Article
Multidisciplinary Sciences
Sten M. M. van Beek, Yvonne M. H. Bruls, Froukje Vanweert, Ciaran E. Fealy, Niels J. J. Connell, Gert Schaart, Esther Moonen-Kornips, Johanna A. A. Jorgensen, Frederic M. Vaz, Ellen T. H. C. Smeets, Peter J. J. Joris, Anne Gemmink, Riekelt H. H. Houtkooper, Matthijs K. C. Hesselink, Tore Bengtsson, Bas Havekes, Patrick Schrauwen, Joris Hoeks
Summary: In a study conducted on healthy young men, it was found that two weeks of treatment with the beta 2-agonist clenbuterol improved insulin-stimulated glucose disposal. This suggests that beta 2-agonist treatment may have therapeutic potential for type 2 diabetes.
NATURE COMMUNICATIONS
(2023)
Article
Respiratory System
Lata Jayaram, Alain C. Vandal, Catherina L. Chang, Chris Lewis, Cecilia Tong, Christine Tuffery, Jill Bell, Wendy Fergusson, Gene Jeon, David Milne, Stuart Jones, Noel Karalus, Sandra Hotu, Conroy Wong
Summary: Tiotropium via the HandiHaler device can significantly improve lung function in patients with stable bronchiectasis and airflow limitation, but does not reduce the frequency of exacerbations.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Miriam R. Bennett, Catherina L. Chang, Chris Tuffery, Sandra Hopping, Robert J. Hancox
Summary: The study investigated the impact of cardio-selective beta(1)-blocker bisoprolol on the response to salbutamol in patients with asthma. The results showed that there was no significant difference in the bronchodilator response to salbutamol after bronchoconstriction induced by mannitol between bisoprolol treatment and placebo.
Article
Nutrition & Dietetics
Jemima S. A. Dzator, Peter R. C. Howe, Kirsten G. Coupland, Rachel H. X. Wong
Summary: This study aimed to investigate the effects of resveratrol on hormonal migraineurs. After three months of supplementation, it was found that resveratrol did not improve the burden index, migraine-related disability, or quality of life in this cohort of hormonal migraineurs.
Article
Chemistry, Multidisciplinary
Amirhossein Mafi, Soo-Kyung Kim, William A. A. Goddard
Summary: In this study, molecular metadynamics computations were used to predict the mechanism of activation of the beta(2)-adrenergic receptor (beta(2)AR) and its cognate Gs protein by an agonist. It was found that attaching the inactive Gs protein to the agonist-bound inactive beta(2)AR can lead to activation of the Gs protein by breaking the ionic lock in the beta(2)AR. Activation of the Gs protein results in opening of the GDP binding pocket and expansion of G alpha s-alpha 5 in the beta(2)AR cytoplasmic region.
Article
Biology
Nana Zhang, Haibo Zhu, Zijian Li, Erdan Dong
Summary: The biased ligand Higenamine acts as a novel beta-arrestin-biased ligand by inducing ERK1/2 phosphorylation via EGFR transactivation. Its action is dependent on beta-arrestin1/2 and inhibits Doxorubicin-induced cardiomyocyte apoptosis. These findings provide insight into Higenamine's potential diagnostic and therapeutic applications.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Nina Lon, Sara Engel, Anders Damholt, Brynjulf Mortensen, Anne B. Haaber, Anja Wellejus, Filip K. Knop
Summary: Oral administration of the bacterial strain Bifidobacterium breve Bif195 can reduce the risk of aspirin-induced gastric mucosal damage. This study suggests that Bif195 may serve as a safe supplement during multiple-dosing aspirin treatment.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Respiratory System
Dave Singh, Jutta Beier, Carol Astbury, Maria G. Belvisi, Carla A. Da Silva, Alexandra Jauhiainen, Eulalia Jimenez, Alejhandra Lei, Sofia Necander, Jaclyn A. Smith, Ulrika Wahlby Hamren, Wenjing Xin, Ioannis Psallidas
Summary: Navafenterol, a new bronchodilator for COPD treatment, was found to improve lung function and alleviate COPD symptoms similar to an established bronchodilator, with good safety profile.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Allergy
Anders Martensson, Franziska U. Nordstrom, Charlotte Cervin-Hoberg, Malin Lindstedt, Christina Sakellariou, Anders Cervin, Lennart Greiff
Summary: The administration of a probiotic assemblage through topical/nasal route does not affect the quality of life, symptoms, or signs of allergic rhinitis. Although it may evoke a minor innate immune response, this treatment method is safe and feasible.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Anesthesiology
Mimmi Gillving, Dyveke Demant, Jakob V. Holbech, Sandra Sif Gylfadottir, Flemming W. Bach, Troels S. Jensen, Nanna B. Finnerup, Soren H. Sindrup
Summary: The experimental study found that the beta(2)-agonist terbutaline had no effect on painful polyneuropathy, while imipramine showed improvement in secondary outcomes.
