Article
Computer Science, Hardware & Architecture
Furong Yang, Qinghua Wu, Zhenyu Li, Yanmei Liu, Giovanni Pau, Gaogang Xie
Summary: This paper introduces BBRv2 and its improved version BBRv2+, analyzes their performance under different network conditions, and demonstrates the advantages of BBRv2+ over BBRv2. BBRv2+ achieves faster responsiveness to bandwidth dynamics and fairness towards CCAs by using delay information, and improves resilience to random losses and network jitter through integrated mechanisms.
Article
Computer Science, Hardware & Architecture
Marcelo Bagnulo, Alberto Garcia-Martinez
Summary: This study examines the interaction between the LEDBAT++ and BBR congestion control algorithms. While LEDBAT++ fails to yield to BBR in some common conditions, the behavior varies for different versions of BBR.
Article
Multidisciplinary Sciences
Liangqian Huang, Trisha Agrawal, Guixin Zhu, Sixiang Yu, Liming Tao, JiaBei Lin, Ronen Marmorstein, James Shorter, Xiaolu Yang
Summary: Protein quality control systems are crucial for cellular function and organismal health. Recent studies have shown that polyD/E proteins, such as DAXX, ANP32A, and SET, may constitute a multifunctional protein quality control system that operates via a distinctive mechanism without relying on ATP.
Article
Cardiac & Cardiovascular Systems
Pingzhu Zhou, Yan Zhang, Isha Sethi, Lincai Ye, Michael A. Trembley, Yangpo Cao, Brynn N. Akerberg, Feng Xiao, Xiaoran Zhang, Kai Li, Blake D. Jardin, Neil Mazumdar, Qing Ma, Aibin He, Bin Zhou, William T. Pu
Summary: This study investigated the chromatin occupancy of GATA4 during heart development. The researchers found that GATA4 occupies genomic regions with lineage-specific enhancers in cardiomyocyte and endocardial lineages. They also discovered that non-pioneer transcription factors NKX2-5 and ETS1 guide the activity of GATA4, promoting its binding and opening of chromatin, and regulating endocardial development.
CIRCULATION RESEARCH
(2022)
Article
Oncology
Shavali Shaik, Shinji Maegawa, Amanda R. Haltom, Feng Wang, Xue Xiao, Tara Dobson, Ajay Sharma, Yanwen Yang, Jyothishmathi Swaminathan, Vikas Kundra, Xiao Nan Li, Keri Schadler, Arif Harmanci, Lin Xu, Vidya Gopalakrishnan
Summary: The master regulator of neurogenesis, RE1-silencing transcription factor (REST), is found to be elevated in medulloblastoma (MB) tumors and plays a role in remodeling the vascular structure of MB tumors, promoting vascular growth through autocrine and paracrine mechanisms.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Alexandros Pergaris, Ioannis Genaris, Ioanna E. Stergiou, Jerzy Klijanienko, Stavros P. Papadakos, Stamatios Theocharis
Summary: DAXX and HJURP are proteins involved in many physiological processes and have been implicated in the development of various tumors. This review summarizes studies investigating the expression of these proteins in different tumor types and highlights their role as potential biomarkers for diagnosis and prognosis in cancer.
Article
Biochemistry & Molecular Biology
Chuanling Wang, Qian Zou, Yinshuang Pu, Zhiyou Cai, Yong Tang
Summary: Mitochondrial dysfunction caused by D-ribose can lead to cognitive impairment in Alzheimer's disease. Berberine has the potential to treat AD by targeting mitochondria. This study explores the role of berberine and D-ribose in DNA methylation, mitophagy, and cognitive function, providing new insights into the mechanisms and treatment of cognitive impairment in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Muhammad Ansar, Muhammad Ali Sikandar, Fadi Althoey, Muhammad Atiq Ur Rehman Tariq, Saleh H. Alyami, Samah Elsayed Elkhatib
Summary: The deterioration of asphalt pavements due to heavy vehicle loads and climatic variations requires the use of construction materials with excellent resilience, resistance to permanent deformation, and longer service life. This study investigates the effects of polycarbonate (PC) and polytetrafluoroethylene (PTFE) modifiers on the performance of bitumen penetration grade (PG) 70 in hot mix asphalt (HMA) pavements against rutting, fatigue, and high temperature cracking. The results show that the modification of neat bitumen with PC and PTFE increases viscosity and rigidity, resulting in improved resistance to permanent deformation and cracking.
