Article
Cardiac & Cardiovascular Systems
Meryl Musicante, Hannah H. Kim, Yuanjian Chen, Fang Liao, Syamal K. Bhattacharya, Lu Lu, Yao Sun
Summary: This study revealed that eNOS plays a beneficial role in preventing cardiac myocyte hypertrophy and fibrosis, supporting the idea that eNOS may modify the severity of HCM phenotypes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, Research & Experimental
Kadiam C. Venkata Subbaiah, Jiangbin Wu, Wai Hong Wilson Tang, Peng Yao
Summary: FAM114A1 is upregulated in failing human and mouse hearts and plays a critical role in cardiac remodeling by regulating angiotensin II signaling and activating cardiac fibroblasts and other cardiac cells.
Review
Cardiac & Cardiovascular Systems
Laura Sartiani, Gianluca Bartolucci, Marco Pallecchi, Valentina Spinelli, Elisabetta Cerbai
Summary: Pirfenidone is a drug approved for the treatment of Idiopathic pulmonary fibrosis, but its mechanism of action is still not well understood. It has attracted attention for its potential therapeutic effects in other pathological fibrotic disorders, but more research is needed to understand its effects on fibroblasts and their interactions with other cell types.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Article
Multidisciplinary Sciences
Peng Qi, Qian Zhai, Xiquan Zhang
Summary: Inhibition of RUNX1 can alleviate cardiac enlargement, improve ejection fraction and fractional shortening in a heart failure animal model. It also reduces myocardial fibrosis and cell apoptosis, potentially through activation of the TGF-beta/Smads signaling pathway.
Article
Pharmacology & Pharmacy
Yinhui Wang, Kun Yu, Chengcheng Zhao, Ling Zhou, Jia Cheng, Dao Wen Wang, Chunxia Zhao
Summary: The study revealed that Follistatin plays a cardioprotective role in attenuating diabetic cardiomyopathy by reducing cardiac fibrosis and reactive oxygen species production, and enhancing matrix metallopeptidase 9 activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Dharshan Sivaraj, Chikage Noishiki, Nina Kosaric, Harriet Kiwanuka, Hudson C. Kussie, Dominic Henn, Katharina S. Fischer, Artem A. Trotsyuk, Autumn H. Greco, Britta A. Kuehlmann, Filiberto Quintero, Melissa C. Leeolou, Maia B. Granoski, Andrew C. Hostler, William W. Hahn, Michael Januszyk, Ferid Murad, Kellen Chen, Geoffrey C. Gurtner
Summary: According to the American Diabetes Association, there is a significant unmet need for new therapies to accelerate the closure of non-healing wounds. In this study, the effects of NO-releasing gel on diabetic wound healing in mice were investigated. The results showed that topical administration of NO-gel significantly accelerated the rate of wound healing and promoted a more regenerative ECM architecture.
FRONTIERS IN MEDICINE
(2023)
Article
Plant Sciences
Jie Yu, Xiuye Zhao, Xiuqing Yan, Wen Li, Yunqi Liu, Jiapan Wang, Jia Wang, Yilian Yang, Yan Hao, Zhen Liang, Yiping Tao, Ye Yuan, Zhimin Du
Summary: This study demonstrates that a natural anthraquinone extract called aloe-emodin (AE) can protect against acute myocardial ischemia and improve cardiac remodeling after chronic myocardial infarction (MI). AE treatment significantly improves cardiac function, reduces structural remodeling, and inhibits cardiac apoptosis and oxidative stress. Furthermore, AE activates the TGF-beta signaling pathway and regulates fibrosis-related gene expression, ultimately improving cardiac function and inhibiting cardiac fibrosis and hypertrophy.
