Article
Chemistry, Multidisciplinary
Xian Chen, Yuan Ning, Shuting Pan, Bohua Liu, Ye Chang, Wei Pang, Xuexin Duan
Summary: A novel acoustic streaming tweezers-enabled microfluidic immunoassay was proposed, allowing for probe particles' purification, reaction, and sensing on the same chip under continuous-flow conditions. The high-speed microscale vortexes enable dynamic trapping and washing of the probe particles and enhance the capture efficiency of heterogeneous particle-based immunoassay through active mixing during trapping. This system achieved a limit of detection of 0.2 ng/mL and a dynamic response range from 0.3 to 10 ng/mL for prostate-specific antigen sensing with only 10 μL of sample in less than 15 minutes total assay time, making it suitable for on-site diagnosis applications.
Article
Multidisciplinary Sciences
Junfei Li, Chen Shen, Tony Jun Huang, Steven A. Cummer
Summary: Acoustic tweezers utilize a single pair of sources and a shadow waveguide to achieve complex particle trapping and manipulation in a boundary-free chamber, without the need for interior structures that would interfere with flow or transport.
Review
Chemistry, Analytical
Wei Wei, Yaping Wang, Zhaoxun Wang, Xuexin Duan
Summary: Acoustofluidics, a branch of microfluidics, has developed rapidly in recent decades, with applications in various biomedical and bioanalytical fields. The manipulation of liquids and bioparticles using acoustic pressure and acoustic streaming effects is the main focus of acoustofluidics. While the use of acoustic radiation force has been extensively studied, the recent development of new piezoelectric devices has sparked interest in particle manipulations using drag force induced by acoustic streaming. This review article summarizes the recent advancements in microscale acoustic streaming, including high-frequency transducer-induced high-speed streaming, confinement and programed streaming, and acoustic streaming tweezers, which combine acoustic radiation force and drag force to overcome size limitations in conventional acoustic manipulations. The article also provides a brief overview of acoustic streaming theory, its generation, applications, and key issues in the field. Lastly, the future prospects of micro acoustic streaming in bioanalytical and biomedical applications are discussed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Acoustics
Qinxin Zhou, Jing Zhang, Xuemei Ren, Zheng Xu, Xiaojun Liu
Summary: The study proposed a fast and cheap method to generate FAV beams in water using an ultrasonic holographic lens, achieving stable trapping and manipulation of particles. The formation of FAV beams comes from the superposition of different phases, creating a strong gradient around the beam axis.
Article
Physics, Applied
Qinlong Ren, Chenxing Liang, Zexiao Wang, Z. G. Qu
Summary: This study successfully achieved stable trapping and recovery rates of bacteria in a designed microfluidic chip device under appropriate parameter conditions using a new numerical simulation method, demonstrating the potential of continuous bacteria trapping from whole blood.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Acoustics
Jonas Helboe Joergensen, Henrik Bruus
Summary: This study presents an effective thermoviscous theory of acoustofluidics, including pressure acoustics, thermoviscous boundary layers, and streaming phenomena in fluids embedded in elastic cavities. By incorporating thermal fields, the effective model extends previous viscous theories and allows for numerical simulations of acoustofluidic systems. The research shows how acoustic streaming is influenced by thermal fields and material parameters, affecting both boundary conditions and body forces in the bulk.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Review
Biochemical Research Methods
Kirill Kolesnik, Mingxin Xu, Peter V. S. Lee, Vijay Rajagopal, David J. Collins
Summary: Acoustic fields are utilized in micromanipulation due to their biocompatibility and ability to generate force gradients at the scale of single cells. Recent advances have focused on improving the flexibility of applying acoustic fields, allowing for the generation of arbitrary arrangements of pressure fields, spatial localization of acoustic fields, and selective translation of individual particles. These developments open up a wide range of applications in tissue engineering, diagnostic devices, high-throughput sorting, and microfabrication.
