Article
Pathology
Seshi R. Sompuram, Kodela Vani, Lori Ryan, Corissa Johnson, Matthias Szabolcs, Leonore Peruyero, Andre Balaton, Sandrine Pierrot, Lija Joseph, Monika Pilichowska, Stephen Naber, Jeffrey Goldsmith, Samantha Green, Steve A. Bogen
Summary: The objective of this study was to evaluate a new FDA-cleared IHC control method using peptide epitopes for HER2, ER, and PR attached to cell-sized microspheres. The performance of IHControls was compared to conventional tissue controls in 5 clinical IHC laboratories and in simulated assay failure experiments. IHControls were found to sensitively and accurately detect IHC assay problems, similar to tissue controls.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Veterinary Sciences
L. Muscatello, F. Gobbo, E. Di Oto, G. Sarli, R. De Maria, A. De Leo, G. Tallini, B. Brunetti
Summary: HER2 amplification was found in a subgroup of canine mammary carcinomas, with the HER2 gene copy number correlated with HER2 protein overexpression but not with tumor behavior. Additionally, a possible translocation of HER2/CRYBA1 was discovered. This study highlights the potential for different amplification patterns in studying HER2 in canine mammary tumors.
VETERINARY SCIENCES
(2022)
Article
Oncology
Hengqiang Zhao, Yiping Gong
Summary: Single estrogen receptor (ER)+ and progesterone receptor (PR)+ tumors account for about 10% of all breast cancers. The prognosis of these tumors varies based on HER2 status, with single ER+ and PR+ patients showing different survival outcomes in different HER2 subtypes. In HER2- subtype, single PR+ patients had poorer prognoses than single ER+ patients, while in HER2+ subtype, single ER+ and PR+ patients showed similar prognoses compared with ER-PR- patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Antonio Martinez-Ortega, Alvaro Flores-Martinez, Eva Venegas-Moreno, Elena Dios, Diego Del Can, Eloy Rivas, Ariel Kaen, Eugenio Cardenas Ruiz-Valdepenas, Elena Fajardo, Florinda Roldan, Natividad Gonzalez-Rivera, Rosario Oliva, Jose Ignacio Fernandez-Pena, Alfonso Soto-Moreno, David A. Cano
Summary: This study systematically analyzed the expression of estrogen receptor alpha (ER alpha) and progesterone receptor (PR) in craniopharyngiomas (CPs) and explored their potential association with tumor aggressiveness features. The results showed that a substantial proportion of CPs displayed PR expression, but most CPs expressed low levels of ER alpha. No major association between PR and ER alpha expression and clinical aggressiveness features was observed in CPs. Additionally, beta-catenin accumulation was not related to tumor recurrence in this series.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Anna Diana, Francesca Carlino, Giuseppe Buono, Giuliano Antoniol, Vincenzo Famiglietti, Carmine De Angelis, Simone Carrano, Antonio Piccolo, Ferdinando De Vita, Fortunato Ciardiello, Bruno Daniele, Grazia Arpino, Michele Orditura
Summary: This study retrospectively analyzed the survival outcomes of 687 luminal-like HER2 negative early breast cancer patients and found that PR and Ki67 levels play an important role in prognostic assessment, confirming their crucial role in the decision-making process.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Gustavo A. Moreno, Mariel Molina, Dan Eastwood, Paul L. Auer, Julie M. Jorns
Summary: This study investigates the expression patterns of nuclear estrogen receptor alpha (ER alpha) and progesterone receptor (PR) in the stroma surrounding invasive carcinoma. The results showed associations between the expression of ER alpha/PR and clinicopathologic features. The study suggests that reproducible expression patterns can provide guidance for the assessment of internal controls in ER alpha/PR evaluation.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Orthopedics
Umile Giuseppe Longo, Alessandro Mazzola, Simone Carotti, Maria Francesconi, Simone Catapano, Francesco Magri, Giuseppe Perrone, Sergio Morini, Sergio De Salvatore, Vincenzo Denaro
Summary: This study investigated the presence of estrogen receptors and progesterone receptor in the supraspinatus tendon of patients with RC tears, finding significantly higher expression in postmenopausal women compared to men. There were positive correlations between ER expression and age in women, as well as between ER expression and histopathological findings. The results suggest a potential role of sex hormones in the pathogenesis of RC tears.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Oncology
Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice Andre, Attila Tordai, Jaime A. Mejia, W. Fraser Symmans, Ana M. Gonzalez-Angulo, Bryan Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobagyi, Lajos Pusztai
Summary: This study compared the response to neoadjuvant chemotherapy and survival between patients with triple-negative breast cancer (TNBC) and non-TNBC. The results showed that TNBC patients had higher pathologic complete response rates but lower 3-year progression-free survival rates and 3-year overall survival rates. TNBC was associated with increased risk for visceral metastases, lower risk for bone recurrence, and shorter postrecurrence survival. Patients with TNBC had worse survival if they had residual disease after neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Claudia A. Pinto, Bruno M. Fonseca, Susana I. Sa
Summary: TAM may modulate the hypothalamus by affecting ER- and/or PR-dependent mechanisms, thus influencing female sexual behavior. By altering estrogen and progesterone levels, it changes rat behavior responses and receptor expressions.
