Article
Medical Informatics
Chantal M. den Bakker, Frederieke G. Schaafsma, Esther C. J. Consten, Steven E. Schraffordt Koops, Eva van der Meij, Peter M. van de Ven, Hendrik J. Bonjer, Judith A. F. Huirne, Johannes R. Anema
Summary: This study aimed to assess the impact of a personalised eHealth programme on patients' return to normal activities after major abdominal surgery. The results showed that patients who received the eHealth intervention had a 13-day earlier return to normal activities compared to those who received standard care.
LANCET DIGITAL HEALTH
(2023)
Article
Medicine, General & Internal
Brad H. Rovin, Y. K. Onno Teng, Ellen M. Ginzler, Cristina Arriens, Dawn J. Caster, Juanita Romero-Diaz, Keisha Gibson, Joshua Kaplan, Laura Lisk, Sandra Navarra, Samir V. Parikh, Simrat Randhawa, Neil Solomons, Robert B. Huizinga
Summary: This study evaluated the efficacy and safety of voclosporin for the treatment of lupus nephritis, showing a superior complete renal response rate with voclosporin in combination with MMF and low-dose steroids compared to MMF and low-dose steroids alone. The safety profile was comparable between the two groups. This finding represents an important advancement in the treatment of patients with active lupus nephritis.
Article
Rheumatology
Pascal Richette, Augustin Latourte, Jeremie Sellam, Daniel Wendling, Muriel Piperno, Philippe Goupille, Yves-Marie Pers, Florent Eymard, Sebastien Ottaviani, Paul Ornetti, Rene-Marc Flipo, Bruno Fautrel, Olivier Peyr, Jean Pierre Bertola, Eric Vicaut, Xavier Chevalier
Summary: The study found that tocilizumab was not more effective than placebo in relieving pain in patients with hand osteoarthritis. Apart from the primary endpoint, there were no significant differences in secondary outcomes between the tocilizumab group and the placebo group.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Thomas Gargadennec, Jean-Ferreol Oilleau, Bertrand Rozec, Nicolas Nesseler, Sigismond Lasocki, Emmanuel Futier, Julien Amour, Michel Durand, Adrien Bougle, Thomas Kerforne, Maelys Consigny, Dauphou Eddi, Olivier Huet
Summary: The study aims to demonstrate the effectiveness of sleep induction by overnight infusion of dexmedetomidine to prevent delirium after cardiac surgery, with the goal of validating the hypothesis that preserving circadian rhythm can lower the occurrence of delirium.
Article
Medicine, General & Internal
Andrew W. Horne, Stephen Tong, Catherine A. Moakes, Lee J. Middleton, W. Colin Duncan, Ben W. Mol, Lucy H. R. Whitaker, Davor Jurkovic, Arri Coomarasamy, Natalie Nunes, Tom Holland, Fiona Clarke, Ann M. Doust, Jane P. Daniels
Summary: This study evaluated whether oral gefitinib in combination with methotrexate is more effective than methotrexate alone in the treatment of tubal ectopic pregnancy. The results showed that oral gefitinib does not offer clinical benefit over methotrexate and increases minor adverse reactions.