Article
Engineering, Electrical & Electronic
Tao Peng, Mingyong Zhou, Shuai Yuan, Bingyan Jiang
Summary: This study demonstrates the application of bubble manipulation in lab-on-chip devices for particle manipulation. By utilizing surface tension and oscillating bubbles, particles can be focused, trapped, extracted, and enriched in a contact-free and continuous manner. The proposed bubble trapping method shows potential for broader applications in chemical, biology, and engineering fields.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Nanoscience & Nanotechnology
Raul Fernandez-Mateo, Victor Calero, Pablo Garcia-Sanchez, Antonio Ramos, Hywel Morgan
Summary: We present a user-friendly, open source software for detecting and counting single particles in a continuous-flow system. The software automatically processes video images of particles, including pre-conditioning and size-based discrimination for fluorescent and non-fluorescent particles of different sizes. It allows real-time quality control of the video files and provides concentration distribution of the particles in the fluid flow direction. This versatile tool is suitable for a wide range of microfluidic applications and does not require expertise in image analysis.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Article
Engineering, Civil
Mohamad Basel Al Sawaf, Kiyosi Kawanisi, Gillang Noor Nugrahaning Gusti, Faruq Khadami, Cong Xiao, Masoud Bahreinimotlagh
Summary: In this study, flood dynamics were monitored using the fluvial acoustic tomography system (FAT), and new equations were proposed to evaluate the expected flow direction. The results showed that the minimum number of acoustic stations required to determine river flow direction in unidirectional streams can be reduced to three, which is more practical and convenient. The study also provided new guidelines for continuously estimating flow direction using a triangular distribution of tomographic systems.
JOURNAL OF HYDROLOGY
(2023)
Article
Engineering, Chemical
Nana Yang, Fengxian Fan, Xiaohong Hu, Mingxu Su
Summary: The influence of seed particles on acoustic agglomeration was studied and it was found that the enhancement is mainly due to the acoustic wake effect. By comparing with other collision kernels, the results demonstrate that the acoustic field remarkably enhances the collision rate.
JOURNAL OF AEROSOL SCIENCE
(2022)
Article
Crystallography
Ningzhe Yan, Hao Luo, Yanan Liu, Haiping Yu, Guangyin Jing
Summary: This study investigates how nanostructures and their local chemical microenvironment dynamically affect the swimming motility of bacteria near surfaces. The results show that ZnO nanowire arrays reduce bacterial motility and ultraviolet irradiation further reduces bacterial locomotion.
Article
Mechanics
Shuren Song, Jia Zhou, Antonino Marciano, Antoine Riaud
Summary: This paper proposes a method of using acoustic streaming to link hydrodynamic filaments in fluids and demonstrates its effectiveness through experiments. The study shows that the inversion of flow chirality can be observed by increasing the topological charge of an acoustic screw dislocation.
Article
Chemistry, Multidisciplinary
Chong Huang, Zhao-Yu Li, Jinshuai Song, Hai-Chao Xu
Summary: This paper presents a catalyst- and reagent-free formal aza-Wacker type cyclization reaction for the synthesis of functionalized saturated N-heterocycles, conducted in a continuous-flow electrochemical reactor. The reactions exhibit broad tolerance of di-, tri-, and tetrasubstituted alkenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Acoustics
Yan-Chun Luo, Xin-Rui Li, Xing-Feng Zhu, Jie Yao, Da-Jian Wu
Summary: The interactions between two Bessel acoustic vortices (BAVs) with different topological charges (TCs) were thoroughly investigated. The results showed that by changing the TCs of the BAVs, the intensity distributions of the coupled-BAVs could switch between the petal mode, the acoustic dark lattice (ADL) mode, and the crescent mode. A well-designed composite spiral plate (CSP) was used to realize the ADL modes, which exhibited strong self-healing properties. Additionally, the CSP was employed to trap multiple micro-particles in water, demonstrating its potential applications in biomedicine.