Article
Oncology
Elham Sajjadi, Konstantinos Venetis, Roberto Piciotti, Donatella Gambini, Concetta Blundo, Letterio Runza, Stefano Ferrero, Elena Guerini-Rocco, Nicola Fusco
Summary: The loss of PTEN is associated with tumorigenesis, tumor progression, and therapy resistance in breast cancer patients. Patients with PTEN-low tumors showed significantly enriched hormone receptor negativity and HER2 negativity compared to those with PTEN-retained tumors. The combined analysis of PTEN, HER2, and hormone receptor status provides relevant information for a more precise risk assessment of patients with breast cancer.
Review
Cell Biology
Emad A. Rakha, Ewa Chmielik, Fernando C. Schmitt, Puay Hoon Tan, Cecily M. Quinn, Grace Gallagy
Summary: The management of breast cancer patients relies on the assessment of prognostic and predictive markers. This review provides an update on the assessment of key molecular markers in breast cancer, including hormone receptors, HER2, and KI67, and highlights some challenges and focus areas.
Article
Medicine, General & Internal
Jun Shen, Lin-bo Wang, Rong-yue Teng, Jian-guo Shen
Summary: This study retrospectively analyzed the efficacy of adjuvant endocrine therapy in ER-negative, PR positive, and HER2 negative breast cancer patients. The results suggest that ER-/PR+ patients may benefit from adjuvant endocrine therapy, with higher survival rates.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Oncology
Khalid Al-Saleh, Abdurrahman Aldiab, Tareq Salah, Maria Arafah, Sufia Husain, Ammar Al-Rikabi, Nashwa Abd El-Aziz
Summary: The study found significant changes in HER2 expression post NACT, but no significant association with disease prognosis. Evaluation of HER2 expression post NACT is crucial for selecting optimal treatment regimens.
CLINICAL BREAST CANCER
(2021)
Article
Oncology
Laura Weydandt, Ivonne Nel, Anne Kreklau, Lars-Christian Horn, Bahriye Aktas
Summary: This study retrospectively analyzed the receptor discordance between the primary tumor tissue and synchronous axillary lymph node metastases in 215 breast cancer patients. The results showed that receptor discordance already occurs at the primary site. This suggests that in the treatment decision for breast cancer, not only the receptor distribution in the tumor tissue should be considered, but also the receptor distribution in synchronous axillary lymph node metastases.
