Article
Chemistry, Analytical
Meng Huang, Carlos Dorta-Quinones, Bradley A. Minch, Manfred Lindau
Summary: Complementary metal-oxide-semiconductor (CMOS) microelectrode arrays combine amplifier arrays with on-chip electrodes to offer high-throughput electrochemical sensing with high spatial and temporal resolution. The cyclic voltammetry (CV) method provides additional information about electrode properties and analytes. A CMOS integrated circuit (IC) with 16 channels and 64 electrodes per channel was demonstrated for cyclic voltammetry (CV) applications, enabling rigorous characterization of electrode performance for low-noise amperometric measurements.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Max L. Wang, Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: On-demand drug delivery systems combined with wireless implants can control drug release, reducing dosage and side effects. Researchers designed a release system based on a modified electroresponsive polypyrrole nanoparticulate film for negatively charged compounds. They also developed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. The feasibility of wireless, controllable drug release was demonstrated through in vitro and in vivo characterization using fluorescein as a model drug.
Review
Chemistry, Multidisciplinary
Weikang Luo, Ruizeng Luo, Jingjing Liu, Zhou Li, Yang Wang
Summary: This review provides a comprehensive insight into recent advances in self-powered controlled drug release systems based on nanogenerators. It emphasizes the importance of autonomous devices and discusses the challenges and prospects from clinical needs and practical translation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiao-Ke Yang, Fu-Li Zhang, Wen-Tao Wu, Yun Tang, Jing Yan, Yan-Ling Liu, Christian Amatore, Wei-Hua Huang
Summary: An electrochemical Glu nanobiosensor was introduced to measure Glu fluxes released via exocytosis by large Glu vesicles in living hippocampal neurons. The study revealed a sub-quantal release mode, where only one third to one half of intravesicular Glu molecules are released by individual vesicles during exocytotic events.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Sarah Perry, Yifu Han, Chengjie Qiu, Chun Chien, Pragya Goel, Samantha Nishimura, Manisha Sajnani, Andreas Schmid, Stephan J. Sigrist, Dion Dickman
Summary: This study identifies a calcium-independent signaling system where active CaMKII detects a short domain encoded in a glutamate receptor C-tail, which gates retrograde homeostatic communication at a model glutamatergic synapse.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Ronaldo Badenhorst, Evgeny Katz, Oleh Smutok
Summary: In this study, bovine serum albumin (BSA) was immobilized on a buckypaper electrode using covalent bonds. By controlling the local pH, BSA release was achieved. Blocking the formation of affinity bonds was crucial for protein release.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Analytical
Hamid Salehzadeh
Summary: The electrochemical modification and behavior of the acetaminophen derivatized electrode are strongly influenced by potential and pH. The release of NAPQI and acetamide can be controlled through applied potential and pH.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jack R. Lake, Alvaro Moreno Soto, Kripa K. Varanasi
Summary: This study investigates how electrochemical bubbles dynamically alter the electrochemically active surface area during bubble evolution. The researchers discover that the most densely microtextured electrodes have the lowest performance due to the inactivation induced by bubbles growing within the denser microtexture. Furthermore, the study shows that the area beneath adhered bubbles is electrochemically active, contrary to currently held assumptions.
Article
Neurosciences
Erwin Neher, Holger Taschenberger
Summary: The study introduces an analysis technique to decompose quantal release during repetitive stimulation, revealing contributions from functionally distinct synaptic vesicle subpools in rat calyx of Held synapses. The high variability in synaptic strength and short-term plasticity of these synapses is successfully described by the method.
Article
Neurosciences
Peter H. Chipman, Richard D. Fetter, Lauren C. Panzera, Samuel J. Bergerson, Daniel Karmelic, Sae Yokoyama, Michael B. Hoppa, Graeme W. Davis
Summary: Homeostatic plasticity is a physiological process that counteracts neuronal perturbations in the brain. Acute AMPAR-specific antagonism can induce compensatory plasticity, leading to potentiation of presynaptic neurotransmitter release. This process can be induced within minutes and requires postsynaptic NMDARs.