Article
Rheumatology
Renaud Felten, Valerie Devauchelle-Pensec, Raphaele Seror, Pierre Duffau, David Saadoun, Eric Hachulla, Hatron Pierre Yves, Carine Salliot, Aleth Perdriger, Jacques Morel, Arsene Mekinian, Olivier Vittecoq, Jean-Marie Berthelot, Emanuelle Dernis, Veronique Le Guern, Philippe Dieude, Claire Larroche, Christophe Richez, Thierry Martin, Charles Zarnitsky, Gilles Blaison, Pierre Kieffer, Francois Maurier, Azeddine Dellal, Stephanie Rist, Emmanuel Andres, Anne Contis, Emmanuel Chatelus, Christelle Sordet, Jean Sibilia, Cecile Arnold, Mira Y. Tawk, Ouafaa Aberkane, Lise Holterbach, Patrice Cacoub, Alain Saraux, Xavier Mariette, Nicolas Meyer, Jacques-Eric Gottenberg
Summary: This study aimed to demonstrate the efficacy of targeting interleukin 6 receptor in patients with primary Sjogren's syndrome-related systemic complications. However, the results showed that over 24 weeks of treatment, tocilizumab did not improve systemic involvement and symptoms in patients with primary Sjogren's syndrome.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Critical Care Medicine
Lu Ke, Jing Zhou, Wenjian Mao, Tao Chen, Yin Zhu, Xinting Pan, Hong Mei, Vikesh Singh, James Buxbaum, Gordon Doig, Chengjian He, Weili Gu, Weihua Lu, Shumin Tu, Haibin Ni, Guoxiu Zhang, Xiangyang Zhao, Junli Sun, Weiwei Chen, Jingchun Song, Min Shao, Jianfeng Tu, Liang Xia, Wenhua He, Qingyun Zhu, Kang Li, Hongyi Yao, Jingyi Wu, Long Fu, Wendi Jiang, He Zhang, Jiajia Lin, Baiqiang Li, Zhihui Tong, John Windsor, Yuxiu Liu, Weiqin Li
Summary: This study aimed to evaluate whether early immune-enhancing Thymosin alpha 1 (T alpha 1) treatment reduces the incidence of infected pancreatic necrosis in patients with predicted severe acute necrotising pancreatitis, but the results showed that this treatment did not reduce the incidence of IPN during the index admission.
INTENSIVE CARE MEDICINE
(2022)
Article
Oncology
Dean A. Fennell, Sean Ewings, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Kayleigh Hill, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Aarti Gaba, Liz Darlison, Peter Wells-Jordan, Cathy Richards, Charlotte Poile, Jason F. Lester, Gareth Griffiths
Summary: The study evaluated the efficacy and safety of nivolumab in patients with pleural or peritoneal malignant mesothelioma who had progressed following platinum-based chemotherapy. Nivolumab showed improved progression-free survival and overall survival compared to placebo in these patients, with manageable treatment-related adverse events. The results suggest that nivolumab might be a beneficial treatment for patients with malignant mesothelioma who have progressed on first-line therapy.
Article
Clinical Neurology
Pedro M. Machado, Michael P. McDermott, Thomas Blaettler, Claus Sundgreen, Anthony A. Amato, Emma Ciafaloni, Miriam Freimer, Summer B. Gibson, Sarah M. Jones, Todd D. Levine, Thomas E. Lloyd, Tahseen Mozaffar, Aziz Shaibani, Matthew Wicklund, Anders Rosholm, Tim Dehli Carstensen, Karen Bonefeld, Anders Norkaer Jorgensen, Karina Phonekeo, Andrew J. Heim, Laura Herbelin, Richard J. Barohn, Michael G. Hanna, Mazen M. Dimachkie
Summary: Arimoclomol did not show efficacy in individuals with inclusion body myositis compared to placebo, but it had an acceptable safety profile. This study provides valuable data on disease progression for future clinical trial designs in inclusion body myositis.
Article
Gastroenterology & Hepatology
Evan S. Dellon, Kathryn A. Peterson, Benjamin L. Mitlyng, Alina Iuga, Christine E. Bookhout, Lindsay M. Cortright, Kacie B. Walker, Timothy S. Gee, Sarah J. McGee, Brenderia A. Cameron, Joseph A. Galanko, John T. Woosley, Swathi Eluri, Susan E. Moist, Ikuo Hirano
Summary: This study aimed to determine the efficacy of mepolizumab in improving dysphagia symptoms and reducing esophageal eosinophil counts in EoE. The results showed that mepolizumab significantly decreased symptoms and eosinophil counts within 3 months, but longer treatment did not yield additional improvement.
