Article
Materials Science, Multidisciplinary
Zeeshan Iqbal, H. A. Shah, M. N. S. Qureshi, W. Masood, Amna Fayyaz
Summary: The propagation of nonlinear coupled drift ion acoustic shock wave in an electron-positron-ion plasma is investigated in the presence of fully degenerate adiabatically trapped electrons. A novel complex nonlinear equation with fractional nonlinear terms is formulated and the phase plane theory of planar dynamical system is applied to study this equation. The results show the existence of a pair of shock structures, which is the most significant finding of this work.
RESULTS IN PHYSICS
(2022)
Article
Chemistry, Analytical
Rui Zheng, Carl Brunius, Lin Shi, Huma Zafar, Linda Paulson, Rikard Landberg, Asa Torinsson Naluai
Summary: Optimal handling is crucial for ensuring adequate sample quality. This study utilized LC-MS metabolomics to predict and evaluate the impact of pre-centrifugation temperature and delay time on plasma samples. Results showed that metabolite profiles were rapidly affected by pre-centrifugation delay at all temperatures, emphasizing the importance of minimizing pre-centrifugation delay for accurate metabolomics analysis.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Brad Ebanks, Ying Wang, Gunjan Katyal, Chloe Sargent, Thomas L. Ingram, Antonia Bowman, Nicoleta Moisoi, Lisa Chakrabarti
Summary: Ageing is a major risk factor for prevalent diseases, and as the global population ages, behavioural interventions that promote healthy ageing can improve quality of life and reduce the socioeconomic burden. Experimentation revealed that age-targeted exercise interventions improved lifespan in fruit flies, with significant increases in complex-II-linked respiration observed in exercised individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Hayley A. Scott, Lisa G. Wood, Evan J. Williams, Natasha Weaver, John W. Upham
Summary: This study compares acute changes in airway and systemic inflammation in physically inactive adults with asthma after a bout of moderate or vigorous exercise. The study found that moderate exercise can reduce eosinophilic airway inflammation, while vigorous exercise has no effect on airway inflammation. Furthermore, the anti-inflammatory effects of moderate exercise are more prominent in participants with eosinophilic asthma.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Genetics & Heredity
Daniel Schmitz, Zhiwei Li, Valeria Lo Faro, Mathias Rask-Andersen, Adam Ameur, Nima Rafati, Asa Johansson
Summary: This study characterized CNVs in a Swedish cohort using whole-genome sequencing and identified CNVs associated with plasma proteins. Validations were done using long-read sequencing. The findings provide insights into the structure and effects of common CNVs on the plasma proteome.
Article
Physics, Applied
Jhon F. Pazos Ospina, Victor Contreras, Jordan Estrada-Morales, Diego Baresch, Joao Luis Ealo, Karen Volke-Sepulveda
Summary: The behavior of particles in an ultrasonic wave depends on their size. Particles within certain size ranges are trapped on the axis, while particles in other size ranges are trapped off the axis. This behavior is related to the sign of the radiation force, which can result in maximum or zero force and trapping stiffness for specific sizes.
PHYSICAL REVIEW APPLIED
(2022)
Article
Physics, Multidisciplinary
G. H. Soliman, M. A. Zahran, I. S. Elkamash
Summary: The study investigates the influence of resonant wave-particle interactions on the characteristics of dust acoustic waves in opposite polarity dust plasma. The results demonstrate the presence of dust acoustic modes in both linear and non-linear regimes and the successful derivation of the stationary solution in the form of a dust acoustic double-layer wave. These findings are highly relevant to astrophysical plasma environments with non-thermal trapped and reflected particles.
Article
Mechanics
Haifa A. Alyousef, Aamir Khan, Ata-ur-Rahman, S. A. El-Tantawy
Summary: Laser or electromagnetic radiation generates orbital angular momentum (OAM) in plasma due to its polarization effects. The study investigates dust-ion-acoustic waves (DIAWs) with static dust particles and the rotational effects caused by laser or electromagnetic interaction. Fluid theory is used to obtain the linear paraxial equation for ion density perturbations and Gaussian and Laguerre Gaussian (LG) beam solutions are discussed, with LG beams being the source of OAM. The electric field components with respect to the LG potential are calculated by determining the electrostatic potential for linear waves. The numerical results demonstrate that the Laguerre Gauss mode varies significantly with changes in plasma parameters, such as the electron superthermality parameter, mode numbers, beam waist, and azimuthal angle. These findings are important for understanding the excitation of dust-ion-acoustic waves by Brillouin backscattering of laser light in plasma.
