期刊
LAB ON A CHIP
卷 11, 期 13, 页码 2222-2230出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1lc20127a
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资金
- NSF [0754880, 0930501]
- ONR
- Office of The Director, NIH [DP2OD006427]
- Bill & Melinda Gates Foundation
- Vodafone Americas Foundation
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB009222] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD006427] Funding Source: NIH RePORTER
We present a field-portable lensfree tomographic microscope, which can achieve sectional imaging of a large volume (similar to 20 mm(3)) on a chip with an axial resolution of < 7 mu m. In this compact tomographic imaging platform (weighing only similar to 110 grams), 24 light-emitting diodes (LEDs) that are each butt-coupled to a fibre-optic waveguide are controlled through a cost-effective micro-processor to sequentially illuminate the sample from different angles to record lensfree holograms of the sample that is placed on the top of a digital sensor array. In order to generate pixel super-resolved (SR) lensfree holograms and hence digitally improve the achievable lateral resolution, multiple sub-pixel shifted holograms are recorded at each illumination angle by electromagnetically actuating the fibre-optic waveguides using compact coils and magnets. These SR projection holograms obtained over an angular range of +/- 50 degrees are rapidly reconstructed to yield projection images of the sample, which can then be back-projected to compute tomograms of the objects on the sensor-chip. The performance of this compact and light-weight lensfree tomographic microscope is validated by imaging micro-beads of different dimensions as well as a Hymenolepis nana egg, which is an infectious parasitic flatworm. Achieving a decent three-dimensional spatial resolution, this field-portable on-chip optical tomographic microscope might provide a useful toolset for telemedicine and high-throughput imaging applications in resource-poor settings.
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