Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments

First human dose escalation study in patients with metastatic malignancies to determine safety and pharmacokinetics of LY2157299, a small molecule inhibitor of the transforming growth factor-beta receptor I kinase

(2017) E. Calvo-Aller et al.   JOURNAL OF CLINICAL ONCOLOGY

Collagen microsphere production on a chip

(2012) Sungmin Hong et al.   LAB ON A CHIP

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis

(2012) Nathan E. Reticker-Flynn et al.   Nature Communications

Development and optimization of a dual-photoinitiator, emulsion-based technique for rapid generation of cell-laden hydrogel microspheres

(2011) C.L. Franco et al.   Acta Biomaterialia

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Bioconjugation of hydrogels for tissue engineering

(2011) Esmaiel Jabbari   CURRENT OPINION IN BIOTECHNOLOGY

High-throughput combinatorial cell co-culture using microfluidics

(2011) Ethan Tumarkin et al.   Integrative Biology

DNA-templated assembly of droplet-derived PEG microtissues

(2011) Cheri Y. Li et al.   LAB ON A CHIP

Suppression of lung adenocarcinoma progression by Nkx2-1

(2011) Monte M. Winslow et al.   NATURE

Multiplexed, high-throughput analysis of 3D microtissue suspensions

(2010) Alice A. Chen et al.   Integrative Biology

Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing

(2010) Linfen Yu et al.   LAB ON A CHIP

Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering

(2010) Colin K. Choi et al.   TRENDS IN CELL BIOLOGY

Beating Poisson encapsulation statistics using close-packed ordering

(2009) Adam R. Abate et al.   LAB ON A CHIP

Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement

(2009) C. Fischbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of Polymerizable Superoxide Dismutase Mimetics to Reduce Reactive Oxygen Species Damage in Transplanted Biomedical Devices

(2008) Charles Y. Cheung et al.   ADVANCED FUNCTIONAL MATERIALS

Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers

(2008) Alice A. Chen et al.   BIOMATERIALS

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Stop-flow lithography to generate cell-laden microgel particles

(2008) Priyadarshi Panda et al.   LAB ON A CHIP

Controlled encapsulation of single-cells into monodisperse picolitre drops

(2008) Jon F. Edd et al.   LAB ON A CHIP

Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor–β Signaling

(2007) Yasushi Shintani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY