Article
Agriculture, Multidisciplinary
Kai-Jing Yin, Jing-Nan Ren, Xiao Li, Gang Fan, Lei Zhao, Zhi Li, Lu-Lu Zhang, Ding-Yuan Xie, Si-Yi Pan, Fang Yuan
Summary: A high-fat diet resulted in significant weight gain, depression-related behavior, decreased preference for sweeteners, increased lipid content in the blood, and decreased gene expression related to dopamine and opioid receptors in mice.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Multidisciplinary Sciences
Mariana Acquarone, A. Poleto, A. F. Perozzo, P. F. R. Goncalves, R. Panizzutti, J. R. L. Menezes, G. A. Neves, Helene Santos Barbosa
Summary: Chronic infection with Toxoplasma gondii may induce behavioral changes associated with neuropsychiatric disorders and dysfunction in glutamatergic neurotransmission, but behavioral and cognitive aspects remain maintained in infected mice despite severe neural damage.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Samuel Hogarth, Emily J. Jaehne, Xiangjun Xu, Quenten Schwarz, Maarten van den Buuse
Summary: The aim of this study was to investigate the role of BDNF and dopamine D3 receptors in the effects of chronic methamphetamine on prepulse inhibition (PPI), an endophenotype of psychosis. The results showed that chronic methamphetamine disrupted PPI regulation in male mice with BDNF haploinsufficiency, regardless of D3 receptor knockout. However, there were no effects of BDNF heterozygosity or D3 knockout on PPI regulation in female mice. These findings suggest a significant involvement of BDNF in the long-term effects of methamphetamine on PPI, particularly in male mice.
Article
Biochemistry & Molecular Biology
Bernardo Stutz, Michael J. Waterson, Matija Sestan-Pesa, Marcelo O. Dietrich, Mario Skarica, Nenad Sestan, Bence Racz, Aletta Magyar, Peter Sotonyi, Zhong-Wu Liu, Xiao-Bing Gao, Ferenc Matyas, Milan Stoiljkovic, Tamas L. Horvath
Summary: This study reveals the important role of hypothalamic AgRP neurons in the control of neuronal pathways that regulate higher-order brain functions during development and adulthood. Impairment or inhibition of AgRP neurons leads to changes in the medial prefrontal cortex, affecting network activity, sensorimotor gating, and ambulatory behavior. These effects are transduced via dopaminergic neurons and may also involve medial thalamic neurons.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Guanlong Guo, Jiaxin Tang, Mengwen Shi, Chengmei Yang, Huaxing Ou, Weihai Chen
Summary: The study revealed that the 5-HT2C receptor agonist MK212 can reverse PPI deficits by influencing the medial prefrontal cortex and ventral hippocampus, while the 5-HT2C receptor antagonist SB242084 is ineffective. This suggests a critical role of these two brain regions in the reversal of PPI deficits.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Nutrition & Dietetics
Jian Han, Pragya Nepal, Anuoluwapo Odelade, Frederick D. Freely, Destiny M. Belton, Joseph L. Graves, Antoniette M. Maldonado-Devincci
Summary: Chronic exposure to a high-fat diet can lead to weight gain and behavioral deficits. In C57BL/6J mice, these effects begin at the 3rd month of dietary exposure and behavioral deficits occur at around 3-4 months after increased body weight.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yangsik Kim, Esther Yang, Hyun Kim
Summary: The study found that deletion of IRSp53 in mice leads to a decrease in prepulse inhibition (PPI), indicating that dysfunction of various modulatory neurons may result in PPI impairment. This suggests that PPI could be broadly affected by changes in various types of modulatory neurons.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Hannah F. Waguespack, Rafael S. Maior, Carolina Campos-Rodriguez, Jessica T. Jacobs, Ludise Malkova, Patrick A. Forcelli
Summary: Sensorimotor gating is disrupted in neuropsychiatric disorders, and prepulse inhibition (PPI) is a form of sensorimotor gating that has been widely studied in rodents. However, recent research shows differences in the circuitry controlling PPI between rodents and macaques. While the nucleus accumbens is a key modulatory node for PPI in rodents, its role in primates has yet to be investigated. In this study, we found that quinpirole disrupts PPI in macaques when infused into the nucleus accumbens, unlike muscimol which had no effect.
