Article
Gastroenterology & Hepatology
European Assoc Study Liver, Catherine Williamson, Melanie Nana, Liona Poon, Limas Kupcinskas, Rebecca Painter, Gloria Taliani, Michael Heneghan, Hanns-Ulrich Marschall, Ulrich Beuers
Summary: Liver diseases in pregnancy, whether gestational or pre-existing, pose significant risks to both mothers and fetuses. In order to provide recommendations for the management of liver disease in pregnancy, the European Association for the Study of Liver Disease has developed clinical practice guidelines, utilizing the best available evidence, for healthcare professionals involved in the care of pregnant women with liver diseases.
JOURNAL OF HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Elvyna Lim, Maria Mouyis, Lucy MacKillop
Summary: Liver disease during pregnancy can be related to pre-existing conditions or develop as a result of pregnancy. Pre-pregnancy counseling is important for women with pre-existing diseases to discuss potential complications and proper management. Pregnant women with liver dysfunction require appropriate investigations and should be managed by a multidisciplinary team.
Article
Gastroenterology & Hepatology
Norah A. Terrault, Catherine Williamson
Summary: Liver disorders unique to pregnancy are important due to their significant impact on maternal and fetal/neonatal morbidity and mortality. Prompt diagnosis and multidisciplinary care are crucial to minimize risks for pregnant women and their babies.
Article
Medicine, General & Internal
Carla Serra, Elton Dajti, Chiara De Molo, Elisa Montaguti, Alberto Porro, Anna Seidenari, Emiliana Angilletta, Vito Bernardi, Ginevra Salsi, Sofia Maria Bakken, Marco Montagnani, Giuseppe Mazzella, Francesco Azzaroli
Summary: This study investigated the association between Doppler ultrasound findings, liver stiffness measurement, and different causes of pregnancy-related liver dysfunction. The results showed that liver stiffness measurement was significantly associated with the diagnosis of gestational hypertensive disorder.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Elton Dajti, Angelo Bruni, Giovanni Barbara, Francesco Azzaroli
Summary: Liver disease during pregnancy is common and can have negative impacts on both the mother and the baby. Physiological changes during pregnancy can mimic or worsen liver disease. It is important for clinicians to accurately diagnose and differentiate between different types of liver disease in order to provide proper treatment and reduce risks. The causes and effects of elevated liver enzymes during pregnancy are still not well understood.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Amr Dokmak, Hirsh D. Trivedi, Alan Bonder, Jacqueline Wolf
Summary: Chronic liver disease poses challenges for women of reproductive age, impacting gestation and perinatal outcomes. Tailored management and a multidisciplinary approach are essential to optimize maternal and fetal wellbeing.
ANNALS OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Gres Karim, Dewan Giri, Tatyana Kushner, Nancy Reau
Summary: Liver disease in pregnancy encompasses a wide range of liver conditions that need to be identified early to provide appropriate care. Evaluation should include careful testing to rule out chronic liver disease, coincidental liver injury, and pregnancy-specific liver injury. Early recognition and management of liver disease in pregnancy are crucial for optimizing outcomes for both mother and baby, and for facilitating referrals to liver specialists and postnatal care if necessary.
CLINICS IN LIVER DISEASE
(2023)
Article
Infectious Diseases
Rasha Eletreby, Rasha Abdelaziz, Hend Ibrahim Shousha, Zeinab Hammam, Ayman Hany, Dina Sabry, Basma Elawady, Naglaa Zayed, Ayman Yosry, Shereen Abdel Alem
Summary: This study aimed to detect the prevalence of CMV infection among pregnant females with and without chronic liver disease and evaluate its effects on LSM and pregnancy outcomes. The results showed that CMV infection carries a significant risk to pregnant females with chronic liver disease. Routine CMV screening for women planning to be pregnant, especially those with chronic liver disease could help to avoid bad maternal and fetal outcomes.