Review
Rehabilitation
Ana Torres-Costoso, Vicente Martinez-Vizcaino, Sara Reina-Gutierrez, Celia Alvarez-Bueno, Maria Jose Guzman-Pavon, Diana P. Pozuelo-Carrascosa, Ruben Fernandez-Rodriguez, Mairena Sanchez-Lopez, Ivan Cavero-Redondo
Summary: This study conducted a network meta-analysis to determine the positive influence of physical exercise on multiple sclerosis fatigue, with combined exercise and resistance training showing the most significant effects on fatigue improvement, particularly in physical and total fatigue. Exercise should be considered an effective strategy in managing fatigue among individuals with MS.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Gastroenterology & Hepatology
Arno R. Bourgonje, Shixian Hu, Lieke M. Spekhorst, Daria Zhernakova, Arnau Vich Vila, Yanni Li, Michiel D. Voskuil, Lisette A. van Berkel, Brenda Bley Folly, Mohammed Charrout, Ahmed Mahfouz, Marcel J. T. Reinders, Julia I. P. van Heck, Leo A. B. Joosten, Marijn C. Visschedijk, Hendrik M. van Dullemen, Klaas Nico Faber, Janneke N. Samsom, Eleonora A. M. Festen, Gerard Dijkstra, Rinse K. Weersma
Summary: This study reveals a strong association between genotype and multiple disease phenotypes with the plasma inflammatory proteome in patients with IBD, identifying disease-associated pathways that may help improve disease management in the future.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Veterinary Sciences
Rachel L. L. Jones, Steven W. W. Frederick, Alan R. R. Cross
Summary: This study aimed to determine which aspiration technique increased plasma platelet concentration and minimized plasma leukocyte and erythrocyte concentrations using a gravitational double-syringe platelet rich plasma (PRP) system.
VETERINARY SURGERY
(2023)
Article
Nutrition & Dietetics
Alexandria Davies, Ashley Paul Akerman, Nancy Jane Rehrer, Simon N. N. Thornton, James David Cotter
Summary: This study investigated the effects of dehydration induced by active or passive heat stress and compared the kinetics of ad libitum rehydration following each method. The results showed that mild dehydration caused comparable increases in plasma osmolality and reductions in plasma volume regardless of the heat stress method. Heat stress itself had a greater impact on hypovolemia than dehydration, while ingesting water to maintain euhydration resulted in significant reductions in plasma osmolality during recovery.
Article
Veterinary Sciences
Francisco Escalera-Valente, Marta E. Alonso, Juan M. Lomillos, Vicente R. Gaudioso, Angel J. Alonso, Jose Ramiro Gonzalez-Montana
Summary: The study assessed plasma minerals concentration in Lidia bulls after intense physical exercise during a bull fight. It was found that calcium, phosphorus, magnesium levels were higher than reported reference values, while cobalt, selenium, and molybdenum levels were lower than other bovine breeds.
VETERINARY SCIENCES
(2021)
Article
Clinical Neurology
Patricia Mulero, Sergio Maroto-Izquierdo, Natan Redondo, Hugo Gonzalo-Benito, Alba Chavarria-Miranda, Hugo Calvo, Maria I. Cabero, Marita Hernandez, Maria Luisa Nieto, Nieves Tellez
Summary: Multiple sclerosis (MS) is a dysimmune and neurodegenerative disease of the central nervous system that remains a major cause of non-traumatic disability in young people. This longitudinal study examines the effects of a short-term training program on neurofilament plasma levels, a biomarker of axonal destruction, in MS patients. The study finds that a 6-week resistance-training program leads to a significant decrease in plasma neurofilament levels, suggesting a neuroprotective effect of resistance training in this population.