Article
Gastroenterology & Hepatology
Sylke Haal, Maimoena S. S. Guman, Thomas C. C. Boerlage, Yair I. Z. Acherman, L. Maurits de Brauw, Sjoerd Bruin, Steve M. M. de Castro, Jeanin E. van Hooft, Arnold W. J. M. van de Laar, Daan E. Moes, Manon Schouten, Ruben Schouten, Ellert J. van Soest, Ruben N. van Veen, Claire E. E. de Vries, Paul Fockens, Marcel G. W. Dijkgraaf, Victor E. A. Gerdes, Rogier P. Voermans
Summary: The study evaluated the efficacy of ursodeoxycholic acid versus placebo for preventing symptomatic gallstone disease after bariatric surgery, finding it effective in patients without gallstones before RYGB surgery but not significant in patients with gallstones. Further research is needed to assess the efficacy of ursodeoxycholic acid after sleeve gastrectomy.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Respiratory System
Dave Singh, Jutta Beier, Carol Astbury, Maria G. Belvisi, Carla A. Da Silva, Alexandra Jauhiainen, Eulalia Jimenez, Alejhandra Lei, Sofia Necander, Jaclyn A. Smith, Ulrika Wahlby Hamren, Wenjing Xin, Ioannis Psallidas
Summary: Navafenterol, a new bronchodilator for COPD treatment, was found to improve lung function and alleviate COPD symptoms similar to an established bronchodilator, with good safety profile.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Medicine, General & Internal
Nilufar Mohebbi, Alexander Ritter, Anna Wiegand, Nicole Graf, Suzan Dahdal, Daniel Sidler, Spyridon Arampatzis, Karine Hadaya, Thomas F. Mueller, Carsten A. Wagner, Rudolf P. Wuethrich
Summary: This study examined the effects of sodium bicarbonate treatment on graft function in kidney transplant recipients. The results showed that treatment with sodium bicarbonate for two years did not affect the decline in estimated glomerular filtration rate (GFR). Therefore, sodium bicarbonate treatment is not generally recommended for preserving GFR in kidney transplant recipients with chronic kidney disease and metabolic acidosis.
Article
Medicine, General & Internal
Emmanuel Futier, Samir Jaber, Matthias Garot, Marie Vignaud, Yves Panis, Karem Slim, Jean-Christophe Lucet, Gilles Lebuffe, Alexandre Ouattara, Younes El Amine, Philippe Couderc, Aurelien Dupre, Audrey De Jong, Sigismond Lasocki, Marc Leone, Julien Pottecher, Bruno Pereira, Catherine Paugam-Burtz
Summary: Oral antimicrobial prophylaxis as an adjunct to intravenous antibiotic prophylaxis can significantly reduce surgical site infections after elective colorectal surgery.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Arvind Dasari, Sara Lonardi, Rocio Garcia-Carbonero, Elena Elez, Takayuki Yoshino, Alberto Sobrero, James Yao, Pilar Garcia-Alfonso, Judit Kocsis, Antonio Cubillo Gracian, Andrea Sartore-Bianchi, Taroh Satoh, Violaine Randrian, Jiri Tomasek, Geoff Chong, Andrew Scott Paulson, Toshiki Masuishi, Jeremy Jones, Tibor Csoszi, Chiara Cremolini, Francois Ghiringhelli, Ardaman Shergill, Howard S. Hochster, John Krauss, Ali Bassam, Michel Ducreux, Anneli Elme, Laurence Faugeras, Stefan Kasper, Eric Van Cutsem, Dirk Arnold, Shivani Nanda, Zhao Yang, William R. Schelman, Marek Kania, Josep Tabernero, Cathy Eng
Summary: This study evaluated the efficacy and safety of fruquintinib, a highly selective and potent oral inhibitor of VEGFRs 1, 2, and 3, in patients with advanced, chemotherapy-refractory colorectal cancer. The results showed that fruquintinib significantly prolonged overall survival compared to placebo in patients with refractory metastatic colorectal cancer, with clinical significance. Therefore, fruquintinib could become a global treatment option for patients with refractory metastatic colorectal cancer.