Article
Behavioral Sciences
Auxiliadora Mena, Sandra Lopez, Juan C. Ruiz-Salas, Aaron Fernandez, Francisco J. Perez-Diaz, Juan C. Lopez
Summary: The study aimed to analyze the relationship between the adult medial prefrontal cortex (mPfc) and dopaminergic involvement in PPI, finding that dopamine is essential for modulating PPI during adulthood, and mPfc plays a crucial role in this modulation.
BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Huaxing Ou, Jiaxin Tang, Guanlong Guo, Mengwen Shi, Chengmei Yang, Weihai Chen
Summary: The 5-HT2A receptor is involved in schizophrenia and the regulation of PPI. Selective 5-HT2A receptor agonists and antagonists have different effects on PPI in rats. The ventral pallidum and nucleus accumbens are critical brain regions responsible for the regulation of PPI by 5-HT2A receptor activity.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Psychiatry
Yangsik Kim, Young Woo Noh, Kyungdeok Kim, Eunjoon Kim
Summary: The lack of IRSp53 results in decreased PPI, and the hyperactive ACC-MDT pathway suppresses PPI.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Jianfeng Liu, Stoyan Dimitrov, Anuck Sawangjit, Jan Born, Ingrid Ehrlich, Manfred Hallschmid
Summary: The study found that three days of high-fat diet reduces synaptic strength in the hypothalamus of rats, but this effect is reversible with normal diet. High-fat diet also increases energy intake, hormone levels in the blood, and duration of wakefulness.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Haelim Jeong, Jun Young Park, Ji-Hyun Lee, Ja-Hyun Baik, Chae-Yeon Kim, Jin-Young Cho, Monica Driscoll, Young-Ki Paik
Summary: The discovery of rcat-1 as a novel negative transcriptional regulator for dopamine metabolism genes has provided insights into the regulation of food search-associated locomotion. The mutants of rcat-1 exhibit abnormal movement behaviors and potential deficiencies in food sensing or locomotion toward food. This finding not only identifies a new subtype of dopamine-related behaviors but also suggests a potential therapeutic target in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
David Erritzoe, Beata R. Godlewska, Gaia Rizzo, Graham E. Searle, Claudio Agnorelli, Yvonne Lewis, Abhishekh H. Ashok, Alessandro Colasanti, Iro Boura, Chloe Farrell, Hollie Parfitt, Oliver Howes, Jan Passchier, Roger N. Gunn, Marios Politis, David J. Nutt, Philip J. Cowen, Gitte M. Knudsen, Eugenii A. Rabiner
Summary: This study compared brain 5-HT release capacity between healthy individuals and patients with depression using [11C]Cimbi-36 positron emission tomography (PET). The results showed that patients with depression have reduced 5-HT release capacity, providing direct evidence for serotonergic dysfunction in depression.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Zhen Tian, Xinyue Wang, Tianshu Han, Maoqing Wang, Hua Ning, Changhao Sun
Summary: In this study, the activation of MAOB under pathological conditions was found to be a novel source of cardiovascular ROS. This ROS-induced endothelial dysfunction contributes to chronic vascular inflammation and atherosclerosis. The study also revealed the role of MAOB inhibitor in reducing oxidative stress and improving endothelial function through modulating gut microbiota.