NEUROLOGICAL SCIENCES
(2023)
Review
Behavioral Sciences
Brittany Intzandt, Tudor Vrinceanu, Julia Huck, Thomas Vincent, Manuel Montero-Odasso, Claudine J. Gauthier, Louis Bherer
Summary: This study critically and systematically compared cognitive training (CT) and exercise training (ET) on brain MRI outcomes in healthy older adults. Results showed that CT improved white matter microstructure, while ET enhanced macrostructural changes, and both interventions had effects on task-based BOLD signal changes. Beneficial effects on cognitive and cerebral outcomes were observed across almost all studies, regardless of the intervention type.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Paulina Bryl-Gorecka, Kreema James, Kristina Torngren, Inger Haraldsson, Li-Ming Gan, Sara Svedlund, Bjorn Olde, Thomas Laurell, Elmir Omerovic, David Erlinge
Summary: Our study revealed a negative correlation between MV levels and CFR values, with higher levels of platelet and endothelial MVs in the low CFR group. The concentration of proatherogenic proteins in MVs was higher in the low CFR group, suggesting a potential clinical value of MVs as biomarkers for vascular dysfunction and poor prognosis, in addition to CFR.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
John Ly, David Minarik, Jonas Jogi, Per Wollmer, Elin Tragardh
Summary: The study introduced an AI-based method to enhance [F-18]FDG-PET images, improving image quality by reducing noise and increasing contrast. Results showed that the AI-enhanced images performed better in terms of noise and contrast, while maintaining stability in maximum and peak standardized uptake values compared to standard images. The method has the potential to provide better images to nuclear medicine physicians or reduce acquisition time/administered activity.
Correction
Multidisciplinary Sciences
Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Rik Ossenkoppele, Ruben Smith, Niklas Mattsson-Carlgren, Colin Groot, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Tomas Olsson, Jonas Jogi, Erik Stormrud, Hanna Cho, Young Hoon Ryu, Jae Yong Choi, Adam L. Boxer, Maria L. Gorno-Tempini, Bruce L. Miller, David Soleimani-Meigooni, Leonardo Iaccarino, Renaud La Joie, Suzanne Baker, Edilio Borroni, Gregory Klein, Michael J. Pontecorvo, Michael D. Devous, William J. Jagust, Chul Hyoung Lyoo, Gil D. Rabinovici, Oskar Hansson
Summary: This study demonstrates the prognostic accuracy of tau PET in predicting cognitive changes, which is superior to MRI and amyloid PET markers, supporting the prognostic process in early stages of Alzheimer's disease.
Letter
Cardiac & Cardiovascular Systems
Paulina Bryl-Gorecka, Bjorn Olde, David Erlinge
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mariam Al-Mashat, Rasmus Borgquist, Marcus Carlsson, Hakan Arheden, Jonas Jogi
Summary: The evaluation of cardiac resynchronization therapy (CRT) in heart failure patients showed that changes in perfusion gradients from ventilation/perfusion single-photon emission computed tomography (V/P SPECT) were associated with improvements in NYHA classification, rather than changes in end-systolic volume (LVESV) from echocardiography. Monitoring perfusion gradients from V/P SPECT may be a more promising measure of left-sided filling pressure in assessing CRT response in heart failure patients.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Clinical Neurology
Antoine Leuzy, Ruben Smith, Nicholas C. Cullen, Olof Strandberg, Jacob W. Vogel, Alexa Pichet Binette, Edilio Borroni, Shorena Janelidze, Tomas Ohlsson, Jonas Jogi, Rik Ossenkoppele, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Gregory Klein, Erik Stomrud, Oskar Hansson
Summary: This study investigated longitudinal tau PET findings across the clinical continuum of Alzheimer's disease and identified biomarker combinations with strong associations for predicting longitudinal tau PET, aiming to optimize clinical trial enrichment strategies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristian Valind, Jonas Jogi, David Minarik, Gustav Brolin, Elin Tragardh
Summary: Renal [F-18]PSMA-1007 PET-CT with imaging at 2 hours post-injection provides acceptable image quality, consistent split renal uptake, and allows for reduction in administered activity. The study demonstrates feasibility of using [F-18]PSMA-1007 PET-CT for renal imaging and suggests potential for dose optimization.