Article
Rheumatology
Boulos Haraoui, Majed Khraishi, Denis Choquette, Larissa Lisnevskaia, Michelle Teo, Cassandra Kinch, Corina Galos, Patrice Roy, David Gruben, John C. Woolcott, Julie Vaillancourt, John S. Sampalis, Edward C. Keystone
Summary: The Canadian Tofacitinib for Rheumatoid Arthritis Observational (CANTORAL) study is the first Canadian prospective observational study assessing the effectiveness and safety of tofacitinib for moderate to severe rheumatoid arthritis. The results showed that tofacitinib was associated with early and sustained improvement in signs and symptoms of RA in real-world patients.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Rheumatology
Casper Webers, Augusta Ortolan, Alexandre Sepriano, Louise Falzon, Xenofon Baraliakos, Robert B. M. Landewe, Sofia Ramiro, Desiree van der Heijde, Elena Nikiphorou
Summary: This study aims to provide updated evidence on the efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) for the revision of management recommendations. The results showed significant efficacy of tumor necrosis factor inhibitors (TNFi) and interleukin-17 inhibitors (IL-17i), while IL-23 inhibitors failed to demonstrate relevant effects. Observational studies are required to confirm the long-term safety of IL-17i.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Augusta Ortolan, Casper Webers, Alexandre Sepriano, Louise Falzon, Xenofon Baraliakos, Robert B. M. Landewe, Sofia Ramiro, Desiree van der Heijde, Elena Nikiphorou
Summary: This study updated the evidence of non-biological treatments for axSpA, providing a basis for the 2022 ASAS-EULAR recommendations. The results showed that education, exercise, and NSAIDs were efficacious in axSpA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Robert B. M. Landewe, Denis Poddubnyy, Proton Rahman, Filip E. Van den Bosch, Rebecca Bolce, Soyi Liu Leage, Jeffrey R. Lisse, So Young Park, Lianne Gensler
Summary: In patients with axial spondyloarthritis who flared after withdrawal of IXE therapy, retreatment with open-label IXE can recapture a certain proportion of patients achieving low disease activity (LDA) or inactive disease (ID).
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Dafne Capelusnik, Diego Benavent, Desiree van der Heijde, Robert Landewe, Denis Poddubnyy, Astrid van Tubergen, Louise Falzon, Victoria Navarro-Compan, Sofia Ramiro
Summary: This study conducted a systematic literature review to summarize the relationship between early treatment and treatment clinical response in patients with SpA. It found that early treatment was associated with better outcomes in patients with non-radiographic axSpA and symptom duration of less than 5 years, but no differences in response to treatment were found in radiographic axSpA or in patients with longer symptom duration.
Article
Medicine, General & Internal
Iain B. McInnes, Akihiko Asahina, Laura C. Coates, Robert Landewe, Joseph F. Merola, Christopher Ritchlin, Yoshiya Tanaka, Laure Gossec, Alice B. Gottlieb, Richard B. Warren, Barbara Ink, Deepak Assudani, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, Philip J. Mease
Summary: This study evaluated the efficacy and safety of Bimekizumab in patients with active psoriatic arthritis who were naive to biologic DMARDs. The results showed that Bimekizumab treatment had superior improvements in joint, skin, and radiographic efficacy outcomes compared with placebo, and the safety profile was consistent with previous studies.
Article
Medicine, General & Internal
Joseph F. Merola, Robert Landewe, Iain B. McInnes, Philip J. Mease, Christopher T. Ritchlin, Yoshiya Tanaka, Akihiko Asahina, Frank Behrens, Dafna D. Gladman, Laure Gossec, Alice B. Gottlieb, Diamant Thaci, Richard B. Warren, Barbara Ink, Deepak Assudani, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, Laura C. Coates
Summary: This study compared the efficacy and safety of Bimekizumab with placebo in patients with active psoriatic arthritis. The results showed that Bimekizumab treatment led to superior improvements in joint and skin efficacy outcomes compared with placebo. The safety profile of Bimekizumab was consistent with previous studies.
