Review
Chemistry, Medicinal
Yosif Almoshari
Summary: Osmotic pumps, a type of novel drug delivery system (NDDS), have gained significant attention in the food and pharmaceutical industries. They are considered the most reliable source for controlled drug delivery due to their unique properties and advantages.
Article
Biochemistry & Molecular Biology
Kathrin Malfeld, Peter Baumhoff, Holger A. Volk, Thomas Lenarz, Verena Scheper
Summary: Noise-induced hearing loss is a major cause of sensorineural hearing loss globally, and there is currently no treatment to restore physiological hearing. The development of preventive drugs is the focus of hearing research.
Article
Oncology
Bessi Qorri, Reza Bayat Mokhtari, William W. Harless, Myron R. Szewczuk
Summary: Repositioning aspirin and oseltamivir phosphate in combination with gemcitabine treatment has shown promise as an effective treatment option for pancreatic cancer. The therapy disrupts chemoresistance, tumor progression, EMT program, cancer stem cells, and metastases in a preclinical mouse model. Additional investigation is warranted to evaluate its potential in clinical settings and improve patient prognosis for this otherwise fatal disease.
Article
Chemistry, Multidisciplinary
Jie Yang, Yingbo Li, Jiemei Sun, Hongyan Zou, Yige Sun, Jing Luo, Qian Xie, A. Rong, Hongbin Wang, Xiaona Li, Kai Wang, Lili Yang, Teng Ma, Lina Wu, Xilin Sun
Summary: Low accumulation of anticancer drugs in tumors and serious systemic toxicity are still major challenges in pharmaceuticals. Pulmonary delivery of nanoscale-based drug delivery systems offers a strategy to increase antitumor activity with minimal adverse exposure. In this study, we report an osimertinib-loaded nanoemulsion system that synergizes with F-19 MRI-guided LIFU for lung cancer therapy. The research validates the potential of this nanoemulsion system for lung cancer treatment, achieving quick distribution and drug release without severe side effects.
Article
Pharmacology & Pharmacy
Seung Ho Lee, Cho Rim Kim, Yong Chan Cho, Se-Na Kim, Byung Hwi Kim, Cheol Lee, Han Bi Ji, Jae Hoon Han, Chun Gwon Park, HyeonJi Hong, Young Bin Choy
Summary: The study introduces a magnetically actuating implantable pump that can accurately infuse human growth hormone without the need for repeated injections, representing a potential non-invasive treatment approach.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Medicinal
Pankaj Bhateja, Rajesh Asija, Yogendra Singh, Mona Piplani
Summary: The conventional drug delivery system provides limited control on drug release, resulting in changing and unpredictable plasma concentrations. Osmotic drug delivery systems, utilizing osmotic pressure, offer a more optimized and controlled release of active pharmaceutical ingredients. Factors such as osmotic pressure, drug solubility, and the size of the delivery orifice, as well as the semipermeable membrane characteristics, influence drug release from these systems. This manuscript aims to study the working principles, limitations, and novel approaches of osmotic pumps, providing a comprehensive understanding of the osmotic drug delivery system.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Article
Pharmacology & Pharmacy
Elise Pape, Astrid Pinzano, Christel Henrionnet, Julien Scala-Bertola, Pierre Gillet, Nicolas Gambier
Summary: Intra-articular injection of rapamycin-loaded nanoparticles shows biocompatibility and extended residency in the synovial joint, leading to reduced blood levels and decreased systemic exposure to the drug.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Stephanie A. Roydhouse, Jane E. Carland, Deborah S. Debono, Melissa T. Baysari, Stephanie E. Reuter, Alice J. Staciwa, Anmol P. K. Sandhu, Richard O. Day, Sophie L. Stocker
Summary: The study found discrepancies between actual and documented administration times for antimicrobial infusions, with no significant impact from day of the week, time of day, or nurse-to-patient ratio. Night administrations had smaller discrepancies, and antimicrobials with shorter half-lives showed less variation in documented times.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Julia Georgieva, Moriah Katt, Zhou Ye, Benjamin J. Umlauf, Cody J. Wenthur, Eric Shusta
Summary: The restrictive nature of the brain vasculature limits the exposure of central nervous system (CNS) to blood-borne biotherapeutics. The use of receptor-mediated transcytosis (RMT) mechanisms in blood-brain barrier endothelial cells can increase the bioavailability of such therapeutics. The antibody 46.1 has been identified to accumulate in the mouse brain and can deliver drug cargo to the CNS, primarily through the cavernous sinus-arterial route.
Article
Pharmacology & Pharmacy
Marites P. Melancon, Steven Yevich, Rony Avritscher, Adam Swigost, Linfeng Lu, Li Tian, Jossana A. Damasco, Katherine Dixon, Andrea C. Cortes, Nina M. Munoz, Dong Liang, David Liu, Alda L. Tam
Summary: A novel nanoemulsion combining irinotecan with lipiodol showed higher irinotecan deposition in the liver via TACE and more irinotecan distribution in the tumor via PVCE compared to traditional delivery methods, demonstrating promising potential for the treatment of metastatic colorectal cancer.
