Review
Biochemistry & Molecular Biology
Evgenii Gusev, Yulia Zhuravleva
Summary: Pro-inflammatory stress is inherent in damaged or threatened cells and is defined by various components. The microvascular inflammatory response plays a key role in the development of classical inflammatory foci, which can also lead to systemic inflammation. The division of inflammation into different variants has evolutionary roots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
E. Epifano, D. Monceau
Summary: Ellingham diagrams are thermodynamic tools used to compare the stability of oxides, commonly for pure metals. However, due to difficulties in obtaining experimental chemical activity data, Ellingham diagrams for complex industrial alloys are rarely reported. This study shows how advanced thermodynamic databases can be used to address this issue by computing the Ellingham diagrams for four widely used alloys and discussing their oxidation behavior and differences from the Ellingham diagrams of pure metals.
Review
Virology
Alexandro Guterres
Summary: Viral load is crucial for monitoring HIV infection and assessing the effectiveness of antiretroviral therapy, and has also gained widespread attention during the COVID-19 pandemic. However, relying solely on Ct values for viral load estimation can be problematic due to variations in PCR assays, sample quality, and assay sensitivity. The lack of standardized methods impedes viral load monitoring in clinical management.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Physiology
Martin E. Heroux, Annie A. Butler, Lucy S. Robertson, Georgia Fisher, Simon C. Gandevia
Summary: This article proposes a novel framework for human proprioception assessment, which includes low-level and high-level proprioceptive judgments. Low-level judgments are made within a single reference frame, while high-level judgments are made in a different reference frame.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Geosciences, Multidisciplinary
Stephen P. Reidel, Karl R. Fecht, Ingrid L. Hutter (Harrold), Terry L. Tolan, Mickie A. Chamness
Summary: The Olympic-Wallowa lineament (OWL) is a controversial geological feature extending nearly 650 km across the Pacific Northwest. It is recognized to be active with deformation continuing from the Miocene to Recent, with two competing interpretations on the style of deformation. Researchers focus on the portion of the OWL in the central Columbia Basin, demonstrating that it consists of north-verging, thrusted anticlines controlled by a basement fault.
GEOLOGICAL SOCIETY OF AMERICA BULLETIN
(2021)
Review
Immunology
Olivia A. C. Lamers, Bas M. Smits, Helen Louisa Leavis, Godelieve J. de Bree, Charlotte Cunningham-Rundles, Virgil A. S. H. Dalm, Hsi-en Ho, John R. Hurst, Hanna IJspeert, Sabine M. P. J. Prevaes, Alex Robinson, Astrid C. van Stigt, Suzanne Terheggen-Lagro, Annick A. J. M. van de Ven, Klaus Warnatz, Janneke H. H. M. van de Wijgert, Joris van Montfrans
Summary: The study conducted a systematic review and synthesis of published literature on the efficacy of treatments for GLILD in CVID patients, finding varying treatment response rates and a trend towards more frequent relapses in patients treated with corticosteroid monotherapy compared to rituximab-containing regimens. There is a need for further research and standardized data collection to facilitate comparison of treatment outcomes and ultimately randomized clinical trials.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Simin Zhang, Carmen Menoni, Vitaly Gruzdev, Enam Chowdhury
Summary: The chirped pulse amplification technique allows for the generation of ultra-short duration pulses with high peak powers. However, the damage of coatings in laser systems limits the further improvement of pulse duration, energy, and repetition rate. In this study, a numerical approach based on strong field electronic dynamics is proposed to estimate the laser induced damage threshold (LID) of dielectric multilayer coatings. The method is applied to simulate the LID threshold of different materials and compared with experimental measurements.
Article
Immunology
Sonia T. Almeida, Ana Cristina Paulo, Filipe Froes, Herminia de Lencastre, Raquel Sa-Leao
Summary: The study found that the pneumococcal carrier state in healthy adults is more dynamic than generally assumed, with frequent acquisition and often long duration of carriage. This suggests that some adults may act as reservoirs of pneumococci, impacting the potential herd effects achievable through children vaccination depending on the community's social structure. These findings are important for designing strategies to prevent pneumococcal disease in adults.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Geosciences, Multidisciplinary
Wojciech W. W. Grabowski, Hanna Pawlowska
Summary: The spectral width of cloud droplet spectrum plays a crucial role in the radiative properties and drizzle/rain development in warm ice-free clouds. In this study, we use an adiabatic rising parcel model to investigate the activation and diffusional growth of cloud droplets, with a focus on the evolution of spectral width in both clean and polluted environments. Our results show that the effects of kinetics, solute, and surface tension have a significant impact on the spectral width evolution above the cloud base. These findings have important implications for cloud modeling, particularly in the application of conventional bin microphysics.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Review
Immunology
Hsi-en Ho, Charlotte Cunningham-Rundles
Summary: Common variable immunodeficiency (CVID) is the most common symptomatic form of primary immunodeficiency. The pathogenesis of the CVID+ phenotype has remained unexplained for most patients, necessitating the need for relevant biomarkers in both the clinic and research settings.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Fabiana Mascarenhas Souza Lima, Myrthes Toledo-Barros, Venancio Avancini Ferreira Alves, Maria Irma Seixas Duarte, Cleusa Takakura, Carlos Felipe Bernardes-Silva, Ana Karolina Barreto Berselli Marinho, Octavio Grecco, Jorge Kalil, Cristina Maria Kokron
Summary: CVID is an inborn immune disorder that can lead to liver disease, specifically nodular regenerative hyperplasia (NRH). This study compared CVID patients with and without liver-spleen axis abnormalities and analyzed liver and duodenal biopsies to understand the pathophysiology of liver injury. The study found that NRH and lymphocytic infiltration were present in the livers of CVID patients with portal hypertension (PH). Patients with PH were more likely to have lymphadenopathy, elevated beta(2)-microglobulin, low B-lymphocyte counts, and low natural killer-lymphocyte counts.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Adi Gabarin, Ludmila Yarmolinsky, Arie Budovsky, Boris Khalfin, Shimon Ben-Shabat
Summary: Cannabis plants have been used in medicine for a long time due to their various medicinal properties. However, few cannabis-related drugs have been approved. Research indicates that targeting the endocannabinoid system and other receptors with cannabinoid compounds shows promise for treating multiple medical conditions.
