期刊
LAB ON A CHIP
卷 11, 期 16, 页码 2725-2730出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1lc20320g
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资金
- BBSRC
- EPSRC
- RCUK
- EPSRC [EP/F040857/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/C511572/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/F040857/1] Funding Source: researchfish
The diagnosis of infectious diseases in the Developing World is technologically challenging requiring complex biological assays with a high analytical performance, at minimal cost. By using an opto-acoustic immunoassay technology, integrating components commonly used in mobile phone technologies, including surface acoustic wave (SAW) transducers to provide pressure driven flow and a CMOS camera to enable lensfree detection technique, we demonstrate the potential to produce such an assay. To achieve this, antibody functionalised microparticles were manipulated on a low-cost disposable cartridge using the surface acoustic waves and were then detected optically. Our results show that the biomarker, interferon-gamma, used for the diagnosis of diseases such as latent tuberculosis, can be detected at pM concentrations, within a few minutes (giving high sensitivity at a minimal cost).
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