Article
Immunology
Nicolas Samartzis, Dimitrios Rafail Kalaitzopoulos, Aurelia Noske, Isabel Ihnenfeld, Juliane Hutmacher, Patrick Imesch, Eleftherios Pierre Samartzis
Summary: This study compared the expression of GPER, ER-alpha, ER-beta, and PR in adenomyosis, eutopic endometrium from the same patients, and eutopic endometrium from patients without adenomyosis. The results showed higher nuclear stromal expression of GPER and lower nuclear expression of GPER in epithelial cells in adenomyosis compared to control endometrium. Adenomyosis also showed lower epithelial nuclear expression of ER-alpha and higher expression of ER-beta compared to control endometrium. This study revealed significant differences in the immuno-histochemical expression of GPER in adenomyosis.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Oncology
Sarah Nicole Hamilton, Alan Nichol, Elaine Wai, Lovedeep Gondara, Hector A. Velasquez Garcia, Caroline Speers, Rekha Diocee, Pauline Truong
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rohan Kapre, Junhan Zhou, Xinzhe Li, Laurel Beckett, Angelique Y. Louie
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Margo E. Pearce, Sofia R. Bartlett, Amanda Yu, Jess Lamb, Cheryl Reitz, Stanley Wong, Maria Alvarez, Mawuena Binka, Hector Velasquez Garcia, Dahn Jeong, Emilia Clementi, Prince Adu, Hasina Samji, Jason Wong, Jane Buxton, Eric Yoshida, Chelsea Elwood, Laura Sauve, Neora Pick, Mel Krajden, Naveed Z. Janjua
Summary: In British Columbia, women and men show similar engagement in the HCV care cascade, but women with concurrent social and health issues such as mental health diagnoses and injection drug use are being left behind. Treatment access may be improved by addressing the needs of younger women, those with mental health diagnoses, and women who use drugs.
Article
Medicine, General & Internal
Yiqing Xia, Huiting Ma, Gary Moloney, Hector A. Velasquez Garcia, Monica Sirski, Naveed Z. Janjua, David Vickers, Tyler Williamson, Alan Katz, Kristy Yiu, Rafal Kustra, David L. Buckeridge, Marc Brisson, Stefan D. Baral, Sharmistha Mishra, Mathieu Maheu-Giroux
Summary: This study aims to understand the geographic concentration of SARS-CoV-2 cases in 16 cities across four Canadian provinces and its association with social determinants of health. The study finds that cases are concentrated in areas with lower income, educational attainment, and a higher proportion of visible minorities, recent immigrants, high-density housing, and essential workers. The study also reveals variations in the concentration of social determinants among different cities.
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Mawuena Binka, Sofia Bartlett, Hector A. Velasquez Garcia, Maryam Darvishian, Dahn Jeong, Prince Adu, Maria Alvarez, Stanley Wong, Amanda Yu, Hasina Samji, Mel Krajden, Jason Wong, Naveed Z. Janjua
Summary: The study assessed the impact of COVID-19-related public health measures on HCV testing and first-time HCV-positive diagnoses in British Columbia. It found that these measures led to a significant decrease in HCV testing and first-time HCV-positive diagnosis rates, which gradually recovered to pre-limit levels, while the anti-HCV positive rate remained unchanged before and after the restrictions.
LIVER INTERNATIONAL
(2021)
Article
Immunology
Sharifa Nasreen, Yossi Febriani, Hector Alexander Velasquez Garcia, Geng Zhang, Mina Tadrous, Sarah A. Buchan, Christiaan H. Righolt, Salaheddin M. Mahmud, Naveed Zafar Janjua, Mel Krajden, Gaston De Serres, Jeffrey C. Kwong
Summary: Based on the test-negative study design conducted in Canada, it is estimated that two doses of mRNA or ChAdOx1 vaccine provide excellent protection against severe outcomes like hospitalization and death due to COVID-19.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Sean P. Harrigan, James Wilton, Mei Chong, Younathan Abdia, Hector Velasquez Garcia, Caren Rose, Marsha Taylor, Sharmistha Mishra, Beate Sander, Linda Hoang, John Tyson, Mel Krajden, Natalie Prystajecky, Naveed Z. Janjua, Hind Sbihi
Summary: This study compared the severity of Omicron and Delta variants and found that Omicron-infected individuals had a lower risk of hospitalization and ICU admission compared to Delta-infected individuals. Additionally, the hospital stay was shorter for Omicron cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Prince A. Adu, Mawuena Binka, Bushra Mahmood, Dahn Jeong, Terri Buller-Taylor, Makuza Jean Damascene, Sarafa Iyaniwura, Notice Ringa, Hector A. Velasquez Garcia, Stanley Wong, Amanda Yu, Sofia Bartlett, James Wilton, Mike A. Irvine, Michael Otterstatter, Naveed Zafar Janjua
Summary: The BC-Mix survey was conducted in British Columbia to measure behavior and contact patterns during the COVID-19 pandemic. As of July 26, 2021, over 61,000 baseline survey responses were received, with 41,375 eligible for analysis. The survey revealed that the majority of respondents were female, over 55 years old, identified as white, and had at least a university degree.
