Article
Medicine, Research & Experimental
Arezoo Hosseini, Tohid Gharibi, Adel Mohammadzadeh, Abbas Ebrahimi-Kalan, Farhad Jadidi-niaragh, Zohreh Babaloo, Dariush Shanehbandi, Elham Baghbani, Behzad Baradaran
Summary: Ruxolitinib ameliorated the severity of EAE by modulating the balance between Th17 cells and Tregs, reducing inflammatory markers levels and increasing levels of anti-inflammatory cytokines.
Review
Neurosciences
Sofia Pereira das Neves, Joao Carlos Sousa, Nuno Sousa, Joao Jose Cerqueira, Fernanda Marques
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system that affects about 2.5 million people worldwide. There is currently no cure for MS and the available treatments only slow the initial phases of the disease. Disease progression and disability in MS are better correlated with the maintenance of a persistent low-grade inflammation inside the CNS, driven by local glial cells like astrocytes.
Article
Biochemistry & Molecular Biology
Nozomi Sachi, Naganori Kamiyama, Benjawan Saechue, Sotaro Ozaka, Astri Dewayani, Shimpei Ariki, Thanyakorn Chalalai, Yasuhiro Soga, Chiaki Fukuda, Yomei Kagoshima, Supanuch Ekronarongchai, Takashi Kobayashi
Summary: Multiple sclerosis is an autoimmune disease characterized by immune attack on the nerve myelin sheath. The balance between pathogenic Th17 cells and regulatory Treg cells, expressing chemokine receptor CCR6, is crucial in determining disease activity. The role of CCL20, the ligand of CCR6, in attracting immune cells to the central nervous system (CNS) in multiple sclerosis has not been fully understood. This study generated CCL20-knockout and CCR6-knockout mice using CRISPR/Cas9 system and found that the migratory function mediated by CCL20/CCR6 may not be necessary for the onset of experimental autoimmune encephalomyelitis (EAE).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Neurosciences
Taekyun Shin, Meejung Ahn, Jeongtae Kim, Kyungsook Jung, Changjong Moon, Moon-Doo Kim
Summary: Visual disabilities are important symptoms in central nervous system autoimmune diseases such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Past studies have focused on neuro-inflammatory changes in the white matter of the brain, but lesions have been found in the visual pathway and retina/optic nerves. While retina and optic nerves are immunologically privileged sites, inflammation can occur via other routes.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chiara Camponeschi, Maria De Carluccio, Susanna Amadio, Maria Elisabetta Clementi, Beatrice Sampaolese, Cinzia Volonte, Maria Tredicine, Vincenzo Romano Spica, Rosa Di Liddo, Francesco Ria, Fabrizio Michetti, Gabriele Di Sante
Summary: The study demonstrated a direct correlation between S100B and inflammatory processes, and investigated the effect of AA on a mouse model of multiple sclerosis by inhibiting astrocytic S100B synthesis. The results showed that the AA-treated group had milder symptoms in the early phase of the disease and reduced various pathological features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Marina Boziki, Paschalis Theotokis, Evangelia Kesidou, Eleni Karafoulidou, Chrystalla Konstantinou, Iliana Michailidou, Yasemin Bahar, Ayse Altintas, Nikolaos Grigoriadis
Summary: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) with a neurodegenerative component. Age plays a role in the disease phenotype and progression, as well as the transition from relapsing-remitting MS (RRMS) to secondary progressive disease. Sex also influences disease phenotype and immune system in both humans and animal models. This review focuses on the effects of sex and aging on MS phenotype, immune system, and CNS, using experimental autoimmune encephalomyelitis (EAE) models.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dafni Birmpili, Imane Charmarke Askar, Lucas Dinh Pham-Van, Thomas Kuntzel, Caroline Spenle, Aurelien Riou, Dominique Bagnard
Summary: In this study, a molecular RNA signature for each phase of multiple sclerosis (MS) was established using the EAE-PLP animal model. By comparing variances of expression of known biomarkers, the study provides insights into the disease features. The research is important for understanding the pathophysiological processes and finding clinically relevant biomarkers of MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Gareth Pryce, Sofia Sisay, Gavin Giovannoni, David L. Selwood, David Baker
Summary: The study found that BK channel openers have neuroprotective effects and can inhibit nerve loss and disability caused by autoimmune diseases. This could make them potential stand-alone neuroprotective agents or add-ons to treat multiple sclerosis.