Article
Neurosciences
Shinsuke Hidese, Miho Ota, Chisato Wakabayashi, Takamasa Noda, Hayato Ozawa, Tsutomu Okubo, Hiroshi Kunugi
ACTA NEUROPSYCHIATRICA
(2017)
Article
Clinical Neurology
Emiko Aizawa, Hirokazu Tsuji, Takashi Asahara, Takuya Takahashi, Toshiya Teraishi, Sumiko Yoshida, Miho Ota, Norie Koga, Kotaro Hattori, Hiroshi Kunugi
JOURNAL OF AFFECTIVE DISORDERS
(2016)
Article
Psychiatry
Hiroaki Hori, Node Koga, Shinsuke Hidese, Anna Nagashima, Yoshiharu Kim, Teruhiko Higuchi, Hiroshi Kunugi
JOURNAL OF PSYCHIATRIC RESEARCH
(2016)
Article
Psychiatry
Junko Matsuo, Miho Ota, Hiroaki Hori, Shinsuke Hidese, Toshiya Teraishi, Ikki Ishida, Moeko Hiraishi, Hiroshi Kunugi
JOURNAL OF PSYCHIATRIC RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Aya Yoshimura, Tadahiro Numakawa, Haruki Odaka, Naoki Adachi, Yoshitaka Tamai, Hiroshi Kunugi
NEUROCHEMISTRY INTERNATIONAL
(2016)
Article
Neurosciences
A. Jalsrai, T. Numakawa, H. Kunugi, D. C. Dieterich, A. Becker
Article
Neurosciences
Shinsuke Hidese, Miho Ota, Chisato Wakabayashi, Takamasa Noda, Hayato Ozawa, Tsutomu Okubo, Hiroshi Kunugi
ACTA NEUROPSYCHIATRICA
(2017)
Article
Psychiatry
Takashi Fujii, Kotaro Hattori, Tomoko Miyakawa, Yoshiaki Ohashi, Hajime Sato, Hiroshi Kunugi
SCHIZOPHRENIA RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Kosuke Saito, Kotaro Hattori, Tomohiro Andou, Yoshinori Satomi, Masamitsu Gotou, Hiroyuki Kobayashi, Shinsuke Hidese, Hiroshi Kunugi
Review
Food Science & Technology
Amira Mohammed Ali, Hiroshi Kunugi
Review
Environmental Sciences
Amira Mohammed Ali, Hiroshi Kunugi
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Review
Biochemistry & Molecular Biology
Amira Mohammed Ali, Hiroshi Kunugi
Summary: Bee honey and propolis are rich in bioactive compounds with antimicrobial, antiviral, and anti-inflammatory properties, showing potential benefits in fighting COVID-19. Flavonoids in propolis and honey may inhibit viral fusion, interactions that trigger cytokine storm, and viral replication. Propolis extracts delivered by nanocarriers exhibit better antiviral effects against SARS-CoV-2 than ethanolic extracts, showing promise as a potential adjuvant treatment for COVID-19.
Review
Environmental Sciences
Amira Mohammed Ali, Hiroshi Kunugi
Summary: Malnutrition is common among severe patients with COVID-19, especially elderly adults and those with comorbidities. Different nutritional screening approaches, such as NRS-2002 and CONUT, have shown promise in diagnosing malnutrition in these patients, while the CONUT score may provide a timely and effective alternative for identifying COVID-19 patients with high nutritional risk. Older males with inflammation, gastrointestinal symptoms, and pre-existing comorbidities are more susceptible to malnutrition and poor COVID-19 outcomes, highlighting the importance of nutritional monitoring and support.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Neurosciences
Amira Mohammed Ali, Amin Omar Hendawy, Ohoud Ahmad, Haleama Al Sabbah, Linda Smail, Hiroshi Kunugi
Summary: The study assessed the psychometric properties of the Perceived Stress Scale (10 items) in a sample of 379 female Emeriti students, finding good internal consistency and stability of the scale across different age, marital, and financial status groups. It was suggested that considering scores from both subscales and total score of the scale is important for a comprehensive evaluation of students' stress levels.
Review
Medicine, General & Internal
Amira Mohammed Ali, Hiroshi Kunugi
Summary: This review summarizes the mechanisms, assessment measures, and interventions related to skeletal muscle insult in COVID-19 patients, highlighting possible causes of muscle injury and the lack of interventions directed towards minimizing muscle loss.
MEDICINA-LITHUANIA
(2021)