Article
Pharmacology & Pharmacy
Rui Xu, Shi Feng, Zhou Ao, Yingxiang Chen, Congping Su, Xiuling Feng, Qin Fu, Xiaoyan Yang
Summary: Psoriasis is a chronic inflammatory disease that affects a significant portion of the population worldwide. Salmeterol, a long-acting beta(2)-AR agonist, alleviates the severity of psoriasis by inhibiting the proliferation and promoting apoptosis of keratinocytes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Urology & Nephrology
Soren B. Poulsen, Lei Cheng, David Penton, Marleen L. A. Kortenoeven, Vladimir V. Matchkov, Johannes Loffing, Robert Little, Sathish K. Murali, Robert A. Fenton
Summary: The beta 2-adrenergic receptor agonist salbutamol can increase NCC activity, affecting sodium and potassium homeostasis and potentially posing a risk factor for hypertension.
KIDNEY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Aung Myat, Simon R. Redwood, Satpal Arri, Bernard J. Gersh, Deepak L. Bhatt, Michael S. Marber
Summary: The study found that prolonged GLP-1R activation did not improve exercise tolerance or haemodynamics in chronic stable angina patients with established obstructive CAD. However, it significantly reduced weight and improved the lipid profile in these patients.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Sten M. M. van Beek, Anastasia Kalinovich, Gert Schaart, Tore Bengtsson, Joris Hoeks
Summary: Prolonged supplementation with the beta(2)-agonist clenbuterol improves glucose homeostasis mainly by activating BAT thermogenesis, but the improvement is independent of UCP1 in the mice models used in the study.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Medicine, General & Internal
Lu Tan, Michael Furian, Taomei Li, Xiangdong Tang
Summary: This study aims to investigate the effects of acetazolamide on 24-hour blood pressure, sleep-disordered disturbance, and daytime cognitive performance in patients with OSA living at high altitude.
Editorial Material
Medicine, General & Internal
Mohammed F. Zaidan, Bill T. Ameredes, William J. Calhoun
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Editorial Material
Medicine, General & Internal
Julia W. Tripple, Bill T. Ameredes, William J. Calhoun
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, General & Internal
Michael Bohm, Kazuomi Kario, David E. Kandzari, Felix Mahfoud, Michael A. Weber, Roland E. Schmieder, Konstantinos Tsioufis, Stuart Pocock, Dimitris Konstantinidis, James W. Choi, Cara East, David P. Lee, Adrian Ma, Sebastian Ewen, Debbie L. Cohen, Robert Wilensky, Chandan M. Devireddy, Janice Lea, Axel Schmid, Joachim Weil, Tolga Agdirlioglu, Denise Reedus, Brian K. Jefferson, David Reyes, Richard D'Souza, Andrew S. P. Sharp, Faisal Sharif, Martin Fahy, Vanessa DeBruin, Sidney A. Cohen, Sandeep Brar, Raymond R. Townsend
Editorial Material
Critical Care Medicine
William J. Calhoun, Alejandro Villasante-Tezanos
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Tim W. Harrison, Pascal Chanez, Francesco Menzella, Giorgio Walter Canonica, Renaud Louis, Borja G. Cosio, Njira L. Lugogo, Arjun Mohan, Annie Burden, Lawrence McDermott, Esther Garcia Gil, James G. Zangrilli
Summary: The study aimed to evaluate the efficacy of benralizumab in severe eosinophilic asthma patients, including onset of effect, impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms. Results showed that benralizumab significantly reduced exacerbation risk and improved HRQOL, lung function, and nasal symptoms early in the treatment period compared to placebo.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Joe G. Zein, Jeffrey M. McManus, Nima Sharifi, Serpil C. Erzurum, Nadzeya Marozkina, Timothy Lahm, Olivia Giddings, Michael D. Davis, Mark D. DeBoer, Suzy A. Comhair, Peter Bazeley, Hyun Jo Kim, William Busse, William Calhoun, Mario Castro, Kian Fan Chung, John Fahy, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, David T. Mauger, Wendy C. Moore, Victor E. Ortega, Michael Peters, Eugene R. Bleecker, Deborah A. Meyers, Yi Zhao, Sally E. Wenzel, Benjamin Gaston
Summary: In human asthma, higher bronchial AR expression and higher levels of androgens are associated with better lung function, fewer symptoms, and lower FENO levels. Female asthma patients are more likely to experience exacerbations and emergency department visits than male patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Medicine, General & Internal
Michael E. Wechsler, Ariel Munitz, Steven J. Ackerman, Matthew G. Drake, David J. Jackson, Andrew J. Wardlaw, Stephanie K. Dougan, Sergejs Berdnikovs, Florence Schleich, Andrea Matucci, Pascal Chanez, Charlene M. Prazma, Peter Howarth, Peter F. Weller, Peter A. Merkel
Summary: Eosinophils are crucial in immune responses, combatting infections and diseases, while also playing pathological roles in various conditions. Biologic therapies targeting eosinophils have shown success, but further investigation is needed for patients who do not respond well. Research has revealed eosinophils' involvement in homeostatic processes, highlighting the need for more understanding in both disease and health contexts.