Review
Rheumatology
Christian Dejaco, Robert B. M. Landewe
Summary: Telemedicine is increasingly used in rheumatology for triage, disease activity monitoring, and patient education. While it offers convenience, there are risks of losing essential information and challenges in building trusting relationships. It is important to complement telemedicine with traditional face-to-face visits for more efficient healthcare.
Article
Rheumatology
Sofia Ramiro, Robert Landewe, Desiree van der Heijde, Alexandre Sepriano, Oliver FitzGerald, Mikkel Ostergaard, Joanne Homik, Ori Elkayam, J. Carter Thorne, Maggie J. Larche, Gianfranco Ferraccioli, Marina Backhaus, Gilles Boire, Bernard Combe, Thierry Schaeverbeke, Alain Saraux, Maxime Dougados, Maurizio Rossini, Marcello Govoni, Luigi Sinigaglia, Alain G. Cantagrel, Cornelia F. Allaart, Cheryl Barnabe, Clifton O. Bingham III, Dirkjan van Schaardenburg, Hilde B. Hammer, Rana Dadashova, Edna Hutchings, Joel Paschke, Walter P. Maksymowych
Summary: The study investigates whether meticulously following a treat-to-target (T2T) strategy in daily clinical practice leads to less radiographic progression in patients with active rheumatoid arthritis (RA). The findings show that a more stringent application of T2T does not result in less radiographic progression compared to a somewhat lenient attitude towards T2T.
Article
Rheumatology
Sytske Anne Bergstra, Alexandre Sepriano, Arvind Chopra, Lai-Ling Winchow, David Vega-Morales, Karen Salomon-Escoto, Xanthe M. E. Matthijssen, Robert B. M. Landewe
Summary: The age of onset of rheumatoid arthritis (RA) is influenced by geographical latitude. This study investigated the extent to which patient-specific factors and country-level socioeconomic indicators explain this variability. The results showed that patients living closer to the equator have a younger age at RA diagnosis, and this gradient is primarily explained by countries' socioeconomic status.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Respiratory System
Marlou T. H. F. Janssen, Mark G. H. Thijssen, Jasenko Krdzalic, Michiel H. M. Gronenschild, Sofia Ramiro, Cesar Magro-Checa, Robert B. M. Landewe, Remy L. M. Mostard
Summary: This study aims to assess the correlation between CT-SS and respiratory outcomes in patients with COVID-19-associated hyperinflammation. The study found that patients with higher CT-SS had worse respiratory outcomes during hospitalization and at 3 months after discharge. Therefore, strict monitoring of patients with high CT-SS is recommended.
BMC PULMONARY MEDICINE
(2023)
Article
Rheumatology
Lotte van Ouwerkerk, Patrick Verschueren, Maarten Boers, Paul Emery, Pascal Hendrik Pieter de Jong, Robert B. M. Landewe, Willem Lems, Josef S. Smolen, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: In patients with rheumatoid arthritis (RA), the use of glucocorticoids (GC) as bridging therapy resulted in a more rapid clinical improvement and fewer changes in medication, but similar long-term GC use compared with patients who did not receive bridging therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Santiago Rodrigues-Manica, Alexandre Sepriano, Sofia Ramiro, Robert Landewe, Pascal Claudepierre, Anna Molto, Maxime Dougados, Miranda van Lunteren, Desiree van der Heijde
Summary: This study aimed to investigate the association between bone marrow edema (BME) and the development of structural lesions at the same anatomical location of the sacroiliac joints (SIJ) in patients with early axial spondyloarthritis (axSpA). The results showed that BME in each quadrant of the SIJ was associated with sclerosis, erosions, and fatty lesions, and the persistent BME pattern was associated with higher structural damage.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Correction
Rheumatology
Janne W. Bolt, Caroline J. Aalbers, Laura Walet, Leonieke J. J. van Mens, Christiaan van Denderen, Irene van der Horst-Bruinsma, Lisa G. M. van Baarsen, Robert Landewe, Marleen G. H. van de Sande
Letter
Rheumatology
Sofia Ramiro, Robert B. M. Landewe, Remy Mostard
ANNALS OF THE RHEUMATIC DISEASES
(2023)