Article
Urology & Nephrology
Adriana V. Gregory, Aleksandar Denic, Amr Moustafa, Praveen G. Dasaraju, Bhavya Poudyal, Joshua J. Augustine, Aidan F. Mullan, Panagiotis Korfiatis, Andrew D. Rule, Timothy L. Kline
Summary: The study investigates the clinical importance of the size and number of kidney lobes. It finds that the cortex and medullary volumes and pyramid counts reflect variations in nephron number and size and age-related nephrosclerosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Naomi Pode-Shakked, Prasad Devarajan
Summary: Acute kidney injury (AKI) is a common and serious problem affecting people of all ages, with a lack of understanding in its pathobiology hindering the development of new diagnostics and therapeutics. Recent advancements in using human stem cells, organoids, and in silico approaches have been made in studying human AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Lei Guo, Zhenxing Hu, Chao Zhao, Xiangnan Xu, Shujuan Wang, Jingjing Xu, Jiyang Dong, Zongwei Cai
Summary: A study established an improved pipeline for accurate spatial segmentation of suborgans/microregions from complex MSI data, using lipidomic-characteristic-based MSI data of a whole-body mouse fetus. The improved pipeline outperformed other pipelines and commercial software in visual inspection, spatial consistence, time-cost, and robustness analysis, demonstrating its effectiveness in accurate localization of physiological positions of suborgans.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Torsten R. Goesch, Nancy A. Wilson, Weifeng Zeng, Bret M. Verhoven, Weixiong Zhong, Maya M. Coumbe Gitter, William E. Fahl
Summary: PrC-210 has shown potential to suppress kidney damage and inflammation caused by allograft kidney transplantation, reducing histologic damage, improving kidney function metrics, and decreasing levels of inflammatory cytokines and activated caspase.
Article
Medicine, General & Internal
Nasrin El-Bandar, Markus H. Lerchbaumer, Robert Peters, Andreas Maxeiner, Katja Kotsch, Arne Sattler, Kurt Miller, Thorsten Schlomm, Bernd Hamm, Klemens Budde, Lutz Liefeldt, Thomas Fischer, Frank Friedersdorff
Summary: This study aimed to investigate the association between contrast-enhanced ultrasound (CEUS) findings and kidney function. CEUS examinations were conducted on 30 living kidney donors, and various perfusion parameters were analyzed. The results showed that mean signal intensity (MeanLin) had a significant correlation with kidney function, especially in normal-weight individuals. These findings suggest that CEUS signal intensity may be influenced by body mass index (BMI).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Marek Drozdzik, Maria Drozdzik, Stefan Oswald
Summary: Chronic kidney disease may affect the expression and function of membrane carriers and transporters, leading to impaired drug elimination and clinical consequences. Understanding the function of these proteins is crucial for characterizing drug pharmacokinetics, drug actions in the kidney, and defining organ pathophysiology.
Review
Biochemistry & Molecular Biology
Paulina Mertowska, Sebastian Mertowski, Iwona Smarz-Widelska, Ewelina Grywalska
Summary: The increasing number of late-diagnosed kidney disease patients has become a serious problem affecting people from all backgrounds. The full etiology of this issue is not yet fully understood, although genetic susceptibility, infections, immune disorders, or high blood pressure have been suggested as contributing factors. Difficulties in timely and accurate diagnosis are due to the lack of research on early molecular markers and insufficient educational and preventive efforts among the public, resulting in delayed detection of kidney diseases. Interleukins play an important role in homeostasis and disease progression, including kidney diseases, by performing various biological functions and interacting with other cells and tissues in the body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Whanhee Lee, Seulkee Heo, Rory Stewart, Xiao Wu, Kelvin C. Fong, Ji-Young Son, Benjamin Sabath, Danielle Braun, Jae Yoon Park, Yong Chul Kim, Jung Pyo Lee, Joel Schwartz, Ho Kim, Francesca Dominici, Michelle L. Bell
Summary: This study aimed to investigate the association between residential greenness and the development of kidney disease. The results showed that higher levels of annual residential greenness were associated with a lower risk of the first hospital admission for kidney diseases.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Kamyar Kalantar-Zadeh, Tazeen H. Jafar, Dorothea Nitsch, Brendon L. Neuen, Vlado Perkovic
Summary: Chronic kidney disease is a progressive disease with no cure, and preserving kidney function through lifestyle adjustments and pharmacological interventions can improve outcomes. A plant-dominant, low-protein, and low-salt diet may help mitigate glomerular hyperfiltration and preserve renal function. Various pharmacotherapies can also be used to alter intrarenal haemodynamics and protect the kidney from further damage.
Article
Cardiac & Cardiovascular Systems
Xiaoguang Xu, James M. Eales, Xiao Jiang, Eleanor Sanderson, Maciej Drzal, Sushant Saluja, David Scannali, Bryan Williams, Andrew P. Morris, Tomasz J. Guzik, Fadi J. Charchar, Michael Holmes, Maciej Tomaszewski
Summary: The study found that genetically predicted body mass index and waist circumference were causally associated with biochemical indices of renal function, kidney health index, and both acute and chronic kidney diseases. The impact of obesity indices on kidney health is largely independent of blood pressure and type 2 diabetes, and signatures of obesity on the human kidney transcriptome were uncovered.
CARDIOVASCULAR RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Ralph Kettritz, Johannes Loffing
Summary: Membrane voltage in excitable cells is controlled by the ratio of extracellular and intracellular potassium concentration. Potassium homeostasis is maintained through the balance of distribution and elimination of potassium, and dyskalemias caused by genetic and acquired diseases, as well as pharmacological interventions, are associated with increased morbidity and mortality. This article discusses the physiological, pathophysiological, and pharmacological aspects of potassium regulation and provides informative case vignettes, aiming to guide clinicians, epidemiologists, and pharmacologists in understanding the complexity of potassium homeostasis and initiating appropriate treatment strategies in dyskalemic patients.
PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Medicine, General & Internal
Dominique Vodovar, Bruno Megarbane, Stephane Gaudry, Didier Dreyfuss, Paul M. Palevsky
Summary: This article discusses the importance and effectiveness of using extracorporeal kidney-replacement therapy in poisonings, even in the absence of acute kidney injury, to rapidly remove toxicants and save lives.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Liang-Ti Huang, Chung-Ming Chen
Summary: Preterm birth and hyperoxia exposure disrupt the development and function of the kidneys, leading to the pathogenesis of chronic kidney disease. Hyperoxia-induced kidney injuries are mediated by various molecular factors, including hypoxia-inducible factor-1 alpha, interleukin-6/Smad2/transforming growth factor-beta, and Wnt/beta-catenin signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Adrianna Westbrook, Ruiyuan Zhang, Mengyao Shi, Alexander C. Razavi, Zhijie Huang, Jing Chen, Jiang He, Tanika Kelly, Ye Shen, Changwei Li
Summary: This study aimed to evaluate the association between baseline telomere length and kidney function. The results showed that participants with longer telomere length were more likely to have consistently normal kidney function, while it was not associated with the rate of eGFR change.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Editorial Material
Urology & Nephrology
Roman D. Buelow, Jesper Kers, Peter Boor
Summary: Artificial intelligence (AI) and deep learning (DL) show great potential in improving pathology diagnostics, particularly in segmenting histology into relevant compartments. While most studies focus on oncologic pathology, there is a growing interest in applying AI and DL to nephropathology, as demonstrated in recent research.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)