Article
Oncology
Ryoichi Fukumura, Ariunbuyan Sukhbaatar, Radhika Mishra, Maya Sakamoto, Shiro Mori, Tetsuya Kodama
Summary: The study found that the osmotic pressure and viscosity of the solvent affected the antitumor effect of cisplatin in a mouse model of lymph node metastasis, with high osmotic pressure and viscosity enhancing drug retention and flow in the lymph nodes, potentially improving the effectiveness of anticancer drugs delivered through the lymphatic drug delivery system.
Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Review
Chemistry, Multidisciplinary
Marco Uboldi, Alice Melocchi, Saliha Moutaharrik, Luca Palugan, Matteo Cerea, Anastasia Foppoli, Alessandra Maroni, Andrea Gazzaniga, Lucia Zema
Summary: Targeted drug delivery in specific sites of the upper GI tract is crucial for effective treatment, especially in chronic diseases. The traditional gastroretentive systems have been widely used, while the development of novel drug delivery systems focuses on injectable oral administration.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Faiza Benaouda, Ricardo Inacio, Chui Hua Lim, Haeeun Park, Thomas Pitcher, Mohamed A. Alhnan, Mazen M. S. Aly, Khuloud Al-Jamal, Ka-lung Chan, Rikhav P. Gala, Daniel Sebastia-Saez, Liang Cui, Tao Chen, Julie Keeble, Stuart A. Jones
Summary: This study demonstrates a novel method for needleless delivery of advanced therapies using a skin patch. By opening the skin appendages with a hypobaric chamber, direct delivery of vaccine antigens and drug nanoparticles was achieved. The patch was shown to enhance immune response to vaccine antigens and effectively reduce rat paw swelling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Rachel J. Kulchar, Rahul Singh, Suwan Ding, Elena Alexander, Henry Daniell, Kam W. Leong
Summary: Biologics are often unaffordable due to high costs of fermentation, purification, and cold chain requirements. During the pandemic, limitations in production and delivery systems were evident, with a small percentage of vaccines reaching low-income countries and doses being wasted due to lack of cold-chain infrastructure. Most FDA-approved biologics are delivered invasively, while oral or topical drugs are preferred by patients. However, only a few oral drugs have been approved since 2015. The recent launch of an oral biologic with significantly reduced costs highlights the potential for simplified regulatory processes. Topical delivery offers targeted delivery of high concentration protein drugs, but there are limited FDA-approved options. This review discusses advancements in oral and topical delivery methods and suggests future directions for research.
Article
Biochemistry & Molecular Biology
Joost C. van den Born, Anne-Roos S. Frenay, Anne M. Koning, Matthias Bachtler, Ineke J. Riphagen, Isidor Minovic, Martin Feelisch, Marinda M. Dekker, Marian L. C. Bulthuis, Ron. T. Gansevoort, Jan-Luuk Hillebrands, Andreas Pasch, Stephan J. L. Bakker, Harry van Goor
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Endocrinology & Metabolism
Lucas M. Wiggenhauser, Haozhe Qi, Sandra J. Stoll, Lena Metzger, Katrin Bennewitz, Gernot Poschet, Guido Krenning, Jan-Luuk Hillebrands, Hans-Peter Hammes, Jens Kroll
Article
Endocrinology & Metabolism
Peter R. van Dijk, Andreas Pasch, Sonja L. Van Ockenburg-Brunet, Femke Waanders, A. Eman Abdulle, Marian J. Muis, J. L. Hillebrands, Henk J. G. Bilo, Harry van Goor
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Endocrinology & Metabolism
Peter R. van Dijk, Femke Waanders, Andreas Pasch, Susan J. J. Logtenberg, Titia Vriesendorp, Klaas H. Groenier, Jan-Luuk Hillebrands, Nanno Kleefstra, Rijk O. B. Gans, Harry van Goor, Henk J. G. Bilo
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Cardiac & Cardiovascular Systems
Salva R. Yurista, Herman H. W. Sillje, Harry van Goor, Jan-Luuk Hillebrands, Hiddo J. L. Heerspink, Luiz de Menezes Montenegro, Silke U. Oberdorf-Maass, Rudolf A. de Boer, B. Daan Westenbrink
CARDIOVASCULAR DRUGS AND THERAPY
(2020)
Article
Pharmacology & Pharmacy
Emilia Bigaeva, Nataly Puerta Cavanzo, Elisabeth G. D. Stribos, Amos J. de Jong, Carin Biel, Henricus A. M. Mutsaers, Michael S. Jensen, Rikke Norregaard, Anna M. Leliveld, Igle J. de Jong, Jan-Luuk Hillebrands, Harry van Goor, Miriam Boersema, Ruud A. Bank, Peter Olinga
Article
Biochemistry & Molecular Biology