Article
Construction & Building Technology
Kristina Hofer, Johannes Mirwald, Amit Bhasin, Bernhard Hofko
Summary: A comprehensive understanding of the low-temperature performance of bitumen is crucial for the durability of asphalt pavements. This study evaluated a new test method for assessing the low-temperature performance grade of bitumen and established a correlation between mechanical and chemical properties.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Immunology
Minglu Yan, Noriko Komatsu, Ryunosuke Muro, Nam Cong-Nhat Huynh, Yoshihiko Tomofuji, Yukinori Okada, Hiroshi Suzuki, Hiroyuki Takaba, Riko Kitazawa, Sohei Kitazawa, Warunee Pluemsakunthai, Yuichi Mitsui, Takashi Satoh, Tadashi Okamura, Takeshi Nitta, Sin-Hyeog Im, Chan Johng Kim, George Kollias, Sakae Tanaka, Kazuo Okamoto, Masayuki Tsukasaki, Hiroshi Takayanagi
Summary: The transcription factor ETS1 plays a key role in regulating pathological tissue-remodeling programs in fibroblasts shared among various diseases. In arthritis, ETS1 orchestrates the polarization of tissue-destructive fibroblasts by regulating osteoclast differentiation factor RANKL and matrix metalloproteinases, impacting bone and cartilage damage. This discovery provides new insights into the mechanistic basis for pathogenic fibroblast polarization and has important therapeutic implications.
Article
Medicine, Research & Experimental
Tingting Zheng, Mengyao Cui, Huan Chen, Jinrui Wang, Hanyi Ye, Qianqian Zhang, Shuhui Sun, Yifan Feng, Yinghua Zhang, Wei Liu, Renping Chen, Ying Li, Zhengqi Dong
Summary: This study reported a simple method for preparing a novel nanocomposite BBR-EGCG nanoparticles (BBR-EGCG NPs). These NPs showed improved biocompatibility and stronger antibacterial effects than free-BBR and first-line antibiotics in both in vitro and in vivo experiments. The combination of BBR and EGCG exhibited synergistic bactericidal effects and biofilm-scavenging effects against S.aureus and MRSA without toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Nitish Gulve, Chenhe Su, Zhong Deng, Samantha S. Soldan, Olga Vladimirova, Jayamanna Wickramasinghe, Hongwu Zheng, Andrew V. Kossenkov, Paul. M. Lieberman
Summary: The tumor suppressor proteins DAXX and ATRX play a critical role in regulating p53 chromatin accessibility and DNA damage response in cancers with alternative lengthening of telomeres (ALT). Disruption of this pathway is essential for the survival of ALT cells.