Article
Materials Science, Biomaterials
Zhili Wang, Zeen Wu, Na Sun, Yi Cao, Xue Cai, Feng Yuan, Hanqing Zou, Chungen Xing, Renjun Pei
Summary: By coating magnetic nanoparticles with a hydrogel layer, high-efficiency capture and recovery of CTCs were achieved with high specificity and stable cell recovery rate.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Analytical
Yang Bu, Sheng Ni, Levent Yobas
Summary: This article investigates the mechanism of synchronous coefficient of drag alteration and finds that using a microfabricated artificial sieve can reduce the purification time of DNA from hours to minutes. An electrophoretic protocol is also proposed to facilitate the collection of purified DNA from the sieve, which can be used for rapid diagnostic applications.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jin Soo Kang, Seoni Kim, T. Alan Hatton
Summary: Emerging electrochemical CO2 capture and release technologies offer a solution by using redox-active sorbents and mediators to reduce energy requirements and broaden the scope for system modifications.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2021)
Article
Chemistry, Analytical
Ishana Kathuria, Arvind Kumar, Satish Kumar
Summary: The research successfully synthesized a photochromic oxazine compound and utilized mercuric ion-induced structural alteration for colorimetric detection of heavy metal ions. The detection process was studied using various techniques including naked eye observation, UV-Visible spectroscopy, cyclic voltammetry, and smartphone-based methods.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Unghwi Lee, Chunghon Choi, Seung Hyun Ryu, Daehun Park, Sang-Eun Lee, Kitae Kim, Yujin Kim, Sunghoe Chang
Summary: The study found that SCAMP5 interacts with NHE6 and regulates NHE6 recruitment to glutamatergic presynaptic terminals. Knockdown of SCAMP5 or perturbation of SCAMP5/NHE6 interaction inhibited axonal trafficking and the presynaptic localization of NHE6, leading to SV hyperacidification. This suggests that SCAMP5 plays a key role in regulating synaptic strength through adjustment of quantal size, and disruptions in their interaction may contribute to synaptic dysfunction in autism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Holly A. Holman, Vy M. Tran, Mausam Kalita, Lynn N. Nguyen, Sailaja Arungundram, Balagurunathan Kuberan, Richard D. Rabbitt
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2016)
Article
Acoustics
M. M. Iversen, D. A. Christensen, D. L. Parker, H. A. Holman, J. Chen, M. J. Frerck, R. D. Rabbitt
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2017)
Article
Neurosciences
Lauren A. Poppi, Hessam Tabatabaee, Hannah R. Drury, Phillip Jobling, Robert J. Callister, Americo A. Migliaccio, Paivi M. Jordan, Joseph C. Holt, Richard D. Rabbitt, Rebecca Lim, Alan M. Brichta
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Ricardo Araujo, Vincent Fernandez, Richard D. Rabbitt, Eric G. Ekdale, Miguel T. Antunes, Rui Castanhinha, Joerg Froebisch, Rui M. S. Martins
Article
Multidisciplinary Sciences
M. M. Iversen, H. Zhu, W. Zhou, C. C. Della Santina, J. P. Carey, R. D. Rabbitt
SCIENTIFIC REPORTS
(2018)
Review
Neurosciences
R. D. Rabbitt
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Article
Neurosciences
Holly A. Holman, Lauren A. Poppi, Micah Frerck, Richard D. Rabbitt
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Editorial Material
Neurosciences
Henrique von Gersdorff, Marta M. Iversen, Richard D. Rabbitt
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Multidisciplinary Sciences
Maria C. Perez-Flores, Jeong H. Lee, Seojin Park, Xiao-Dong Zhang, Choong-Ryoul Sihn, Hannah A. Ledford, Wenying Wang, Hyo Jeong Kim, Valeriy Timofeyev, Vladimir Yarov-Yarovoy, Nipavan Chiamvimonvat, Richard D. Rabbitt, Ebenezer N. Yamoah
Article
Multidisciplinary Sciences
Holly A. Holman, Yong Wan, Richard D. Rabbitt
Article
Multidisciplinary Sciences
Richard D. Rabbitt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Jan Kubanek, Matthew Wilson, Richard D. Rabbitt, Celeste J. Armstrong, Alexander J. Farley, H. M. Arif Ullah, Alex Shcheglovitov
Summary: By studying human brain organoids, we found that ultrasound stimulation can modulate the activity of neural networks in the brain, which is important for personalized diagnosis and treatment of brain disorders.
Article
Multidisciplinary Sciences
Richard D. Rabbitt, Tamara C. Bidone
Summary: This study investigates the variation of cochlear outer hair cell (OHC) properties along the tonotopic map to optimize electromechanical power conversion. A simple model of a single isolated OHC driving a mechanical load was used for testing. Results indicate the presence of three non-dimensional ratios that optimize power conversion, which should be universal constants independent of frequency and species. These ratios act as control parameters to maximize power output by positioning the OHC operating point on the edge of a dynamic instability.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Neurosciences
Leo L. Shen, Nicholas S. Andresen, Divya A. Chari, Jacob M. Pogson, Amanda M. Lauer, Richard D. Rabbitt, John P. Carey, Felipe Santos, Bryan K. Ward
Summary: Meniere's disease is a debilitating disorder with unclear pathophysiology. This study examines the dissociation between two vestibular function tests commonly used in patients with MD and reveals the presence of otolith membrane herniation in the semicircular canals of MD ears, which is associated with abnormal caloric responses. The study also suggests the relative size of the membranous duct to the bony canal may be important in understanding the mechanisms of MD.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2023)
Article
Biophysics
Marta M. Iversen, Richard D. Rabbitt
BIOPHYSICAL JOURNAL
(2017)