BMC INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Yiling Qian, Yu Zhang, Xiaofang Fan, Hongmei Yan, Xuesong Li, Yujuan Fan, Yuping Song, Shuai Ma, Zheng Hu, Xin Gao, Jialin Yang
Summary: This study found that pregnant women with normal weight and NAFLD have a higher risk for adverse pregnancy outcomes. Even women with normal weight at the start of pregnancy still had a higher odds of adverse pregnancy outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Agriculture, Dairy & Animal Science
Chunjiang Cai, Ying Ren, Jianhua Cao, Shengya Fang, Leying Zhang, Ling Yang
Summary: This study found that early pregnancy induces changes in the I kappa B family, which are closely related to maternal peripheral tolerance and pregnancy establishment in sheep. This suggests that the regulation of the I kappa B family may be favorable for maternal hepatic functions during pregnancy.
Review
Pathology
Jacqueline E. Birkness-Gartman, Kiyoko Oshima
Summary: Liver dysfunction in pregnancy can be caused by a variety of conditions, with intrahepatic cholestasis of pregnancy (ICP), acute fatty liver of pregnancy (AFLP), and hypertensive disorders of pregnancy being among the most common. These conditions can pose risks to both maternal and fetal health, with some cases requiring expedient delivery.
PATHOLOGY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Seung Mi Lee, Young Mi Jung, Eun Saem Choi, Soo Heon Kwak, Ja Nam Koo, Ig Hwan Oh, Byoung Jae Kim, Sun Min Kim, Sang Youn Kim, Gyoung Min Kim, Sae Kyung Joo, Bo Kyung Koo, Sue Shin, Errol R. Norwitz, Chan-Wook Park, Jong Kwan Jun, Won Kim, Joong Shin Park
Summary: This study investigated the impact of MAFLD on pregnancy complications. The results showed that MAFLD was associated with an increased risk of subsequent adverse pregnancy outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Sherouk Fouda, Madhu Mathew Vennikandam, Joseph M. Pappachan, Cornelius J. Fernandez
Summary: The intricate relationship between metabolic-associated fatty liver disease (MAFLD) and maternal complications poses a significant health threat to pregnant women and their babies. This review explores the effects of MAFLD during pregnancy on maternal complications and outcomes, and the impact of pregnancy on the development and progression of MAFLD. It highlights the need for better representation of pregnant women in clinical trials to improve the understanding and management of MAFLD.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Sherouk Fouda, Madhu Mathew Vennikandam, Joseph M. Pappachan, Cornelius J. Fernandez
Summary: The intricate relationship between MAFLD and maternal complications poses a significant health threat to pregnant women, highlighting the need for more clinical research and management. The presence of MAFLD during pregnancy can exacerbate metabolic complications for both mother and baby, emphasizing the importance of understanding and addressing this issue.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mussarat N. Rahim, Eleni Theocharidou, Katherine Gar Yen Lau, Refah Ahmed, Flevin Marattukalam, Lisa Long, Mary D. Cannon, Michael A. Heneghan
Summary: IVF can be successful in women with liver-related sub-fertility, but potential risks such as ovarian hyperstimulation syndrome, obstetric cholestasis, and prematurity should be taken into consideration.
JOURNAL OF HEPATOLOGY
(2021)
Article
Obstetrics & Gynecology
Andra H. James
Summary: Anemia, characterized by low red blood cell count, hematocrit, or hemoglobin concentration, is common during pregnancy and may impact maternal and fetal health. Screening with a complete blood count can help diagnose anemia, with oral iron as the first-line treatment option.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Rheumatology
Megan E. B. Clowse, Aardra Rajendran, Amanda Eudy, Stephanie Giattino, Aparna Swaminathan, Andra H. James
Summary: This study examined the maternal and pregnancy outcomes in a large cohort of patients with ILD, and found that although adverse pregnancy outcomes were common, overall maternal morbidity and mortality were low, suggesting that women with ILD may be able to safely attempt pregnancy.
