medication use in pregnancy and breastfeeding by building an ecosystem and leveraging a common data model. The model enables European data sources to contribute to major projects and facilitate effective deployment of distributed analytics.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Peripheral Vascular Disease
Keeran Vickneson, Amy Rogers, Thineskrishna Anbarasan, David A. Rorie, Thomas M. MacDonald, Isla S. Mackenzie
Summary: This study found that active participation and long-term commitment to home blood pressure monitoring are associated with factors like age, positive family history of hypertension, number of antihypertensive medications, and deprivation levels. Higher BMI and smoking were associated with lower participation rates.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Rheumatology
Pawel Krzemien, Slawomir Kasperczyk, Maciej Banach, Aleksandra Kasperczyk, Michal Dobrakowski, Tomasz Tomasik, Adam Windak, Miroslaw Mastej, Alberico Catapano, Kausik K. Ray, Dimitri P. Mikhailidis, Peter P. Toth, George Howard, Gregory Y. H. Lip, Maciej Tomaszewski, Fadi J. Charchar, Naveed Sattar, Bryan Williams, Thomas M. MacDonald, Peter E. Penson, Jacek J. Jozwiak
Summary: The prevalence of antinuclear autoantibody (ANA) in the Polish adult population depends on age, sex, and the cutoff threshold used for detection. Women and elderly individuals are more likely to have ANA, and setting the 1:160 cutoff threshold could reduce the number of positive results released in Polish laboratories.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Pawel Krzemien, Slawomir Kasperczyk, Maciej Banach, Aleksandra Kasperczyk, Michal Dobrakowski, Tomasz Tomasik, Adam Windak, Miroslaw Mastej, Alberico Catapano, Kausik K. Ray, Dimitri P. Mikhailidis, Peter P. Toth, George Howard, Gregory Yh Lip, Maciej Tomaszewski, Fadi J. Charchar, Naveed Sattar, Bryan Williams, Thomas M. MacDonald, Peter E. Penson, Jacek J. Jozwiak
Summary: This study found a decrease in oxidative stress levels in samples positive for anti-DFS70 antibodies, especially in samples with a high antibody titer. Anti-DFS70 antibodies can be considered as an indirect marker of reduced oxidative stress or a marker indicating recent intensification of antioxidant processes.
BIOMARKER INSIGHTS
(2022)
Article
Medicine, General & Internal
Amy Rogers, Evelien Rooke, Steve Morant, Greg Guthrie, Alex Doney, Andrew Duncan, Isla Mackenzie, Rebecca Barr, Filippo Pigazzani, Krists Zutis, Thomas M. MacDonald
Summary: This study provides reassuring data on the low incidence of adverse events after COVID-19 vaccination. Differences in reactogenicity-type adverse events profiles were observed between ChAdOx1 and BNT162b2 vaccines.
Article
Pharmacology & Pharmacy
Victoria Palin, Tjeerd P. Van Staa, Stephanie Steels, Andrea B. Troxel, Rolf H. H. Groenwold, Tom M. MacDonald, David Torgerson, Douglas Faries, Pierre Mancini, Mario Ouwens, Lucy J. Frith, Kate Tsirtsonis, Graham MacLennan, Clementine Nordon
Summary: This study aimed to identify and address statistical challenges in pragmatic clinical trials (PCTs) through a modified Delphi method. A panel of 11 experts in clinical trials and statistics reached a consensus on a list of important issues, including attrition risk, heterogeneity of usual care, absence of blinding, subjective endpoint, and trial estimand alignment. The study provides recommendations for trial protocol design and data analysis approaches to anticipate and minimize these challenges.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Isla S. Mackenzie, Thomas M. MacDonald
EUROPEAN HEART JOURNAL
(2022)
Article
Endocrinology & Metabolism
Huan Wang, Ruth L. M. Cordiner, Yu Huang, Louise Donnelly, Simona Hapca, Andrew Collier, John J. McKnight, Brian R. Kennon, Fraser R. Gibb, Paul McKeigue, Sarah Wild, Helen Colhoun, John Chalmers, John Petrie, Naveed Sattar, Thomas MacDonald, Rory McCrimmon, Daniel Morales, Ewan Pearson
Summary: This study developed a robust methodology for causal inference and assessed the real-world cardiovascular safety of sulfonylureas compared to dipeptidyl peptidase 4 inhibitors and thiazolidinediones. The findings suggest that second-line sulfonylureas are unlikely to increase cardiovascular risk or all-cause mortality.
Letter
Peripheral Vascular Disease
George Stergiou, Thomas MacDonald, Robin Young, Konstantinos G. Kyriakoulis, Anastasios Kollias, Bryan Williams, Maciej Tomaszewski
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Kamila Osadnik, Tadeusz Osadnik, Marek Gierlotka, Adam Windak, Tomasz Tomasik, Miroslaw Mastej, Agnieszka Kuras, Kacper Jozwiak, Peter E. Penson, Gregory Y. H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Alberico L. Catapano, Kausik K. Ray, George Howard, Maciej Tomaszewski, Fadi J. Charchar, Naveed Sattar, Bryan Williams, Thomas M. MacDonald, Maciej Banach, Jacek Jozwiak
Summary: This study examined the association between metabolic syndrome (MetS) and long-term all-cause mortality. The findings showed that MetS was associated with increased mortality risk in both obese and non-obese individuals. The concept of metabolically healthy obesity should be reconsidered, and maintaining normal body weight is important for overall health.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Biographical-Item
Peripheral Vascular Disease
Adrian J. B. Brady, Alan Jardine, Thomas M. Macdonald, Anthony M. Heagerty, Guido Grassi, Giuseppe Mancia
JOURNAL OF HYPERTENSION
(2023)
Article
Health Care Sciences & Services
Anthony Chen, Chengsheng Ju, Isla S. Mackenzie, Thomas M. MacDonald, Allan D. Struthers, Li Wei, Kenneth K. C. Man
Summary: This study investigated the association between beta-blocker use and mortality or cardiovascular outcomes in patients with obstructive sleep apnoea (OSA). The findings showed that beta-blocker treatment in OSA patients was associated with an increased risk of cardiovascular diseases and a trend for an increased risk of mortality.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Peripheral Vascular Disease
Luca Faconti, Spoorthy Kulkarni, Christian Delles, Vikas Kapil, Philip Lewis, Mark Glover, Thomas M. Macdonald, Ian B. Wilkinson
Summary: There is a lack of uniformity among international guidelines and consensus documents on primary hyperaldosteronism, and the National UK guidelines on hypertension do not provide extensive recommendations on this condition. To provide support to clinicians, a document was prepared by the BIHS Guidelines and Information Service Standing Committee, incorporating feedback from members and results of a survey conducted in different regions of the UK. The final document was approved by the panel after considering existing literature and expert opinions, despite the limited data available from randomized controlled trials.
JOURNAL OF HUMAN HYPERTENSION
(2023)