期刊
LAB ON A CHIP
卷 12, 期 4, 页码 702-704出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc21058d
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- JST, Japan
We have developed a method to analyze the substrate transport of ATP-binding cassette (ABC) transporters, which are associated with drug resistance in tumor cells. Our microfluidic method is well suited to the single-vesicle estimation of substrate transport and the rapid drug screening of ABC transporters. Using this method, we have demonstrated, for the first time, the analysis of substrate transport by a single transporter and performed drug-inhibition experiments in less than 3 h.
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