Alexandra M. Smink, Avid Najdahmadi, Michael Alexander, Shiri Li, Samuel Rodriquez, Harry van Goor, Jan-Luuk Hillebrands, Elliot Botvinick, Jonathan R. T. Lakey, Paul de Vos
Article
Hematology
Coby Eelderink, Charlotte A. te Velde-Keyzer, Anne-Roos S. Frenay, Emma A. Vermeulen, Matthias Bachtler, Parisa Aghagolzadeh, Peter R. van Dijk, Ronald T. Gansevoort, Marc G. Vervloet, Jan-Luuk Hillebrands, Stephan J. L. Bakker, Harry van Goor, Andreas Pasch, Martin H. de Borst
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Melanie Reijrink, Stefanie A. de Boer, Ines F. Antunes, Daan S. Spoor, Hiddo J. L. Heerspink, Monique E. Lodewijk, Mirjam F. Mastik, Ronald Boellaard, Marcel J. W. Greuter, Stan Benjamens, Ronald J. H. Borra, Riemer H. J. A. Slart, Jan-Luuk Hillebrands, Douwe J. Mulder
Summary: This study investigated the role of insulin resistance and inflammation in [F-18]FDG uptake in adipose tissue of patients with type 2 diabetes. The results showed that in vivo VAT [F-18]FDG uptake was negatively correlated with HOMA-IR and positively correlated with adiponectin levels, while ex vivo VAT [F-18]FDG uptake was associated with GLUT4 expression.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Stan Benjamens, Ines F. Antunes, Jan-Luuk Hillebrands, Melanie Reijrink, Marian L. C. Bulthuis, Stefan P. Berger, Cyril Moers, Martin H. de Borst, Riemer H. J. A. Slart, Robert A. Pol
Summary: Nephrocalcinosis is common in kidney transplant recipients and is associated with poor graft outcomes. In this study, [F-18]-sodium fluoride imaging was used to detect microcalcifications in donor and transplanted kidneys, revealing higher tracer activity in transplanted kidneys. The correlation between [F-18]-NaF uptake and histology-proven microcalcifications could potentially lead to a better understanding of the impact of microcalcifications on kidney transplant function.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Lydian A. Huisman, Pieter J. Steinkamp, Jan-Luuk Hillebrands, Clark J. Zeebregts, Matthijs D. Linssen, Annelies Jorritsma-Smit, Riemer H. J. A. Slart, Gooitzen M. van Dam, Hendrikus H. Boersma
Summary: VEGF-A is believed to be involved in the development and rupture of vulnerable plaques in the atherosclerotic process. Using a VEGF-A targeted fluorescent antibody, researchers were able to visualize the distribution of VEGF-A in carotid plaques ex vivo and found more intense fluorescent signals in the culprit plaques compared to non-culprit plaques. Cross-correlation with VEGF-A immunohistochemistry showed co-localization of VEGF-A over-expression in most culprit plaques, suggesting potential for visualizing VEGF-A overexpression in atherosclerotic plaques in vivo.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Rik Mencke, Amarens van der Vaart, Andreas Pasch, Geert Harms, Femke Waanders, Henk J. G. Bilo, Harry van Goor, Jan-Luuk Hillebrands, Peter R. van Dijk
Summary: The study found that in patients with type 2 diabetes, serum T-50 values were closely related to factors such as gender, smoking, blood sugar control, blood pressure, insulin use, and diabetes history, but not related to cardiovascular event history or microvascular disease. This indicates that serum calcification propensity is independently associated with glycemic control in diabetic patients, suggesting that lower HbA1c levels may be associated with better cardiovascular outcomes. Prospective studies are needed to further investigate the relationship between T-50 and a history of macrovascular events.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Surgery
Timna Agur, Johannes Wedel, Sayantan Bose, A. G. Pramoda Sahankumari, Daniel Goodman, Sek Won Kong, Chandra C. Ghosh, David M. Briscoe
Summary: The study demonstrates the impact of mevalonate on the immunoregulatory phenotype of endothelial cells and the inhibitory effect of simvastatin on mevalonate metabolism, leading to decreased T cell proliferation and pro-inflammatory cytokine production. These findings suggest the critical role of mevalonate metabolism in sustaining endothelial cell-dependent immune mechanisms.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Immunology
Stan Benjamens, Ines F. Antunes, Jan-Luuk Hillebrands, Stefan P. Berger, Martin H. de Borst, Riemer H. J. A. Slart, Robert A. Pol
Meeting Abstract
Physiology
Marloes Sol, Paul van der Leest, Jiedong Qiu, Johan van der Vlag, Jaap van den Born, Benito Yard, Jan-Luuk Hillebrands, Jan A. A. M. Kamps, Guido Krenning
JOURNAL OF VASCULAR RESEARCH
(2019)