Article
Cell Biology
Chao Ma, Guangxing Liu, Wei Liu, Wei Xu, Hongtu Li, Shuhua Piao, Yang Sui, Wenhua Feng
Summary: The study demonstrates the essential role of CXCL1 in decidual angiogenesis, which is mediated through promoting endothelial cell proliferation and migration, and modulating the expression of VEGF-A. Experimental validation has confirmed the mechanism by which CXCL1 functions in angiogenesis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Ruth M. M. Urbantat, Claudius Jelgersma, Peter Vajkoczy, Susan Brandenburg, Gueliz Acker
Summary: The combination therapy of TMZ and SB has significant effects on gene and protein expression levels in endothelial cells, particularly in the proangiogenic pathway of CXCL2/IL8/CXCR2.
Article
Immunology
Yang Li, Shukun Han, Baokang Wu, Chongli Zhong, Yu Shi, Chao Lv, Lei Fu, Yizhou Zhang, Qi Lang, Zhiyun Liang, Yang Yu, Yu Tian
Summary: CXCL11 expression is higher in tumor tissue and has associations with prognosis, immune cell infiltration, tumor mutation burden, and microsatellite instability. Further investigation into CXCL11 may improve cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Kenta Nakamura, Atsuko Ashida, Yukiko Kiniwa, Ryuhei Okuyama
Summary: This study found that CCL5 and CXCL12 in blood may serve as biomarkers to predict the therapeutic effect of anti-PD-1 therapy in patients with advanced malignant melanoma. Patients with lower levels of CCL5 and CXCL12 had more TILs and better disease-specific survival rates, indicating these chemokines could be useful predictors for treatment outcomes.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Xiang Liu, Yijia Shao, Jiazichao Tu, Jiapan Sun, Bing Dong, Zhichao Wang, Jianrong Zhou, Long Chen, Jun Tao, Jimei Chen
Summary: This study reveals a novel mechanism by which TMAO impairs endothelial function through stimulating hepatocytes to produce exosomes with distinctive activity. The crosstalk between the liver and vascular endothelium mediated by these exosomes may provide a new target for restraining the harmful effects induced by TMAO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Linping Gu, Yaxian Yao, Zhiwei Chen
Summary: The study explored the interaction among CXCL1/2/8 expressions in NSCLC patients. It revealed that high expression of CXCL1 was associated with worse disease-free survival and overall survival, while high expression of CXCL2 was also linked to poorer survival outcomes. High expression of CXCL1 was identified as an independent factor predicting shorter survival time.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Immunology
Mengmeng Li, Ying Xu, Kexue Pu, Jie Fan, Zheng Cheng, Hao Chen, Li Zhou
Summary: This study revealed a significant association between CXCL10 gene polymorphisms and the risk of chronic HBV infection in Chinese Han population. The A allele of the rs4508917 in CXCL10 was identified as a risk factor for persistent HBV infection, affecting the response to nucleos(t)ide analogues treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Sven H. Loosen, Tom F. Ulmer, Simon Labuhn, Jan Bednarsch, Sven A. Lang, Patrick H. Alizai, Anne T. Schneider, Mihael Vucur, Ulf P. Neumann, Tom Luedde, Christoph Roderburg
Summary: This study identified circulating levels of CXCL13 as a previously unrecognized marker for predicting outcomes following the resection of BTC, highlighting the potential role of the CXC chemokine family in BTC pathogenesis.
Article
Oncology
Nobuyuki Ishikura, Masamichi Sugimoto, Keigo Yorozu, Mitsue Kurasawa, Osamu Kondoh
Summary: The efficacy and effects of combination therapy with anti-PD-L1 and anti-VEGF antibodies were investigated in patients with PD-L1 (low) or immune desert tumors. The study found that combination therapy inhibited tumor growth, increased the percentage of CD8(+) T cells and levels of CXCR3 ligands in tumor tissues, and showed better efficacy compared to monotherapy.
Article
Cell & Tissue Engineering
L. Tao, Y. Zhou, B. Zeng, X. Yang, M. Su
Summary: miR-183 was downregulated in tissue samples from patients and mice with OA. In DMM mice, overexpression of miR-183 inhibited the expression of proinflammatory cytokines (IL-6, IL-1 beta, TNF-alpha) and pain-related factors (TRPV1, Nav1.3, Nav1.7, Nav1.8) in DRG. OA pain was relieved by miR-183-mediated inhibition of macrophage infiltration, and dual luciferase reporter assay demonstrated that miR-183 directly targeted TGF alpha.
BONE & JOINT RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Feiyi Yang, Qian Zhang, Qiuyan Guo, Qingshan Pan, Chunping Wen, Xinya Lv, Wufu Zhu, Pengwu Zheng
Summary: A class of 4-phenoxy-pyridine/pyrimidine derivatives were synthesized and evaluated as potent dual VEGFR-2/c-Met inhibitors. Among them, compound 23k showed excellent anti-cancer cell proliferative activity and low toxicity. Further studies demonstrated that compound 23k induced apoptosis and blocked the cell cycle. Molecular docking and simulation revealed the binding modes of 23k to VEGFR-2 and c-Met.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Cell & Tissue Engineering
Worachat Namangkalakul, Shigenori Nagai, Chengxue Jin, Ken-ichi Nakahama, Yuki Yoshimoto, Satoshi Ueha, Kazunari Akiyoshi, Kouji Matsushima, Tomoki Nakashima, Masaki Takechi, Sachiko Iseki
Summary: FGF18 is involved in osteogenesis, chondrogenesis, and bone healing. It promotes the polarization of M2 macrophages by inducing the production of CCL2. However, the enhanced effect of FGF18 on bone healing with BMP2 is diminished in Ccr2-deleted mice.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Oncology
Gaoyang Chen, Zhen Zhou, Jun Jin, Yan Zhou, Yanqing Liu, Weimin Wang
Summary: This study found that CXCR4 and VEGF play important roles in predicting the prognosis of patients with gastric cancer, affecting survival rates by regulating cell invasive and migratory abilities. Additionally, their high expression is associated with poorer overall survival and are independent negative biomarkers.
Article
Rheumatology
Eun Jeong Won, Hui-Ju Kim, Yu Jeong Lee, Moon-Ju Kim, Hae-In Lee, Hyun Hee Jang, Seong Hoon Kim, Ji-Hyoun Kang, Ki-Jeong Park, Seung Cheol Shim, Sungsin Jo, Tae-Hwan Kim, Tae-Jong Kim
Summary: This study aims to examine the effectiveness of CCL20 inhibition in treating inflammation in AS. The results show that CCL20 affects the migration of Th17 cells and that the CCL20 inhibitor can reduce joint inflammation in AS patients. Therefore, targeting CCL20 inhibition could be a novel therapeutic approach for AS treatment.
Article
Urology & Nephrology
Wenjin Liu, Lulu Wang, Xiurong Li, Chaoqing Gao, Jianmei Zhou, Jiajun Zhou, Liang Wang, Zhuxing Sun, Hong Chu, Wei Fan, Youwei Bai, Junwei Yang
Summary: The study identified CXCL16 as a potent predictor for all-cause mortality and cardiovascular events in dialysis patients. Compared to IL-6 and CRP, CXCL16 showed stronger predictive power and was an independent predictor after adjusting for covariates.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)