NATURE COMMUNICATIONS
(2022)
Article
Construction & Building Technology
Zenggang Zhao, Shaopeng Wu, Jun Xie, Chao Yang, Xinkui Yang, Shuaichao Chen, Quantao Liu
Summary: In this study, asphalt rubber modifier pellets (ARP) were prepared using a screw extruder, which can be directly injected to simplify the production process and reduce energy consumption. The optimal composition for preparing asphalt rubber pellets was found to be 50% crumb rubber, 40% asphalt, and 10% calcium hydroxide. Modified asphalt with ARP showed better fatigue and crack resistance, as well as lower high temperature performance compared to PelletPAVE.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Review
Endocrinology & Metabolism
Qiongyao He, Hui Dong, Yujin Guo, Minmin Gong, Qingsong Xia, Fuer Lu, Dingkun Wang
Summary: This paper reviews the relationship between type 2 diabetes, intestinal microbiota, and the active ingredient berberine in the microbiota. Changes in the intestinal microbiota can affect the development of diabetes, while berberine can protect the microbiota and have therapeutic effects on diabetes and other metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Chang Sun, Yuan Qi, Natalie Fowlkes, Nina Lazic, Xiaoping Su, Guillermina Lozano, Amanda R. Wasylishen
Summary: Daxx functions as a histone chaperone for the histone H3 variant H3.3 and is essential for embryonic development. It interacts with Atrx to deposit H3.3 into heterochromatin, and this interaction is dispensable for viability. However, the interaction between Daxx and H3.3 is essential for postnatal viability and is important for silencing endogenous retroviruses and maintaining proper immune cell composition.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Lubing Gu, Hailong Zhang, Tao Liu, Sheng Zhou, Yuhong Du, Jing Xiong, Sha Yi, Cheng-Kui Qu, Haian Fu, Muxiang Zhou
Article
Clinical Neurology
Changshu Ke, Qiuhong Duan, Hui Yang, Feng Zhu, Meng Yan, San-peng Xu, Sheng Zhou, Feng Wan, Kai Shu, Ting Lei, Li-ming Xia
Article
Oncology
Jing Xiong, Tiefen Su, Zhiling Qu, Qin Yang, Yu Wang, Jiansha Li, Sheng Zhou
Article
Oncology
Changyu Liu, Yongde Liao, Sheng Fan, Xiangning Fu, Jing Xiong, Sheng Zhou, Man Zou, Jianmiao Wang
Article
Oncology
Sheng Fan, Yongde Liao, Changyu Liu, Quanfu Huang, Huifang Liang, Bo Ai, Shegnling Fu, Sheng Zhou
Article
Peripheral Vascular Disease
Jing Xiong, Qin Yang, Jiansha Li, Sheng Zhou
Article
Cell Biology
Yuxi Ma, Zihan Xia, Chunmei Ye, Chong Lu, Sheng Zhou, Juan Pan, Cuiwei Liu, Jieying Zhang, Tao Liu, Ting Hu, Linka Xie, Gang Wu, Yanxia Zhao
Article
Oncology
Mingyou Xing, Jun Wang, Qin Yang, Yu Wang, Jiansha Li, Jing Xiong, Sheng Zhou
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2019)
Article
Oncology
Sheng Fan, Yongde Liao, Wenlin Qiu, Quanfu Huang, Han Xiao, Changyu Liu, Dong Li, Xiaonian Cao, Lequn Li, Huifang Liang, Bo Ai, Sheng Zhou
Article
Oncology
Xianglan Yi, Liping Lou, Jun Wang, Jing Xiong, Sheng Zhou
Summary: Honokiol enhances doxorubicin sensitivity in breast cancer cells by downregulating miR-188-5p and involving the FBXW7/c-Myc signaling pathway.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xianglan Yi, Mengxin Qi, Mingxiang Huang, Sheng Zhou, Jing Xiong
Summary: The study demonstrated that honokiol (HNK) inhibits HIF-1 alpha-mediated glycolysis and the progression of human breast cancer. HNK reduces glucose uptake and lactate production, and increases oxygen consumption in breast cancer cells. Additionally, HNK downregulates the expression of HIF-1 alpha and its downstream regulators.
FRONTIERS IN PHARMACOLOGY
(2022)
Meeting Abstract
Clinical Neurology
Changshu Ke, Meng Yan, Lin Liu, San-peng Xu, Jing Xiong, Sheng Zhou, Bei Liu, Huaqiu Zhang, Ting Lei, Qiu-hong Duan
Article
Oncology
Jing Xiong, Jiansha Li, Qin Yang, Jun Wang, Tiefen Su, Sheng Zhou
BREAST CANCER RESEARCH
(2017)
Article
Cell Biology
Yuan Li, Wentao Yang, Qin Yang, Sheng Zhou
HISTOLOGY AND HISTOPATHOLOGY
(2012)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)