期刊
LAB ON A CHIP
卷 13, 期 16, 页码 3183-3187出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc50276g
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资金
- NIH [R01 GM086727]
- NIH NIBIB Kirschstein Predoctoral Fellowship [F31 EB008330]
- US Department of Energy, Office of Basic Energy Sciences [DE-AC02-06CH11357]
- UIUC
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [F31EB008330] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM086727, P01GM077596] Funding Source: NIH RePORTER
We report a microfluidic approach for de novo protein structure determination via crystallization screening and optimization, as well as on-chip X-ray diffraction data collection. The structure of phosphonoacetate hydrolase (PhnA) has been solved to 2.11 angstrom via on-chip collection of anomalous data that has an order of magnitude lower mosaicity than what is typical for traditional structure determination methods.
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