Article
Multidisciplinary Sciences
Jingwen Xiao, Yan Zhang, Yuan Tang, Hengfen Dai, Yu OuYang, Chuanchuan Li, Meiqin Yu
Summary: MiR-1202 is up-regulated in atrial fibrillation and plays a crucial role in myocardial fibrosis by regulating cell proliferation, protein levels, and collagen deposition. Moreover, MiR-1202 targets nNOS to modulate the fibrosis process in HCFs.
Article
Medicine, Research & Experimental
Mathieu Cinato, Laurie Guitou, Amira Saidi, Andrei Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N. Zolov, Sai Srinivas Panapakkam Giridharan, Lois S. Weisman, Laurent O. Martinez, Jerome Roncalli, Oksana Kunduzova, Helene Tronchere, Frederic Boal
Summary: The study highlights the inhibitory effects of Apilimod on cardiac fibrotic remodeling, controlling the TGF beta signaling pathway to prevent adverse remodeling. It also suggests a novel function for PIKfyve in regulating myocardial fibrosis and TGF beta pathway.
Article
Cell & Tissue Engineering
Priya Mohindra, Justin X. Zhong, Qizhi Fang, Darnell L. Cuylear, Cindy Huynh, Huiliang Qiu, Dongwei Gao, Bhushan N. Kharbikar, Xiao Huang, Matthew L. Springer, Randall J. Lee, Tejal A. Desai
Summary: This study leverages hyaluronic acid microstructures loaded with anti-fibrotic decorin to attenuate cardiac fibrosis after myocardial infarction. The results demonstrate that treatment with decorin microstructures leads to significant improvement in cardiac function and remodeling.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Weiwei Lu, Zhaojie Meng, Rebecca Hernandez, Changcheng Zhou
Summary: The study demonstrates the crucial role of IKK-beta in regulating fibroblast functions and cardiac remodeling, showing that fibroblast-specific IKK-beta deficiency can protect mice from hypertension-induced adverse cardiac remodeling, including hypertrophy, fibrosis, and macrophage infiltration. Ablation of fibroblast IKK-beta inhibits proinflammatory and profibrogenic responses, leading to improved cardiac remodeling and function.
Article
Pharmacology & Pharmacy
Tuling Li, Bo Bao, Yixian Hao, Jinpeng Liu, Hongsheng Bi, Dadong Guo
Summary: Myopia is a common eye disease that affects children and adolescents worldwide. The pathogenesis of myopia is still unclear and effective drugs are scarce. This study found that lens-induced myopia in guinea pigs led to increased choroidal fibrosis, accompanied by changes in refraction, axial length, and choroidal thickness. However, intravitreal injection of the NOS inhibitor L-NMMA alleviated choroidal fibrosis and improved the myopic condition. These findings suggest a positive correlation between choroidal fibrosis and axial length increase in myopic guinea pigs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Shih-Yi Lee, Yueh-Hsiung Kuo, Chen-Xuan Du, Cheng-Wei Huang, Hui-Chun Ku
Summary: Differentiation of cardiac fibroblasts into myofibroblasts is a critical event in the progression of cardiac fibrosis. The study investigated the effect of caffeic acid ethanolamide (CAEA) on cardiac remodeling induced by Angiotensin (Ang) II. CAEA inhibited fibroblast differentiation, protected against cardiac fibrosis and dysfunction, and regulated the TGF-beta/SMAD/NOX4 signaling pathway. The study supports CAEA administration as a viable method to prevent Ang II-induced cardiac remodeling.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Xin Liu, Guo-Ping Shi, Junli Guo
Summary: Pressure overload and heart failure are major causes of cardiovascular morbidity and mortality, where innate immune cells and inflammatory mediators play crucial roles. Different innate immune cells, including mast cells, macrophages, monocytes, neutrophils, dendritic cells, eosinophils, and natural killer T cells, exhibit varying levels of activity in these pathological processes, with some exacerbating cardiodysfunction and others displaying cardioprotective activities. Overall, immune regulation of cardiac innate immune cells holds promise as a therapeutic approach in experimental cardiac disease treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)