Review
Immunology
Suran L. Fernando, Helena S- Jang, Jamma Li
Summary: CVID is a heterogeneous collection of immune dysregulation disorders, with majority of patients experiencing non-infectious complications such as autoimmunity, enteropathy, polyclonal lymphocytosis, and malignancy. Advances in next generation sequencing have led to a better understanding of the genetic basis of CVID disorders, allowing for improved diagnosis and targeted therapies. The identification of cellular abnormalities in T-cell and B-cell compartments, along with the role of innate lymphoid cells in promoting inflammation, provides valuable insights into the immune dysregulation seen in CVID patients.
IMMUNOLOGY LETTERS
(2021)
Article
Chemistry, Analytical
Ngoc Mai Duong, Angelina Noclain, Victoria E. Reichel, Pierre de Cordovez, Jean-Marc Di Meglio, Pascal Hersen, Gaelle Charron
Summary: In this study, a calibration-free quantitative SERS analysis strategy was proposed using a colorimetric volumetric titration method. By monitoring the progression of the titration through the SERS signal of a complexometric indicator, the equivalence point can be determined conveniently. Three mineral waters with divalent metal concentrations varying by a factor of 25 were successfully titrated using this method with satisfactory accuracy. Remarkably, this procedure can be completed in less than an hour and is suitable for field measurements without the need for laboratory-grade equipment.
Article
Allergy
James W. Verbsky, Mary K. Hintermeyer, Pippa M. Simpson, Mingen Feng, Jody Barbeau, Nagarjun Rao, Carlyne D. Cool, Luis A. Sosa-Lozano, Dhiraj Baruah, Erin Hammelev, Alyssa Busalacchi, Amy Rymaszewski, Jeff Woodliff, Shaoying Chen, Mary Bausch-Jurken, John M. Routes
Summary: The study showed that immunosuppressive therapy can improve the HRCT scan scores and pulmonary function test results of patients with CVID and GLILD, with a majority of patients achieving sustained remissions. However, some patients experienced relapse, and there were complications such as pneumonia during treatment and mortality after therapy completion. Whole exome sequencing identified damaging mutations in certain genes associated with primary immunodeficiency in a subset of patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Amy B. Kolbe, Robert P. Hartman, Tanya L. Hoskin, Rickey E. Carter, Daniel E. Maddox, Christopher H. Hunt, Gina K. Hesley
Article
Allergy
Desiree Larenas-Linnemann, Robert Esch, Greg Plunkett, Shannon Brown, Daniel Maddox, Charles Barnes, Derek Constable
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2011)
Meeting Abstract
Immunology
Avni Joshi, Miguel Park, John Hagan, Thomas Boyce, James Li, Ann Reed, Daniel Maddox, Martha Hartz, Gerald Volcheck, Matthew Rank, Jerry Katzmann, Melissa Snyder, Roshini Abraham
CLINICAL IMMUNOLOGY
(2009)
Letter
Allergy
Roshini S. Abraham, Mike Recher, Silvia Giliani, Jolan E. Walter, Yu Nee Lee, Francesco Frugoni, Daniel E. Maddox, Salman Kirmani, Luigi D. Notarangelo
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2013)
Review
Anesthesiology
David W. Barbara, Kevin P. Ronan, Daniel E. Maddox, Mark A. Warner
JOURNAL OF CLINICAL ANESTHESIA
(2013)
Letter
Medicine, General & Internal
Miguel A. Park, James T. Li, John B. Hagan, Daniel E. Maddox, Roshini S. Abraham
Article
Urology & Nephrology
Nelson Leung, Alfonso Eirin, Maria V. Irazabal, Daniel E. Maddox, Heidi D. Gunderson, Fernando C. Fervenza, Vesna D. Garovic
Article
Radiology, Nuclear Medicine & Medical Imaging
Jennifer S. McDonald, Nicholas B. Larson, Amy B. Kolbe, Christopher H. Hunt, John J. Schmitz, Daniel E. Maddox, Robert P. Hartman, David F. Kallmes, Robert J. McDonald
Summary: The study found that using iodinated contrast material (ICM) substitution was more effective for preventing repeat allergic-like reactions in high-risk patients with a previous allergic-like reaction to ICM compared to using steroid premedication.
Article
Allergy
A Madaan, DE Maddox
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
(2003)
Review
Allergy
RG Van Dellen, DE Maddox, EJ Dutta
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2002)