Review
Cell Biology
Maria Concetta Geloso, Nadia D'Ambrosi
Summary: Microglia can rapidly respond to environmental changes and play a role in shaping neuronal wiring. They regulate the elimination of weaker synapses, actively participating in modulating neuronal function. Synaptic dysfunction may be an early and independent event in the neurodegenerative process associated with diseases like multiple sclerosis.
Review
Immunology
Donghui Shen, Kang Liu, Hongyan Wang, Haifeng Wang
Summary: Autophagy plays a significant role in both protective and detrimental effects in multiple sclerosis (MS). Targeting autophagy may be a potential therapeutic approach, but further studies are needed to determine its mechanisms.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
Wenlin Hao, Qinghua Luo, Michael D. Menger, Klaus Fassbender, Yang Liu
Summary: Anti-CD52 therapy demonstrates neuroprotective effects in EAE mice by reducing T lymphocyte counts, preventing myelin loss, and protecting neurons. Neuronal BDNF regulates the neuroprotective and anti-inflammatory effects of CD52 antibody in EAE mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shishi Shen, Xi Cheng, Luyao Zhou, Yipeng Zhao, Hai Wang, Jie Zhang, Xiaobo Sun, Yuge Wang, Yaqing Shu, Yanteng Xu, Yu Tao, Mingqiang Li, Zhengqi Lu, Wei Cai, Guangjun Nie, Wei Qiu
Summary: This study developed neutrophil-derived nanovesicles (NNVs) to enhance the efficiency of myelin debris clearance in microglia for multiple sclerosis (MS) therapy. The results showed that NNVs treatment ameliorated lesional neuroinflammation and improved neurological functions and white matter integrity in a mouse model of MS. Additionally, NNVs treatment upregulated the expression of NRF2 in microglia and activated the transcription of RUBCN, leading to enhanced phagocytosis of myelin debris.
Article
Immunology
Byunghyun Park, Yu Sun Jeong, Wonseok Hu, Mingyu Lee, Ji Cheol Kim, Geon Ho Bae, Yong-Soo Bae, Yoe-Sik Bae
Summary: Multiple sclerosis (MS) is a disease that damages the brain and spinal cord, leading to paralysis. Recent research has shown that B cells play a significant role in the pathogenesis of MS, as autoantibodies from B cells are closely related to central nervous system damage and prognosis. Regulating the activity of antibody secreting cells may be linked to the severity of MS symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Javier Marin-Prida, Nancy Pavon-Fuentes, Nielsen Lagumersindez-Denis, Hanlet Camacho-Rodriguez, Ana Margarita Garcia-Soca, Rocio De La Caridad Sarduy-Chavez, Erica Leandro Marciano Vieira, Juliana Carvalho-Tavares, Viviana Falcon-Cama, Julio Raul Fernandez-Masso, Ignacio Hernandez-Gonzalez, Gillian Martinez-Donato, Gerardo Guillen-Nieto, Eduardo Penton-Arias, Mauro Martins Teixeira, Giselle Penton-Rol
Summary: In this study, the potential benefits and mechanisms of action of Phycocyanobilin (PCB) in combating chronic experimental autoimmune encephalomyelitis (EAE), a nonclinical model of multiple sclerosis (MS), were evaluated. The study found that PCB can improve neurological symptoms, reduce inflammatory cytokine levels, and regulate relevant genes at the genetic level. In addition, PCB can reduce demyelination, decrease neuronal damage, and promote the generation of oligodendrocyte precursor cells. The combination of PCB with Interferon-beta (IFN-beta) showed better therapeutic effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qiu-Xia Zhang, Sheng-Nan Zhang, Lin-Jie Zhang, Da-Qi Zhang, Li Yang
Summary: Research suggests that irisin levels fluctuate with disease progression in MS and EAE, indicating the potential involvement of irisin in the pathological processes of these diseases.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lynn Daboul, Carly M. O'Donnell, Quy Cao, Moein Amin, Paulo Rodrigues, John Derbyshire, Christina Azevedo, Amit Bar-Or, Eduardo Caverzasi, Peter Calabresi, Bruce A. C. Cree, Leorah Freeman, Roland G. Henry, Erin E. Longbrake, Kunio Nakamura, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Rohini D. Samudralwar, Suradech Suthiphosuwan, Matthew K. Schindler, Elias S. Sotirchos, Nancy L. Sicotte, Andrew J. Solomon, Russell T. Shinohara, Daniel S. Reich, Daniel Ontaneda, Pascal Sati
Summary: This study assesses the impact of gadolinium-based contrast agent (GBCA) on the evaluation of central vein sign (CVS) and the diagnostic performance of CVS for multiple sclerosis (MS). The results show that the use of GBCA enhances the detection rate of CVS on FLAIR* images and improves the sensitivity of CVS for the diagnosis of MS.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Review
Clinical Neurology
Melanie Filser, Axel Buchner, Gereon Rudolf Fink, Stefan M. Gold, Iris-Katharina Penner
