Review
Biochemistry & Molecular Biology
Eleonore Froehlich, Richard Wahl
Summary: Thyroid-stimulating hormone (TSH) and thyroid hormone levels are important parameters in blood analysis, but immunoassays used may produce inaccurate results due to interference from certain materials in the sample. Macro-TSH, a complex of TSH with immunoglobulin or albumin, can lead to falsely elevated TSH concentrations. While less well-known, PT-TSH plays a significant role in central regulation of thyroid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Xin Zhou, Zaishuan Liu, Yining Ma, Chongwei Zhang, Yongkang Wu
Summary: The developed mathematical algorithm allows for harmonizing TSH measurements between different instruments, enabling comparability of TSH data across laboratories.
CLINICA CHIMICA ACTA
(2023)
Article
Endocrinology & Metabolism
Jinyun Wang, Dingwei Liu, Yong Xie
Summary: The study found that high levels of thyroid stimulating hormone are associated with H. pylori infection, especially among male, overweight, and elderly individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Molla Mesele Wassie, Lisa Gaye Smithers, Shao Jia Zhou
Summary: This study systematically reviewed the associations between newborn TSH and childhood neurodevelopment and growth. Findings showed a negative association between newborn TSH and cognitive development in iodine deficient populations, while a null association was found in iodine sufficient populations. Null association was observed between TSH and psychomotor development regardless of iodine status.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Geriatrics & Gerontology
Madeleen Bosma, Robert S. Du Puy, Bart E. P. B. Ballieux
Summary: By comparing fT4-based screening with TSH-based screening, our study suggests that screening for thyroid dysfunction in older individuals in primary care can be improved by using fT4 or adjusting the TSH cutoff value. This could potentially reduce costs and minimize unnecessary monitoring for patients.
Article
Chemistry, Analytical
Yan Man, Meijing Ban, Xinxin Jin, An Li, Jing Tao, Ligang Pan
Summary: A portable and equipment-free microfluidic aptasensor was developed for on-site quantitative detection of Salmonella. This aptasensor utilized microcolumns-based vortex micromixing and incubation, nitrocellulose membranes with single-strand binding proteins (SSBP-NCMs) for enrichment and separation, and distance-readout for visual quantitative detection. The aptasensor showed good specificity and reliability, and could detect Salmonella typhimurium as low as 3.7 x 101 cfu mL-1.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Weiming Lin, Liwen Yuan, Zehang Gao, Gaozhe Cai, Cheng Liang, Min Fan, Xianjie Xiu, Zufang Huang, Shilun Feng, Jing Wang
Summary: A chip-based surface-enhanced Raman spectroscopy (SERS) platform was proposed for comprehensive characterization of tumor-derived extracellular vesicles (EVs). The platform exhibited sensitive detection capability and the ability to differentiate EVs from different cell lines.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biochemistry & Molecular Biology
Krzysztof Kaliszewski, Dorota Diakowska, Marta Rzeszutko, Lukasz Nowak, Beata Wojtczak, Krzysztof Sutkowski, Maksymilian Ludwig, Bartlomiej Ludwig, Maria Greniuk, Urszula Tokarczyk, Jerzy Rudnicki
Summary: This study found that preoperative serum TSH levels are associated with cytological and histopathological diagnosis of thyroid nodules. Patients with AUS/FLUS diagnosis had significantly higher TSH concentrations than those with benign tumors. Serum TSH levels can serve as a prognostic factor for predicting the risk of malignancy in patients with thyroid nodules.
Article
Multidisciplinary Sciences
Hosu Kim, Jaehoon Jung, Young-Seok Cho, Joon Young Choi, Hyunju Park, You-Bin Lee, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim
Summary: This study examined the relationship between preoperative TSH levels and the prognosis of DTC by analyzing clinical records of patients at a medical center. Results showed a linear association between preoperative TSH levels and extra-thyroidal extension and lymph node metastasis, while primary tumor size and initial distant metastasis exhibited a bimodal pattern. The study provides insights into the complex relationship between preoperative TSH levels and DTC prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Samaneh Nakhaee, Maryam Rezayee, Borhan Mansouri, Ali Hadianfar, Alireza Amirabadi Zadeh, Mahmoud Zardast, Malihe Parsa Sefat, Omid Mehrpour
Summary: This study found that lead poisoning affects thyroid function, reducing TSH levels and increasing T4 levels. The linear regression model results showed a significant difference between the two groups in terms of T3 and TSH levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Nutrition & Dietetics
Klara Gustin, Marie Vahter, Malin Barman, Bo Jacobsson, Helena Skroder, Helena Filipsson Nystrom, Anna Sandin, Ann-Sofie Sandberg, Agnes E. Wold, Maria Kippler
Summary: This study assessed the associations between thyroid hormones and the combined status of iodine, selenium, and zinc in pregnant women. The results showed a positive correlation between the joint status of these micronutrients and plasma TSH concentrations, with zinc and selenium having a greater influence on hormone concentrations compared to iodine. This study highlights the importance of considering multiple micronutrients in studies of thyroid hormone status.
JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Mirjana Babic Leko, Iva Juresko, Iva Rozic, Nikolina Pleic, Ivana Gunjaca, Tatijana Zemunik
Summary: Vitamin D is important for the normal functioning of organs, including the thyroid. Vitamin D deficiency is considered a risk factor for thyroid disorders, but the interaction between vitamin D and thyroid function is not fully understood. Studies comparing vitamin D status with thyroid function and the effect of vitamin D supplementation show inconsistent results, making it difficult to draw a definite conclusion. Additional studies with larger sample sizes are needed to fully understand the effect of vitamin D on thyroid function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yeqing Gu, Zimin Song, Qingkui Li, Jinhan Wang, Yanqi Song, Ge Meng, Hongmei Wu, Shunming Zhang, Xuena Wang, Juanjuan Zhang, Xinran Lu, Qiang Liu, Tao Huang, Jian Yang, Kaijun Niu
Summary: This study investigated the causal association between TSH levels and all-cause mortality using Mendelian randomization analysis. The results showed that higher TSH levels were associated with a lower risk of all-cause mortality, particularly respiratory disease mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemical Research Methods
Yunfeng Zai, Chao Min, Zunliang Wang, Yongjun Ding, Huan Zhao, Enben Su, Nongyue He
Summary: The COVID-19 pandemic has posed an unprecedented threat to the global health system, especially in resource-limited areas. This study presents a gravity-driven microfluidic cartridge design for rapid and sensitive viral RNA/DNA diagnostic testing without the need for auxiliary hardware. The system exhibited comparable detection performance to the gold standard qPCR instrument and showed high diagnostic accuracy, making it highly promising for infectious disease prevention and control in poor-resource areas.
Article
Endocrinology & Metabolism
Sarai M. Keestra, Irina Motoc, Anita C. J. Ravelli, Tessa J. Roseboom, Martijn J. J. Finken
Summary: This study found no differences in the incidence of adult thyroid disease at age 50 according to prenatal exposure to famine. However, women exposed to famine in mid gestation had slightly lower TSH levels than those not exposed, indicating potential sex-specific effects of famine exposure on thyroid axis regulation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