ARTHRITIS CARE & RESEARCH
(2023)
Letter
Hematology
Mary Yurashevich, Daniel Weikel, Andra H. James, Terrence K. Allen
THROMBOSIS RESEARCH
(2022)
Article
Obstetrics & Gynecology
Anna E. E. Denoble, Julia M. M. Moyett, Sarah A. A. Goldstein, Cary C. C. Ward, Tracy Truong, Alaattin Erkanli, Andra H. H. James, Chad A. A. Grotegut
Summary: Obese pregnant individuals had lower NT-proBNP levels than nonobese individuals during pregnancy, but similar levels postpartum. Furthermore, obese patients had a prolonged elevation in NT-proBNP postpartum, indicating a possibly slower recovery of cardiac function in this population.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Luke A. Gatta, Jeremy M. Weber, Jennifer B. Gilner, Paula S. Lee, Chad A. Grotegut, Katherine A. Herbert, Mustafa Bashir, Carl F. Pieper, James Ronald, Waleska Pabon-Ramos, Ashraf S. Habib, Kyle C. Strickland, Angeles Alvarez Secord, Andra H. James
Summary: This study compares the use of a multidisciplinary algorithm, including P-UAE and selective use of delayed hysterectomy, in the treatment of patients with placenta accreta spectrum (PAS) to patients treated without the algorithm. The algorithm was found to be associated with a lower rate of blood transfusion in scheduled cases.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Andra H. James, Ronan Sugrue, Jerome J. Federspiel
Summary: Increasing rates of thromboembolic complications in pregnancy and postpartum require the use of anticoagulant and antiplatelet drugs. These drugs are commonly used in intensive care units to prevent or treat thromboembolism, as it is both a cause and complication of severe maternal morbidity. This review summarizes commonly used anticoagulants and antiplatelet agents and discusses the potential role of newly developed antithrombotic agents for pregnant and postpartum patients.
CLINICAL OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Luis D. Pacheco, George R. Saade, Andra H. James
Summary: The maternal and fetal implications of inherited bleeding disorders include von Willebrand disease (VWD), hemophilia, other congenital clotting factor deficiencies, inherited platelet disorders, defects of fibrinolysis, and connective tissue disorders. The most common diagnosed bleeding disorder among women is VWD, while other bleeding disorders, such as hemophilia carriership, are less common. Management for maternal includes obtaining clotting factor levels, planning for delivery at a center with hemostasis expertise, and using hemostatic agents. Fetal management includes prepregnancy counseling, preimplantation genetic testing, and consideration of cesarean delivery for potentially affected male neonates with hemophilia.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Victoria Fashakin, Jeremy M. Weber, Tracy Truong, Amanda Craig, Sarahn M. Wheeler, Andra H. James
Summary: The incidence of preterm birth is significantly higher in women with sickle cell disease, and it is more likely to be medically indicated.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Meeting Abstract
Obstetrics & Gynecology
Derek S. Sim, Terry W. Hermiston, Terrence K. Allen, Daekyeong Bae, Jennifer Gilner, Seung-Chul Kim, Sul Lee, Cornell R. Mallari, Andra H. James
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Julia Barsoum, Kirk Hansen, Andra H. James, Kjersti M. Aagaard, Alisa S. Wolberg, Homa K. Ahmadzia
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Jennifer J. Cate, Alexandra C. Sundermann, Ronan P. Sugrue, Alexa Campbell, Sarah K. Dotters-Katz, Jerome J. Federspiel
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Hematology
Jerome J. Federspiel, Lauren E. Wein, Ryan Duggal, Evan R. Myers, Kimberly A. Boggess, Andra H. James
Summary: The adoption of different guidelines has notable implications for clinical practice and the rate of VTE following cesarean delivery may vary accordingly.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Jennifer J. M. Cate, Alexandra C. Sundermann, Alexa I. K. Campbell, Ronan Sugrue, Sarah K. Dotters-Katz, Andra H. James, Evan R. Myers, Jerome J. Federspiel
Summary: Pregnant patients with cancer have a higher risk of venous thromboembolism (VTE) in the postpartum period, and cesarean delivery further increases this risk.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Andra H. James, Jerome J. Federspiel, Homa K. Ahmadzia
Summary: The outcomes of pregnancy, both for the mother and the fetus, vary greatly depending on the pregnant woman's community and condition. The leading cause of maternal death worldwide is hemorrhage, with most cases occurring in low- or middle-income countries. However, these countries often lack the necessary resources to control bleeding effectively.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Meeting Abstract
Obstetrics & Gynecology
Anna DeNoble, Julia Moyett, Sarah Goldstein, Cary Ward, Andra H. James, Chad Grotegut
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
