Article
Biochemistry & Molecular Biology
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park
Summary: For several decades, excessive glucocorticoids (GCs) have been known to inhibit collagen synthesis and accelerate skin aging, but the molecular mechanisms involved are not well understood. In this study, the researchers identified potential glucocorticoid receptor (GR) target genes that may contribute to the inhibition of collagen synthesis. They confirmed that dexamethasone, a synthetic GC, activates canonical GR signaling in dermal fibroblasts and identified six candidate genes involved in the GC-mediated inhibition of collagen synthesis. This study provides insights into the molecular mechanisms of GC-mediated skin aging and lays the foundation for further research on the biological characteristics of individual GR target genes.
Article
Allergy
Maya E. Kotas, Neil N. Patel, Emily K. Cope, Jose G. Gurrola II, Andrew N. Goldberg, Steven D. Pletcher, Max A. Seibold, Camille M. Moore, Erin D. Gordon
Summary: This study reveals that IL-13-induced epithelial remodeling is characterized by alterations in cell types and prostaglandin E2 stimulation in nasal polyposis, while IL-17 signaling is more prominent in CRS without polyps. Clinical severity correlates with the degree of IL-13-driven epithelial remodeling.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Wesuk Kang, Dabin Choi, Bomin Son, Soyoon Park, Taesun Park
Summary: In recent years, there has been increasing interest in the ectopic roles of olfactory receptors (ORs) throughout the human body, especially in the skin. This study found that suberic acid, through its interaction with the specific olfactory receptor OR10A3, can promote collagen synthesis in UVB-irradiated dermal fibroblasts, suggesting it as a promising target for anti-aging treatments for the skin.
Article
Biochemistry & Molecular Biology
Qin Zou, Xue Wang, Rong Yuan, Zhengyin Gong, Chenggang Luo, Ying Xiong, Yanzhi Jiang
Summary: Skin thickness is influenced by the expression of collagen I in fibroblasts. Using Chenghua pigs as model animals, this study identified significant morphological differences between Chenghua pigs and Large White pigs at the transcript level. Additionally, a circRNA called circ0044633 was found to promote fibroblast proliferation and collagen I synthesis by sponging miR-23b and regulating CADM3 and MAP4K4 expression. Over-expression of circ0044633 increased skin thickness and collagen I content in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Sepideh Mohammadi, Hossein Ravanbakhsh, Sareh Taheri, Guangyu Bao, Luc Mongeau
Summary: This study reports the use of hybrid nanocomposite microgels containing interleukin-10 (IL-10) to modulate tissue macrophage phenotype during wound healing. The microgels, which have tissue-mimetic elasticity and interconnected micropores, promote fibroblast proliferation and migration. The incorporation of hyaluronic acid further enhances macrophage infiltration. These microgels show potential for regenerative healing by harnessing the antifibrotic behavior of host macrophages.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Ophthalmology
Tim Berger, Nora Szentmary, Lorenz Latta, Berthold Seitz, Tanja Stachon
Summary: The study found that untreated KC-HCFs showed higher mRNA expression of NF-kappa B, iNOS, Col 1, and Col 5 compared to the healthy control group, while IL-6 expression was lower. Following CXL, NF-kappa B and IL-6 mRNA expression increased in HCFs. The IL-6 concentration in the cell culture supernatant and cell lysate increased in both HCFs and KC-HCFs after CXL.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Immunology
Wuling Li, Xiuxiu Zhu, Yanmin Xu, Jun Chen, Hongtao Zhang, Zhi Yang, Yanan Qi, Juan Hong, Yunyan Li, Guixue Wang, Junjie Shen, Cheng Qian
Summary: This study designed a novel UCAR-T cell that could avoid allo-rejection and resist allogenic NK cell rejection, and validated its safety and efficacy ex vivo and in vivo. The results showed that HLA-II deficiency could promote the persistence of CAR-T, while TCR deficiency had a negative impact on the shorter-term anti-tumor efficacy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Parkyong Song, Han-Seul Jo, Wan-Seog Shim, Yang Woo Kwon, Sungwon Bae, Yonghoon Kwon, Bakhovuddin Azamov, Jin Hur, Dongjun Lee, Sung Ho Ryu, Jong Hyuk Yoon
Summary: Emodin promotes type I collagen synthesis in dermal fibroblasts, potentially serving as a candidate for treating skin aging and wrinkles.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maria Blanco, Noelia Sanz, Ana C. Sanzhez, Begona Correa, Ricardo I. Perez-Martin, Carmen G. Sotelo
Summary: This study aimed to achieve a high molecular weight (Mw) in Blue Shark Collagen Hydrolysate by studying different hydrolysis parameters and testing its effect on mRNA Type I collagen expression. Analysis revealed differences in Mw of blue shark collagen hydrolysates depending on hydrolysis conditions, with papain leading to higher Mw hydrolysate than Alcalase. The highest Mw hydrolysate showed no cytotoxicity or proliferation effect on fibroblast cell culture, but exhibited an increasing effect on mRNA expression and pro-collagen I production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Tieyuan Zhu, Zhang Ying, Xinghua Zhang, Huimin Wang, Huagang Liu
Summary: The study demonstrates that piceatannol can protect against oxidative injury and collagen synthesis during pulmonary fibrosis (PF) by inhibiting the activation of the JAK2/STAT3 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
S. Bolivar, J. A. Espitia-Corredor, F. Olivares-Silva, P. Valenzuela, C. Humeres, R. Anfossi, E. Castro, R. Vivar, A. Salas-Hernandez, V. Pardo-Jimenez, G. Diaz-Araya
Summary: Cardiac fibroblasts (CF) play a key role in maintaining the extracellular matrix balance in cardiac tissue, while IFN-beta exhibits anti-fibrotic effects on CF through STAT1 and STAT2, with STAT3 showing no involvement.