Article
Physiology
Tom Gyllenhammar, Marcus Carlsson, Jonas Jogi, Hakan Arheden, Henrik Engblom
Summary: This study found that patients with suspected microvascular angina have lower global myocardial perfusion during stress compared with healthy controls but higher than patients with coronary artery disease. Additionally, there appears to be a sex difference in global myocardial perfusion during stress, with females having higher perfusion levels. This suggests the need for sex-specific normal limits when assessing quantitative myocardial perfusion.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2022)
Article
Medicine, General & Internal
Elin Tragardh, Olof Enqvist, Johannes Ulen, Jonas Jogi, Ulrika Bitzen, Fredrik Hedeer, Kristian Valind, Sabine Garpered, Erland Hvittfeldt, Pablo Borrelli, Lars Edenbrandt
Summary: The aim of this study was to develop an artificial intelligence (AI)-based method for the detection and quantification of prostate tumours, local recurrence, lymph node metastases, and bone metastases. The AI method was compared to manual segmentations performed by nuclear medicine physicians. The results showed that the AI method had a sensitivity comparable to that of the physicians.
Article
Physiology
Kristian Valind, Jonas Jogi, David Minarik, Elin Tragardh
Summary: This study aimed to investigate the relationship between renal uptake of [F-18]PSMA-1007 and estimated glomerular filtration rate (eGFR). PET image analysis revealed a significant correlation between standardized uptake value (SUVmean) and segmentation volume of the kidneys with eGFR, indicating that [F-18]PSMA-1007 uptake parameters can serve as indicators of renal cortical function.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander F. Santillo, Antoine Leuzy, Michael Honer, Maria Landqvist Waldo, Pontus Tideman, Luke Harper, Tomas Ohlsson, Svenja Moes, Lucia Giannini, Jonas Jogi, Colin Groot, Rik Ossenkoppele, Olof Strandberg, John van Swieten, Ruben Smith, Oskar Hansson
Summary: The uptake of [F-18]RO948 is not significantly increased in the majority of FTD patients, with the exception of specific MAPT mutations. The observed tracer retention does not overlap with the cortical atrophy, expected pattern of atrophy, or verified protein pathology distribution.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Rik Ossenkoppele, Alexa Pichet Binette, Colin Groot, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Pontus Tideman, Tomas Ohlsson, Jonas Jogi, Keith Johnson, Reisa Sperling, Vincent Dore, Colin L. Masters, Christopher Rowe, Denise Visser, Bart N. M. van Berckel, Wiesje M. van der Flier, Suzanne Baker, William J. Jagust, Heather J. Wiste, Ronald C. Petersen, Clifford R. Jack, Oskar Hansson
Summary: Abnormal amyloid and tau PET in cognitively unimpaired individuals is strongly associated with short-term cognitive decline and subsequent development of dementia.
Article
Clinical Neurology
Ruben Smith, Douglas Hagerstrom, Daria Pawlik, Gregory Klein, Jonas Jogi, Tomas Ohlsson, Erik Stomrud, Oskar Hansson
Summary: This study aimed to determine the clinical value of tau positron emission tomography (PET) in the diagnosis of Alzheimer's disease (AD). The results showed that the addition of tau PET to the diagnostic workup led to changes in diagnosis and medication, and significantly increased the certainty of underlying etiology.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristian Valind, David Minarik, Sabine Garpered, Eva Persson, Jonas Jogi, Elin Tragardh
Summary: This study aimed to compare [F-18]PSMA-1007 PET with [(99)mTc]Tc-DMSA SPECT in patients with prostate cancer regarding split renal uptake and renal uptake defects. The results showed that [F-18]PSMA-1007 PET is comparable to [(99)mTc]Tc-DMSA SPECT in detecting uptake defects and the measurements of split renal function are strongly correlated between the two imaging modalities.
EUROPEAN JOURNAL OF HYBRID IMAGING
(2023)