Summary: Patients with multiple sclerosis (MS) are at increased risk of experiencing mental health problems, including depression and anxiety. However, there is limited knowledge about the assessment and association of these affective symptoms in MS. Further research is needed to improve diagnosis and care.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Arzu Ceylan Has Silemek, Guido Nolte, Jana Poettgen, Andreas K. Engel, Christoph Heesen, Stefan M. Gold, Jan-Patrick Stellmann
Summary: This study aimed to explore the longitudinal reorganization of brain networks in multiple sclerosis (MS) patients over a period of 2 years, and analyze its association with cognition. The results showed a decline in hub connectivity and global connectivity at a structural level in MS patients, while the hub connectivity in the default-mode network was preserved. In addition, the network models based on functional MRI and magnetoencephalography were similar to diffusion tensor imaging, but had weaker associations with cognition in MS patients.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ke Chen, Torsten Wuestenberg, Victoria Stiglbauer, Linda El-Ahmad, Annika Rosenthal, Patricia Pelz, Stefan M. Gold, Andreas Heinz, Miriam Sebold
Summary: Social exclusion contributes to alcohol consumption and can lead to the exclusion of people with alcohol dependence (AD), while AD can also cause social exclusion. Previous research has found that patients with AD exhibit altered neural responses to experimental social exclusion. Our study aimed to investigate the behavioral response and inflammatory effects of social exclusion in male patients with a history of AD. We analyzed ball tossing behavior and the cytokine interleukin (IL)-1b levels in saliva before and after a Cyberball game among AD patients and healthy controls. The results revealed a distinct dynamic behavioral response to social exclusion in male patients with a history of AD.
Article
Clinical Neurology
Woo Ri Chae, Jens Baumert, Julia Nuebel, Jelena Brasanac, Stefan M. Gold, Ulfert Hapke, Christian Otte
Summary: Inflammation and metabolic dysregulations are likely to underlie atypical depressive symptoms such as appetite and sleep alterations. This study aimed to replicate associations between individual depressive symptoms and immunometabolic markers, extend previous findings with additional markers, and evaluate their relative contribution to depressive symptoms. The results indicated that appetite alterations and insomnia were the most important symptoms associated with metabolic markers.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Penelope Tilsley, Isanbert Arun Strohmeyer, Inga Heinrich, Friederike Rosenthal, Stefan Patra, Karl Heinz Schulz, Sina C. Rosenkranz, Caren Ramien, Jana Poettgen, Christoph Heesen, Arzu Ceylan Has, Stefan M. Gold, Jan-Patrick Stellmann
Summary: The aim of this study was to explore the interaction between fitness, brain networks, and disability in progressive MS. The results showed that exercise increased functional connectivity in highly connected brain regions, but no structural changes were observed. The correlation between fitness and functional outcomes was influenced by connectivity, especially in more disrupted brain networks.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Charlotte Schubert, Lea Steinberg, Julia Peper, Caren Ramien, Kerstin Hellwig, Sascha Koepke, Alessandra Solari, Andrea Giordano, Stefan M. Gold, Tim Friede, Christoph Heesen, Anne Christin Rahn
Summary: The influence of pregnancy on the course of multiple sclerosis has long been controversial. Recent research shows that women with MS have a significantly increased relapse rate in the first 6 months postpartum, but a decreased relapse rate at 10-12 months postpartum. Disease-modifying therapies and exclusive breastfeeding play important roles in influencing postpartum relapse risk.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Medicine, Research & Experimental
Sarwareddy Kartik Kumar, Manda Venkata Sasidhar
Summary: Small extracellular vesicles (sEVs) are important for cell-to-cell communication and maintaining cellular homeostasis. They have potential as a tool for cancer drug delivery due to their ability to transfer biological cargo to target cells. Advances in sEV engineering, EV mimetics, and ligand-directed targeting have improved the effectiveness of anticancer drug delivery. However, there are still gaps in understanding how to effectively use sEVs to treat solid tumor malignancies. This article provides an overview of recent sEV research and its potential for targeted elimination of cancer cells, which could advance cancer research and bring sEV formulations into clinical use.