Article
Pharmacology & Pharmacy
Xiaolu Yu, Junnan Zhou, Fuli Zhao, Xuan Liu, Yuhang Mao, Li Diao, Chuanjun Wen, Mei Liu
Summary: Tomatidine (Td) shows inhibitory effects on inflammatory responses in arthritis and therapeutic effects on synovial inflammation and joint destruction in rats. Td can significantly suppress the production of pro-inflammatory cytokines and may act by reducing the activation of MAPKs and NF-κB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
David Achudhan, Shan-Chi Liu, Yen-You Lin, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, I-Ping Chiang, Yueh-Hsiung Kuo, Chih-Hsin Tang
Summary: The study demonstrates that Antcin K, a compound isolated from Antrodia cinnamomea, shows anti-inflammatory effects by inhibiting proinflammatory cytokine production in human rheumatoid synovial fibroblasts. This indicates the potential of Antcin K in treating rheumatoid arthritis by reducing inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fan Deng, Jing-Juan Hu, Xiao Yang, Qi-Shun Sun, Ze-Bin Lin, Bing-Cheng Zhao, Zhi-Wen Yao, Si-Dan Luo, Ze-Ling Chen, Ying Liu, Zheng-Zheng Yan, Cai Li, Wei-Feng Liu, Ke-Xuan Liu
Summary: The study demonstrates that pravastatin can attenuate intestinal I/R injury by promoting the release of IL-13 from ILC2s, revealing a novel mechanism and therapeutic strategy for intestinal I/R injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiangying Ma, Zhiheng Zhang, Meilun Shen, Yuanqiang Ma, Rouqian Li, Xiaodi Jin, Li Gao, Zhi Wang
Summary: Osteoarthritis is characterized by progressive degeneration of cartilage and remodeling of subchondral bone, induced by pro-inflammatory cytokines like IL-1 beta. Biomarkers for diagnosing OA effectively are currently not available. Studying the mechanism of cartilage injury and changes in biomarker concentrations during pathogenesis can provide a theoretical basis for evaluation and early diagnosis of OA.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Engineering, Biomedical
Sayuri Yoshizawa, Andrew Brown, Aaron Barchowsky, Charles Sfeir
ACTA BIOMATERIALIA
(2014)
Article
Cell Biology
Sayuri Yoshizawa, Andrew Brown, Aaron Barchowsky, Charles Sfeir
CONNECTIVE TISSUE RESEARCH
(2014)
Article
Dentistry, Oral Surgery & Medicine
J. Yonehiro, Y. Yoshida, A. Yamashita, S. Yoshizawa, K. Ohta, N. Kamata, T. Okihara, F. Nishimura
INTERNATIONAL ENDODONTIC JOURNAL
(2013)
Article
Dentistry, Oral Surgery & Medicine
J. Yonehiro, A. Yamashita, Y. Yoshida, S. Yoshizawa, K. Ohta, N. Kamata, T. Okihara, F. Nishimura
INTERNATIONAL ENDODONTIC JOURNAL
(2012)
Article
Dentistry, Oral Surgery & Medicine
Y. Okada, M. Meguro, H. Ohyama, S. Yoshizawa, K. Takeuchi-Hatanaka, N. Kato, S. Matsushita, S. Takashiba, F. Nishimura
JOURNAL OF PERIODONTAL RESEARCH
(2009)
Article
Multidisciplinary Sciences
Andrew J. Glowacki, Sayuri Yoshizawa, Siddharth Jhunjhunwala, Andreia E. Vieira, Gustavo P. Garlet, Charles Sfeir, Steven R. Little
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Proceedings Paper
Engineering, Biomedical
Siladitya Pal, Amy Chaya, Sayuri Yoshizawa, Da-Tren Chou, Daeho Hong, Spandan Maiti, Prashant N. Kumta, Charles Sfeir
ASME 2013 CONFERENCE ON FRONTIERS IN MEDICAL DEVICES: APPLICATIONS OF COMPUTER MODELING AND SIMULATION
(2013)
Article
Dentistry, Oral Surgery & Medicine
S. Yoshizawa, M. Meguro, H. Ohyama, K. Takeuchi-Hatanaka, S. Matsushita, S. Takashiba, F. Nishimura
JOURNAL OF PERIODONTAL RESEARCH
(2007)
Article
Endocrinology & Metabolism
Akiko Yamashita, Yoshihiko Soga, Yoshihiro Iwamoto, Sayuri Yoshizawa, Hirotaka Iwata, Susumu Kokeguchi, Shogo Takashiba, Fusanori Nishimura
Article
Biochemistry & Molecular Biology
Hirotaka Iwata, Yoshihiko Soga, Michio Meguro, Sayuri Yoshizawa, Yuka Okada, Yoshihiro Iwamoto, Akiko Yamashita, Shogo Takashiba, Fusanori Nishimura
JOURNAL OF ENDOTOXIN RESEARCH
(2007)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)