Article
Public, Environmental & Occupational Health
Prince A. Adu, Sarafa A. Iyaniwura, Bushra Mahmood, Dahn Jeong, Jean Damascene Makuza, Georgine Cua, Mawuena Binka, Hector A. Velasquez Garcia, Notice Ringa, Stanley Wong, Amanda Yu, Mike A. Irvine, Michael Otterstatter, Naveed Z. Janjua
Summary: The study found that among unvaccinated individuals in British Columbia, those with high contact rates are more likely to exhibit vaccine hesitancy, and therefore may be at a higher risk of acquiring and transmitting infection.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Zaeema Naveed, Julia Li, Michelle Spencer, James Wilton, Monika Naus, Hector Alexander Velasquez Garcia, Michael Otterstatter, Naveed Zafar Janjua
Summary: This study used population health administrative data from British Columbia to estimate the incidence of myocarditis after SARS-CoV-2 mRNA vaccination. The results showed a low number of myocarditis cases within 7 and 21 days post-vaccination, but age, sex, and vaccine type were important factors affecting the incidence rate. The risk of myocarditis was lower for individuals aged 18-29 who received the BNT162b2 vaccine.
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Zaeema Naveed, Julia Li, James Wilton, Michelle Spencer, Monika Naus, Hector A. Velasquez Garcia, Jeffrey C. Kwong, Caren Rose, Michael Otterstatter, Naveed Z. Janjua
Summary: This study compares the risk of myocarditis, pericarditis, and myopericarditis between BNT162b2 and mRNA-1273 COVID-19 vaccines. The study found that individuals who received mRNA-1273 had higher rates of myocarditis and pericarditis compared to those who received BNT162b2. The association was stronger among men and younger age groups. These findings may have implications for vaccine choice and policy decisions.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Laurel A. Beckett
Summary: Alzheimer’s disease is characterized by brain damage caused by tau and amyloid aggregates, particularly in the hippocampus and the default network. A new study in PLOS Biology reveals sex differences in these patterns of damage and their associations with risk and protective factors.
Article
Immunology
Mawuena Binka, Braeden Klaver, Georgine Cua, Alyson W. Wong, Chad Fibke, Hector A. Velasquez Garcia, Prince Adu, Adeera Levin, Sharmistha Mishra, Beate Sander, Hind Sbihi, Naveed Z. Janjua
Summary: An algorithm was developed to accurately identify long COVID patients using population-level health administrative data, providing crucial information for clinical assessment and decision-making.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Mawuena Binka, Prince Asumadu Adu, Dahn Jeong, Nirma Khatri Vadlamudi, Hector Alexander Velasquez Garcia, Bushra Mahmood, Terri Buller-Taylor, Michael Otterstatter, Naveed Zafar Janjua
Summary: This study assessed the usage patterns of face masks among British Columbia residents during the COVID-19 pandemic and evaluated the impact of mask mandates. The findings showed that mask mandates supported high face mask usage rates, which were further increased with the introduction of the provincial mask mandate. Factors associated with face mask use included age, ethnicity, health region, mode of travel, destination, and time period. These findings emphasize the importance of mask mandates in promoting high face mask usage rates during the pandemic.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Infectious Diseases
Zaeema Naveed, Julia Li, Monika Naus, Hector Alexander Velasquez Garcia, James Wilton, Naveed Z. Janjua
Summary: This study aimed to estimate the rate of myocarditis after mRNA COVID-19 booster vaccination by vaccine type, age, and sex. Data from the British Columbia COVID-19 Cohort were used. The overall rate of myocarditis after the booster dose was lower than the second dose, and this difference was more significant for the mRNA-1273 vaccine type.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)