MOLECULAR PHARMACEUTICS
(2023)
Review
Psychiatry
Ole Kohler-Forsberg, Victoria Stiglbauer, Jelena Brasanac, Woo Ri Chae, Frederike Wagener, Kim Zimbalski, Oskar H. Jefsen, Shuyan Liu, Malik R. Seals, Stefanie Gamradt, Christoph U. Correll, Stefan M. Gold, Christian Otte
Summary: This umbrella systematic review and meta-analysis aimed to evaluate the efficacy and safety of antidepressant use in populations with medical diseases and comorbid depression. The results showed that antidepressants are effective and safe in treating and preventing depression in patients with comorbid medical disease.
Article
Clinical Neurology
Julia Peper, Sascha Kopke, Alessandra Solari, Andrea Giordano, Stefan M. Gold, Kerstin Hellwig, Lea Steinberg, Anke Steckelberg, Christoph Heesen, Anne Christin Rahn
Summary: This study aimed to assess the measurement properties of two patient-reported outcome measures on motherhood choice in MS and explore the information and support needs of women with MS concerning motherhood. The results suggested that both questionnaires were suitable and acceptable measures for assessing knowledge and worries about motherhood/pregnancy in MS. The findings emphasized the importance of providing evidence-based information on motherhood in MS to increase knowledge, reduce worries, and support women with MS in making informed decisions.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Medical Informatics
Stefan M. Gold, Tim Friede, Bjoern Meyer, Rona Moss-Morris, Joanna Hudson, Susanna Asseyer, Judith Bellmann-Strobl, Andreas Leisdon, Leonie Issels, Kristin Ritter, David Schymainski, Hayley Pomeroy, Sharon G. Lynch, Julia S. Cozart, Joan Thelen, Cristina A. F. Roman, Margaret Cadden, Erin Guty, Stephanie Lau, Jana Poettgen, Caren Ramien, Susan Seddiq-Zai, Anna-Maria Kloidt, Johannes Wieditz, Iris-Katharina Penner, Friedemann Paul, Nancy L. Sicotte, Jared M. Bruce, Peter A. Arnett, Christoph Heesen
Summary: Depression is more common in patients with neurological and inflammatory disorders. This study evaluated the safety and efficacy of an internet-based cognitive behavioural therapy program specific to multiple sclerosis in reducing depressive symptoms. The results showed that the program significantly reduced depressive symptoms, providing a new treatment option for patients with multiple sclerosis.
LANCET DIGITAL HEALTH
(2023)
Meeting Abstract
Clinical Neurology
Christina Tan, Laura Locke, Pascal Sati, Brooke Guerrero, Nancy Sicotte, Omar Al-Louzi
Meeting Abstract
Clinical Neurology
Sargis Manukyan, Gabriela Zabala, Laura Locke, Brooke Guerrero, Marwa Kaisey, Afshin Khodabakhsh, Nancy Sicotte, Pascal Sati, Omar Al-Louzi
Meeting Abstract
Clinical Neurology
Francesca Bagnato, Pascal Sati, Christopher Hemond, Colm Elliott, Susan Gauthier, Daniel Harrison, Caterina Mainero, Jiwon Oh, David Pitt, Russell Shinohara, Seth Smith, Trapp Bruce, Christina Azevedo, Peter Calabresi, Roland Henry, Cornelia Laule, Daniel Ontaneda, William Rooney, Nancy Sicotte, Daniel Reich, Martina Absinta
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)