Article
Biochemistry & Molecular Biology
Mariana Duarte, Prabal Subedi, Ecevit Yilmaz, Katrin Marcus, Thomas Laurell, Simon Ekstrom
JOURNAL OF MOLECULAR RECOGNITION
(2018)
Article
Chemistry, Analytical
Kevin Cushing, Eva Undvall, Yvonne Ceder, Hans Lilja, Thomas Laurell
ANALYTICA CHIMICA ACTA
(2018)
Review
Chemistry, Analytical
Karl Olofsson, Bjoern Hammarstroem, Martin Wiklund
Article
Acoustics
Zaid Shaglwf, Bjorn Hammarstrom, Dina Shona Laila, Martyn Hill, Peter Glynne-Jones
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2019)
Article
Acoustics
Davood Saeidi, Mohsen Saghafian, Shaghayegh Haghjooy Javanmard, Bjorn Hammarstrom, Martin Wiklund
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Angela Tait, Peter Glynne-Jones, Alison R. Hill, David E. Smart, Cornelia Blume, Bjorn Hammarstrom, Adam L. Fisher, Martin C. Grossel, Emily J. Swindle, Martyn Hill, Donna E. Davies
SCIENTIFIC REPORTS
(2019)
Article
Biotechnology & Applied Microbiology
Bjorn Hammarstrom, Massimo Vassalli, Peter Glynne-Jones
JOURNAL OF APPLIED PHYCOLOGY
(2020)
Article
Biology
Vincent O. Baron, Mingzhou Chen, Bjorn Hammarstrom, Robert J. H. Hammond, Peter Glynne-Jones, Stephen H. Gillespie, Kishan Dholakia
COMMUNICATIONS BIOLOGY
(2020)
Article
Biochemical Research Methods
Julian Mejia Morales, Bjorn Hammarstrom, Gian Luca Lippi, Massimo Vassalli, Peter Glynne-Jones
Summary: This study presents a low-cost device for registration-free quantitative phase microscopy (QPM) based on the transport of intensity equation, using acoustic focusing to align cells into a single plane and generate phase maps without the need to segment and register individual objects. By tilting the acoustic focusing plane with respect to the microscope's focal plane, cell images can be obtained at multiple focal positions, enabling a cost-effective and robust implementation of QPM. The device is tested on blood samples, demonstrating its ability to recover the phase map of single red blood cells flowing through the microchip.
Article
Acoustics
Bjorn Hammarstrom, Nils R. Skov, Karl Olofsson, Henrik Bruus, Martin Wiklund
Summary: This study introduces a novel concept for acoustic trapping of particles and cells, enabling dynamic trapping patterns in a simple and inexpensive setup by using a modified piezoelectric transducer in direct contact with the liquid sample. The system allows for dynamic arraying of levitated trapping sites at low power with potential applications in cell-based sample preparation and cell culture.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Chemistry, Analytical
Ksenia Loskutova, Karl Olofsson, Bjoern Hammarstroem, Martin Wiklund, Anna J. Svagan, Dmitry Grishenkov
Summary: In this study, the compressibility of droplets stabilized with cellulose nanofibers was estimated using acoustophoresis, showing a constant value across different droplet diameters. The results revealed a negative acoustic contrast factor for the droplets, indicating their relocation to pressure antinodes during ultrasonic actuation. The compressibility of the droplets was found to be higher than that of water but lower than that of pure perfluoropentane.
Article
Chemistry, Analytical
Bjorn Hammarstrom, Thomas J. Lane, Hazal Batili, Raymond Sierra, Martin Wiklund, Jonas A. Sellberg
Summary: Researchers developed an acoustic 2D focusing method for real-time online characterization of protein microcrystals, which improves the reliability and efficiency of serial femtosecond crystallography.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Bjorn Hammarstrom, Thomas J. Lane, Hazal Batili, Raymond Sierra, Martin Wiklund, Jonas A. Sellberg
Summary: This study developed an acoustic 2D focusing method for real-time online characterization of protein microcrystals in capillaries. By achieving focusing and controlling concentration, the data collection rate was improved, which aids in the development of improved sample delivery systems.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Karl Olofsson, Bjorn Hammarstrom, Martin Wiklund
Article
Biochemical Research Methods
Anke Urbansky, Franziska Olm, Stefan Scheding, Thomas Laurell, Andreas Lenshof