MAYO CLINIC PROCEEDINGS
(2021)
Review
Allergy
Eileen Wang, Michael E. Wechsler
Summary: This article reviews key literature on asthma biologic therapeutics, including currently available and under investigation biologic therapies. Precision medicine guidance and shared decision-making are important factors in selecting biologic therapeutics. Consideration of biomarkers and key clinical characteristics can help guide the selection of biologics.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Obdulia Covarrubias-Zambrano, Massoud Motamedi, Bill T. Ameredes, Bing Tian, William J. Calhoun, Yingxin Zhao, Allan R. Brasier, Madumali Kalubowilage, Aruni P. Malalasekera, Asanka S. Yapa, Hongwang Wang, Christopher T. Culbertson, Deryl L. Troyer, Stefan H. Bossmann
Summary: This article reports the design and application of iron/iron oxide nanoparticle-based optical nanobiosensors for detecting biomarkers of lung diseases. The concept of using exhaled breath condensate and nanobiosensors for diagnosing/monitoring airway inflammation is explored.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Letter
Critical Care Medicine
Shu-Yi Liao, Anthony N. Gerber, Pearlanne Zelarney, Barry Make, Michael E. Wechsler
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Letter
Medicine, General & Internal
Michael E. Wechsler, Steven J. Ackerman, Peter F. Weller
MAYO CLINIC PROCEEDINGS
(2022)
Review
Allergy
Michael E. Wechsler, Bernhard Hellmich, Maria C. Cid, David Jayne, Xinping Tian, Lee Baylis, Florence Roufosse
Summary: Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA) are rare systemic inflammatory disorders with gaps in understanding of pathologic mechanisms, diagnostic difficulties, and lack of reliable predictive markers and treatment stratification biomarkers. Specialist referral pathways and disease-specific activity scores need improvement. This review highlights the limitations and areas for future work to improve patient management and outcomes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Michael E. Wechsler, John J. Oppenheimer
Summary: This review examined the evidence for the use of open-inhaler (ICS + LABA + LAMA) and single-inhaler triple therapy (ICS/LABA/LAMA combination) in patients with uncontrolled asthma. The study found that open-inhaler triple therapy reduced hospitalizations, exacerbations, and the need for oral corticosteroids and antibiotics. Single-inhaler triple therapy showed better lung function, asthma control, and health status, and was noninferior to open-inhaler triple therapy for Asthma Quality of Life Questionnaire scores.
Article
Rheumatology
Benjamin Terrier, David R. W. Jayne, Bernhard H. Hellmich, Jane Bentley, Jonathan W. Steinfeld, Steven Yancey, Namhee Kwon, Praveen Akuthota, Paneez Khoury, Lee E. Baylis, Michael Wechsler, EGPA mepolizumab study team
Summary: This study evaluated the efficacy of mepolizumab in patients with eosinophilic granulomatosis with polyangiitis (EGPA) with and without a vasculitic phenotype. The results showed that mepolizumab was more effective than placebo in terms of remission duration and proportion of patients in remission at different time points. Mepolizumab also reduced the occurrence of relapses. Therefore, mepolizumab provides clinical benefits for patients with EGPA, regardless of the presence of a vasculitic phenotype.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Respiratory System
Bradley E. Chipps, Nizar Jarjour, William J. Calhoun, Ahmar Iqbal, Tmirah Haselkorn, Ming Yang, Jochen Brumm, Jonathan Corren, Cecile T. J. Holweg, Mona Bafadhel
Summary: Intrinsic, extrinsic, and technical factors can influence the clinical interpretation of eosinophil counts, and a single measurement may not be sufficient when using eosinophil counts for the diagnosis and management of eosinophilic asthma.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)